CA3143509A1 - Compositions et methodes de traitement de troubles du snc - Google Patents

Compositions et methodes de traitement de troubles du snc Download PDF

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Publication number
CA3143509A1
CA3143509A1 CA3143509A CA3143509A CA3143509A1 CA 3143509 A1 CA3143509 A1 CA 3143509A1 CA 3143509 A CA3143509 A CA 3143509A CA 3143509 A CA3143509 A CA 3143509A CA 3143509 A1 CA3143509 A1 CA 3143509A1
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CA
Canada
Prior art keywords
substituted
unsubstituted
rga
group
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3143509A
Other languages
English (en)
Inventor
Francesco G. Salituro
Maria Jesus Blanco-Pillado
Marshall Lee Morningstar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sage Therapeutics Inc
Original Assignee
Sage Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sage Therapeutics Inc filed Critical Sage Therapeutics Inc
Publication of CA3143509A1 publication Critical patent/CA3143509A1/fr
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J61/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by contraction of only one ring by one or two atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/002—Expansion of ring A by one atom, e.g. A homo steroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

L'invention concerne un composé de Formule I, II, IlIa, IlIb, V, VIa, Vlb, VII, VIII, IX, ou XI : ou un sel pharmaceutiquement acceptable de celui-ci, des compositions pharmaceutiques comprenant un composé de formule I, IlIa, IlIb, V, VIa, VIb, VII, VIII, IX, ou X, et des procédés d'utilisation des composés, par exemple dans le traitement de troubles liés au SNC.
CA3143509A 2019-06-27 2020-06-29 Compositions et methodes de traitement de troubles du snc Pending CA3143509A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962867618P 2019-06-27 2019-06-27
US62/867,618 2019-06-27
PCT/US2020/040153 WO2020264509A1 (fr) 2019-06-27 2020-06-29 Compositions et méthodes de traitement de troubles du snc

Publications (1)

Publication Number Publication Date
CA3143509A1 true CA3143509A1 (fr) 2020-12-30

Family

ID=71728947

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3143509A Pending CA3143509A1 (fr) 2019-06-27 2020-06-29 Compositions et methodes de traitement de troubles du snc

Country Status (13)

Country Link
US (1) US12552829B2 (fr)
EP (1) EP3990469A1 (fr)
JP (2) JP7787635B2 (fr)
KR (1) KR20220038680A (fr)
CN (1) CN114391019A (fr)
AR (1) AR119305A1 (fr)
AU (1) AU2020302748A1 (fr)
BR (1) BR112021026462A2 (fr)
CA (1) CA3143509A1 (fr)
IL (1) IL289172A (fr)
MX (3) MX2021015942A (fr)
TW (1) TWI896547B (fr)
WO (1) WO2020264509A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2882708A1 (fr) 2012-08-21 2014-02-27 Sage Therapeutics, Inc. Procedes de traitement de l'epilepsie ou d'un etat de mal epileptique
KR102396328B1 (ko) 2013-04-17 2022-05-10 세이지 테라퓨틱스, 인크. 19-노르 c3,3-이치환된 c21-n-피라졸릴 스테로이드 및 그의 사용 방법
US10246482B2 (en) 2014-06-18 2019-04-02 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
JOP20200195A1 (ar) 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
WO2016082789A1 (fr) 2014-11-27 2016-06-02 Sage Therapeutics, Inc. Compositions et procédés pour traiter des troubles du snc
EP3504189A1 (fr) 2016-08-23 2019-07-03 Sage Therapeutics, Inc. Stéroïde c21-n-pyrazolyle 3-disubstitué en 19-nor c3 cristallin
MA51046A (fr) 2017-12-08 2021-03-17 Sage Therapeutics Inc Dérivés de 21-[4-cyano-pyrazol-1-yl]-19-nor-pregan-3. alpha-ol-20-one deutérés pour le traitement de troubles du snc
SG11202112391UA (en) 2019-05-31 2021-12-30 Sage Therapeutics Inc Neuroactive steroids and compositions thereof
CA3143509A1 (fr) 2019-06-27 2020-12-30 Sage Therapeutics, Inc. Compositions et methodes de traitement de troubles du snc

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2969M (fr) 1963-05-22 1964-11-30 Roussel Uclaf Nouveau médicament notamment pour le traitement des spasmes d'origine coronarienne on viscérale.
ES432106A1 (es) 1973-11-30 1976-11-01 Schering Ag Procedimiento para la preparacion de d-homo-20-cetopregna- nos.
IL48628A0 (en) 1974-12-23 1976-02-29 Schering Ag D-homo-20-keto-pregnanes and process for their manufactur
GB1570394A (en) 1976-01-06 1980-07-02 Glaxo Lab Ltd 11-acyloxy-3-hydroxy steroids
US4060295A (en) 1976-03-15 1977-11-29 Molex Incorporated Zero insertion force printed circuit board edge connector assembly
GB1581234A (en) 1976-04-05 1980-12-10 Glaxo Operations Ltd 11a - amino - 3a - hydroxysteroids
GB1581235A (en) 1977-04-04 1980-12-10 Glaxo Operations Ltd 11a-amino-3a-hydroxy-steroids
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
NZ298567A (en) 1994-11-23 2000-01-28 Cocensys Inc Androstane and pregnane derivatives, pharmaceutical compositions and methods of treatment
WO1998005337A1 (fr) 1996-08-01 1998-02-12 Cocensys, Inc. Utilisation de ligands de recepteurs gaba et nmda pour le traitement des cephalees de la migraine
WO2005105822A2 (fr) 2004-04-23 2005-11-10 Euro-Celtique S.A. Procede de fabrication de steroides 3-alpha-hydroxy sustitues, nouveaux derives de steroides et leurs applications
CN101585862B (zh) * 2008-05-20 2014-12-17 梅克芳股份公司 甾族化合物
CA2848212C (fr) 2011-09-08 2022-03-29 Sage Therapeutics, Inc. Steroides neuroactifs, compositions et leurs utilisations
KR102396328B1 (ko) 2013-04-17 2022-05-10 세이지 테라퓨틱스, 인크. 19-노르 c3,3-이치환된 c21-n-피라졸릴 스테로이드 및 그의 사용 방법
ES2805598T3 (es) 2014-05-29 2021-02-12 Sage Therapeutics Inc Esteroides neuroactivos, composiciones y usos de los mismos
CN117024501A (zh) * 2014-10-16 2023-11-10 萨奇治疗股份有限公司 靶向cns障碍的组合物和方法
WO2017049044A1 (fr) 2015-09-16 2017-03-23 Bartolucci Giampiero Acide ursodésoxycholique et de troubles cérébraux
KR20240157128A (ko) 2016-03-08 2024-10-31 세이지 테라퓨틱스, 인크. 신경활성 스테로이드, 조성물, 및 그의 용도
WO2018013615A1 (fr) * 2016-07-11 2018-01-18 Sage Therapeutics, Inc. Stéroïdes neuroactifs substitués en c7, c12 et c16 et méthodes d'utilisation associées
CA3068462A1 (fr) 2017-06-23 2019-12-27 The Board Of Trustees Of The University Of Illinois Traitement des troubles neuropsychiatriques a l'aide de neurosteroides et analogues de ceux-ci
WO2019041078A1 (fr) 2017-08-28 2019-03-07 Zhejiang Jiachi Pharmaceutical Development Ltd. Synthèse asymétrique et utilisations de composés dans des traitements de maladies
WO2019051264A1 (fr) * 2017-09-07 2019-03-14 Sage Therapeutics, Inc. Stéroïdes neuroactifs et leurs méthodes d'utilisation
BR112020012761A2 (pt) * 2017-12-22 2021-02-17 Sage Therapeutics, Inc. composições e métodos para o tratamento de distúrbios do snc
WO2019154257A1 (fr) 2018-02-11 2019-08-15 江苏豪森药业集团有限公司 Régulateur de dérivé de stéroïde, son procédé de préparation et son utilisation
KR20250174100A (ko) 2018-12-05 2025-12-11 세이지 테라퓨틱스, 인크. 신경활성 스테로이드 및 이의 사용 방법
CN115651054B (zh) 2019-01-08 2024-06-21 成都康弘药业集团股份有限公司 甾体类化合物、用途及其制备方法
WO2020210117A1 (fr) * 2019-04-08 2020-10-15 Athenen Therapeutics, Inc. Stéroïdes ayant des propriétés pharmacocinétiques modifiées et leurs procédés d'utilisation
WO2020210116A1 (fr) * 2019-04-08 2020-10-15 Athenen Therapeutics, Inc. Stéroïdes ayant des propriétés pharmacocinétiques modifiées et leurs procédés d'utilisation
SG11202112391UA (en) * 2019-05-31 2021-12-30 Sage Therapeutics Inc Neuroactive steroids and compositions thereof
JP7754725B2 (ja) 2019-06-27 2025-10-15 セージ セラピューティクス， インコーポレイテッド Ｃｎｓ障害を治療するための組成物及び方法
CA3143509A1 (fr) * 2019-06-27 2020-12-30 Sage Therapeutics, Inc. Compositions et methodes de traitement de troubles du snc
CN114729000A (zh) 2019-06-27 2022-07-08 萨奇治疗股份有限公司 用于治疗cns病症的化合物
WO2022115381A1 (fr) * 2020-11-25 2022-06-02 Sage Therapeutics, Onc. Compositions et méthodes de traitement de troubles du système nerveux central et application associée

Also Published As

Publication number Publication date
JP2022538299A (ja) 2022-09-01
IL289172A (en) 2022-02-01
US20220380405A1 (en) 2022-12-01
WO2020264509A1 (fr) 2020-12-30
JP7787635B2 (ja) 2025-12-17
CN114391019A (zh) 2022-04-22
AR119305A1 (es) 2021-12-09
MX2021015942A (es) 2022-04-18
MX2024009925A (es) 2024-08-22
BR112021026462A2 (pt) 2022-03-15
TWI896547B (zh) 2025-09-11
EP3990469A1 (fr) 2022-05-04
MX2024009926A (es) 2024-08-22
TW202114700A (zh) 2021-04-16
US20230303616A9 (en) 2023-09-28
JP2025060984A (ja) 2025-04-10
AU2020302748A1 (en) 2022-01-06
US12552829B2 (en) 2026-02-17
KR20220038680A (ko) 2022-03-29

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