CA3169140C - Extraction d'alcaloides psychoactifs capables de phosphorylation a dephosphorylation controlee - Google Patents

Extraction d'alcaloides psychoactifs capables de phosphorylation a dephosphorylation controlee

Info

Publication number
CA3169140C
CA3169140C CA3169140A CA3169140A CA3169140C CA 3169140 C CA3169140 C CA 3169140C CA 3169140 A CA3169140 A CA 3169140A CA 3169140 A CA3169140 A CA 3169140A CA 3169140 C CA3169140 C CA 3169140C
Authority
CA
Canada
Prior art keywords
psychoactive
alkaloid
solvent
weight
psychoactive alkaloid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3169140A
Other languages
English (en)
Other versions
CA3169140A1 (fr
Inventor
Benjamin Lightburn
Ryan Moss
Lisa Ranken
Original Assignee
Psilo Scientific Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA3088384A external-priority patent/CA3088384C/fr
Priority claimed from CA3097246A external-priority patent/CA3097246C/fr
Priority claimed from CA3101765A external-priority patent/CA3101765A1/fr
Priority claimed from CA3103707A external-priority patent/CA3103707C/fr
Application filed by Psilo Scientific Ltd filed Critical Psilo Scientific Ltd
Priority to CA3173030A priority Critical patent/CA3173030C/fr
Publication of CA3169140A1 publication Critical patent/CA3169140A1/fr
Application granted granted Critical
Publication of CA3169140C publication Critical patent/CA3169140C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/078—Psilocybe
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0215—Solid material in other stationary receptacles
    • B01D11/0253—Fluidised bed of solid materials
    • B01D11/0257—Fluidised bed of solid materials using mixing mechanisms, e.g. stirrers, jets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/028—Flow sheets
    • B01D11/0284—Multistage extraction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0288—Applications, solvents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0292—Treatment of the solvent

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Linvention concerne lextraction de composés psychoactifs dorganismes destinés à être utilisés en médecine. L'extraction est réalisée avec un acide fort ou une base forte pour favoriser ou inhiber la déphosphorylation. L'extrait sous forme de suspension est standardisé avec un excipient ajouté de sorte que, lorsque lextrait est séché, la composition en poudre a une concentration en alcaloïde psychoactif totale spécifiée selon un rapport connu dalcaloïdes psychoactifs phosphorylés et déphosphorylés.
CA3169140A 2020-06-17 2021-06-14 Extraction d'alcaloides psychoactifs capables de phosphorylation a dephosphorylation controlee Active CA3169140C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3173030A CA3173030C (fr) 2020-06-17 2021-06-14 Extraction d'alcaloide psychoactif principalement phosphoryle au moyen d'alcali

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US202063040317P 2020-06-17 2020-06-17
US63/040,317 2020-06-17
US202063046089P 2020-06-30 2020-06-30
US63/046,089 2020-06-30
CA3088384A CA3088384C (fr) 2020-06-17 2020-07-29 Extraction de composes psychoactifs de champignons psilocybines
CA3088384 2020-07-29
CA3089455A CA3089455C (fr) 2020-06-17 2020-08-07 Extraction au methanol de composes psychoactifs de champignons
CA3089455 2020-08-07
CA3097246A CA3097246C (fr) 2020-10-23 2020-10-23 Processus d`obtention d`une solution alcaloide psychoactive purifiee
CA3097246 2020-10-23
CA3101765 2020-12-04
CA3101765A CA3101765A1 (fr) 2020-12-04 2020-12-04 Extraction d'alcaloide psychoactif et composition avec dephosphorylation controlee
CA3103707 2020-12-18
CA3103707A CA3103707C (fr) 2020-12-18 2020-12-18 Composition normalisee d'extrait d'alcaloide psychoactif

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA3137016A Division CA3137016C (fr) 2019-06-17 2021-06-14 Extraction d'alcaloide psychoactif et composition avec dephosphorylationattenuees

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3173030A Division CA3173030C (fr) 2020-06-17 2021-06-14 Extraction d'alcaloide psychoactif principalement phosphoryle au moyen d'alcali

Publications (2)

Publication Number Publication Date
CA3169140A1 CA3169140A1 (fr) 2021-12-17
CA3169140C true CA3169140C (fr) 2024-10-22

Family

ID=79268788

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3173030A Active CA3173030C (fr) 2020-06-17 2021-06-14 Extraction d'alcaloide psychoactif principalement phosphoryle au moyen d'alcali
CA3169140A Active CA3169140C (fr) 2020-06-17 2021-06-14 Extraction d'alcaloides psychoactifs capables de phosphorylation a dephosphorylation controlee

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA3173030A Active CA3173030C (fr) 2020-06-17 2021-06-14 Extraction d'alcaloide psychoactif principalement phosphoryle au moyen d'alcali

Country Status (2)

Country Link
CA (2) CA3173030C (fr)
WO (1) WO2021253116A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114787363A (zh) 2019-10-01 2022-07-22 恩派瑞安神经科学公司 对真菌进行遗传工程化以调节色胺表达
CA3200255A1 (fr) * 2020-12-16 2022-06-23 Andrew R. Chadeayne Composes d'amanite tue-mouche
WO2022153266A1 (fr) 2021-01-15 2022-07-21 Beckley Psytech Limited Analogues d'ergoline
US11312684B1 (en) 2021-02-10 2022-04-26 Eleusis Therapeutics Us, Inc. Pharmaceutically acceptable salts of psilocin and uses thereof
US20220370413A1 (en) 2021-03-06 2022-11-24 Mind Medicine, Inc. Formulations of psilocin that have enhanced stability
WO2023130078A2 (fr) 2021-12-31 2023-07-06 Empyrean Neuroscience, Inc. Mycélium génétiquement modifié pour la production d'alcaloïdes psychotropes
EP4486448A1 (fr) 2022-03-04 2025-01-08 Reset Pharmaceuticals, Inc. Co-cristaux ou sels comprenant de la psilocine
US12264131B2 (en) 2022-08-19 2025-04-01 Beckley Psytech Limited Pharmaceutically acceptable salts and compositions thereof
US12246005B2 (en) 2023-06-13 2025-03-11 Beckley Psytech Limited 5-methoxy-n,n-dimethyltryptamine (5-MeO-DMT) formulations
GB202313750D0 (en) * 2023-09-08 2023-10-25 Psyence Group Inc A process for obtaining a purified psychoactive alkaloid

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU36879A1 (fr) 1958-02-21

Also Published As

Publication number Publication date
CA3173030A1 (fr) 2021-12-17
CA3173030C (fr) 2024-05-14
CA3169140A1 (fr) 2021-12-17
WO2021253116A1 (fr) 2021-12-23

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US11510952B2 (en) Ethanol extraction of psychoactive compounds from psilocybin fungus
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