CA3173702A1 - Nouveaux agents antiviraux derives de la spiropyrrolidine - Google Patents

Nouveaux agents antiviraux derives de la spiropyrrolidine Download PDF

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Publication number
CA3173702A1
CA3173702A1 CA3173702A CA3173702A CA3173702A1 CA 3173702 A1 CA3173702 A1 CA 3173702A1 CA 3173702 A CA3173702 A CA 3173702A CA 3173702 A CA3173702 A CA 3173702A CA 3173702 A1 CA3173702 A1 CA 3173702A1
Authority
CA
Canada
Prior art keywords
optionally substituted
compound
nri3r14
acetone
nmr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3173702A
Other languages
English (en)
Inventor
Ruichao Shen
Yong He
Xuechao Xing
Matthew C. Rhodes
Joseph D. Panarese
Samuel Bartlett
Wei Li
Hui Cao
Jiajun Zhang
Xiaowen Peng
Guoqiang Wang
Yat Sun Or
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Enanta Pharmaceuticals Inc
Original Assignee
Enanta Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US17/479,248 external-priority patent/US11325916B1/en
Application filed by Enanta Pharmaceuticals Inc filed Critical Enanta Pharmaceuticals Inc
Priority claimed from PCT/US2022/024772 external-priority patent/WO2023009187A1/fr
Publication of CA3173702A1 publication Critical patent/CA3173702A1/fr
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3173702A 2021-07-29 2022-04-14 Nouveaux agents antiviraux derives de la spiropyrrolidine Pending CA3173702A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202163227206P 2021-07-29 2021-07-29
US63/227,206 2021-07-29
US17/479,248 2021-09-20
US17/479,248 US11325916B1 (en) 2021-07-29 2021-09-20 Spiropyrrolidine derived antiviral agents
US202263324367P 2022-03-28 2022-03-28
US63/324,367 2022-03-28
PCT/US2022/024772 WO2023009187A1 (fr) 2021-07-29 2022-04-14 Nouveaux agents antiviraux dérivés de spiropyrrolidine

Publications (1)

Publication Number Publication Date
CA3173702A1 true CA3173702A1 (fr) 2023-01-29

Family

ID=85025187

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3173702A Pending CA3173702A1 (fr) 2021-07-29 2022-04-14 Nouveaux agents antiviraux derives de la spiropyrrolidine

Country Status (7)

Country Link
EP (1) EP4376834A4 (fr)
JP (1) JP2024529476A (fr)
KR (1) KR20240044452A (fr)
AU (1) AU2022319598A1 (fr)
CA (1) CA3173702A1 (fr)
IL (1) IL310246A (fr)
MX (1) MX2024001377A (fr)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006061714A2 (fr) * 2004-12-09 2006-06-15 Pfizer Inc. Compositions et composes anti-coronaviraux, leur utilisation pharmaceutique et materiaux destines a leur synthese
NZ575193A (en) * 2006-08-30 2011-12-22 Unversity Of Michigan Small molecule inhibitors of MDM2 comprising a spiropyrrolidine
JP2010519329A (ja) * 2007-02-27 2010-06-03 バーテックス ファーマシューティカルズ インコーポレイテッド セリンプロテアーゼ阻害剤
TW201817714A (zh) * 2016-08-30 2018-05-16 英商葛蘭素史密斯克藍智慧財產權有限公司 抑制3c及3cl蛋白酶之化合物及其使用方法
US12398147B2 (en) * 2021-05-11 2025-08-26 Enanta Pharmaceuticals, Inc. Macrocyclic spiropyrrolidine derived antiviral agents
US11919910B2 (en) * 2021-11-12 2024-03-05 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
CN118909031B (zh) * 2021-12-29 2025-05-27 上海柯君医药科技有限公司 抗冠状病毒化合物及其组合物和用途

Also Published As

Publication number Publication date
KR20240044452A (ko) 2024-04-04
AU2022319598A1 (en) 2024-02-08
IL310246A (en) 2024-03-01
MX2024001377A (es) 2024-03-08
EP4376834A1 (fr) 2024-06-05
EP4376834A4 (fr) 2025-06-18
JP2024529476A (ja) 2024-08-06

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