CA3201704A1 - Derives de tetrahydrocannabinol a base de silicium et leurs compositions - Google Patents

Derives de tetrahydrocannabinol a base de silicium et leurs compositions

Info

Publication number
CA3201704A1
CA3201704A1 CA3201704A CA3201704A CA3201704A1 CA 3201704 A1 CA3201704 A1 CA 3201704A1 CA 3201704 A CA3201704 A CA 3201704A CA 3201704 A CA3201704 A CA 3201704A CA 3201704 A1 CA3201704 A1 CA 3201704A1
Authority
CA
Canada
Prior art keywords
silicon
tetrahydrocannabinol
derivative according
group
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3201704A
Other languages
English (en)
Inventor
Barry C. Arkles
Taewoo Min
Jonathan D. Goff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gelest Inc
Original Assignee
Gelest Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gelest Inc filed Critical Gelest Inc
Publication of CA3201704A1 publication Critical patent/CA3201704A1/fr
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0834—Compounds having one or more O-Si linkage
    • C07F7/0838—Compounds with one or more Si-O-Si sequences
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
    • A61K8/585—Organosilicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/10—General cosmetic use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Birds (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

L'invention concerne des dérivés de tétrahydrocannabinol à base de silicium et des procédés pour leur synthèse, les dérivés contenant une molécule de tétrahydrocannabinol et au moins un groupe à base de silicium contenant des liaisons Si-O-Si. Les dérivés sont utiles dans des compositions topiques et dermatologiques, ont des propriétés topiques bénéfiques potentielles, et améliorent la solubilité et la compatibilité dans des formulations topiques et dermatologiques contenant les matériaux à base de silicium.
CA3201704A 2020-12-10 2020-12-10 Derives de tetrahydrocannabinol a base de silicium et leurs compositions Pending CA3201704A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2020/064235 WO2022125095A1 (fr) 2020-12-10 2020-12-10 Dérivés de tétrahydrocannabinol à base de silicium et leurs compositions

Publications (1)

Publication Number Publication Date
CA3201704A1 true CA3201704A1 (fr) 2022-06-16

Family

ID=74125705

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3201704A Pending CA3201704A1 (fr) 2020-12-10 2020-12-10 Derives de tetrahydrocannabinol a base de silicium et leurs compositions

Country Status (6)

Country Link
EP (1) EP4259065A1 (fr)
JP (1) JP7637241B2 (fr)
KR (1) KR102980081B1 (fr)
CN (1) CN116685595A (fr)
CA (1) CA3201704A1 (fr)
WO (1) WO2022125095A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4471038A1 (fr) * 2023-05-30 2024-12-04 Tresco Holding GmbH Procédé de synthèse de diméthylsiloxane à l'acide tétrahydrocannabinolique et diméthylsiloxane à l'acide tétrahydrocannabinolique

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5292899A (en) * 1991-11-27 1994-03-08 Synthetic Technology Corporation Synthesis of 11-nor-Δ-9-tetrahydrocannabinol-9-carboxylic acid glucuronide
FR2854896B1 (fr) * 2003-05-16 2007-08-17 Mayoly Spindler Lab Nouveaux tensioactifs, compositions les comprenant
DK2176208T3 (en) 2007-07-30 2015-04-27 Zynerba Pharmaceuticals Inc Prodrugs of cannabidiol, compositions containing prodrugs of cannabidiol and methods of use thereof
PL2963031T3 (pl) 2007-11-30 2019-08-30 Zynerba Pharmaceuticals, Inc. Proleki tetrahydrokannabinolu, kompozycje zawierające proleki tetrahydrokannabinolu i sposoby ich stosowania
WO2018148785A1 (fr) * 2017-02-15 2018-08-23 Botanix Pharmaceuticals Ltd Formulations de cannabinoïdes pour le traitement de la dermatite et de maladies cutanées inflammatoires
WO2018148787A1 (fr) * 2017-02-15 2018-08-23 Botanix Pharmaceuticals Ltd Formulations de cannabinoïdes pour le traitement du psoriasis
WO2020214574A1 (fr) * 2019-04-15 2020-10-22 Trustees Of Boston University Synthèse à médiation par l'écoulement en une étape de cannabidiol (cbd) et de ses dérivés
CN112047973B (zh) * 2019-06-06 2022-11-18 上海科技大学 一种大麻素类化合物，其制备方法、组合物和用途

Also Published As

Publication number Publication date
JP2023554329A (ja) 2023-12-27
KR102980081B1 (ko) 2026-06-19
EP4259065A1 (fr) 2023-10-18
CN116685595A (zh) 2023-09-01
KR20230143137A (ko) 2023-10-11
WO2022125095A1 (fr) 2022-06-16
JP7637241B2 (ja) 2025-02-27

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