CA3247638A1 - Traitement de patients souffrant de carcinome pulmonaire non à petites cellules (cpnpc) avec des thérapies lymphocytaires infiltrant les tumeurs - Google Patents

Traitement de patients souffrant de carcinome pulmonaire non à petites cellules (cpnpc) avec des thérapies lymphocytaires infiltrant les tumeurs

Info

Publication number
CA3247638A1
CA3247638A1 CA3247638A CA3247638A CA3247638A1 CA 3247638 A1 CA3247638 A1 CA 3247638A1 CA 3247638 A CA3247638 A CA 3247638A CA 3247638 A CA3247638 A CA 3247638A CA 3247638 A1 CA3247638 A1 CA 3247638A1
Authority
CA
Canada
Prior art keywords
tils
population
tumor
days
expansion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3247638A
Other languages
English (en)
Inventor
Maria Fardis
Friedrich Graf Finck VON FINCKENSTEIN
Frederick G. Vogt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Iovance Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iovance Biotherapeutics Inc filed Critical Iovance Biotherapeutics Inc
Publication of CA3247638A1 publication Critical patent/CA3247638A1/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2302—Interleukin-2 (IL-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/515—CD3, T-cell receptor complex

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

"Il est décrit des procédés et des méthodes améliorés et/ou raccourcis pour préparer des lymphocytes infiltrant les tumeurs afin de préparer des populations thérapeutiques de lymphocytes infiltrant les tumeurs avec une efficacité thérapeutique accrue pour le traitement du cancer, y compris le carcinome pulmonaire non à petites cellules (CPNPC), où le CPNPC est réfractaire au traitement avec un anticorps anti-PD-1 et/ou un anticorps anti-PD-Ll et/ou un inhibiteur du facteur de croissance de l'endothélium vasculaire, et/ou où le cancer, par exemple ou CPNPC, présente un score de proportion tumorale prédéterminé, et y compris lorsque les lymphocytes infiltrant les tumeurs pour l'expansion sont obtenus avant que le patient ne reçoive un traitement anticancéreux."
CA3247638A 2022-04-06 2023-04-05 Traitement de patients souffrant de carcinome pulmonaire non à petites cellules (cpnpc) avec des thérapies lymphocytaires infiltrant les tumeurs Pending CA3247638A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263328236P 2022-04-06 2022-04-06
US63/328,236 2022-04-06
PCT/US2023/065404 WO2023196877A1 (fr) 2022-04-06 2023-04-05 Traitement de patients souffrant de cpnpc avec des thérapies lymphocytaires infiltrant les tumeurs

Publications (1)

Publication Number Publication Date
CA3247638A1 true CA3247638A1 (fr) 2023-10-12

Family

ID=86424695

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3247638A Pending CA3247638A1 (fr) 2022-04-06 2023-04-05 Traitement de patients souffrant de carcinome pulmonaire non à petites cellules (cpnpc) avec des thérapies lymphocytaires infiltrant les tumeurs

Country Status (4)

Country Link
EP (1) EP4504220A1 (fr)
JP (1) JP2025512313A (fr)
CA (1) CA3247638A1 (fr)
WO (1) WO2023196877A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025101484A1 (fr) * 2023-11-06 2025-05-15 Iovance Biotherapeutics, Inc. Traitement de cancers endométriaux avec des thérapies lymphocytaires infiltrant les tumeurs
WO2025189025A2 (fr) * 2024-03-07 2025-09-12 Biontech Us Inc. Procédés et compositions pour ingénierie de lymphocytes t

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