CA976085A - Method of preparing protamine alkali metal or ammonium insulin - Google Patents

Method of preparing protamine alkali metal or ammonium insulin

Info

Publication number: CA976085A
Authority: CA; Canada
Prior art keywords: alkali metal; protamine; preparing; ammonium insulin; insulin
Prior art date: 1971-04-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA140,826A

Other languages

English (en)

Other versions

CA140826S (en

Inventor

Richard L. Jackson

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Eli Lilly and Co

Original Assignee

Eli Lilly and Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1971-04-30

Filing date

1972-04-28

Publication date

1975-10-14

1972-04-28 Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co

1975-10-14 Application granted granted Critical

1975-10-14 Publication of CA976085A publication Critical patent/CA976085A/en

Status Expired legal-status Critical Current

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 title 1
102000004877 Insulin Human genes 0.000 title 1
108090001061 Insulin Proteins 0.000 title 1
102000007327 Protamines Human genes 0.000 title 1
108010007568 Protamines Proteins 0.000 title 1
229910052783 alkali metal Inorganic materials 0.000 title 1
150000001340 alkali metals Chemical class 0.000 title 1
229940125396 insulin Drugs 0.000 title 1
229940048914 protamine Drugs 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

CA140,826A 1971-04-30 1972-04-28 Method of preparing protamine alkali metal or ammonium insulin Expired CA976085A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US13912071A	1971-04-30	1971-04-30

Publications (1)

Publication Number	Publication Date
CA976085A true CA976085A (en)	1975-10-14

Family

ID=22485216

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA140,826A Expired CA976085A (en)	1971-04-30	1972-04-28	Method of preparing protamine alkali metal or ammonium insulin

Country Status (23)

Country	Link
US (1)	US3758683A (de)
JP (1)	JPS5735185B1 (de)
BE (1)	BE782651A (de)
CA (1)	CA976085A (de)
CH (1)	CH566784A5 (de)
CS (1)	CS209458B2 (de)
DD (1)	DD100708A5 (de)
DE (1)	DE2219635C3 (de)
DK (1)	DK131760C (de)
ES (1)	ES402176A1 (de)
FI (1)	FI49773C (de)
FR (1)	FR2134658B1 (de)
GB (1)	GB1385086A (de)
HU (1)	HU166989B (de)
IL (1)	IL39181A (de)
NL (1)	NL178258C (de)
NO (1)	NO137178C (de)
PL (1)	PL86966B1 (de)
RO (1)	RO64387A (de)
SE (1)	SE378066B (de)
SU (1)	SU508162A3 (de)
YU (1)	YU36155B (de)
ZA (1)	ZA722243B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK140801B (da) *	1975-01-15	1979-11-19	Nordisk Insulinlab	Fremgangsmåde til fremstilling af et stabilt langtidsvirkende insulinpræparat.
NL193099C (nl) *	1981-10-30	1998-11-03	Novo Industri As	Gestabiliseerde insuline-oplossing.
WO1988002633A1 (en) *	1986-10-20	1988-04-21	Novo Industri A/S	Protamine zinc insulin preparations
ES2053723T3 (es) *	1987-02-25	1994-08-01	Novo Nordisk As	Nuevos derivados de insulina.
DE19726167B4 (de) *	1997-06-20	2008-01-24	Sanofi-Aventis Deutschland Gmbh	Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
US6624141B1 (en) *	1999-03-17	2003-09-23	The Regents Of The University Of Michigan	Protamine fragment compositions and methods of use
DE10114178A1 (de) *	2001-03-23	2002-10-10	Aventis Pharma Gmbh	Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
DE10227232A1 (de) *	2002-06-18	2004-01-15	Aventis Pharma Deutschland Gmbh	Saure Insulinzubereitungen mit verbesserter Stabilität
PT3228320T (pt)	2008-10-17	2020-03-26	Sanofi Aventis Deutschland	Combinação de uma insulina e de um agonista do glp-1
PH12011502708B1 (en)	2009-07-06	2017-11-10	Sanofi Aventis Deutschland	Insulin preparations containing methionine
SG10201500871TA (en)	2009-11-13	2015-04-29	Sanofi Aventis Deutschland	Pharmaceutical composition comprising a glp-1 agonist and methionine
JP5832439B2 (ja)	2009-11-13	2015-12-16	サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング	Ｇｌｐ−１アゴニスト、インスリン及びメチオニンを含む薬学的組成物
CN103179978A (zh)	2010-08-30	2013-06-26	赛诺菲-安万特德国有限公司	Ave0010用于制造供治疗2型糖尿病用的药物的用途
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
JP6367115B2 (ja)	2011-08-29	2018-08-01	サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング	２型糖尿病患者の血糖コントロールに使用する組合せ医薬
TWI559929B (en)	2011-09-01	2016-12-01	Sanofi Aventis Deutschland	Pharmaceutical composition for use in the treatment of a neurodegenerative disease
CN107206058A (zh)	2014-12-12	2017-09-26	赛诺菲-安万特德国有限公司	甘精胰岛素/利西拉来固定比率配制剂
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
BR112020002804A2 (pt)	2017-08-24	2020-07-28	Novo Nordisk A/S	composição farmacêutica líquida, e, kit
IL294521A (en)	2020-02-18	2022-09-01	Novo Nordisk As	glp-1 compounds and their uses
CN122005837A (zh) *	2023-08-07	2026-05-12	浙江大学	一种糖响应鱼精蛋白胰岛素及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR5038E (fr) *	1904-03-09	1905-12-02	Georges Frederic Brade	Perfectionnements dans la fabrication des organes du métronome
GB889769A (en) *	1957-07-18	1962-02-21	Nordisk Insulinlab	Slowly acting insulin preparation in crystalline form

1971
- 1971-04-30 US US00139120A patent/US3758683A/en not_active Expired - Lifetime
1972
- 1972-04-04 ZA ZA722243A patent/ZA722243B/xx unknown
- 1972-04-10 IL IL39181A patent/IL39181A/en unknown
- 1972-04-17 FI FI721077A patent/FI49773C/fi active
- 1972-04-20 DD DD162448A patent/DD100708A5/xx unknown
- 1972-04-21 DE DE2219635A patent/DE2219635C3/de not_active Expired
- 1972-04-24 NO NO1423/72A patent/NO137178C/no unknown
- 1972-04-26 SU SU1778186A patent/SU508162A3/ru active
- 1972-04-26 BE BE782651A patent/BE782651A/xx not_active IP Right Cessation
- 1972-04-26 JP JP4209072A patent/JPS5735185B1/ja active Pending
- 1972-04-27 DK DK209472A patent/DK131760C/da not_active IP Right Cessation
- 1972-04-27 PL PL1972155003A patent/PL86966B1/pl unknown
- 1972-04-27 ES ES402176A patent/ES402176A1/es not_active Expired
- 1972-04-28 CH CH633872A patent/CH566784A5/xx not_active IP Right Cessation
- 1972-04-28 CA CA140,826A patent/CA976085A/en not_active Expired
- 1972-04-28 NL NLAANVRAGE7205865,A patent/NL178258C/xx not_active IP Right Cessation
- 1972-04-28 HU HUEI419A patent/HU166989B/hu unknown
- 1972-04-28 GB GB1974172A patent/GB1385086A/en not_active Expired
- 1972-04-28 FR FR7215270A patent/FR2134658B1/fr not_active Expired
- 1972-04-28 YU YU1142/72A patent/YU36155B/xx unknown
- 1972-04-28 SE SE7205698A patent/SE378066B/xx unknown
- 1972-04-28 CS CS722923A patent/CS209458B2/cs unknown
- 1972-04-29 RO RO7270743A patent/RO64387A/ro unknown

Also Published As

Publication number	Publication date
IL39181A0 (en)	1972-06-28
DK131760B (da)	1975-09-01
NO137178C (no)	1978-01-18
YU114272A (en)	1981-06-30
JPS5735185B1 (de)	1982-07-27
DE2219635C3 (de)	1981-10-15
US3758683A (en)	1973-09-11
ZA722243B (en)	1973-11-28
NO137178B (no)	1977-10-10
HU166989B (de)	1975-07-28
SU508162A3 (ru)	1976-03-25
NL7205865A (de)	1972-11-01
NL178258B (nl)	1985-09-16
RO64387A (fr)	1979-07-15
DE2219635A1 (de)	1972-11-09
FI49773B (de)	1975-06-30
DD100708A5 (de)	1973-10-05
FR2134658B1 (de)	1975-10-17
PL86966B1 (de)	1976-06-30
BE782651A (fr)	1972-10-26
FI49773C (fi)	1975-10-10
IL39181A (en)	1974-09-10
DK131760C (da)	1976-02-02
ES402176A1 (es)	1975-03-01
GB1385086A (en)	1975-02-26
CH566784A5 (de)	1975-09-30
YU36155B (en)	1982-02-25
NL178258C (nl)	1986-02-17
SE378066B (de)	1975-08-18
DE2219635B2 (de)	1980-11-27
FR2134658A1 (de)	1972-12-08
CS209458B2 (en)	1981-12-31

Publication	Publication Date	Title
YU36155B (en)	1982-02-25	Process for obtaining alkali metal or ammonium saltes of insulin-protamine complex
CA980088A (en)	1975-12-23	Methods for production of alkali metal polysilicates
AU464307B2 (en)	1975-08-21	Process forthe preparation of urea
CA1025851A (en)	1978-02-07	Process for manufacturing alkali metal or ammonium insulin
CA987208A (en)	1976-04-13	Method of pretreating metal surfaces
CA974880A (en)	1975-09-23	Long-acting injectable zn or a1 salt preparations of gonadotropins
CA961274A (en)	1975-01-21	Process for recovery of metal values
AU446386B2 (en)	1974-03-21	Method of preparing acrylic powders
CA998203A (en)	1976-10-12	Modified alkali metal hexatitanate and process of producing same
CA962455A (en)	1975-02-11	Recovery of refractory metal values
AU479548B2 (en)	1975-12-04	Process for manufacturing alkali metal or ammonium insulin
CA972923A (en)	1975-08-19	Process for the preparation of ammonium nitrate
AU454143B2 (en)	1973-11-01	A method of preparing a titanium oxide
AU464459B2 (en)	1975-08-13	Production of ammonium phosphates
CA924069A (en)	1973-04-10	Method of producing elongated highly-densified powdered metal articles
CA968916A (en)	1975-06-10	Method of forming shaped metal articles
CA908941A (en)	1972-09-05	Mixed alkali metal polyphosphates and methods of preparing them
CA988274A (en)	1976-05-04	Method of manufacturing alkali metal silicofluorides
CA887635A (en)	1971-12-07	Mechanical working of malleable metals
CA866113A (en)	1971-03-16	Process for stabilizing alkali metal and alkaline earth metal hydrides
CA881324A (en)	1971-09-21	Recovery of metal values by leaching
CA941690A (en)	1974-02-12	Method of making metal articles
CA834748A (en)	1970-02-17	Method of preparing phosphonoalkylene ammonium compounds
CA862270A (en)	1971-01-26	Electrolysis of alkali metal compounds
CA848973A (en)	1970-08-11	Method of reacting rosin with formaldehyde