NL178258C - Werkwijze ter bereiding van een insulinezout-protaminecomplex en werkwijze ter bereiding van een insulinepreparaat. - Google Patents

Werkwijze ter bereiding van een insulinezout-protaminecomplex en werkwijze ter bereiding van een insulinepreparaat.

Info

Publication number: NL178258C
Authority: NL; Netherlands
Prior art keywords: preparing; insulin; salt; protamine complex; preparation
Prior art date: 1971-04-30

Application number

NLAANVRAGE7205865,A

Other languages

English (en)

Dutch (nl)

Other versions

NL7205865A (de

NL178258B (nl

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1971-04-30

Filing date

1972-04-28

Publication date

1986-02-17

1972-04-28 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1972-11-01 Publication of NL7205865A publication Critical patent/NL7205865A/xx

1985-09-16 Publication of NL178258B publication Critical patent/NL178258B/xx

1986-02-17 Application granted granted Critical

1986-02-17 Publication of NL178258C publication Critical patent/NL178258C/xx

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 3
238000004519 manufacturing process Methods 0.000 title 2
102000004877 Insulin Human genes 0.000 title 1
108090001061 Insulin Proteins 0.000 title 1
102000007327 Protamines Human genes 0.000 title 1
108010007568 Protamines Proteins 0.000 title 1
229940125396 insulin Drugs 0.000 title 1
229940048914 protamine Drugs 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

NLAANVRAGE7205865,A 1971-04-30 1972-04-28 Werkwijze ter bereiding van een insulinezout-protaminecomplex en werkwijze ter bereiding van een insulinepreparaat. NL178258C (nl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US13912071A	1971-04-30	1971-04-30

Publications (3)

Publication Number	Publication Date
NL7205865A NL7205865A (de)	1972-11-01
NL178258B NL178258B (nl)	1985-09-16
NL178258C true NL178258C (nl)	1986-02-17

Family

ID=22485216

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NLAANVRAGE7205865,A NL178258C (nl)	1971-04-30	1972-04-28	Werkwijze ter bereiding van een insulinezout-protaminecomplex en werkwijze ter bereiding van een insulinepreparaat.

Country Status (23)

Country	Link
US (1)	US3758683A (de)
JP (1)	JPS5735185B1 (de)
BE (1)	BE782651A (de)
CA (1)	CA976085A (de)
CH (1)	CH566784A5 (de)
CS (1)	CS209458B2 (de)
DD (1)	DD100708A5 (de)
DE (1)	DE2219635C3 (de)
DK (1)	DK131760C (de)
ES (1)	ES402176A1 (de)
FI (1)	FI49773C (de)
FR (1)	FR2134658B1 (de)
GB (1)	GB1385086A (de)
HU (1)	HU166989B (de)
IL (1)	IL39181A (de)
NL (1)	NL178258C (de)
NO (1)	NO137178C (de)
PL (1)	PL86966B1 (de)
RO (1)	RO64387A (de)
SE (1)	SE378066B (de)
SU (1)	SU508162A3 (de)
YU (1)	YU36155B (de)
ZA (1)	ZA722243B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK140801B (da) *	1975-01-15	1979-11-19	Nordisk Insulinlab	Fremgangsmåde til fremstilling af et stabilt langtidsvirkende insulinpræparat.
NL193099C (nl) *	1981-10-30	1998-11-03	Novo Industri As	Gestabiliseerde insuline-oplossing.
WO1988002633A1 (en) *	1986-10-20	1988-04-21	Novo Industri A/S	Protamine zinc insulin preparations
ES2053723T3 (es) *	1987-02-25	1994-08-01	Novo Nordisk As	Nuevos derivados de insulina.
DE19726167B4 (de) *	1997-06-20	2008-01-24	Sanofi-Aventis Deutschland Gmbh	Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
US6624141B1 (en) *	1999-03-17	2003-09-23	The Regents Of The University Of Michigan	Protamine fragment compositions and methods of use
DE10114178A1 (de) *	2001-03-23	2002-10-10	Aventis Pharma Gmbh	Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
DE10227232A1 (de) *	2002-06-18	2004-01-15	Aventis Pharma Deutschland Gmbh	Saure Insulinzubereitungen mit verbesserter Stabilität
PT3228320T (pt)	2008-10-17	2020-03-26	Sanofi Aventis Deutschland	Combinação de uma insulina e de um agonista do glp-1
PH12011502708B1 (en)	2009-07-06	2017-11-10	Sanofi Aventis Deutschland	Insulin preparations containing methionine
SG10201500871TA (en)	2009-11-13	2015-04-29	Sanofi Aventis Deutschland	Pharmaceutical composition comprising a glp-1 agonist and methionine
JP5832439B2 (ja)	2009-11-13	2015-12-16	サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング	Ｇｌｐ−１アゴニスト、インスリン及びメチオニンを含む薬学的組成物
CN103179978A (zh)	2010-08-30	2013-06-26	赛诺菲-安万特德国有限公司	Ave0010用于制造供治疗2型糖尿病用的药物的用途
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
JP6367115B2 (ja)	2011-08-29	2018-08-01	サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング	２型糖尿病患者の血糖コントロールに使用する組合せ医薬
TWI559929B (en)	2011-09-01	2016-12-01	Sanofi Aventis Deutschland	Pharmaceutical composition for use in the treatment of a neurodegenerative disease
CN107206058A (zh)	2014-12-12	2017-09-26	赛诺菲-安万特德国有限公司	甘精胰岛素/利西拉来固定比率配制剂
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
BR112020002804A2 (pt)	2017-08-24	2020-07-28	Novo Nordisk A/S	composição farmacêutica líquida, e, kit
IL294521A (en)	2020-02-18	2022-09-01	Novo Nordisk As	glp-1 compounds and their uses
CN122005837A (zh) *	2023-08-07	2026-05-12	浙江大学	一种糖响应鱼精蛋白胰岛素及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR5038E (fr) *	1904-03-09	1905-12-02	Georges Frederic Brade	Perfectionnements dans la fabrication des organes du métronome
GB889769A (en) *	1957-07-18	1962-02-21	Nordisk Insulinlab	Slowly acting insulin preparation in crystalline form

1971
- 1971-04-30 US US00139120A patent/US3758683A/en not_active Expired - Lifetime
1972
- 1972-04-04 ZA ZA722243A patent/ZA722243B/xx unknown
- 1972-04-10 IL IL39181A patent/IL39181A/en unknown
- 1972-04-17 FI FI721077A patent/FI49773C/fi active
- 1972-04-20 DD DD162448A patent/DD100708A5/xx unknown
- 1972-04-21 DE DE2219635A patent/DE2219635C3/de not_active Expired
- 1972-04-24 NO NO1423/72A patent/NO137178C/no unknown
- 1972-04-26 SU SU1778186A patent/SU508162A3/ru active
- 1972-04-26 BE BE782651A patent/BE782651A/xx not_active IP Right Cessation
- 1972-04-26 JP JP4209072A patent/JPS5735185B1/ja active Pending
- 1972-04-27 DK DK209472A patent/DK131760C/da not_active IP Right Cessation
- 1972-04-27 PL PL1972155003A patent/PL86966B1/pl unknown
- 1972-04-27 ES ES402176A patent/ES402176A1/es not_active Expired
- 1972-04-28 CH CH633872A patent/CH566784A5/xx not_active IP Right Cessation
- 1972-04-28 CA CA140,826A patent/CA976085A/en not_active Expired
- 1972-04-28 NL NLAANVRAGE7205865,A patent/NL178258C/xx not_active IP Right Cessation
- 1972-04-28 HU HUEI419A patent/HU166989B/hu unknown
- 1972-04-28 GB GB1974172A patent/GB1385086A/en not_active Expired
- 1972-04-28 FR FR7215270A patent/FR2134658B1/fr not_active Expired
- 1972-04-28 YU YU1142/72A patent/YU36155B/xx unknown
- 1972-04-28 SE SE7205698A patent/SE378066B/xx unknown
- 1972-04-28 CS CS722923A patent/CS209458B2/cs unknown
- 1972-04-29 RO RO7270743A patent/RO64387A/ro unknown

Also Published As

Publication number	Publication date
IL39181A0 (en)	1972-06-28
DK131760B (da)	1975-09-01
NO137178C (no)	1978-01-18
YU114272A (en)	1981-06-30
JPS5735185B1 (de)	1982-07-27
CA976085A (en)	1975-10-14
DE2219635C3 (de)	1981-10-15
US3758683A (en)	1973-09-11
ZA722243B (en)	1973-11-28
NO137178B (no)	1977-10-10
HU166989B (de)	1975-07-28
SU508162A3 (ru)	1976-03-25
NL7205865A (de)	1972-11-01
NL178258B (nl)	1985-09-16
RO64387A (fr)	1979-07-15
DE2219635A1 (de)	1972-11-09
FI49773B (de)	1975-06-30
DD100708A5 (de)	1973-10-05
FR2134658B1 (de)	1975-10-17
PL86966B1 (de)	1976-06-30
BE782651A (fr)	1972-10-26
FI49773C (fi)	1975-10-10
IL39181A (en)	1974-09-10
DK131760C (da)	1976-02-02
ES402176A1 (es)	1975-03-01
GB1385086A (en)	1975-02-26
CH566784A5 (de)	1975-09-30
YU36155B (en)	1982-02-25
SE378066B (de)	1975-08-18
DE2219635B2 (de)	1980-11-27
FR2134658A1 (de)	1972-12-08
CS209458B2 (en)	1981-12-31

Legal Events

Date	Code	Title
1979-05-25	BA	A request for search or an international-type search has been filed
1981-02-25	BB	A search report has been drawn up
1981-07-01	BC	A request for examination has been filed
1985-01-01	A85	Still pending on 85-01-01
1988-12-16	V1	Lapsed because of non-payment of the annual fee

Publication	Publication Date	Title
NL178258B (nl)	1985-09-16	Werkwijze ter bereiding van een insulinezout-protaminecomplex en werkwijze ter bereiding van een insulinepreparaat.
NL152908B (nl)	1977-04-15	Werkwijze ter bereiding van een poederlakpreparaat.
NL152909B (nl)	1977-04-15	Werkwijze ter bereiding van een poederlakpreparaat.
NL174943C (nl)	1984-09-03	Werkwijze ter bereiding van farmaceutische preparaten en werkwijze ter bereiding van een 8-azapurin-6-onderivaat.
NL158072B (nl)	1978-10-16	Werkwijze ter bereiding van een kosmetisch preparaat.
NL159083B (nl)	1979-01-15	Werkwijze ter bereiding van chinonen.
BE813801A (nl)	1974-10-16	Huid-preparaat.
NL148634B (nl)	1976-02-16	Werkwijze ter bereiding van poederlakpreparaten.
NL174547C (nl)	1984-07-02	Werkwijze ter bereiding van benzoylpropionzuurderivaten, werkwijze ter bereiding van farmaceutische preparaten en gevormde farmaceutische preparaten.
BG21611A3 (bg)	1976-07-20	Метод за получаване на цефалексинови комплекси
NL148635B (nl)	1976-02-16	Werkwijze ter bereiding van poederlakpreparaten.
FI51825C (fi)	1977-04-12	Menetelmä laktuloosijauheen valmistamiseksi.
NL173628C (nl)	1984-02-16	Werkwijze ter bereiding van alfa-aluminiumoxyde.
NL177386B (nl)	1985-04-16	Werkwijze ter bereiding van een farmaceutisch preparaat met anti-allergische werking.
NL161742C (nl)	1980-03-17	Werkwijze ter bereiding van een optisch actief alfa-amino-arylacetonitrile.
NL152578B (nl)	1977-03-15	Werkwijze ter bereiding van carbodiimideschuimen.
NL166971C (nl)	1981-10-15	Werkwijze ter bereiding van zinkstof bevattende, corro- siewerende bekledingspreparaten.
NL156710B (nl)	1978-05-16	Werkwijze ter bereiding van sorptiemiddelen, alsmede gevormde sorptiemiddelen bereid volgens deze werkwijze.
NL174798C (nl)	1984-08-16	Werkwijze ter bereiding van acaricide preparaten.
NL174356C (nl)	1984-06-01	Werkwijze ter bereiding van distannanen.
NL172126C (nl)	1983-07-18	Werkwijze ter bereiding van een oxychloreringskatalysator en gevormde voortbrengsels, bestaande uit de aldus bereide katalysator.
NL172049C (nl)	1983-07-01	Werkwijze ter bereiding van kunstmest.
NL168335B (nl)	1981-10-16	Werkwijze ter bereiding van een glycerol-standaard- oplossing.
NL152883B (nl)	1977-04-15	Werkwijze ter bereiding van een stijf schuim met carbodiimidegroepen.
NL7408383A (nl)	1975-02-11	Werkwijze ter bereiding van 3-thiafuranen en 3-mercaptofuranen.