CA976085A - Method of preparing protamine alkali metal or ammonium insulin - Google Patents

Method of preparing protamine alkali metal or ammonium insulin

Info

Publication number: CA976085A
Authority: CA; Canada
Prior art keywords: alkali metal; protamine; preparing; ammonium insulin; insulin
Prior art date: 1971-04-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA140,826A

Other languages

English (en)

Other versions

CA140826S (en

Inventor

Richard L. Jackson

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Eli Lilly and Co

Original Assignee

Eli Lilly and Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1971-04-30

Filing date

1972-04-28

Publication date

1975-10-14

1972-04-28 Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co

1975-10-14 Application granted granted Critical

1975-10-14 Publication of CA976085A publication Critical patent/CA976085A/en

Status Expired legal-status Critical Current

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 title 1
102000004877 Insulin Human genes 0.000 title 1
108090001061 Insulin Proteins 0.000 title 1
102000007327 Protamines Human genes 0.000 title 1
108010007568 Protamines Proteins 0.000 title 1
229910052783 alkali metal Inorganic materials 0.000 title 1
150000001340 alkali metals Chemical class 0.000 title 1
229940125396 insulin Drugs 0.000 title 1
229940048914 protamine Drugs 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

CA140,826A 1971-04-30 1972-04-28 Method of preparing protamine alkali metal or ammonium insulin Expired CA976085A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US13912071A	1971-04-30	1971-04-30

Publications (1)

Publication Number	Publication Date
CA976085A true CA976085A (en)	1975-10-14

Family

ID=22485216

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA140,826A Expired CA976085A (en)	1971-04-30	1972-04-28	Method of preparing protamine alkali metal or ammonium insulin

Country Status (23)

Country	Link
US (1)	US3758683A (pl)
JP (1)	JPS5735185B1 (pl)
BE (1)	BE782651A (pl)
CA (1)	CA976085A (pl)
CH (1)	CH566784A5 (pl)
CS (1)	CS209458B2 (pl)
DD (1)	DD100708A5 (pl)
DE (1)	DE2219635C3 (pl)
DK (1)	DK131760C (pl)
ES (1)	ES402176A1 (pl)
FI (1)	FI49773C (pl)
FR (1)	FR2134658B1 (pl)
GB (1)	GB1385086A (pl)
HU (1)	HU166989B (pl)
IL (1)	IL39181A (pl)
NL (1)	NL178258C (pl)
NO (1)	NO137178C (pl)
PL (1)	PL86966B1 (pl)
RO (1)	RO64387A (pl)
SE (1)	SE378066B (pl)
SU (1)	SU508162A3 (pl)
YU (1)	YU36155B (pl)
ZA (1)	ZA722243B (pl)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK140801B (da) *	1975-01-15	1979-11-19	Nordisk Insulinlab	Fremgangsmåde til fremstilling af et stabilt langtidsvirkende insulinpræparat.
NL193099C (nl) *	1981-10-30	1998-11-03	Novo Industri As	Gestabiliseerde insuline-oplossing.
AU8175387A (en) *	1986-10-20	1988-05-06	Novo Industri A/S	Protamine zinc insulin preparations
DE3880346T2 (de) *	1987-02-25	1993-07-29	Novonordisk As	Insulinderivate.
DE19726167B4 (de) *	1997-06-20	2008-01-24	Sanofi-Aventis Deutschland Gmbh	Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
US6624141B1 (en)	1999-03-17	2003-09-23	The Regents Of The University Of Michigan	Protamine fragment compositions and methods of use
DE10114178A1 (de) *	2001-03-23	2002-10-10	Aventis Pharma Gmbh	Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
DE10227232A1 (de) *	2002-06-18	2004-01-15	Aventis Pharma Deutschland Gmbh	Saure Insulinzubereitungen mit verbesserter Stabilität
PT3228320T (pt)	2008-10-17	2020-03-26	Sanofi Aventis Deutschland	Combinação de uma insulina e de um agonista do glp-1
KR101853606B1 (ko)	2009-07-06	2018-05-03	사노피-아벤티스 도이칠란트 게엠베하	메티오닌을 함유하는 수성 인슐린 제제
DK2498802T3 (en)	2009-11-13	2015-04-13	Sanofi Aventis Deutschland	Pharmaceutical composition comprising a GLP-1 agonist, insulin and a methionine
KR101337322B1 (ko)	2009-11-13	2013-12-06	사노피-아벤티스 도이칠란트 게엠베하	Ｇｌｐ-1 효능제 및 메티오닌을 포함하는 약제학적 조성물
ES2606554T3 (es)	2010-08-30	2017-03-24	Sanofi-Aventis Deutschland Gmbh	Uso de AVE0010 para la fabricación de un medicamento para el tratamiento de la diabetes mellitus de tipo 2
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
PL2750699T3 (pl)	2011-08-29	2015-12-31	Sanofi Aventis Deutschland	Kombinacja farmaceutyczna do stosowania w kontroli glikemii u pacjentów z cukrzycą typu 2
AR087744A1 (es)	2011-09-01	2014-04-16	Sanofi Aventis Deutschland	Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
AU2015359376B2 (en)	2014-12-12	2021-09-09	Sanofi-Aventis Deutschland Gmbh	Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
HUE066356T2 (hu)	2017-08-24	2024-07-28	Novo Nordisk As	GLP-1 készítmények és alkalmazásaik
PE20221575A1 (es)	2020-02-18	2022-10-06	Novo Nordisk As	Formulaciones farmaceuticas
WO2025031391A1 (zh) *	2023-08-07	2025-02-13	浙江大学	一种糖响应鱼精蛋白胰岛素及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR5038E (fr) *	1904-03-09	1905-12-02	Georges Frederic Brade	Perfectionnements dans la fabrication des organes du métronome
GB889769A (en) *	1957-07-18	1962-02-21	Nordisk Insulinlab	Slowly acting insulin preparation in crystalline form

1971
- 1971-04-30 US US00139120A patent/US3758683A/en not_active Expired - Lifetime
1972
- 1972-04-04 ZA ZA722243A patent/ZA722243B/xx unknown
- 1972-04-10 IL IL39181A patent/IL39181A/en unknown
- 1972-04-17 FI FI721077A patent/FI49773C/fi active
- 1972-04-20 DD DD162448A patent/DD100708A5/xx unknown
- 1972-04-21 DE DE2219635A patent/DE2219635C3/de not_active Expired
- 1972-04-24 NO NO1423/72A patent/NO137178C/no unknown
- 1972-04-26 SU SU1778186A patent/SU508162A3/ru active
- 1972-04-26 BE BE782651A patent/BE782651A/xx not_active IP Right Cessation
- 1972-04-26 JP JP4209072A patent/JPS5735185B1/ja active Pending
- 1972-04-27 ES ES402176A patent/ES402176A1/es not_active Expired
- 1972-04-27 DK DK209472A patent/DK131760C/da not_active IP Right Cessation
- 1972-04-27 PL PL1972155003A patent/PL86966B1/pl unknown
- 1972-04-28 FR FR7215270A patent/FR2134658B1/fr not_active Expired
- 1972-04-28 SE SE7205698A patent/SE378066B/xx unknown
- 1972-04-28 HU HUEI419A patent/HU166989B/hu unknown
- 1972-04-28 NL NLAANVRAGE7205865,A patent/NL178258C/xx not_active IP Right Cessation
- 1972-04-28 CS CS722923A patent/CS209458B2/cs unknown
- 1972-04-28 CA CA140,826A patent/CA976085A/en not_active Expired
- 1972-04-28 CH CH633872A patent/CH566784A5/xx not_active IP Right Cessation
- 1972-04-28 GB GB1974172A patent/GB1385086A/en not_active Expired
- 1972-04-28 YU YU1142/72A patent/YU36155B/xx unknown
- 1972-04-29 RO RO7270743A patent/RO64387A/ro unknown

Also Published As

Publication number	Publication date
YU114272A (en)	1981-06-30
NO137178C (no)	1978-01-18
NL7205865A (pl)	1972-11-01
FI49773C (fi)	1975-10-10
FR2134658A1 (pl)	1972-12-08
CH566784A5 (pl)	1975-09-30
RO64387A (fr)	1979-07-15
IL39181A (en)	1974-09-10
JPS5735185B1 (pl)	1982-07-27
CS209458B2 (en)	1981-12-31
DE2219635A1 (de)	1972-11-09
DE2219635C3 (de)	1981-10-15
SU508162A3 (ru)	1976-03-25
DK131760C (da)	1976-02-02
NL178258B (nl)	1985-09-16
SE378066B (pl)	1975-08-18
US3758683A (en)	1973-09-11
IL39181A0 (en)	1972-06-28
PL86966B1 (pl)	1976-06-30
NL178258C (nl)	1986-02-17
DD100708A5 (pl)	1973-10-05
BE782651A (fr)	1972-10-26
YU36155B (en)	1982-02-25
FR2134658B1 (pl)	1975-10-17
ES402176A1 (es)	1975-03-01
ZA722243B (en)	1973-11-28
GB1385086A (en)	1975-02-26
DE2219635B2 (de)	1980-11-27
HU166989B (pl)	1975-07-28
FI49773B (pl)	1975-06-30
NO137178B (no)	1977-10-10
DK131760B (da)	1975-09-01

Publication	Publication Date	Title
YU36155B (en)	1982-02-25	Process for obtaining alkali metal or ammonium saltes of insulin-protamine complex
CA980088A (en)	1975-12-23	Methods for production of alkali metal polysilicates
CA1025851A (en)	1978-02-07	Process for manufacturing alkali metal or ammonium insulin
AU464307B2 (en)	1975-08-21	Process forthe preparation of urea
CA987208A (en)	1976-04-13	Method of pretreating metal surfaces
CA974880A (en)	1975-09-23	Long-acting injectable zn or a1 salt preparations of gonadotropins
CA961274A (en)	1975-01-21	Process for recovery of metal values
CA962455A (en)	1975-02-11	Recovery of refractory metal values
CA972923A (en)	1975-08-19	Process for the preparation of ammonium nitrate
CA998203A (en)	1976-10-12	Modified alkali metal hexatitanate and process of producing same
CA978295A (en)	1975-11-18	Method of preparing acrylic powders
CA924069A (en)	1973-04-10	Method of producing elongated highly-densified powdered metal articles
CA968916A (en)	1975-06-10	Method of forming shaped metal articles
CA908941A (en)	1972-09-05	Mixed alkali metal polyphosphates and methods of preparing them
AU479548B2 (en)	1975-12-04	Process for manufacturing alkali metal or ammonium insulin
CA988274A (en)	1976-05-04	Method of manufacturing alkali metal silicofluorides
CA887635A (en)	1971-12-07	Mechanical working of malleable metals
CA866113A (en)	1971-03-16	Process for stabilizing alkali metal and alkaline earth metal hydrides
CA881324A (en)	1971-09-21	Recovery of metal values by leaching
CA941690A (en)	1974-02-12	Method of making metal articles
CA834748A (en)	1970-02-17	Method of preparing phosphonoalkylene ammonium compounds
CA862270A (en)	1971-01-26	Electrolysis of alkali metal compounds
CA848973A (en)	1970-08-11	Method of reacting rosin with formaldehyde
PH9766A (en)	1976-03-12	Process for preparing alkali metal and ammonium polyacrylates
CA882274A (en)	1971-09-28	Method of preparing blood smears