CH113104A - Process for the preparation of a compound of diallyl barbituric acid. - Google Patents

Process for the preparation of a compound of diallyl barbituric acid.

Info

Publication number
CH113104A
CH113104A CH113104DA CH113104A CH 113104 A CH113104 A CH 113104A CH 113104D A CH113104D A CH 113104DA CH 113104 A CH113104 A CH 113104A
Authority
CH
Switzerland
Prior art keywords
compound
barbituric acid
dimethyl
phenyl
acid
Prior art date
Application number
Other languages
German (de)
Inventor
F Hoffmann- Aktiengesellschaft
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CH113104A publication Critical patent/CH113104A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C07D239/62—Barbituric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren zur Herstellung einer Verbindung der     Diallylbar        bitursäure.       Gegenstand der vorliegenden Erfindung  ist. ein Verfahren zur Herstellung einer Ver  bindung der     Diallylbarbitursäure,    welches  darin besteht, dass man     Diallylbarbitursäure     mit     l-Phenyl-2,3-dimethyl-4-dimethylamino-          5--pyrazolo#n    zusammenschmilzt.

   Auch wenn  man für die Schmelze die Komponenten nicht  im Verhältnis von 1     Mol.        Diallylbarbitur-          säure    zu 1     Mol.        1-Phenyl-2,3-dimethyl-4-di-          methylamino-5-pyrazolo@n    verwendet, erhält  man gleichwohl die Doppelverbindung, wel  che mit dem überschüssigen Ausgangsstoff  vermischt ist.  



  Aus den beiden farblosen Ausgangs  stoffen entsteht ein gelb gefärbtes Pulver,  das, wenn zur Schmelze 1     Mol.        Diallylbarbi-          tursäure    auf 1     Mol.        1-Phenyl-2,3-dimethyl-4-          dimethylamina-5-pyra.zolon    verwendet     wurde.     bei<B>83'</B> schmilzt. Die Verbindung der     Di-          allylbarbitursäure    mit 1 -     Phenyl-2,3-dime-          thyl-4-dimethylamino-5-pyrazolon    ist in ,den  meisten organischen     Lösungsmitteln    leicht  löslich und soll als Arzneimittel Verwendung  finden.  



  <I>Beispiel:</I>  208 Teile     Diallylbarbitursäure    werden mit  231 Teilen 1- Phenyl-2.3-dimethyl-4-dime-         thylamino-5-pyrazolon    im Ölbad, dessen  Temperatur 130 bis 140   beträgt, erhitzt,  bis ein klarer     Schmelzfluss    entstanden ist. Die  homogene Schmelze wird auf etwa<B>70'</B> ab  gekühlt, erforderlichenfalls geimpft und ge  rührt. Sie erstarrt zu einem festen gelblichen  Kuchen. Dieser wird nachdem vollständigen  Erkalten zerschlagen und gepulvert.



  Process for the preparation of a compound of diallylbar bituric acid. The subject of the present invention is. a process for producing a compound of diallyl barbituric acid, which consists in fusing diallyl barbituric acid with l-phenyl-2,3-dimethyl-4-dimethylamino-5-pyrazolo # n.

   Even if the components are not used for the melt in a ratio of 1 mol. Diallylbarbituric acid to 1 mol. 1-phenyl-2,3-dimethyl-4-dimethylamino-5-pyrazolo @ n, the double compound is nonetheless obtained which is mixed with the excess raw material.



  A yellow colored powder is formed from the two colorless starting materials, which, if 1 mol of diallylbarbituric acid to 1 mol of 1-phenyl-2,3-dimethyl-4-dimethylamina-5-pyra.zolon was used for the melt. melts at <B> 83 '</B>. The compound of diallyl barbituric acid with 1-phenyl-2,3-dimethyl-4-dimethylamino-5-pyrazolone is easily soluble in most organic solvents and is said to be used as a medicament.



  <I> Example: </I> 208 parts of diallyl barbituric acid are heated with 231 parts of 1-phenyl-2,3-dimethyl-4-dimethylamino-5-pyrazolone in an oil bath, the temperature of which is 130 to 140, until a clear melt flow is formed is. The homogeneous melt is cooled to about <B> 70 '</B>, if necessary inoculated and stirred. It solidifies into a firm yellowish cake. After it has cooled down completely, it is smashed and powdered.

Claims (1)

PATEINTANSPRUCIi: Verfahren zur Herstellung einer Verbin dung der Diallylbarbitursäure, dadurch ge kennzeichnet, dass man Diallylbarbitursäure mit 1-Phenyl-2,3-dimethyl-4-dimethyla@mino- 5-pyrazolon zusammenschmilzt. Aus den beiden farblosen Ausgansstoffen entsteht ein gelb gefärbtes Pulver, das., wenn zur Schmelze 1 Mol. Diallylbarbitursäure auf 1 Mol. 1-Phenyl-2,3-dimethyl-4-dimethyl- amino-5-pyra,zolon verwendet wurde, bei<B>83'</B> schmilzt. PATEINTANSPRUCIi: A process for the production of a compound of diallyl barbituric acid, characterized in that diallyl barbituric acid is fused with 1-phenyl-2,3-dimethyl-4-dimethyla @mino-5-pyrazolone. A yellow colored powder is formed from the two colorless starting materials, which, if 1 mole of diallylbarbituric acid to 1 mole of 1-phenyl-2,3-dimethyl-4-dimethylamino-5-pyrazolone was used for the melt <B> 83 '</B> melts. Die Verbindung der Diallylba.rbi- tursäure mit 1-Phenyl-2,3-dimethyl-4-clime- thyl.amino-5-pyrazolo@n ist in den meisten or ganischen Lösungsmitteln leicht löslich und soll als Arzneimittel Verwendung finden. The compound of diallylba.rbituric acid with 1-phenyl-2,3-dimethyl-4-climethyl.amino-5-pyrazolo@n is easily soluble in most organic solvents and is said to be used as a medicinal product.
CH113104D 1921-09-05 1924-07-23 Process for the preparation of a compound of diallyl barbituric acid. CH113104A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH97751T 1921-09-05
CH113104T 1924-07-23

Publications (1)

Publication Number Publication Date
CH113104A true CH113104A (en) 1925-12-16

Family

ID=25705311

Family Applications (1)

Application Number Title Priority Date Filing Date
CH113104D CH113104A (en) 1921-09-05 1924-07-23 Process for the preparation of a compound of diallyl barbituric acid.

Country Status (1)

Country Link
CH (1) CH113104A (en)

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