CH121981A - Process for the preparation of a compound of phenylethylbarbituric acid with 1-phenyl-2. 3-dimethyl-5-pyrazolone. - Google Patents
Process for the preparation of a compound of phenylethylbarbituric acid with 1-phenyl-2. 3-dimethyl-5-pyrazolone.Info
- Publication number
- CH121981A CH121981A CH121981DA CH121981A CH 121981 A CH121981 A CH 121981A CH 121981D A CH121981D A CH 121981DA CH 121981 A CH121981 A CH 121981A
- Authority
- CH
- Switzerland
- Prior art keywords
- dimethyl
- pyrazolone
- phenyl
- compound
- preparation
- Prior art date
Links
- DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 title claims description 7
- 150000001875 compounds Chemical class 0.000 title claims description 6
- 238000000034 method Methods 0.000 title claims description 4
- 238000002360 preparation method Methods 0.000 title description 3
- 239000000155 melt Substances 0.000 claims description 3
- 230000000202 analgesic effect Effects 0.000 claims description 2
- 230000001754 anti-pyretic effect Effects 0.000 claims description 2
- 239000002221 antipyretic Substances 0.000 claims description 2
- VEQOALNAAJBPNY-UHFFFAOYSA-N antipyrine Chemical compound CN1C(C)=CC(=O)N1C1=CC=CC=C1 VEQOALNAAJBPNY-UHFFFAOYSA-N 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- QOWNLVDMKSLAJU-UHFFFAOYSA-N 2,3-dimethyl-4-phenyl-1h-pyrazol-5-one Chemical compound O=C1NN(C)C(C)=C1C1=CC=CC=C1 QOWNLVDMKSLAJU-UHFFFAOYSA-N 0.000 claims 1
- 239000013078 crystal Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
- C07D231/26—1-Phenyl-3-methyl-5- pyrazolones, unsubstituted or substituted on the phenyl ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
- C07D239/62—Barbituric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
Verfahren zur Herstellung einer Verbindung vier Phenyläthylbarbitursäure mit 1-Phenyl-2.3-dimethyl-5-pyrazolon. Gegenstand der vorliegenden Erfindung ist ein Verfahren zur Herstellung einer Verbindung der Phenyläthylbarbitursäure mit 1-Phenyl-2. 3-dimethyl-5-pyrazolon, wel ches dadurch gekennzeichnet ist, dass man Phenyläthylbarbitursäure mit 1-Phenyl-2. 3- dimethyl-5-pyrazolon im molekularen Ver hältnis zusammenschmilzt.
Die neue Verbindung schmilzt bei 112'. Ihre Löslichkeit ist grösser als diejenige der Komponenten. Sie soll in der Therapie Ver wendung finden, da sie wesentlich stärker antipyretisch und analgetisch wirkt als 1- Phen,yl-2. 3-dimethyl-5-pyrazolon.
<I>Beispiel</I> 232 Gewichtsteile Phenyläthylbarbitur- säure und 188 Gewichtsteile 1-Phenyl-2.3- dimethyl-5-pyrazolori werden in einem dop pelwandigen Kessel mit gespanntem Dampf erhitzt und verrührt, bis eine homogene Schmelze entstanden ist. Dann lässt man auf etwa<B>70'</B> erkalten und impft wenn möglich an und rührt, bis alles zu einem Kuchen erstarrt ist, der aus feinen Kristallnadeln besteht" welche bei 112 schmelzen.
Process for the preparation of a compound four phenylethylbarbituric acid with 1-phenyl-2,3-dimethyl-5-pyrazolone. The present invention relates to a process for the preparation of a compound of phenylethylbarbituric acid with 1-phenyl-2. 3-dimethyl-5-pyrazolone, wel Ches is characterized in that one phenylethylbarbituric acid with 1-phenyl-2. 3- dimethyl-5-pyrazolone melts together in the molecular ratio.
The new compound melts at 112 '. Their solubility is greater than that of the components. It should be used in therapy, since it has a much stronger antipyretic and analgesic effect than 1-phen, yl-2. 3-dimethyl-5-pyrazolone.
<I> Example </I> 232 parts by weight of phenylethylbarbituric acid and 188 parts by weight of 1-phenyl-2,3-dimethyl-5-pyrazolori are heated and stirred in a double-walled kettle with pressurized steam until a homogeneous melt has formed. Then let it cool to about <B> 70 '</B> and if possible inoculate and stir until everything has solidified into a cake made of fine crystal needles "which melt at 112.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH121981T | 1925-05-09 | ||
| CH120098T | 1925-05-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH121981A true CH121981A (en) | 1927-08-01 |
Family
ID=25709399
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH121981D CH121981A (en) | 1925-05-09 | 1925-05-09 | Process for the preparation of a compound of phenylethylbarbituric acid with 1-phenyl-2. 3-dimethyl-5-pyrazolone. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH121981A (en) |
-
1925
- 1925-05-09 CH CH121981D patent/CH121981A/en unknown
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