CH113455A - Process for the preparation of an arsenic compound. - Google Patents
Process for the preparation of an arsenic compound.Info
- Publication number
- CH113455A CH113455A CH113455DA CH113455A CH 113455 A CH113455 A CH 113455A CH 113455D A CH113455D A CH 113455DA CH 113455 A CH113455 A CH 113455A
- Authority
- CH
- Switzerland
- Prior art keywords
- arsenic compound
- preparation
- acid
- arsenic
- arsic
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 8
- 150000001495 arsenic compounds Chemical class 0.000 title claims description 6
- 239000002253 acid Substances 0.000 claims description 7
- ASSKVPFEZFQQNQ-UHFFFAOYSA-N 2-benzoxazolinone Chemical compound C1=CC=C2OC(O)=NC2=C1 ASSKVPFEZFQQNQ-UHFFFAOYSA-N 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- KWSLGOVYXMQPPX-UHFFFAOYSA-N 5-[3-(trifluoromethyl)phenyl]-2h-tetrazole Chemical compound FC(F)(F)C1=CC=CC(C2=NNN=N2)=C1 KWSLGOVYXMQPPX-UHFFFAOYSA-N 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- 229940000488 arsenic acid Drugs 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 235000013345 egg yolk Nutrition 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 229910001379 sodium hypophosphite Inorganic materials 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Darstellung einer Arsenoverbindung. In dem Patent Nr. 111664 wird gezeigt, dass 5 . 5'-Arsenobenzoxazolon dargestellt wer den kann, wenn man 4-Amino-3-oxybenzol-l- arsinsäure in der üblichen Weise zur Arseno- verbindung reduziert und diese mit Phosgen behandelt.
EMI0001.0007
Dieses 5.5'-Arsenobenzoxazolon lässt sich nun auch, wie gefunden wurde, dadurch er halten, dass man die nach dem Verfahren des Patentes Nr. 109390 (Behandlung der 4-Amino-3-oxybenzol-l-arsinsäure mit Phos- gen) erhältliche Benzoxazolon-5-arsinsäure in der üblichen Weise zur Arsenoverbindung reduziert.
EMI0001.0014
Überraschenderweise findet weder Abspaltung von Arsen noch Aufspaltung des Benzoxazolon- ringes statt.
Dem Verfahren des Patentes Nr. 111664 gegenüber besitzt das neue Ver fahren den Vorteil, dass man nicht von der unbeständigen, schwer zu handhabenden Ar- senoverbindung, sondern von der gut kristalli sierenden luftbeständigen Arsinsäure ausgeht, aus der man durch Reduktion direkt 5-Arseno- benzoxazolon erhält.
<I>Beispiel:</I> 100 gi, Natriumhypophosphit werden in 50 cm3 heissen Wassers gelöst, mit 500 cm' Methylalkohol und 200 cm' Salzsäure (1,18 sp.) versetzt;
die abgekühlte Lösung wird filtriert und mit einer Lösung von 50 gr der nach Patent Nr. 109390 aus 4-Amino-3-oxybenzol- 1-ärsinsäure und Phosgen erhältlichen Benz- oxazolon-5-arsinsäure in 550 cm3lVIethylalkohol und 140 cms conc. Salzsäure (1,18 sp.) bei gewöhnlicher Temperatur vermischt. Man fügt etwas Jodwasserstoffsäure hinzu und erwärmt auf 35-40 .
Es bildet sich ein eigelber Niederschlag, der mit dem nach dem Ver fahren des Patentes Nr. 111664 hergestellten 5 . 5'-Arsenobenzoxazolon identisch ist.
Process for the preparation of an arsenic compound. Patent No. 111664 shows that 5. 5'-arsenobenzoxazolone can be prepared if 4-amino-3-oxybenzene-larsic acid is reduced to the arsenic compound in the usual way and this is treated with phosgene.
EMI0001.0007
This 5.5'-arsenobenzoxazolone can now also be obtained, as has been found, by using the benzoxazolone obtainable by the process of patent no. 109390 (treatment of 4-amino-3-oxybenzene-1-arsic acid with phosgene) -5-arsic acid reduced to the arsenic compound in the usual way.
EMI0001.0014
Surprisingly, neither arsenic nor the benzoxazolone ring are split off.
Compared to the process of patent no. 111664, the new process has the advantage that one does not start from the unstable, difficult-to-use arsenic compound, but from the well-crystallizing, air-resistant arsic acid, from which 5-arsenic acid is obtained directly by reduction benzoxazolone receives.
<I> Example: </I> 100 gi of sodium hypophosphite are dissolved in 50 cm3 of hot water, 500 cm of methyl alcohol and 200 cm of hydrochloric acid (1.18 sp.) Are added;
the cooled solution is filtered and mixed with a solution of 50 g of the benzoxazolone-5-arsic acid obtainable according to patent no. 109390 from 4-amino-3-oxybenzene-1-arsic acid and phosgene in 550 cm3 of ethyl alcohol and 140 cms of conc. Hydrochloric acid (1.18 sp.) Mixed at ordinary temperature. A little hydriodic acid is added and the mixture is warmed to 35-40.
An egg yolk precipitate forms, which with the 5 produced according to the method of patent no. 5'-arsenobenzoxazolone is identical.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE113455X | 1923-06-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH113455A true CH113455A (en) | 1926-01-02 |
Family
ID=5653372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH113455D CH113455A (en) | 1923-06-09 | 1924-05-07 | Process for the preparation of an arsenic compound. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH113455A (en) |
-
1924
- 1924-05-07 CH CH113455D patent/CH113455A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE2207287B2 (en) | Process for the preparation of biscarboxyethyl germanium sesquioxide | |
| CH113455A (en) | Process for the preparation of an arsenic compound. | |
| AT112135B (en) | Process for the preparation of basic oxime ethers and their salts. | |
| DE374366C (en) | Process for the preparation of an unsaturated bile acid | |
| DE637531C (en) | Process for the production of highly effective preparations from corpora lutea | |
| CH144988A (en) | Process for the preparation of p-glycolylaminobenzenic acid. | |
| AT37386B (en) | Process for preparing soluble starch. | |
| AT210563B (en) | Process for the production of a new therapeutically valuable calcium salt | |
| DE545266C (en) | Process for the preparation of diiodochelidamic acid | |
| DE372284C (en) | Process for the production of solid, water-soluble formaldehyde solutions | |
| AT91238B (en) | Process for the preparation of allylarsic acid. | |
| CH144432A (en) | Process for the preparation of 4-glycolylamino-3'-amino-4'-oxy-arsenobenzene. | |
| CH208533A (en) | Process for the preparation of 4-oxybenzthiazole. | |
| CH200302A (en) | Process for the preparation of a quaternary ammonium compound. | |
| CH150744A (en) | Process for the preparation of a molecular compound of 2-phenylquinoline-4-carboxylic acid calcium with 1-phenyl-2,3-dimethyl-4-dimethylamino-5-pyrazolone. | |
| CH119328A (en) | Process for the preparation of an acyl compound of amino-3-chloro-4-oxybenzene-1-arsic acid. | |
| CH202716A (en) | Process for producing a water-soluble nitrogen-containing compound. | |
| CH169578A (en) | Process for the preparation of the salt of 2,3-dimethoxy-6-nitro-9- (Y-diethylamino-B-oxy-propylamino) -acridine with p-glycolylaminobenzolaric acid. | |
| CH198052A (en) | Process for the preparation of a quaternary aminoacetic acid amide derivative. | |
| CH191339A (en) | Process for the preparation of a stereoisomeric alcohol. | |
| CH159590A (en) | Process for preparing an asymmetric arsenobenzene compound. | |
| CH99452A (en) | Process for the preparation of 1-phenyl-2. 3-dimethyl-4-dimethylamino-5-pyrazolone. | |
| CH161176A (en) | Process for preparing an asymmetric arsenobenzene compound. | |
| CH152791A (en) | Process for the preparation of a molecular compound of sodium 2-phenylquinoline-4-carboxylic acid with 1-phenyl-2,3-dimethyl-4-dimethylamino-5-pyrazolone. | |
| CH109390A (en) | Process for the preparation of a new arsenic compound of the aromatic series. |