CH146997A - Process for producing a soluble organic antimony compound. - Google Patents
Process for producing a soluble organic antimony compound.Info
- Publication number
- CH146997A CH146997A CH146997DA CH146997A CH 146997 A CH146997 A CH 146997A CH 146997D A CH146997D A CH 146997DA CH 146997 A CH146997 A CH 146997A
- Authority
- CH
- Switzerland
- Prior art keywords
- acid
- pyrocatechol
- antimony
- salt
- water
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 6
- 150000001463 antimony compounds Chemical class 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims description 9
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 claims description 8
- CJAZCKUGLFWINJ-UHFFFAOYSA-N 3,4-dihydroxybenzene-1,2-disulfonic acid Chemical compound OC1=CC=C(S(O)(=O)=O)C(S(O)(=O)=O)=C1O CJAZCKUGLFWINJ-UHFFFAOYSA-N 0.000 claims description 7
- AQTIRDJOWSATJB-UHFFFAOYSA-K antimonic acid Chemical compound O[Sb](O)(O)=O AQTIRDJOWSATJB-UHFFFAOYSA-K 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- ZDINGUUTWDGGFF-UHFFFAOYSA-N antimony(5+) Chemical compound [Sb+5] ZDINGUUTWDGGFF-UHFFFAOYSA-N 0.000 claims description 5
- 229910052787 antimony Inorganic materials 0.000 claims description 3
- WATWJIUSRGPENY-UHFFFAOYSA-N antimony atom Chemical compound [Sb] WATWJIUSRGPENY-UHFFFAOYSA-N 0.000 claims description 3
- HIFJUMGIHIZEPX-UHFFFAOYSA-N sulfuric acid;sulfur trioxide Chemical compound O=S(=O)=O.OS(O)(=O)=O HIFJUMGIHIZEPX-UHFFFAOYSA-N 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 2
- 230000007935 neutral effect Effects 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 150000001447 alkali salts Chemical class 0.000 claims 1
- -1 amine salt Chemical class 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 2
- 229940126601 medicinal product Drugs 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- BFSVOASYOCHEOV-UHFFFAOYSA-N 2-diethylaminoethanol Chemical compound CCN(CC)CCO BFSVOASYOCHEOV-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229940058905 antimony compound for treatment of leishmaniasis and trypanosomiasis Drugs 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229940072033 potash Drugs 0.000 description 1
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Substances [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 1
- 235000015320 potassium carbonate Nutrition 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Herstellung einer löslichen organischen Antimonverbindung. Es wurde gefunden, dass man lösliche or ganische Antimonverbindungen duech Ein wirken von Verbindungen des 5-wertigen An timons auf aromatische Polyogyverbindungen, die mindestens 2 Hydroxylgruppen in o-Stel- lung und saure, salzbildende Substituenten enthalten, herstellen kann.
Man erhält dabei Produkte von besonders herabgesetzter Giftigkeit bei vorhandener therapeutischer Wirkung, - also für Arznei mittel besonders geeignete Verbindungen.
Gegenstand dieses Patentes ist die Dar stellung eines Antimonbrenzkatechindisulfo- nats. Die Darstellung dieses neuen Produktes gestaltet sich so, dass man auf Brenzkatechin- disulfosäure, erhalten durch Sulfonieren von Brenzkatechin mit rauchender Schwefelsäure oder ein Salz dieser Säure, eine Verbindung des 5-wertigen Antimons einwirken lässt und in üblicher Weise eine etwa neutrale End- reaktion bei der Umsetzung bewirkt.
Zweck mässig wird die Brenzkatechindisulfosäure in Form ihrer Alkali- oder Amirsalze verwendet. Geeignete Verbindungen des 5-wertigen An timons sind Antimonsäure, die zweckmässig in frisch gefälltem Zustand verwandt wird, und deren wasserlösliche Salze. Das gebildete Komplexsalz wird in bekannter Weise ab getrennt und soll als Heilmittel Verwendung finden.
<I>Beispiel:</I> 20 gr brenzkatechindisrrlfosaures Kali. er halten aus mit rauchender Schwefelsäure sulfoniertem Brenzkatechin, werden in 100 <B>CM-'</B> Wasser gelöst und die Lösung mit über schüssiger Antimonsäure, zweckmässig in frisch gefälltem Zustand, einige Zeit erwärmt. An Stelle von Antimonsäure kann man auch wasserlösliche antimonsaure Salze, zum Bei spiel antimonsaures Diäthylaminoätiianol (siehe schweiz. Patentschrift 142671) verwen den.
Man lässt erkalten, filtriert vom Unge lösten ab, neutralisiert das Filtrat mit ver- dünnter Kalilauge und fällt durch Eingiessen in Methylalkohol aus. Man erhält ein farb loses Pulver, das sich leicht in Wasser löst.
Process for producing a soluble organic antimony compound. It has been found that soluble organic antimony compounds can be produced by means of compounds of the pentavalent antimony having an effect on aromatic polyogy compounds which contain at least 2 hydroxyl groups in the o-position and acidic, salt-forming substituents.
This gives products of particularly reduced toxicity with an existing therapeutic effect - that is, compounds particularly suitable for medicinal products.
The subject of this patent is the presentation of an antimony catechol disulfonate. This new product is presented in such a way that a compound of pentavalent antimony is allowed to act on pyrocatechol disulfonic acid, obtained by sulfonating pyrocatechol with fuming sulfuric acid or a salt of this acid, and in the usual way an approximately neutral end reaction is achieved of implementation.
The pyrocatechol disulfonic acid is expediently used in the form of its alkali or amir salts. Suitable compounds of the pentavalent antimony are antimonic acid, which is expediently used in the freshly precipitated state, and its water-soluble salts. The complex salt formed is separated off in a known manner and is intended to be used as a medicinal product.
<I> Example: </I> 20 grams of catechol disrrlfosaures potash. They are made from pyrocatechol sulfonated with fuming sulfuric acid, are dissolved in 100 <B> CM- '</B> water and the solution is heated for some time with excess antimonic acid, preferably freshly precipitated. Instead of antimonic acid, it is also possible to use water-soluble antimonic acid salts, for example antimonic acid diethylaminoethanol (see Swiss patent specification 142671).
It is allowed to cool, the undissolved material is filtered off, the filtrate is neutralized with dilute potassium hydroxide solution and precipitated by pouring it into methyl alcohol. A colorless powder is obtained which easily dissolves in water.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE146997X | 1928-11-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH146997A true CH146997A (en) | 1931-05-15 |
Family
ID=5671729
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH146997D CH146997A (en) | 1928-11-06 | 1929-10-25 | Process for producing a soluble organic antimony compound. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH146997A (en) |
-
1929
- 1929-10-25 CH CH146997D patent/CH146997A/en unknown
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