CH156342A - Process for the preparation of an organic mercury compound. - Google Patents
Process for the preparation of an organic mercury compound.Info
- Publication number
- CH156342A CH156342A CH156342DA CH156342A CH 156342 A CH156342 A CH 156342A CH 156342D A CH156342D A CH 156342DA CH 156342 A CH156342 A CH 156342A
- Authority
- CH
- Switzerland
- Prior art keywords
- compound
- mercury
- preparation
- organic mercury
- mercury compound
- Prior art date
Links
- 229940100892 mercury compound Drugs 0.000 title claims description 5
- 150000002731 mercury compounds Chemical class 0.000 title claims description 5
- 238000000034 method Methods 0.000 title claims description 4
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 claims description 6
- 229910052753 mercury Inorganic materials 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- WRYNUJYAXVDTCB-UHFFFAOYSA-M acetyloxymercury Chemical compound CC(=O)O[Hg] WRYNUJYAXVDTCB-UHFFFAOYSA-M 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical class [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 3
- 150000001805 chlorine compounds Chemical class 0.000 claims description 3
- 239000002934 diuretic Substances 0.000 claims description 2
- 230000001882 diuretic effect Effects 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- YAPQBXQYLJRXSA-UHFFFAOYSA-N theobromine Chemical compound CN1C(=O)NC(=O)C2=C1N=CN2C YAPQBXQYLJRXSA-UHFFFAOYSA-N 0.000 description 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229960004559 theobromine Drugs 0.000 description 3
- BTFHIKZOEZREBX-UHFFFAOYSA-N 3,7-dimethyl-1-prop-2-enylpurine-2,6-dione Chemical compound CN1C(=O)N(CC=C)C(=O)C2=C1N=CN2C BTFHIKZOEZREBX-UHFFFAOYSA-N 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- HIVLDXAAFGCOFU-UHFFFAOYSA-N ammonium hydrosulfide Chemical compound [NH4+].[SH-] HIVLDXAAFGCOFU-UHFFFAOYSA-N 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/10—Mercury compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Darstellung einer organischen Quecksilberverbindung. Im Hauptpatent ist ein Verfahren zur Darstellung einer organischen Quecksilber- verbingung durch Einwirkung von Quecksil beracetat auf 1-Allyltheobromin beschrieben.
Gegenstand der vorliegenden Erfindung ist ein \erfahren zur Darstellung einer Queck silberverbindung des 1-Allylomethyltheobt-o- tnins, welches dadurch gekennzeichnet ist, dass man Quecksilberacetat auf 1-Allylouiethyl- theobromin einwirken lässt.
Die bisher nicht bekannte Verbindung ist ein Öl, das durch Schütteln in Wasser mit einer gesättigten Kochsalzlösung in die ent sprechende Chlorverbindung von einem, dem theoretischen Quecksilbergehalt von 39,9% entsprechenden Quecksilbergehalt von 39,9 % übergeführt werden kann. Die _ Verbindung soll als Arzneimittel, speziell als starkes Diuretikum Verwendung finden.
<I>'Beispiel</I> 4,68 gr 1- Allylomethyltheobromin (ans Theobrominnatt#ium+Allylomethylbromid er- hältlich) in 50 .m3 Methylalkohol werden 18 Stunden mit 6,37 gr Quecksilberacetat in 50 eins Wasser geschüttelt. Das Ganze wird im Vakuum eingedampft, der Rückstand mit Wasser aufgenommen und neutralisiert. Die neutrale Lösung wird mit Chloroform aus gezogen. Aus dem Chloroform wird ein Öl erhalten, das die Quecksilberacetatanlagerungs- verhindung an Allylomethyltheobromin dar stellt.
Durch Versetzen seiner Lösung in Wasser mit Kochsalzlösung entsteht die ent sprechende Chlorverbindung, die durch Um kristallisieren aus Diäthylinwasser rein er- halten- wird. Gef. 39,9 %, ber. 39,9 % ffg für C12H1 , O3N4HgC1.
In dem Endprodukt ist das Quecksilber komplex gebunden; es wird mit Natronlauge nicht abgespalten, sondern erst nach längerer Einwirkung von Schwefelammonium in der Wärme.
Process for the preparation of an organic mercury compound. The main patent describes a process for the preparation of an organic mercury compound by the action of mercury beracetat on 1-allyl theobromine.
The subject matter of the present invention is an experience for the preparation of a mercury compound of 1-allylomethyl theobt-o-tnine, which is characterized in that mercury acetate is allowed to act on 1-allylomethyl theobromine.
The previously unknown compound is an oil that can be converted into the corresponding chlorine compound by shaking in water with a saturated saline solution from a mercury content of 39.9% corresponding to the theoretical mercury content of 39.9%. The compound is said to be used as a drug, especially as a strong diuretic.
<I> 'Example </I> 4.68 g 1- allylomethyltheobromine (available from theobromine natt + allylomethyl bromide) in 50 m3 methyl alcohol are shaken with 6.37 g mercury acetate in 50 l water for 18 hours. The whole is evaporated in vacuo, the residue is taken up in water and neutralized. The neutral solution is drawn off with chloroform. An oil is obtained from the chloroform, which prevents the addition of mercury acetate to allylomethyl theobromine.
By adding saline to its solution in water, the corresponding chlorine compound is formed, which is obtained in pure form by recrystallizing from diethyline water. Found 39.9%, calc. 39.9% ffg for C12H1, O3N4HgC1.
In the end product, the mercury is bound in a complex; it is not split off with caustic soda, but only after prolonged exposure to ammonium sulfur in the heat.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH152088T | 1930-10-22 | ||
| CH156342T | 1930-10-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH156342A true CH156342A (en) | 1932-07-31 |
Family
ID=25715942
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH156342D CH156342A (en) | 1930-10-22 | 1930-10-22 | Process for the preparation of an organic mercury compound. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH156342A (en) |
-
1930
- 1930-10-22 CH CH156342D patent/CH156342A/en unknown
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