CH156343A - Process for the preparation of an organic mercury compound. - Google Patents
Process for the preparation of an organic mercury compound.Info
- Publication number
- CH156343A CH156343A CH156343DA CH156343A CH 156343 A CH156343 A CH 156343A CH 156343D A CH156343D A CH 156343DA CH 156343 A CH156343 A CH 156343A
- Authority
- CH
- Switzerland
- Prior art keywords
- mercury
- preparation
- compound
- organic mercury
- mercury compound
- Prior art date
Links
- 229940100892 mercury compound Drugs 0.000 title claims description 5
- 150000002731 mercury compounds Chemical class 0.000 title claims description 5
- 238000000034 method Methods 0.000 title claims description 5
- 238000002360 preparation method Methods 0.000 title claims description 5
- 229910052753 mercury Inorganic materials 0.000 claims description 7
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- WRYNUJYAXVDTCB-UHFFFAOYSA-M acetyloxymercury Chemical compound CC(=O)O[Hg] WRYNUJYAXVDTCB-UHFFFAOYSA-M 0.000 claims description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical class [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 3
- 150000001805 chlorine compounds Chemical class 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 3
- 239000002934 diuretic Substances 0.000 claims description 2
- 230000001882 diuretic effect Effects 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229960001701 chloroform Drugs 0.000 description 2
- BTFHIKZOEZREBX-UHFFFAOYSA-N 3,7-dimethyl-1-prop-2-enylpurine-2,6-dione Chemical compound CN1C(=O)N(CC=C)C(=O)C2=C1N=CN2C BTFHIKZOEZREBX-UHFFFAOYSA-N 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N Theophylline Natural products O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 1
- HIVLDXAAFGCOFU-UHFFFAOYSA-N ammonium hydrosulfide Chemical compound [NH4+].[SH-] HIVLDXAAFGCOFU-UHFFFAOYSA-N 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- -1 methyl theophylline Chemical compound 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- QVGLHVDBDYLFON-UHFFFAOYSA-M sodium;1,3-dimethylpurin-7-ide-2,6-dione Chemical compound [Na+].O=C1N(C)C(=O)N(C)C2=C1[N-]C=N2 QVGLHVDBDYLFON-UHFFFAOYSA-M 0.000 description 1
- 229960000278 theophylline Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/10—Mercury compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Darstellung einer organischen Quecksilberverbindung. Im Hauptpatent ist ein Verfahren zur Darstellung einer organischen Quecksilber verbindung durch Einwirkung von Queck- silberacetat auf 1 - Allyltheobromin be schrieben.
Gegenstand der vorliegenden Erfindung ist ein Verfahren zur Darstellung einer Quecksilberverbindung des 7-Allylomethyl- phyllins, welches dadurch gekennzeichnet ist, dass man Quecksilberacetat auf 7-Allylo- methyltheophyllin einwirken lässt.
Die bisher nicht bekannte Verbindung ist ein 01, da-s durch Schütteln in Wasser mit einer gesättigten Kochsalzlösung in die entsprechende Chlorverbindung von einem dem theoretischen Quecksilbergehalt von 39,9 % entsprechenden Quecksilbergehalt von 39,9% übergeführt werden kann. Die Ver bindung soll als Arzneimittel, speziell als starkes Diuretikum, Verwendung finden.
<I>Beispiel:</I> 4,68 .gr 7-Allylomethyltheophyllin (aus Theophyllinnatrium -i- Allylomethylbromid erhältlich) in 50 cm' Methylalkohol werden 18 Stunden mit 6,87 gr Quecksilberacetat in 50 cm3 Wasser geschüttelt. Das Ganze wird im Vakuum eingedampft, der Rück stand mit Wasser aufgenommen und neu tralisiert. Die neutrale Lösung wird mit Chloroform ausgezogen.
Aus dem Chloro form wird -ein <B>-01</B> erhalten., das die Queck- silberaoetatanlagerungsverbindung an Allylo- methy ltheophyllin darstellt. Durch Ver setzen seiner Lösung in Wasser mit Koch salzlösung entsteht die entsprechende Chlor verbindung, die durch Umkristallisieren aus Diäthylin-Wasser rein erhalten wird. Gefunden 3,9,9 %, berechnet 89,9 % Hg für C12H1703N4HgCl.
In dem Endprodukt ist das Quecksilber komplex gebunden; es wird mit Natronlauge nicht abgespalten, sondern erst nach länge rer Einwirkung von Schwefelammonium in der Wärme.
Process for the preparation of an organic mercury compound. The main patent describes a process for the preparation of an organic mercury compound by the action of mercury acetate on 1 - allyl theobromine be.
The present invention relates to a method for the preparation of a mercury compound of 7-allylomethylphylline, which is characterized in that mercury acetate is allowed to act on 7-allylomethyltheophylline.
The previously unknown compound is an 01 that can be converted into the corresponding chlorine compound by shaking it in water with a saturated saline solution, with a mercury content of 39.9% corresponding to the theoretical mercury content of 39.9%. The connection is intended to be used as a drug, especially as a strong diuretic.
<I> Example: </I> 4.68 .gr 7-allylomethyltheophylline (obtainable from theophylline sodium -i- allylomethyl bromide) in 50 cm 'of methyl alcohol are shaken with 6.87 g of mercury acetate in 50 cm3 of water for 18 hours. The whole thing is evaporated in vacuo, the residue was taken up with water and neutralized again. The neutral solution is extracted with chloroform.
A <B> -01 </B> is obtained from the chloro form, which is the mercury aoetate addition compound to allylo methyl theophylline. By Ver put its solution in water with saline solution, the corresponding chlorine compound is formed, which is obtained in pure form by recrystallization from diethylene-water. Found 3.9.9%, calculated 89.9% Hg for C12H1703N4HgCl.
In the end product the mercury is bound in a complex; it is not split off with caustic soda, but only after prolonged exposure to sulfur ammonium in the heat.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH156343T | 1930-10-22 | ||
| CH152088T | 1930-10-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH156343A true CH156343A (en) | 1932-07-31 |
Family
ID=25715943
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH156343D CH156343A (en) | 1930-10-22 | 1930-10-22 | Process for the preparation of an organic mercury compound. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH156343A (en) |
-
1930
- 1930-10-22 CH CH156343D patent/CH156343A/en unknown
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