CH163203A - Process for the preparation of a complex compound of antimony. - Google Patents
Process for the preparation of a complex compound of antimony.Info
- Publication number
- CH163203A CH163203A CH163203DA CH163203A CH 163203 A CH163203 A CH 163203A CH 163203D A CH163203D A CH 163203DA CH 163203 A CH163203 A CH 163203A
- Authority
- CH
- Switzerland
- Prior art keywords
- compound
- antimony
- barium
- water
- complex
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims description 11
- 238000000034 method Methods 0.000 title claims description 6
- 238000002360 preparation method Methods 0.000 title claims description 3
- 229910052787 antimony Inorganic materials 0.000 title claims 2
- WATWJIUSRGPENY-UHFFFAOYSA-N antimony atom Chemical compound [Sb] WATWJIUSRGPENY-UHFFFAOYSA-N 0.000 title claims 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims description 6
- ADCOVFLJGNWWNZ-UHFFFAOYSA-N antimony trioxide Chemical compound O=[Sb]O[Sb]=O ADCOVFLJGNWWNZ-UHFFFAOYSA-N 0.000 claims description 6
- 229940050410 gluconate Drugs 0.000 claims description 6
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims description 5
- 239000000174 gluconic acid Substances 0.000 claims description 5
- 235000012208 gluconic acid Nutrition 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- FMAUXABAQODLLT-UHFFFAOYSA-N [Sb].[Ba] Chemical compound [Sb].[Ba] FMAUXABAQODLLT-UHFFFAOYSA-N 0.000 claims description 3
- 150000001553 barium compounds Chemical class 0.000 claims description 3
- 150000002927 oxygen compounds Chemical class 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 2
- 150000007513 acids Chemical class 0.000 claims description 2
- 239000003513 alkali Substances 0.000 claims description 2
- 150000001412 amines Chemical class 0.000 claims description 2
- SZOADBKOANDULT-UHFFFAOYSA-K antimonous acid Chemical compound O[Sb](O)O SZOADBKOANDULT-UHFFFAOYSA-K 0.000 claims description 2
- 229910052788 barium Inorganic materials 0.000 claims description 2
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-M bisulphate group Chemical group S([O-])(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 150000007522 mineralic acids Chemical class 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 150000003467 sulfuric acid derivatives Chemical class 0.000 claims description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 claims 1
- 239000007795 chemical reaction product Substances 0.000 claims 1
- 238000000354 decomposition reaction Methods 0.000 claims 1
- 239000000243 solution Substances 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- FAWGZAFXDJGWBB-UHFFFAOYSA-N antimony(3+) Chemical compound [Sb+3] FAWGZAFXDJGWBB-UHFFFAOYSA-N 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- WDIHJSXYQDMJHN-UHFFFAOYSA-L barium chloride Chemical compound [Cl-].[Cl-].[Ba+2] WDIHJSXYQDMJHN-UHFFFAOYSA-L 0.000 description 1
- 229910001626 barium chloride Inorganic materials 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Landscapes
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Darstellung einer liomplexverbindung des Autimons. Gegenstand vorliegender Erfindung ist ein Verfahren zur Darstellung einer Kom plexverbindung des Autimons, welches da durch o-ekennzeichnet ist, dass man eine Sauer stoffverbindung des dreiwertigen Antimons, Glukonsäure, Alkali und eine Bariumverbin- dung in Lösung aufeinander einwirken lässt.
Zweckmä,ssigerweise verwendet man als Sauerstoffverbindung des dreiwertigen Anti mons Antimenhydroxyd oder Antimontri- oxyd.
Man löst<B>6</B> Teile Glukonsäure in 45 Tei len einer 13.%igen Natroulauge und fügt zu der siedenden Lösung in kleinen Anteilen 4,3 Teile Antimontrioxyd, die sich restlos auflösen. Man kühlt nunmehr ab und gibt eine Lösung von<B>7,2</B> Teilen krist. Barium- chlorid in<B>25</B> Teilen Wasser hinzu. Hierbei entsteht vorübergehend eine Fällung, nach Zuo,eben allen Bariumehlorids ist die Lösung aber wieder vollkommen klar.
Erhitzt man diese zum Sieden, so seheidet sich das basische Barium-Antimon-Glukonat als weisser, krist. Niederschlag<B>ab.</B> Derselbe muss in der E#itze abgesaugt werden, da er beim Abkühlen der Flüssigkeit wieder in Lösung geht. Ehe man den Niederschlag von Flüssigkeit trennt-, hält man letztere noch einige Zeit im Sieden und wäscht den auf dem Filter befindlic'hen Niederschlag mit heissem Wasser, dann mit Alkohol und Aceton aus und trocknet auf Ton.
Die Verbindung hat nach der Analyse die Zusammensetzung: CIH70,Sb <B>-</B> Ba<B>+</B> aq. Der Körper stellt ein feines, weisses Pulver dar, das in Wasser fast unlöslich ist. Von überschüssigen anorganischen Säuren wird die Komplexverbindung zerstört, Polyoxycarbon- säuren dagegen, zum Beispiel Glukonsäure selbst, lösen die Verbindung, wenn sie der selben in äquimolekularer Menge in wässe riger Lösung zugesetzt werden, unzersetzt auf und man erhält wasserlösliche Körper, in denen der Komplex erhalten geblieben ist.
Setzt man das Barium-Antimon-Glukonat mit Sulfaten oder Bisulfaten von Alkalien oder Aminen um, so erhält man durch diese dop- pelte Umsetzung ebenfalls wasserlösliche Komplexverbiudungen. Ba-Sb-Glukonat ist feinkristallin und luftbeständig.
Die neue Verbindung soll als Arzneimittel oder als Zwischenprodukt für die Herstellung von Arzneimitteln Verwendung finden.
Method for representing a complex connection of the Autimon The present invention relates to a method for the preparation of a complex compound of autimony, which is characterized by the fact that an oxygen compound of trivalent antimony, gluconic acid, alkali and a barium compound is allowed to act on one another in solution.
It is advisable to use antimony hydroxide or antimony trioxide as the oxygen compound of the trivalent antimony.
6 parts of gluconic acid are dissolved in 45 parts of a 13% sodium hydroxide solution and 4.3 parts of antimony trioxide are added in small proportions to the boiling solution, which dissolve completely. It is now cooled and a solution of 7.2 parts of crystalline is added. Add barium chloride in <B> 25 </B> parts of water. This creates a temporary precipitate, but according to Zuo, the solution is completely clear again for all barium aurides.
If this is heated to the boil, the basic barium antimony gluconate appears as a white, crystalline substance. Precipitation <B> off. </B> The same must be sucked off in the upper part, as it goes back into solution when the liquid cools. Before the precipitate is separated from the liquid, the latter is kept boiling for some time and the precipitate on the filter is washed with hot water, then with alcohol and acetone, and dried on clay.
According to the analysis, the compound has the following composition: CIH70, Sb <B> - </B> Ba <B> + </B> aq. The body is a fine, white powder that is almost insoluble in water. The complex compound is destroyed by excess inorganic acids, whereas polyoxycarboxylic acids, for example gluconic acid itself, dissolve the compound without decomposing if it is added to the same in an equimolecular amount in aqueous solution, and water-soluble bodies are obtained in which the complex is obtained stayed.
If the barium antimony gluconate is reacted with sulphates or bisulphates of alkalis or amines, water-soluble complex compounds are also obtained through this double reaction. Ba-Sb-gluconate is finely crystalline and air-resistant.
The new compound is intended to be used as a drug or as an intermediate for the manufacture of drugs.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE163203X | 1930-12-15 | ||
| CH159266T | 1931-12-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH163203A true CH163203A (en) | 1933-07-31 |
Family
ID=25717212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH163203D CH163203A (en) | 1930-12-15 | 1931-12-12 | Process for the preparation of a complex compound of antimony. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH163203A (en) |
-
1931
- 1931-12-12 CH CH163203D patent/CH163203A/en unknown
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