CH175258A - Process for obtaining a therapeutically valuable product. - Google Patents

Process for obtaining a therapeutically valuable product.

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Publication number
CH175258A
CH175258A CH175258DA CH175258A CH 175258 A CH175258 A CH 175258A CH 175258D A CH175258D A CH 175258DA CH 175258 A CH175258 A CH 175258A
Authority
CH
Switzerland
Prior art keywords
resorcinol
hexyl
obtaining
therapeutically valuable
valuable product
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH175258A publication Critical patent/CH175258A/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur     Gewinnung    eines therapeutisch wertvollen Produktes.    Gegenstand des Hauptpatentes ist ein  Verfahren zur Darstellung von     Chlor-4-(n-          Octyl-1')-resorcin.     



  Gegenstand des vorliegenden Patentes ist  ein Verfahren zur Darstellung von     Dichlor-          4-(n-hexyl-1')-resorcin.    Das Verfahren , ist  dadurch gekennzeichnet, dass man auf     4-(n-          Hexyl-1')-resorciri    ein     Chlorierungsmittel    in  mindestens     dimolekularem    Verhältnis einwir  ken lässt. Als     Chlorierungsmittel    verwendet  man zweckmässig     Sulfurylchlorid,    auch kann  man freies Chlor, zweckmässig in Gegenwart der  üblichen Katalysatoren, wie Eisen     bezw.    Ei  senchlorid, zur Anwendung bringen.

   Die  Reaktion kann in Gegenwart oder Abwesen  heit     eines        Lösemittels,    wie Chlorbenzol,     Ni-          trobenzol        oder-Ligroin    oder     Tetrachlorkohlen-          stoff    und dergleichen ausgeführt werden. Das  so erhältliche     Dichlor-4-(n-hexyl-1')-resorcin     siedet unter 0,5 mm Druck bei 145  . Es ist  in Wasser kaum löslich, löst sich aber in  Natronlauge,     Natriumcarbonatlösung    und in    organischen Lösemitteln. Das neue Produkt  soll therapeutische Anwendung finden.  



       Beispiel:     13     gr        4-(n-Hexyl-1')-resorcin    werden fein  gepulvert und in 26     gr    frisch destilliertes       Sulfurylchlorid,    das sich in einem mit Rück  flusskühler versehenen Kolben befindet, ein  getragen. Es tritt starke Reaktion ein. Man  lässt 10 Stunden stehen. Dann erwärmt man  noch 1-2 Stunden ohne Kühler auf dem  Wasserbad und destilliert im Hochvakuum.  Das so erhaltene     Dichlor-4-(n-hexyl-1')-resor-          cin    siedet unter 0,5 mm Druck bei 145  .  Es löst sich in Natronlauge und     Sodalösung.  



  Process for obtaining a therapeutically valuable product. The subject of the main patent is a process for the preparation of chloro-4- (n-octyl-1 ') - resorcinol.



  The subject of the present patent is a process for the preparation of dichloro-4- (n-hexyl-1 ') - resorcinol. The process is characterized in that a chlorinating agent is allowed to act on 4- (n-hexyl-1 ') - resorciri in at least a dimolecular ratio. The chlorinating agent used is advantageously sulfuryl chloride, and free chlorine can also be used, advantageously in the presence of the customary catalysts, such as iron or. Egg chloride, apply.

   The reaction can be carried out in the presence or absence of a solvent such as chlorobenzene, nitrobenzene or ligroin or carbon tetrachloride and the like. The dichloro-4- (n-hexyl-1 ') - resorcinol thus obtainable boils under 0.5 mm pressure at 145. It is hardly soluble in water, but it dissolves in caustic soda, sodium carbonate solution and in organic solvents. The new product should find therapeutic application.



       Example: 13 grams of 4- (n-hexyl-1 ') - resorcinol are finely powdered and carried in 26 grams of freshly distilled sulfuryl chloride, which is in a flask equipped with a reflux condenser. There is a strong reaction. It is left to stand for 10 hours. Then the mixture is heated for another 1-2 hours on a water bath without a condenser and distilled in a high vacuum. The dichloro-4- (n-hexyl-1 ') resorcinol thus obtained boils at 145 under 0.5 mm pressure. It dissolves in caustic soda and soda solution.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung von Dichlor- 4-(n-hexyl-1')-resorcin, dadurch gekennzeich net, dass man auf 4-(n-Hexyl-1')-resorcin ein Chlorierungsmittel in mindestens dimoleku- larem Verhältnis zur Einwirkung bringt. Das so erhältliche Dichlor-4-(n-hexyl-1')- resorcin siedet unter 0,5 mm Druck bei 1450. UNTERANSPRÜCHE: 1. Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass Sulfurylchlorid als Chlorierungsmittel Verwendung findet. 2. PATENT CLAIM: Process for the preparation of dichloro-4- (n-hexyl-1 ') - resorcinol, characterized in that 4- (n-hexyl-1') - resorcinol is a chlorinating agent in at least a dimolecular ratio to the action brings. The dichloro-4- (n-hexyl-1 ') - resorcinol thus obtainable boils under 0.5 mm pressure at 1450. SUBClaims: 1. Process according to patent claim, characterized in that sulfuryl chloride is used as the chlorinating agent. 2. Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass in Gegenwart eines indifferenten Lösemittels gearbeitet wird. Process according to patent claim, characterized in that it is carried out in the presence of an inert solvent.
CH175258D 1932-02-29 1933-02-21 Process for obtaining a therapeutically valuable product. CH175258A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE175258X 1932-02-29
CH167652T 1933-02-21

Publications (1)

Publication Number Publication Date
CH175258A true CH175258A (en) 1935-02-15

Family

ID=25718446

Family Applications (1)

Application Number Title Priority Date Filing Date
CH175258D CH175258A (en) 1932-02-29 1933-02-21 Process for obtaining a therapeutically valuable product.

Country Status (1)

Country Link
CH (1) CH175258A (en)

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