CH175256A - Process for obtaining a therapeutically valuable product. - Google Patents

Process for obtaining a therapeutically valuable product.

Info

Publication number
CH175256A
CH175256A CH175256DA CH175256A CH 175256 A CH175256 A CH 175256A CH 175256D A CH175256D A CH 175256DA CH 175256 A CH175256 A CH 175256A
Authority
CH
Switzerland
Prior art keywords
hexyl
obtaining
chlorine
therapeutically valuable
valuable product
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH175256A publication Critical patent/CH175256A/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

      Verfahren    zur Gewinnung eines therapeutisch wertvollen     Produktes.       Gegenstand des Hauptpatentes ist ein  Verfahren zur Darstellung von     Chlor-4-(n-          octyl-1')-resoi-cin.     



  Gegenstand des vorliegenden Patentes ist  ein Verfahren zur Darstellung von     Chlor-4-          (n-hexyl-1')-resorcin.    Das Verfahren ist da  durch gekennzeichnet, dass man auf     4-(n-          Hexyl-1')-i#esoi-ciri    ein     Ohlorierungsmittel    in  etwa molekularem Verhältnis einwirken lässt.  Als     Chlorierungsmittel    verwendet man zweck  mässig     Sulfurylchlorid    ; auch kann man freies  Chlor, zweckmässig in Gegenwart der übli  chen Katalysatoren, wie Eisen     bezw.    Eisen  chlorid, zur Anwendung bringen.

   Die Reak  tion kann in Gegenwart oder Abwesenheit  eines Lösemittels, wie Chlorbenzol,     Nitro-          benzol,        Ligroin,        Tetrachlorkohlenstoff    und  dergleichen ausgeführt werden. Das so er  hältliche.Chlor-4-(n-hexyl-1')-resorcin destilliert  als farbloses Öl unter 5-6 mm Druck bei  170-173  . Es ist schwer löslich in Wasser,  leicht löslich in organischen     Löseinittelri.       Das neue Produkt soll therapeutische An  wendung finden.  



       Beispiel:     30     gr        4-(n-Hexyl-1')-resoroin    werden in  etwa 100     eins    Chlorbenzol gelöst. Dazu lässt  man unter Rühren am     Rückflusskühler    bei  <B>50-60</B> 17     #i,        Sulfurylchlorid        zutropfen.     Wenn die Reaktion beendet ist, erwärmt  man noch eine Stunde auf dein Wasserbad  und treibt das     Lösungsmittel        ini        Nahnum     ab. Der Rückstand wird unter vermindertem  Druck destilliert.

   Das     Chlor-4-(n-hexyl-1')-          resorcin    siedet unter 5-6 mm     Druch    bei       170-17311.    Es ist schwer löslich in Wasser,  leicht löslich in organischen Lösungsmitteln.



      Process for obtaining a therapeutically valuable product. The subject of the main patent is a process for the preparation of chlorine-4- (n-octyl-1 ') - resoi-cin.



  The subject of the present patent is a process for the preparation of chloro-4- (n-hexyl-1 ') - resorcinol. The process is characterized in that 4- (n-hexyl-1 ') - i # esoi-ciri an chlorinating agent is allowed to act in an approximately molecular ratio. The chlorinating agent used is advantageously sulfuryl chloride; also you can bezw free chlorine, conveniently in the presence of übli chen catalysts such as iron. Iron chloride, apply.

   The reaction can be carried out in the presence or absence of a solvent such as chlorobenzene, nitrobenzene, ligroin, carbon tetrachloride and the like. The chlorine-4- (n-hexyl-1 ') resorcinol is distilled as a colorless oil under 5-6 mm pressure at 170-173. It is sparingly soluble in water, easily soluble in organic solvents. The new product is intended to find therapeutic applications.



       Example: 30 grams of 4- (n-hexyl-1 ') - resoroin are dissolved in about 100 liters of chlorobenzene. For this purpose, sulfuryl chloride is added dropwise with stirring on a reflux condenser at <B> 50-60 </B> 17%. When the reaction has ended, the mixture is warmed on your water bath for another hour and the solvent is driven off in the Nahnum. The residue is distilled under reduced pressure.

   The chlorine-4- (n-hexyl-1 ') - resorcinol boils below 5-6 mm diameter at 170-17311. It is sparingly soluble in water, slightly soluble in organic solvents.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung von Chlor-4- (n-hexyl-1')-i,esorcin, dadurch gekennzeichnet, dass man auf 4-(n-Hexyl-1')-resorcin ein Chlorierungsmittel in etwa molekularem Ver hältnis zur Einwirkung bringt. Das so erhältliche Chlor-4-(n-hexyl-1@)- resorcin destilliert als farbloses Öl unter 5-ö mm Druck bei 170-1730. UNTERANSPRüCEE 1. Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass Sulfurylchlorid als Chlorierungsmittel Verwendung finden. 2. PATENT CLAIM: Process for the preparation of chlorine-4- (n-hexyl-1 ') - i, esorcinol, characterized in that 4- (n-hexyl-1') - resorcinol is a chlorinating agent in an approximately molecular ratio to the action brings. The chlorine-4- (n-hexyl-1 @) - resorcinol thus obtainable distilled as a colorless oil under 5 mm pressure at 170-1730. SUB-CLAIMS 1. A method according to claim, characterized in that sulfuryl chloride is used as the chlorinating agent. 2. Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass in Gegenwart eines indifferenten Lösungsmittels gearbeitet wird. Process according to patent claim, characterized in that it is carried out in the presence of an inert solvent.
CH175256D 1932-02-29 1933-02-21 Process for obtaining a therapeutically valuable product. CH175256A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE175256X 1932-02-29
CH167652T 1933-02-21

Publications (1)

Publication Number Publication Date
CH175256A true CH175256A (en) 1935-02-15

Family

ID=25718444

Family Applications (1)

Application Number Title Priority Date Filing Date
CH175256D CH175256A (en) 1932-02-29 1933-02-21 Process for obtaining a therapeutically valuable product.

Country Status (1)

Country Link
CH (1) CH175256A (en)

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