CH192305A - Process for the preparation of an oil-soluble bismuth salt. - Google Patents
Process for the preparation of an oil-soluble bismuth salt.Info
- Publication number
- CH192305A CH192305A CH192305DA CH192305A CH 192305 A CH192305 A CH 192305A CH 192305D A CH192305D A CH 192305DA CH 192305 A CH192305 A CH 192305A
- Authority
- CH
- Switzerland
- Prior art keywords
- oil
- salt
- soluble
- preparation
- bismuth salt
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 6
- 150000001621 bismuth Chemical class 0.000 title claims description 5
- 159000000000 sodium salts Chemical class 0.000 claims description 9
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims description 4
- 229960001138 acetylsalicylic acid Drugs 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 4
- RXPAJWPEYBDXOG-UHFFFAOYSA-N hydron;methyl 4-methoxypyridine-2-carboxylate;chloride Chemical compound Cl.COC(=O)C1=CC(OC)=CC=N1 RXPAJWPEYBDXOG-UHFFFAOYSA-N 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 4
- 239000000243 solution Substances 0.000 description 3
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
- 229960004889 salicylic acid Drugs 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- USBHFGNOYVOTON-UHFFFAOYSA-K bis(dimethylcarbamothioylsulfanyl)bismuthanyl n,n-dimethylcarbamodithioate Chemical class [Bi+3].CN(C)C([S-])=S.CN(C)C([S-])=S.CN(C)C([S-])=S USBHFGNOYVOTON-UHFFFAOYSA-K 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Herstellung eines öllöslichen Wismatsalzes. Das Hauptpatent betrifft ein Verfahren zur Herstellung eines öllöslichen Wismut salzes, welches dadurch gekennzeichnet ist, dass man ein Mol Wismutnitrat mit zwei Mol des Natriumsalzes der Camphenilansäure und einem Mol des Natriumsalzes der Salicylsäure in wässeriger Lösung zur Umsetzung bringt.
Es wurde nun weiter gefunden, dass man ein öllösliches Wismutsalz auch dann erhalten kann, wenn man im Vergleich zum oben umschriebenen "Verfahren das Natriumsalz der Salicylsäure durch das Natriumsalz der Acetylsalicylsäure ersetzt.
Das vorliegende Patent betrifft demnach ein Verfahren zur Herstellung eines öllös lichen Wismutsalzes, welches dadurch ge kennzeichnet ist, dass man ein Mol Wismut nitrat mit zwei Mol des Natriumsalzes der Camphenilansäure und einem Mol des Na triumsalzes der Acetylsalicylsäure in wässe riger Lösung zur Umsetzung bringt.
Das so erhältliche neue Produkt bildet ein weisses, beim Erhitzen zersetzliches Salz, das öllöslich und wasserunlöslich ist. Seine Öllösung soll zu Reilzwecken, insbesondere zur parenteralen Behandlung von Protozoen- erkrankungen dienen.
Beispiel: Man löst 84 g Campbenilansäure und 18 g Acetylsalicylsäure zusammen als Natrium salze in 150 cm' Wasser und lässt dazu eine Lösung von 49 g Wismutnitrat in 450 cm3 20-prozentiger Mannitlösung fliessen. Die Weiterverarbeitung geschieht analog wie im Beispiel des Hauptpatentes.
Process for the preparation of an oil-soluble bismate salt. The main patent relates to a process for the production of an oil-soluble bismuth salt, which is characterized in that one mole of bismuth nitrate is reacted with two moles of the sodium salt of camphenilanic acid and one mole of the sodium salt of salicylic acid in aqueous solution.
It has now also been found that an oil-soluble bismuth salt can also be obtained if the sodium salt of salicylic acid is replaced by the sodium salt of acetylsalicylic acid in comparison with the “method described above.
The present patent accordingly relates to a process for the production of an oil-soluble bismuth salt, which is characterized in that one mole of bismuth nitrate is reacted with two moles of the sodium salt of camphenilanic acid and one mole of the sodium salt of acetylsalicylic acid in an aqueous solution.
The new product thus obtainable forms a white salt that decomposes when heated and is oil-soluble and water-insoluble. Its oil solution is intended to be used for Reil purposes, in particular for the parenteral treatment of protozoal diseases.
Example: 84 g of campbenilanic acid and 18 g of acetylsalicylic acid are dissolved together as sodium salts in 150 cm 'of water and a solution of 49 g of bismuth nitrate in 450 cm3 of 20 percent mannitol solution is allowed to flow. The further processing takes place analogously to the example of the main patent.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE192305X | 1934-05-04 | ||
| CH187249T | 1935-04-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH192305A true CH192305A (en) | 1937-07-31 |
Family
ID=25721502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH192305D CH192305A (en) | 1934-05-04 | 1935-04-30 | Process for the preparation of an oil-soluble bismuth salt. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH192305A (en) |
-
1935
- 1935-04-30 CH CH192305D patent/CH192305A/en unknown
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