CH206088A - Process for producing a pyrimidine compound. - Google Patents

Process for producing a pyrimidine compound.

Info

Publication number
CH206088A
CH206088A CH206088DA CH206088A CH 206088 A CH206088 A CH 206088A CH 206088D A CH206088D A CH 206088DA CH 206088 A CH206088 A CH 206088A
Authority
CH
Switzerland
Prior art keywords
ethyl
amino
acid
pyrimidine compound
producing
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH206088A publication Critical patent/CH206088A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Description

  

  Verfahren zur Herstellung einer     Pyrimidinverbindung.       Gegenstand des Hauptpatentes ist ein  Verfahren zur Herstellung einer     Pyrimidin-          verbindung,    welches dadurch gekennzeichnet  ist,     dass    man     2-Methyl-4-amino-5-aminome-          thylpyrimidin    durch Einwirkung von salpe  triger Säure in das     2-Methyl-4-amino-5-oxy-          methylpyrimidin    umwandelt.  



  Gegenstand des vorliegenden Patentes ist  ein Verfahren     zur    Herstellung einer     Pyrimi-          dinverbindung,    welches dadurch gekennzeich  net ist,     dass    man     2-Äthyl-4-amino-5-amino-          methylpyrimidin    durch Einwirken von sal  petriger Säure in das     2-Äthyl-4-amino-5-oxy-          methylpyrimidiii    umwandelt. Die salpetrige  Säure kann man in der Reaktionsmischung       aug    ihren Verbindungen, im besonderen ihren  Salzen entstehen lassen, indem man z. B.  die salpetrige Säure aus Ihren Salzen durch  Zusatz einer stärkeren Säure in, Freiheit  setzt.

   Diese starke Säure kann auch an das       2-Äthyl-4-amiiio-5-amiijomethylpyp,imidin    ge  bunden sein.    Das so erhältliche     2-Ätbyl-4-amino-5-oxy-          methylpyrimidin    bildet farblose Kristalle vom  F.<B>1151.</B> Es soll als     Ausgangsstoff    bei che  mischen Synthesen Verwendung finden.    <I>Beispiel:</I>    <B>67,5 g</B>     2-Athyl-5-aminomethyl-4-amino-          pyrimidinhydrochlorid    werden bei<B>50-60 0</B> in  <B>600</B> cm' Wasser gelöst. Bei     dieserTempera-          tur    wird eine Lösung von 22<B>g</B>     Natriumnitrit     in 200 cm' Wasser eingetropft.

   Man erhitzt  2 Stunden auf     50-601,    setzt 45<B>g</B> wasser  freies     Natriumcarbonat    dazu und verdampft  unter     vermindertemDruck    zur Trockne. Der  pulverisierte Rückstand wird mit Aceton heiss  ausgezogen. Beim Eindampfen des Acetons  erhält man das     2-Äthyl-4-amino-5-oxymethyl-          pyrimidin    in farblosen Kristallen vom F.<B>116 0.</B>



  Process for producing a pyrimidine compound. The main patent relates to a process for the production of a pyrimidine compound, which is characterized in that 2-methyl-4-amino-5-aminomethylpyrimidine is converted into 2-methyl-4-amino-5 by the action of nitrous acid -oxymethylpyrimidine converts.



  The present patent relates to a process for the preparation of a pyrimidine compound, which is characterized in that 2-ethyl-4-amino-5-aminomethylpyrimidine is converted into 2-ethyl-4-amino by the action of saline acid -5-oxymethylpyrimidiii converts. The nitrous acid can be formed in the reaction mixture aug its compounds, in particular its salts, by z. B. the nitrous acid from your salts by adding a stronger acid in, freedom.

   This strong acid can also be bound to the 2-ethyl-4-amiiio-5-amiijomethylpyp, imidine. The 2-ethyl-4-amino-5-oxymethylpyrimidine obtainable in this way forms colorless crystals of F. 1151. It is said to be used as a starting material in chemical syntheses. <I> Example: </I> <B> 67.5 g </B> of 2-ethyl-5-aminomethyl-4-aminopyrimidine hydrochloride are used at <B> 50-60 0 </B> in <B> 600 cm 'of water dissolved. At this temperature, a solution of 22 g sodium nitrite in 200 cm of water is added dropwise.

   The mixture is heated to 50-601 for 2 hours, 45 g of anhydrous sodium carbonate are added and the mixture is evaporated to dryness under reduced pressure. The pulverized residue is extracted hot with acetone. Evaporation of the acetone gives 2-ethyl-4-amino-5-oxymethylpyrimidine in colorless crystals of F. 116 0. </B>

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung einer Pyrimi- dinverbindung, dadurch gekennzeichnet, dass man 2-Äthyl-4-amino-5-amiriomethylpyi-i- midin durch Einwirken von salpetriger Säure in 2-Äthyl-4-amino-5-oxymethylpyrimidiii umwandelt. Die so erhältliche Verbindung bildet farb lose Kristalle vom F.<B>115 0.</B> UNTERANSPRüCHE: <B>1.</B> Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man salpetrige Säure verwendet, die aus Alkalinitrit und einer Säure hergestellt wurde. 2. Claim: Process for the preparation of a pyrimidine compound, characterized in that 2-ethyl-4-amino-5-amiriomethylpyi-imidine is converted into 2-ethyl-4-amino-5-oxymethylpyrimidiii by the action of nitrous acid. The compound obtainable in this way forms colorless crystals of F. <B> 115 0. </B> SUBClaims: <B> 1. </B> Process according to patent claim, characterized in that nitrous acid is used, which is composed of alkali metal nitrite and a Acid was produced. 2. Verfahren gemäss Unteranspruch<B>1,</B> dadurch gekennzeichnet, dass man salpetrige Säure verwendet, die aus Alkalinitrit und der durch Hydrolyse eines Salzes des 2-Äthyl- 4-amino-5-ainitiomethylpyrimidin gebil deten Säure hergestellt wurde. Process according to dependent claim 1, characterized in that nitrous acid is used which was prepared from alkali metal nitrite and the acid formed by hydrolysis of a salt of 2-ethyl-4-amino-5-ainitiomethylpyrimidine.
CH206088D 1936-05-15 1937-04-27 Process for producing a pyrimidine compound. CH206088A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE206088X 1936-05-15
CH199455T 1937-04-27

Publications (1)

Publication Number Publication Date
CH206088A true CH206088A (en) 1939-07-15

Family

ID=25723285

Family Applications (1)

Application Number Title Priority Date Filing Date
CH206088D CH206088A (en) 1936-05-15 1937-04-27 Process for producing a pyrimidine compound.

Country Status (1)

Country Link
CH (1) CH206088A (en)

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