CH227703A - Process for the preparation of a salt of a p-aminobenzenesulfamido-thiazole. - Google Patents

Process for the preparation of a salt of a p-aminobenzenesulfamido-thiazole.

Info

Publication number
CH227703A
CH227703A CH227703DA CH227703A CH 227703 A CH227703 A CH 227703A CH 227703D A CH227703D A CH 227703DA CH 227703 A CH227703 A CH 227703A
Authority
CH
Switzerland
Prior art keywords
thiazole
salt
preparation
aminobenzenesulfamido
sodium
Prior art date
Application number
Other languages
German (de)
Inventor
Gesellschaft Fuer Chemis Basel
Original Assignee
Chem Ind Basel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem Ind Basel filed Critical Chem Ind Basel
Publication of CH227703A publication Critical patent/CH227703A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/50—Nitrogen atoms bound to hetero atoms
    • C07D277/52—Nitrogen atoms bound to hetero atoms to sulfur atoms, e.g. sulfonamides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren zur Darstellung eines Salzes eines     p-Aminobenzolsulfamido-thiazols.       Es wurde gefunden, dass, man ein Salz  eines     p-Aminoib,enzolsulfamido-thiazols    her  stellen kann, wenn     man        2-,(p-Aminobenzol-          ,sulfamido)-thiazol    mit einem Wasserstoff  durch Natrium ersetzenden Mittel     umsetzt.     



  Die .neue Verbindung kristallisiert in  weissen     spiessigen        Blättchen    und ist in  Wasser mit schwach alkalischer Reaktion  leicht löslich. Sie soll als Heilmittel Ver  wendung finden.  



       Beispiel:     51     g        2-(p-Aminobenzolsulfamido)-thiazol          werdien    in 400 cm'     n-Natronlauge    gelöst und  mit 700     oms    gesättigter Kochsalzlösung ver  setzt. Nach     Stehen    über Nacht kristallisiert  das     Natriumsalz    in weissen spiessigen Blätt  chen aus. Es wird     abgesaugt    und mit Koch  salzlösung ausgewaschen. Es kann aus wenig  Wasser umkristallisiert werden.  



  Die gleiche Verbindung kann auch durch       Umsetzung    von     2-(p-Aminobenzolsulfamido)-          thiazol    mit einer Lösung von Natrium in  Alkohol hergestellt werden.



  Process for the preparation of a salt of a p-aminobenzenesulfamido-thiazole. It has been found that a salt of a p-aminoib, enzenesulfamido-thiazole can be produced if 2 -, (p-aminobenzene-, sulfamido) -thiazole is reacted with an agent which replaces hydrogen with sodium.



  The new compound crystallizes in white, sticky leaves and is easily soluble in water with a weakly alkaline reaction. It should be used as a remedy.



       Example: 51 g of 2- (p-aminobenzenesulfamido) thiazole are dissolved in 400 cm of sodium hydroxide solution and treated with 700 oms of saturated sodium chloride solution. After standing overnight, the sodium salt crystallizes out in white, sticky leaves. It is suctioned off and washed out with saline solution. It can be recrystallized from a little water.



  The same compound can also be prepared by reacting 2- (p-aminobenzene sulfamido) thiazole with a solution of sodium in alcohol.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung eines Salzes eines p-Aminobenzolsulfamido-thiazols, da durch gekennzeichnet, dass man 2-(p-Amino- b@enzolsulfamido)-thiazo. mit einem Wasser stoff .durch Natrium ersetzenden Mittel um setzt. Die neue Verbindung kristallisiert in weissen spiessigen Blättchen und ist in Wasser mit schwach alkalischer Reaktion leicht löslich. Claim: Process for the preparation of a salt of a p-aminobenzene sulfamido-thiazole, characterized in that one is 2- (p-amino-b @ enzolsulfamido) -thiazo. with a hydrogen, sodium-replacing agent. The new compound crystallizes in white, bite-sized leaves and is easily soluble in water with a weakly alkaline reaction. Sie soll als Heilmittel Ver wendung finden. <B>UNTERANSPRÜCHE:</B> 1. Verfahren nach Patentanspruch, da durch .gekennzeichnet, dass man mit Natron lauge umsetzt. 2. Verfahren nach Patentanspruch, da- ,durch gekennzeichnet, @dass man mit einer Lösung von Natrium in Alkohol umsetzt. It should be used as a remedy. <B> SUBClaims: </B> 1. Process according to patent claim, as indicated by the fact that one reacts with caustic soda. 2. The method according to claim, characterized in that @that is reacted with a solution of sodium in alcohol.
CH227703D 1939-10-16 1939-10-16 Process for the preparation of a salt of a p-aminobenzenesulfamido-thiazole. CH227703A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH227703T 1939-10-16

Publications (1)

Publication Number Publication Date
CH227703A true CH227703A (en) 1943-06-30

Family

ID=4455189

Family Applications (1)

Application Number Title Priority Date Filing Date
CH227703D CH227703A (en) 1939-10-16 1939-10-16 Process for the preparation of a salt of a p-aminobenzenesulfamido-thiazole.

Country Status (1)

Country Link
CH (1) CH227703A (en)

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