CH176253A - Process for the preparation of 2-n-propylmercury-mercapto-benzoxazole-5-carboxylic acid sodium. - Google Patents
Process for the preparation of 2-n-propylmercury-mercapto-benzoxazole-5-carboxylic acid sodium.Info
- Publication number
- CH176253A CH176253A CH176253DA CH176253A CH 176253 A CH176253 A CH 176253A CH 176253D A CH176253D A CH 176253DA CH 176253 A CH176253 A CH 176253A
- Authority
- CH
- Switzerland
- Prior art keywords
- carboxylic acid
- mercapto
- benzoxazole
- acid sodium
- propylmercury
- Prior art date
Links
- -1 2-n-propylmercury-mercapto-benzoxazole-5-carboxylic acid sodium Chemical compound 0.000 title claims description 5
- 238000000034 method Methods 0.000 title claims description 4
- 238000002360 preparation method Methods 0.000 title description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 3
- ZLAYJSKLDWSALK-UHFFFAOYSA-M chloro(propyl)mercury Chemical compound CCC[Hg]Cl ZLAYJSKLDWSALK-UHFFFAOYSA-M 0.000 claims description 3
- 230000002421 anti-septic effect Effects 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 235000019441 ethanol Nutrition 0.000 claims description 2
- 159000000000 sodium salts Chemical class 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- GUGDWCNTMFYFRB-UHFFFAOYSA-N 2-sulfanylidene-3h-1,3-benzoxazole-5-carboxylic acid Chemical compound OC(=O)C1=CC=C2OC(=S)NC2=C1 GUGDWCNTMFYFRB-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- YYQQVAQHGCXUAM-UHFFFAOYSA-N propan-2-ylmercury Chemical compound CC(C)[Hg] YYQQVAQHGCXUAM-UHFFFAOYSA-N 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Description
Verfahren zur Herstellung von 2-n-propylquecksilber-mercapto-benzogazol-5-carbon- saurem Natrium. Gegenstand der vorliegenden Erfindung ist ein Verfahren zur Herstellung von 2-ii- propylquecksilber- mercapto -benzoxazol-5-car- bonsaurem Natrium, das dadurch gekennzeich net ist, dass man n-Propylquecksilberchlorid mit 2-Mercaptobenzoxazol-5-carbonsäure um setzt und die so erhaltene Säure in das Na triumsalz überführt.
Die entstandene neue Verbindung ist leicht löslich in Wasser und Methylalkohol, schwerer in Äthylalkohol und unlöslich in Äther und Aceton. Sie soll als Arzneimittel und Anti- septicum verwendet werden.
Beispiel: Zu einer wässerigen Aufschlämmung von 8,33 gr n-Propylquecksilberehlorid, dargestellt nach Journ. f. praktische Chemie 120, 1929, S. 275, lässt man unter Rühren eine Lösung von 8,2 gr 2-mercaptobenzoxazol-5-carbon- saurem Natrium in stark alkalisch-wässeriger Lösung zulaufen. Nach längerem Stehen wird der dicke, farblose Brei abgesaugt, in Wasser gelöst, filtriert und mit verdünnter Schwefel säure angesäuert.
Die ausgeschiedene, farb lose, quecksilberhaltige Säure wird abgesaugt, mit Wasser gewaschen und in analoger Weise, wie imHauptpatent angegeben, auf 2-n-propyl- quecksilber - mereaptobenzoxazol - 5 - carbon saures Natrium von der Formel
EMI0001.0025
verarbeitet. Der farblose Körper zeigt dieselben Löslichkeitseigenschaften wie die entspre chende Äthylverbindung.
Process for the preparation of 2-n-propylmercury-mercapto-benzogazole-5-carboxylic acid sodium. The present invention relates to a process for the preparation of 2-iisopropylmercury mercapto-benzoxazole-5-carboxylic acid sodium, which is characterized in that n-propylmercury chloride is reacted with 2-mercaptobenzoxazole-5-carboxylic acid and the acid obtained in this way converted into the sodium salt.
The resulting new compound is easily soluble in water and methyl alcohol, more difficult in ethyl alcohol and insoluble in ether and acetone. It is said to be used as a medicine and an antiseptic.
Example: For an aqueous slurry of 8.33 g of n-propyl mercury chloride, prepared according to Journ. f. Practical Chemistry 120, 1929, p. 275, a solution of 8.2 g of 2-mercaptobenzoxazole-5-carboxylic acid sodium in a strongly alkaline aqueous solution is allowed to run in with stirring. After standing for a long time, the thick, colorless paste is suctioned off, dissolved in water, filtered and acidified with dilute sulfuric acid.
The precipitated, colorless, mercury-containing acid is filtered off with suction, washed with water and in an analogous manner, as indicated in the main patent, on 2-n-propyl mercury - mereaptobenzoxazole - 5 - carbonic acid sodium of the formula
EMI0001.0025
processed. The colorless body shows the same solubility properties as the corresponding ethyl compound.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE176253X | 1932-04-16 | ||
| CH167320T | 1933-04-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH176253A true CH176253A (en) | 1935-03-31 |
Family
ID=25718406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH176253D CH176253A (en) | 1932-04-16 | 1933-04-13 | Process for the preparation of 2-n-propylmercury-mercapto-benzoxazole-5-carboxylic acid sodium. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH176253A (en) |
-
1933
- 1933-04-13 CH CH176253D patent/CH176253A/en unknown
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