CH235437A - Process for the preparation of a reactive ester of an oxyalkylamidine. - Google Patents

Process for the preparation of a reactive ester of an oxyalkylamidine.

Info

Publication number
CH235437A
CH235437A CH235437DA CH235437A CH 235437 A CH235437 A CH 235437A CH 235437D A CH235437D A CH 235437DA CH 235437 A CH235437 A CH 235437A
Authority
CH
Switzerland
Prior art keywords
ether
oxyalkylamidine
preparation
reactive ester
process according
Prior art date
Application number
Other languages
German (de)
Inventor
Gesellschaft Fuer Chemis Basel
Original Assignee
Chem Ind Basel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem Ind Basel filed Critical Chem Ind Basel
Publication of CH235437A publication Critical patent/CH235437A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/195—Radicals derived from nitrogen analogues of carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)

Description

  

  Verfahren zur Darstellung eines     reaktionsfähigen    Esters eines     Ozyalkylamidins.       Es wurde gefunden, dass man zu einem  reaktionsfähigen Ester eines     Oxyalkylamidins     gelangen kann, wenn man einen     Chloracet-          imidoäther    mit     Piperidin    umsetzt. Zweck  mässig arbeitet man in Gegenwart eines     Lö-          sunbmittels.     



  Das     @so    gewonnene     Chloracetpiperidin-          amidin    der Formel  
EMI0001.0012     
    bildet ein     farbloses    Hydrochlorid vom F.176 .  In Wasser     isst    es leicht löslich. Es soll als  Zwischenprodukt Verwendung finden.    <I>Beispiel:</I>    15, 7 Teile     Chloracetimidoäthyläther        -          hydrochlorid    werden unter guter     Kühlung     in eine alkoholische Lösung von 8,5 Teilen       Piperidin    eingetragen und einige Zeit ge  schüttelt, wobei die Komponenten in     Lösung       gehen.

   Hierauf wird das     Lösungsmittel    im  Vakuum     abdestilliert    und der Rückstand  mehrmals mit Aceton ausgezogen. Der un  lösliche Teil stellt     Chloracetpiperidinamdin-          hydrochlorid    vom F.     1716!     dar.  



  An Stelle des     Chloracetimidoäthyläthers     kann man auch einen andern Äther ver  wenden.



  Process for the preparation of a reactive ester of an ozyalkylamidine. It has been found that a reactive ester of an oxyalkylamidine can be obtained if a chloroacetimido ether is reacted with piperidine. It is advisable to work in the presence of a solvent.



  The @so obtained chloroacetpiperidineamidine of the formula
EMI0001.0012
    forms a colorless hydrochloride of F.176. It is easily soluble in water. It should be used as an intermediate product. <I> Example: </I> 15.7 parts of chloroacetimidoethyl ether hydrochloride are introduced into an alcoholic solution of 8.5 parts of piperidine with good cooling and shaken for some time, the components dissolving.

   The solvent is then distilled off in vacuo and the residue is extracted several times with acetone. The insoluble part is Chloracetpiperidinamdin- hydrochloride from the F. 1716! represent.



  Instead of the chloroacetimidoethyl ether, another ether can be used.

Claims (1)

PATENTANSPRUCH Verfahren zur Darstellung eines reak tionsfähigen Esters eines Oxyalkylamidins, dadurch gpkennzeiöhnet, dass man einen Chloracetimidoäther mit Piperidin umsetzt. Das so gewonnene Chloracetpiperidin- amidin der Formel EMI0001.0036 bildet ein farbloses Hydrochlorid vom F. 176'. In Wasser ist es leicht löslich. Es soll als Zwischenprodukt Verwendung finden. UNTERANSPRÜCIIE 1. PATENT CLAIM A process for the preparation of a reactive ester of an oxyalkylamidine, characterized in that a chloroacetimido ether is reacted with piperidine. The chloroacetpiperidineamidine of the formula obtained in this way EMI0001.0036 forms a colorless hydrochloride of F. 176 '. It is easily soluble in water. It should be used as an intermediate product. SUBCLAIM 1. Verfahren nach Patentanspruch, da durch gekennzeichnet, dass man zur L?m- setzung Chloracetimidoäthyläther verwendet. Verfahren nach Patentanspruch, da durch gekennzeichnet, dass man einen Chlor- acetimidoälher .verwendet, der aus einem Salz desselben erhalten wurde. 3. Verfahren nach Unteranspruch ?, da durch gekennzeichnet, dass man einen Chlor acetimidoäther verwendet, der aus einem Hydrohalogenid desselben erhalten wurde. 4. Process according to patent claim, characterized in that chloroacetimidoethyl ether is used for the solution. Process according to patent claim, characterized in that one uses a chloroacetimido ether which was obtained from a salt thereof. 3. The method according to dependent claim?, Characterized in that a chlorine acetimido ether is used, which was obtained from a hydrohalide of the same. 4th Verfahren nach Patentanspruch und den Unteransprüchen. 2 und 3" dadurch ge- kennzeichnet, dass man einen Chloracetimido- äther verwendet, der aus einem Hydrochlorid desselben erhalten wurde. 5. Verfahren nach Patentansprueh, da durch gekennzeichnet, dass man in Gegen wart eines Lösungsmittels arbeitet. _ 6. Verfahren nach Patentanspruch und den Unteransprüchen 1 bis 4, dadurch be- kennzeichnet, dass man Chloracetimidoäthyl- äther verwendet, der aus dem Hydrochlorid desselben erhalten wurde. Method according to claim and the subclaims. 2 and 3 "characterized in that a chloroacetimido ether is used which was obtained from a hydrochloride of the same. 5. Process according to patent claim, characterized in that one works in the presence of a solvent. _ 6. Process according to patent claim and the dependent claims 1 to 4, characterized in that chloroacetimidoethyl ether is used, which was obtained from the hydrochloride of the same.
CH235437D 1938-05-11 1938-05-11 Process for the preparation of a reactive ester of an oxyalkylamidine. CH235437A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH235437T 1938-05-11
CH229606T 1938-05-11

Publications (1)

Publication Number Publication Date
CH235437A true CH235437A (en) 1944-11-30

Family

ID=25727372

Family Applications (1)

Application Number Title Priority Date Filing Date
CH235437D CH235437A (en) 1938-05-11 1938-05-11 Process for the preparation of a reactive ester of an oxyalkylamidine.

Country Status (1)

Country Link
CH (1) CH235437A (en)

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