CH240400A - Process for the preparation of an acylated, aliphatic aminocarboxamide. - Google Patents

Process for the preparation of an acylated, aliphatic aminocarboxamide.

Info

Publication number
CH240400A
CH240400A CH240400DA CH240400A CH 240400 A CH240400 A CH 240400A CH 240400D A CH240400D A CH 240400DA CH 240400 A CH240400 A CH 240400A
Authority
CH
Switzerland
Prior art keywords
sep
acylated
preparation
aliphatic
aminocarboxamide
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH240400A publication Critical patent/CH240400A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren     zier        Darstellung    eines     acylierten,        aliphatisehen        Aminocarbonsäureaniids.       Gegenstand des vorliegenden Zusatz  patentes ist ein Verfahren zur Darstellung  eines     acylierten,        aliphatischen        Aminocarbon-          säureamids.Das    Verfahren     ist    dadurch gekenn  zeichnet, dass ein     a-Halogen-n-buttersäure-          methyläthylamid    mit     Äthylamin    umgesetzt  und das Reaktionsprodukt mit einer das Ra  dikal der     ss,

  ss-Dimethyl-acrylsäure    abgeben  den Verbindung     acyliert    wird.  



  Das     N-(l,ss-Dimethyl    -     acroyl)        -a-äthyl-          amino    - n -     buttersäuremethyläthylamid    der  Formel  
EMI0001.0021     
    bildet eine farblose Flüssigkeit vom Siede  punkt 125-l26  unter 0,1 mm.  



  Die neue Verbindung soll therapeutische       Verwendung    finden.    <I>Beispiel:</I>       3'4,2    Teile     a-Äthylamino-n-buttersäure-          methyläthylamid,        Kp13    106-109  (darge  stellt aus     a-Brom-n-buttersäuremethyläthyl-          amid    durch Erhitzen mit     Äthylamin),

      wer  den in 200 Teilen Äther gelöst und unter  Rühren und Kühlen 12 Teile     f'"8-Dimethyl-          acrylsäurechlorid        zugetropft.    Nach     2stündi-          gem    Rühren wird vom     a-Äthylamino-n-          buttersäuremethyläthylamid-chlorhydrat        erb-          filtriert    und die ätherische Lösung mit ge  sättigter     Kalilauge    geschüttelt. Nach dem       Abdestillieren    des     Lösungsmittels        wird    das  Reaktionsprodukt im Hochvakuum rektifi  ziert.

   Die neue     Verbindung    siedet bei 125  bis 126  unter 0,1 mm und ist leicht löslich  in Wasser und organischen Lösungsmitteln.



  Process for the preparation of an acylated, aliphatic aminocarboxylic acid aniide. The subject of the present additional patent is a process for the preparation of an acylated, aliphatic aminocarboxylic acid amide. The process is characterized in that an α-halo-n-butyric acid methylethylamide is reacted with ethylamine and the reaction product is

  ss-dimethyl acrylic acid release the compound is acylated.



  The N- (l, ss-dimethyl-acroyl) -a-ethyl-amino-n-butyric acid methylethylamide of the formula
EMI0001.0021
    forms a colorless liquid with a boiling point of 125-126 below 0.1 mm.



  The new compound should find therapeutic use. <I> Example: </I> 3'4.2 parts of a-ethylamino-n-butyric acid methylethylamide, Kp13 106-109 (shown from a-bromo-n-butyric acid methylethylamide by heating with ethylamine),

      are dissolved in 200 parts of ether and 12 parts of 8-dimethyl acrylic acid chloride are added dropwise with stirring and cooling After the solvent has been distilled off, the reaction product is rectified in a high vacuum.

   The new compound boils below 0.1 mm at 125 to 126 mm and is easily soluble in water and organic solvents.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung eines acylier- ten, aliphatischen Aminocarbonsäureamids, dadurch gekennzeichnet, dass ein a-Halogen- n-buttersäuremethyläthylamid mit Äthyl- EMI0002.0001 amin <SEP> umbesetzt <SEP> und <SEP> das <SEP> Reaktionsprodukt <tb> mit <SEP> einer <SEP> das <SEP> Radikal <SEP> der <SEP> ss,p-Dimetliyl aerylsäure <SEP> abgebenden <SEP> Verbindung <SEP> acyliert <tb> wird. <tb> Das <SEP> N-(l.l-Dimetliyl-aeroyl) PATENT CLAIM: Process for the preparation of an acylated, aliphatic aminocarboxamide, characterized in that an α-halogen n-butyric acid methylethylamide with ethyl EMI0002.0001 amine <SEP> repopulates <SEP> and <SEP> the <SEP> reaction product <tb> with <SEP> an <SEP> acylates the <SEP> radical <SEP> of the <SEP> ss, p-dimethyl aerylic acid <SEP> releasing <SEP> compound <SEP> <tb> will. <tb> The <SEP> N- (l.l-Dimetliyl-aeroyl) -a-ätliyl amino <SEP> - <SEP> n <SEP> - <SEP> buttersäuremethyleithylaniid <SEP> der <tb> Formel EMI0002.0002 bildet eine farblose Flüssigkeit vom Siede punkt 125-I26 unter 0,1 mm. Die neue Verbindung soll therapeutische Verwendung finden. -a-ätliyl amino <SEP> - <SEP> n <SEP> - <SEP> butyric acid methyl ethyl amide <SEP> der <tb> formula EMI0002.0002 forms a colorless liquid with a boiling point of 125-126 below 0.1 mm. The new compound should find therapeutic use.
CH240400D 1942-12-18 1942-12-18 Process for the preparation of an acylated, aliphatic aminocarboxamide. CH240400A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH234453T 1942-12-18
CH240400T 1942-12-18

Publications (1)

Publication Number Publication Date
CH240400A true CH240400A (en) 1945-12-15

Family

ID=25727917

Family Applications (1)

Application Number Title Priority Date Filing Date
CH240400D CH240400A (en) 1942-12-18 1942-12-18 Process for the preparation of an acylated, aliphatic aminocarboxamide.

Country Status (1)

Country Link
CH (1) CH240400A (en)

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