CH291680A - Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane. - Google Patents

Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.

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Publication number
CH291680A
CH291680A CH291680DA CH291680A CH 291680 A CH291680 A CH 291680A CH 291680D A CH291680D A CH 291680DA CH 291680 A CH291680 A CH 291680A
Authority
CH
Switzerland
Prior art keywords
bis
alkane
quaternary ammonium
preparation
aminoalkoxy
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH291680A publication Critical patent/CH291680A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

      Verfahren    zur Herstellung     einer        quaternären        Ammoniumverbindung     eines     Bis-aminoalkoxy-alkans.            CTegenstand    vorliegenden Patentes ist ein  Verfahren zur Herstellung einer     quaternären          Ammoniumverbindung    eines     Bis-amino-alkoxy-          alkans.    Das Verfahren ist dadurch gekenn  zeichnet, dass man auf ein     Mol        1,4-Bis-(ss-jod-          äthoxy    )

  -betan zwei     Mol        Trimethylamin    ein  wirken lässt.  



  Die erhaltene neue Verbindung, das     1,4-          Bis-        (ss-trimethylammonium    -     äthoxy)        -butan-di-          ,jodid,    schmilzt bei 235 . Sie soll therapeutische  Verwendung finden.  



       Beispiel:          3,98    Teile     1,4-Bis-(ss-jod-äthoxy)-butan     (erhalten durch Kochen von     1,4-Bis-(ss-brom-          iitlioxy        )-betan    mit     Natriumjodid    in Aceton)       werden    mit 1.2 Teilen einer     methanolischen          7'i#imethj-laminlösung        (20%)        im    Einschmelz-    rohe 4 Stunden im siedenden Wasserbad  erwärmt. Anschliessend versetzt man die Lö  sung mit etwas     Butanon,    dampft sie bis zur  beginnenden Trübung ein und lässt in der  Kälte kristallisieren.

   Das erhaltene     1,4-Bis-          (ss    -     trimethyl    -     ammonium    -     äthoxy)        -butan-dij        o-          did        schmilzt    nach     Umkristallisation    aus Me  thanol     -i-        Butanon    bei 235 .



      Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane. The subject of the present patent is a process for the preparation of a quaternary ammonium compound of a bis-amino-alkoxyalkane. The process is characterized in that one mole of 1,4-bis (ss-iodo-ethoxy)

  -Betan two moles of trimethylamine can act.



  The new compound obtained, the 1,4-bis- (ss-trimethylammonium-ethoxy) -butane-di- iodide, melts at 235. It should find therapeutic use.



       Example: 3.98 parts of 1,4-bis- (ss-iodo-ethoxy) -butane (obtained by boiling 1,4-bis- (ss-bromo-iitlioxy) -betane with sodium iodide in acetone) are 1.2 parts a methanolic 7'i # imethj-lamin solution (20%) in the melt-down crude heated for 4 hours in a boiling water bath. Then the solution is mixed with a little butanone, evaporated until it starts to become cloudy and allowed to crystallize in the cold.

   The 1,4-bis (ss-trimethyl-ammonium-ethoxy) -butane-dijodide obtained melts at 235 after recrystallization from methanol-butanone.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung einer quat.er- nären Ammoniumverbindung eines Bis-amino- a.lkoxy-alkans, dadurch gekennzeichnet, dass man auf ein Mol 1,4-Bis-(ss-jod-äthoxy)-butan zwei Mol Trimethylamin einwirken lässt. Die erhaltene neue Verbindung, das 1,4- Bis- (ss-trimethyl-ammonium-äthoxy)-biitan-di- jodid, schmilzt bei 235 . Claim: Process for the production of a quaternary ammonium compound of a bis-amino-a.lkoxy-alkane, characterized in that two moles of trimethylamine act on one mole of 1,4-bis- (ß-iodo-ethoxy) -butane leaves. The new compound obtained, 1,4-bis- (ss-trimethyl-ammonium-ethoxy) -biitane-di-iodide, melts at 235.
CH291680D 1952-04-21 1949-12-07 Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane. CH291680A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH291680T 1952-04-21

Publications (1)

Publication Number Publication Date
CH291680A true CH291680A (en) 1953-06-30

Family

ID=4487541

Family Applications (1)

Application Number Title Priority Date Filing Date
CH291680D CH291680A (en) 1952-04-21 1949-12-07 Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.

Country Status (1)

Country Link
CH (1) CH291680A (en)

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