CH293940A - Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane. - Google Patents

Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.

Info

Publication number
CH293940A
CH293940A CH293940DA CH293940A CH 293940 A CH293940 A CH 293940A CH 293940D A CH293940D A CH 293940DA CH 293940 A CH293940 A CH 293940A
Authority
CH
Switzerland
Prior art keywords
sep
bis
alkane
quaternary ammonium
ammonium compound
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH293940A publication Critical patent/CH293940A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren     zur        Herstellung    einer     quaternären        Ammoniumverbindung     eines     Bis-aminoalkogy-alkans.     
EMI0001.0006     
  
    Gegenstand <SEP> vorliegenden <SEP> Patentes <SEP> ist <SEP> ein
<tb>  Verfahren <SEP> zur <SEP> Verstellung- <SEP> einer <SEP> qtiatei-näreti
<tb>  Aniniotiiumverbindutig <SEP> eines <SEP> Bis-aininoalkoxy  alkans. <SEP> Das <SEP> Verfahren <SEP> ist <SEP> dadurch <SEP> gekenn  zeichnet, <SEP> dass <SEP> man <SEP> auf <SEP> ein <SEP> 11o1 <SEP> 1,1.0-Bis-(;r-di  inet <SEP> liy)iiniitio-liropoxy)-dekaii <SEP> zwei <SEP> 11o1 <SEP> hleth.-1  jodid <SEP> einwirken <SEP> lässt.
<tb>  



  Die <SEP> erhaltene <SEP> neue <SEP> Verbindung, <SEP> das <SEP> 1,10  Bis- <SEP> (@ <SEP> -triniethylaninionium-propoxy)-clekan  dijodid, <SEP> schmilzt <SEP> bei <SEP> 1-18 <SEP> bis <SEP> 150". <SEP> Sie <SEP> soll
<tb>  therapeutische <SEP> Verwendung <SEP> finden.            Beispiel:     
EMI0001.0008     
  
    17,2 <SEP> Teile <SEP> 1.,10-Bis-(;-dimet.hyla.inino-prop  oxy)-ilekan <SEP>  -erden <SEP> mit <SEP> 80 <SEP> Teilen <SEP> troekenein
<tb>  Aceton <SEP> und <SEP> 78 <SEP> Teilen <SEP> liethyljoclicl <SEP> 1.4 <SEP> Stunden
<tb>  in <SEP> einem <SEP> Wasserbad <SEP> von <SEP> 50 <SEP> bis <SEP> 60  <SEP> erwärmt.
<tb>  Nach <SEP> Erkalten <SEP> wird <SEP> abgesaugt <SEP> und <SEP> das <SEP> erhal  tene <SEP> 1,l0-Bis- <SEP> (;

   <SEP> -trimethylammonium-prop-            oxv)-dekan-dijodid        \gewünsehtenfalls    durch       Umkristallisieren        aus        Butanon    +     weni-        abs.     :Methanol     gereinigt,    indem das Salz in\ mög  lichst wenig heissem     3lethanol    gelöst und  darauf so viel heisses     Butanon    zugefügt wird,  dass in der Hitze noch alles gelöst bleibt. Das  umkristallisierte Produkt schmilzt bei 148  bis 150 .



  Process for the preparation of a quaternary ammonium compound of a bis-aminoalkogyalkane.
EMI0001.0006
  
    The subject of <SEP> present <SEP> patent <SEP> is <SEP> a
<tb> Method <SEP> for <SEP> adjustment- <SEP> of a <SEP> qtiatei-näreti
<tb> Aniniotium-binding <SEP> of a <SEP> bis-aininoalkoxy alkane. <SEP> The <SEP> method <SEP> is <SEP> characterized by <SEP>, <SEP> that <SEP> man <SEP> on <SEP> <SEP> 11o1 <SEP> 1,1.0-bis - (; r-di inet <SEP> liy) iiniitio-liropoxy) -dekaii <SEP> lets two <SEP> 11o1 <SEP> hleth.-1 jodid <SEP> take effect <SEP>.
<tb>



  The <SEP> received <SEP> new <SEP> compound, <SEP> the <SEP> 1.10 bis- <SEP> (@ <SEP> -triniethylaninionium-propoxy) -clekan diiodide, <SEP> melts <SEP> for <SEP> 1-18 <SEP> to <SEP> 150 ". <SEP> you should <SEP>
Find <tb> therapeutic <SEP> use <SEP>. Example:
EMI0001.0008
  
    17.2 <SEP> parts <SEP> 1., 10-bis - (; - dimet.hyla.inino-prop oxy) -ilekan <SEP> -erden <SEP> with <SEP> 80 <SEP> parts <SEP > dry no
<tb> Acetone <SEP> and <SEP> 78 <SEP> parts <SEP> liethyljoclicl <SEP> 1.4 <SEP> hours
<tb> in <SEP> a <SEP> water bath <SEP> heated from <SEP> 50 <SEP> to <SEP> 60 <SEP>.
<tb> After <SEP> has cooled down <SEP> <SEP> is extracted <SEP> and <SEP> the <SEP> received <SEP> 1, 10-bis- <SEP> (;

   <SEP> -trimethylammonium-prop- oxv) -dekan-dijodid \ if desired by recrystallization from butanone + less abs. : Methanol is purified by dissolving the salt in as little hot 3lethanol as possible and then adding so much hot butanone that everything remains dissolved in the heat. The recrystallized product melts at 148 to 150.

Claims (1)

<B>PATENTANSPRUCH:</B> Verfahren zur Herstellung einer quaternä- ren Ammoniumverbindung eines Bis-amino- a.lkoxy-alkans, dadurch gekennzeichnet, dass man auf ein 11o1 1,10-Bis-("-dimethylamino- propoxy)-dekan zwei 11o1 llethyljodid ein wirken lässt. <B> PATENT CLAIM: </B> Process for the production of a quaternary ammonium compound of a bis-amino-a.lkoxy-alkane, characterized in that a 1,10-bis - ("- dimethylamino-propoxy) - Dekan allows two 11o1 llethyl iodide to work. Die erhaltene neue Verbindung, das 1,10- Bis- (y-trimethylammonium-propoxy )-dekan- dijodid, schmilzt bei 148 bis 150 . The new compound obtained, the 1,10-bis (γ-trimethylammonium-propoxy) -dekan- diiodide, melts at 148 to 150.
CH293940D 1949-12-07 1949-12-07 Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane. CH293940A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH293940T 1949-12-07
CH290449T 1952-04-21

Publications (1)

Publication Number Publication Date
CH293940A true CH293940A (en) 1953-10-15

Family

ID=25733000

Family Applications (1)

Application Number Title Priority Date Filing Date
CH293940D CH293940A (en) 1949-12-07 1949-12-07 Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.

Country Status (1)

Country Link
CH (1) CH293940A (en)

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