CH311097A - Process for the preparation of an N-aryl-N'-aminoalkyl urea. - Google Patents

Process for the preparation of an N-aryl-N'-aminoalkyl urea.

Info

Publication number
CH311097A
CH311097A CH311097DA CH311097A CH 311097 A CH311097 A CH 311097A CH 311097D A CH311097D A CH 311097DA CH 311097 A CH311097 A CH 311097A
Authority
CH
Switzerland
Prior art keywords
ethyl
urea
aryl
preparation
formula
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH311097A publication Critical patent/CH311097A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  



  Verfahren zur Herstellung eines   N-Aryl-N'-aminoalkyl-harnstoffes.   



   Gegenstand vorliegenden Patentes ist ein Verfahren zur Herstellung eines N-Aryl-N'aminoalkyl-harnstoffes. Das Verfahren ist dadurch gekennzeichnet, dass man eine Verbindung der Formel
EMI1.1     
 auf eine Verbindung der Formel
EMI1.2     
 einwirken lässt, worin X und Y reaktions  fähige,    sich unmittelbar zur Gruppe
EMI1.3     
 verbindende Reste bedeuten, wobei X die Atomgruppierung
EMI1.4     
   Itnd    Y die Atomgruppierung
EMI1.5     
 enthält. Beispielsweise kann man 2,6-Dimethylphenylisocyanat auf   N, N-Diäthyl-N'-äthyl-    äthylendiamin einwirken lassen.



   Die erhaltene neue Verbindung, der N  (2,6-Dimethyl-phenyl)-N'-äthyl-N'-   (ss-diäthyl-      amino-äthyl)-harnstoff,    sehmilzt bei   55 .    Sie soll als Arzneimittel und als Zwischenprodukt für Arzneimittel Verwendung finden.



   Beispiel :
In eine Lösung von 8,7 Teilen N, N-Di äthyl-N'-äthyl-äthylendiamin in 40 Volumteilen abs.   Xther    werden innerhalb 10 Minuten 9 Teile 2,6-Dimethyl-phenylisocyanat eingetropft, das Ganze noch 1 Stunde unter   Rück-    fluss gekocht und anschliessend   der Xther    abdestilliert. Der ölige Rückstand kann durch Zusatz von Petroläther zur Kristallisation gebracht werden. Der   N- (2, 6-Dimethyl-phenyl)-    N'-äthyl-N'-   (ss-diäthylamino-äthyl)-harnstoff    schmilzt bei   55 .     



   PATENTANSPRUCH :
Verfahren zur Herstellung eines N-Aryl  NT'-aminoalkyl-harnstoffes,    dadurch gekennzeichnet, dass man eine Verbindung der Formel
EMI1.6     
 auf eine Verbindung der Formel
EMI1.7     
 

**WARNUNG** Ende DESC Feld konnte Anfang CLMS uberlappen**.





  



  Process for the preparation of an N-aryl-N'-aminoalkyl urea.



   The subject of the present patent is a process for the preparation of an N-aryl-N'aminoalkyl-urea. The process is characterized in that a compound of the formula
EMI1.1
 to a compound of the formula
EMI1.2
 can act, in which X and Y are reactive, directly to the group
EMI1.3
 mean connecting radicals, where X is the atomic grouping
EMI1.4
   Itnd Y the atom grouping
EMI1.5
 contains. For example, 2,6-dimethylphenyl isocyanate can be allowed to act on N, N-diethyl-N'-ethyl-ethylenediamine.



   The new compound obtained, N (2,6-dimethylphenyl) -N'-ethyl-N'- (ss-diethyl-amino-ethyl) -urea, melts at 55. It is intended to be used as a medicinal product and as an intermediate for medicinal products.



   Example:
In a solution of 8.7 parts of N, N-diet ethyl-N'-ethyl-ethylenediamine in 40 parts by volume of abs. 9 parts of 2,6-dimethylphenyl isocyanate are added dropwise to Xther within 10 minutes, the whole is refluxed for a further hour and the Xther is then distilled off. The oily residue can be made to crystallize by adding petroleum ether. The N- (2,6-dimethyl-phenyl) -N'-ethyl-N'- (ss-diethylamino-ethyl) -urea melts at 55.



   PATENT CLAIM:
Process for the preparation of an N-aryl NT'-aminoalkyl urea, characterized in that a compound of the formula
EMI1.6
 to a compound of the formula
EMI1.7
 

** WARNING ** End of DESC field could overlap beginning of CLMS **.

Claims (1)

**WARNUNG** Anfang CLMS Feld konnte Ende DESC uberlappen **. ** WARNING ** Beginning of CLMS field could overlap end of DESC **. Verfahren zur Herstellung eines N-Aryl-N'-aminoalkyl-harnstoffes. Process for the preparation of an N-aryl-N'-aminoalkyl urea. Gegenstand vorliegenden Patentes ist ein Verfahren zur Herstellung eines N-Aryl-N'aminoalkyl-harnstoffes. Das Verfahren ist dadurch gekennzeichnet, dass man eine Verbindung der Formel EMI1.1 auf eine Verbindung der Formel EMI1.2 einwirken lässt, worin X und Y reaktions fähige, sich unmittelbar zur Gruppe EMI1.3 verbindende Reste bedeuten, wobei X die Atomgruppierung EMI1.4 Itnd Y die Atomgruppierung EMI1.5 enthält. Beispielsweise kann man 2,6-Dimethylphenylisocyanat auf N, N-Diäthyl-N'-äthyl- äthylendiamin einwirken lassen. The subject of the present patent is a process for the preparation of an N-aryl-N'aminoalkyl-urea. The process is characterized in that a compound of the formula EMI1.1 to a compound of the formula EMI1.2 can act, in which X and Y are reactive, directly to the group EMI1.3 mean connecting radicals, where X is the atomic grouping EMI1.4 Itnd Y the atom grouping EMI1.5 contains. For example, 2,6-dimethylphenyl isocyanate can be allowed to act on N, N-diethyl-N'-ethyl-ethylenediamine. Die erhaltene neue Verbindung, der N (2,6-Dimethyl-phenyl)-N'-äthyl-N'- (ss-diäthyl- amino-äthyl)-harnstoff, sehmilzt bei 55 . Sie soll als Arzneimittel und als Zwischenprodukt für Arzneimittel Verwendung finden. The new compound obtained, N (2,6-dimethylphenyl) -N'-ethyl-N'- (ss-diethyl-amino-ethyl) -urea, melts at 55. It is intended to be used as a medicinal product and as an intermediate for medicinal products. Beispiel : In eine Lösung von 8,7 Teilen N, N-Di äthyl-N'-äthyl-äthylendiamin in 40 Volumteilen abs. Xther werden innerhalb 10 Minuten 9 Teile 2,6-Dimethyl-phenylisocyanat eingetropft, das Ganze noch 1 Stunde unter Rück- fluss gekocht und anschliessend der Xther abdestilliert. Der ölige Rückstand kann durch Zusatz von Petroläther zur Kristallisation gebracht werden. Der N- (2, 6-Dimethyl-phenyl)- N'-äthyl-N'- (ss-diäthylamino-äthyl)-harnstoff schmilzt bei 55 . Example: In a solution of 8.7 parts of N, N-diet ethyl-N'-ethyl-ethylenediamine in 40 parts by volume of abs. 9 parts of 2,6-dimethylphenyl isocyanate are added dropwise to Xther within 10 minutes, the whole is refluxed for a further hour and the Xther is then distilled off. The oily residue can be made to crystallize by adding petroleum ether. The N- (2,6-dimethyl-phenyl) -N'-ethyl-N'- (ss-diethylamino-ethyl) -urea melts at 55. PATENTANSPRUCH : Verfahren zur Herstellung eines N-Aryl NT'-aminoalkyl-harnstoffes, dadurch gekennzeichnet, dass man eine Verbindung der Formel EMI1.6 auf eine Verbindung der Formel EMI1.7 einwirken lässt, worin X und Y reaktions fähige, sich unmittelbar zur Gruppe EMI2.1 verbindende Reste bedeuten, wobei X die Atomgruppierung EMI2.2 und Y die Atomgruppierung EMI2.3 enthält. PATENT CLAIM: Process for the preparation of an N-aryl NT'-aminoalkyl urea, characterized in that a compound of the formula EMI1.6 to a compound of the formula EMI1.7 can act, in which X and Y are reactive, directly to the group EMI2.1 mean connecting radicals, where X is the atomic grouping EMI2.2 and Y the atomic grouping EMI2.3 contains. Die erhaltene neue Verbindung, der N (2,6-Dimethyl-phenyl)-N'-äthyl-N'- (ss-diäthyl amino-äthyl)-harnstoff, schmilzt bei 55 . The new compound obtained, N (2,6-dimethylphenyl) -N'-ethyl-N'- (ss-diethylamino-ethyl) -urea, melts at 55. UNTERANSPRUCH : Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man 2, 6-Dimethyl-phe nyl-isocyanat auf N, N-Diäthyl-N'-äthyl-äthy- lendiamin einwirken lässt. SUBClaim: Process according to patent claim, characterized in that 2,6-dimethylphenyl isocyanate is allowed to act on N, N-diethyl-N'-ethyl-ethylenediamine.
CH311097D 1952-06-10 1952-06-10 Process for the preparation of an N-aryl-N'-aminoalkyl urea. CH311097A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH308133T 1952-06-10
CH311097T 1952-06-10

Publications (1)

Publication Number Publication Date
CH311097A true CH311097A (en) 1955-11-15

Family

ID=25735475

Family Applications (1)

Application Number Title Priority Date Filing Date
CH311097D CH311097A (en) 1952-06-10 1952-06-10 Process for the preparation of an N-aryl-N'-aminoalkyl urea.

Country Status (1)

Country Link
CH (1) CH311097A (en)

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