CH312527A - Verfahren zur Herstellung eines neuen Pyridinderivates. - Google Patents
Verfahren zur Herstellung eines neuen Pyridinderivates.Info
- Publication number
- CH312527A CH312527A CH312527DA CH312527A CH 312527 A CH312527 A CH 312527A CH 312527D A CH312527D A CH 312527DA CH 312527 A CH312527 A CH 312527A
- Authority
- CH
- Switzerland
- Prior art keywords
- preparation
- pyridine derivative
- new pyridine
- new
- isonicotinyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 4
- 238000002360 preparation method Methods 0.000 title description 2
- 150000003222 pyridines Chemical class 0.000 title description 2
- NOGFHTGYPKWWRX-UHFFFAOYSA-N 2,2,6,6-tetramethyloxan-4-one Chemical compound CC1(C)CC(=O)CC(C)(C)O1 NOGFHTGYPKWWRX-UHFFFAOYSA-N 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000000155 melt Substances 0.000 claims 1
- WRPAIENEKRBNFP-UHFFFAOYSA-N n'-(pyridin-4-ylmethyl)benzohydrazide Chemical compound C=1C=CC=CC=1C(=O)NNCC1=CC=NC=C1 WRPAIENEKRBNFP-UHFFFAOYSA-N 0.000 claims 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- CHIHQLCVLOXUJW-UHFFFAOYSA-N benzoic anhydride Chemical compound C=1C=CC=CC=1C(=O)OC(=O)C1=CC=CC=C1 CHIHQLCVLOXUJW-UHFFFAOYSA-N 0.000 description 1
- QRXWMOHMRWLFEY-UHFFFAOYSA-N isoniazide Chemical compound NNC(=O)C1=CC=NC=C1 QRXWMOHMRWLFEY-UHFFFAOYSA-N 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Description
Verfahren zur Herstellung eines neuen Pyridinderivates. (-egenstand des vorliegenden Patentes ist ein Verfahren zur Herstellun u von 1-Isonieo- tiiiyl-?-ben7oyl-hyclra7in, das dadurch gekenn- zeielinet ist, dass Isonieotinylhydrazin mit Benzoesäilreanhydrid umgesetzt wird.
Die neue Verbindung soll als Therapeuti- eiun, besonders zur Bekämpfung der Tuber kulose, Verwendung finden.
Beispiel: Einer Lösung von 35 g Benzoesäureanhy- drid in 300 em3 Dioxan werden 20 g Isonico- tinylhydrazin zugesetzt, worauf die %vährend 7/2 Stunde im Dampfbad erwärmt. wird. Das gebildete 1-Isonieotinyl-?-benzoy l- liydra7in scheidet sich ab.
Die Mischung wird auf Zimmertemperatur abgekühlt und das l-Isonicotinyl-2-benzoyl-hydrazin abfiltriert. Naeh dem Umkristallisieren in Methanol ge winnt man es in Form feiner weisser Nadeln vom Schmelzpunkt 227,5-228,5 C.
Claims (1)
- PATENTANSPRUCH: Verfahren zur Herstellung von 1-Isonico- tinyl - 2 - benzoylhydr azin, dadurch gekenn zeichnet, dass - Isonicotinylhydrazin mit Ben- zoesäureanhydrid umgesetzt wird. Die neue Verbindung schmilzt bei 227,5 bis 228.5 C.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US312527XA | 1951-11-03 | 1951-11-03 | |
| CH309035T | 1952-10-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH312527A true CH312527A (de) | 1955-12-31 |
Family
ID=25735566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH312527D CH312527A (de) | 1951-11-03 | 1952-10-16 | Verfahren zur Herstellung eines neuen Pyridinderivates. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH312527A (de) |
-
1952
- 1952-10-16 CH CH312527D patent/CH312527A/de unknown
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