CH363018A - Verfahren zur Herstellung eines Chloralderivates - Google Patents

Verfahren zur Herstellung eines Chloralderivates

Info

Publication number: CH363018A
Authority: CH; Switzerland
Prior art keywords: chloral; derivative; chloral hydrate; preparation; pentanediol
Prior art date: 1956-12-08

Application number

CH5329457A

Other languages

German (de)

English (en)

Inventor

Tind Christensen Jorgen Erik

Original Assignee

Dumex Ltd As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1956-12-08

Filing date

1957-12-02

Publication date

1962-07-15

1957-12-02 Application filed by Dumex Ltd As filed Critical Dumex Ltd As

1962-07-15 Publication of CH363018A publication Critical patent/CH363018A/de

Links

HFFLGKNGCAIQMO-UHFFFAOYSA-N trichloroacetaldehyde Chemical class ClC(Cl)(Cl)C=O HFFLGKNGCAIQMO-UHFFFAOYSA-N 0.000 title claims description 13
238000000034 method Methods 0.000 title claims description 8
238000002360 preparation method Methods 0.000 title description 4
RNFNDJAIBTYOQL-UHFFFAOYSA-N chloral hydrate Chemical compound OC(O)C(Cl)(Cl)Cl RNFNDJAIBTYOQL-UHFFFAOYSA-N 0.000 claims description 18
229960002327 chloral hydrate Drugs 0.000 claims description 18
VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 claims description 11
SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims description 10
238000006243 chemical reaction Methods 0.000 claims description 5
DLHWKJDYXPNWAI-UHFFFAOYSA-N 2,2,2-trichloro-1-ethoxyethanol Chemical compound CCOC(O)C(Cl)(Cl)Cl DLHWKJDYXPNWAI-UHFFFAOYSA-N 0.000 claims description 2
239000000203 mixture Substances 0.000 claims description 2
UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 claims description 2
239000000376 reactant Substances 0.000 claims description 2
-1 trichloro-l-hydroxy - ethoxy Chemical group 0.000 claims description 2
OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 claims 1
XTEGARKTQYYJKE-UHFFFAOYSA-M Chlorate Chemical compound [O-]Cl(=O)=O XTEGARKTQYYJKE-UHFFFAOYSA-M 0.000 description 6
238000002474 experimental method Methods 0.000 description 6
241001465754 Metazoa Species 0.000 description 5
229950005499 carbon tetrachloride Drugs 0.000 description 5
230000000694 effects Effects 0.000 description 5
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 4
229910052801 chlorine Inorganic materials 0.000 description 4
239000000460 chlorine Substances 0.000 description 4
230000007062 hydrolysis Effects 0.000 description 4
238000006460 hydrolysis reaction Methods 0.000 description 4
230000000622 irritating effect Effects 0.000 description 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
150000001875 compounds Chemical class 0.000 description 3
239000013078 crystal Substances 0.000 description 3
239000006187 pill Substances 0.000 description 3
238000011084 recovery Methods 0.000 description 3
239000000243 solution Substances 0.000 description 3
210000002784 stomach Anatomy 0.000 description 3
231100000419 toxicity Toxicity 0.000 description 3
230000001988 toxicity Effects 0.000 description 3
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
241000699666 Mus <mouse, genus> Species 0.000 description 2
241000699670 Mus sp. Species 0.000 description 2
241000283973 Oryctolagus cuniculus Species 0.000 description 2
235000019441 ethanol Nutrition 0.000 description 2
230000009965 odorless effect Effects 0.000 description 2
239000011541 reaction mixture Substances 0.000 description 2
239000002904 solvent Substances 0.000 description 2
238000003756 stirring Methods 0.000 description 2
239000000126 substance Substances 0.000 description 2
210000002700 urine Anatomy 0.000 description 2
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 1
206010001580 Albuminuria Diseases 0.000 description 1
102000001554 Hemoglobins Human genes 0.000 description 1
108010054147 Hemoglobins Proteins 0.000 description 1
208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
238000013019 agitation Methods 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
229940125717 barbiturate Drugs 0.000 description 1
HNYOPLTXPVRDBG-UHFFFAOYSA-N barbituric acid Chemical group O=C1CC(=O)NC(=O)N1 HNYOPLTXPVRDBG-UHFFFAOYSA-N 0.000 description 1
150000007656 barbituric acids Chemical class 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
235000019658 bitter taste Nutrition 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
239000008280 blood Substances 0.000 description 1
230000037396 body weight Effects 0.000 description 1
239000002775 capsule Substances 0.000 description 1
QVFWZNCVPCJQOP-UHFFFAOYSA-N chloralodol Chemical compound CC(O)(C)CC(C)OC(O)C(Cl)(Cl)Cl QVFWZNCVPCJQOP-UHFFFAOYSA-N 0.000 description 1
150000001804 chlorine Chemical class 0.000 description 1
230000001684 chronic effect Effects 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
230000003111 delayed effect Effects 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
230000001079 digestive effect Effects 0.000 description 1
210000003743 erythrocyte Anatomy 0.000 description 1
210000001156 gastric mucosa Anatomy 0.000 description 1
206010022437 insomnia Diseases 0.000 description 1
238000011835 investigation Methods 0.000 description 1
230000007794 irritation Effects 0.000 description 1
210000000265 leukocyte Anatomy 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
210000004400 mucous membrane Anatomy 0.000 description 1
230000017074 necrotic cell death Effects 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
239000002245 particle Substances 0.000 description 1
230000000149 penetrating effect Effects 0.000 description 1
239000000843 powder Substances 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
230000009291 secondary effect Effects 0.000 description 1
239000000932 sedative agent Substances 0.000 description 1
230000001624 sedative effect Effects 0.000 description 1
239000000725 suspension Substances 0.000 description 1
235000019640 taste Nutrition 0.000 description 1
230000007306 turnover Effects 0.000 description 1

Landscapes

Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

CH5329457A 1956-12-08 1957-12-02 Verfahren zur Herstellung eines Chloralderivates CH363018A (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK429656A DK86631C (da)	1956-12-08	1956-12-08	Fremgangsmåde til fremstilling af 2-metyl-2-hydroxy-4-(2,2,2-triklor-1-hydroxyætoxy)-pentan.

Publications (1)

Publication Number	Publication Date
CH363018A true CH363018A (de)	1962-07-15

Family

ID=8132177

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH5329457A CH363018A (de)	1956-12-08	1957-12-02	Verfahren zur Herstellung eines Chloralderivates

Country Status (3)

Country	Link
CH (1)	CH363018A (da)
DK (1)	DK86631C (da)
ES (1)	ES238869A1 (da)

1956
- 1956-12-08 DK DK429656A patent/DK86631C/da active
1957
- 1957-11-29 ES ES0238869A patent/ES238869A1/es not_active Expired
- 1957-12-02 CH CH5329457A patent/CH363018A/de unknown

Also Published As

Publication number	Publication date
DK86631C (da)	1958-12-15
ES238869A1 (es)	1958-05-16

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