CH364786A - Verfahren zur Herstellung eines parasiticiden Komplexsalzes - Google Patents

Verfahren zur Herstellung eines parasiticiden Komplexsalzes

Info

Publication number: CH364786A
Authority: CH; Switzerland
Prior art keywords: ethidium; suramin; chloride; preparation; complex
Prior art date: 1958-01-20

Application number

CH6848259A

Other languages

German (de)

English (en)

Inventor

Williamson James

Original Assignee

Nat Res Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1958-01-20

Filing date

1959-01-19

Publication date

1962-10-15

1959-01-19 Application filed by Nat Res Dev filed Critical Nat Res Dev

1962-10-15 Publication of CH364786A publication Critical patent/CH364786A/de

Links

238000002360 preparation method Methods 0.000 title claims description 15
150000003839 salts Chemical class 0.000 title claims description 14
238000000034 method Methods 0.000 title claims description 10
230000000590 parasiticidal effect Effects 0.000 title claims description 7
229960005314 suramin Drugs 0.000 claims description 12
BITVSRNAFFZUFW-UHFFFAOYSA-N 5-ethyl-6-phenylphenanthridin-5-ium-3,8-diamine;chloride Chemical compound [Cl-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 BITVSRNAFFZUFW-UHFFFAOYSA-N 0.000 claims description 10
ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 claims description 10
229960005542 ethidium bromide Drugs 0.000 claims description 10
FIAFUQMPZJWCLV-UHFFFAOYSA-N suramin Chemical compound OS(=O)(=O)C1=CC(S(O)(=O)=O)=C2C(NC(=O)C3=CC=C(C(=C3)NC(=O)C=3C=C(NC(=O)NC=4C=C(C=CC=4)C(=O)NC=4C(=CC=C(C=4)C(=O)NC=4C5=C(C=C(C=C5C(=CC=4)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O)C)C=CC=3)C)=CC=C(S(O)(=O)=O)C2=C1 FIAFUQMPZJWCLV-UHFFFAOYSA-N 0.000 claims description 10
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 8
239000000243 solution Substances 0.000 claims description 8
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
241000283690 Bos taurus Species 0.000 claims description 6
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 6
239000007864 aqueous solution Substances 0.000 claims description 5
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims description 4
235000011187 glycerol Nutrition 0.000 claims description 4
238000010438 heat treatment Methods 0.000 claims description 4
-1 3-benzamido-p-toluoylamino Chemical group 0.000 claims description 3
150000001768 cations Chemical class 0.000 claims description 3
239000007858 starting material Substances 0.000 claims description 3
QTANTQQOYSUMLC-UHFFFAOYSA-O Ethidium cation Chemical compound C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 QTANTQQOYSUMLC-UHFFFAOYSA-O 0.000 claims description 2
239000013543 active substance Substances 0.000 claims description 2
230000009918 complex formation Effects 0.000 claims description 2
150000001875 compounds Chemical class 0.000 claims description 2
238000001816 cooling Methods 0.000 claims description 2
238000001035 drying Methods 0.000 claims description 2
238000002474 experimental method Methods 0.000 claims description 2
239000012530 fluid Substances 0.000 claims description 2
230000009931 harmful effect Effects 0.000 claims description 2
238000004519 manufacturing process Methods 0.000 claims description 2
238000003756 stirring Methods 0.000 claims description 2
125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 claims 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/32—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
- C07C309/51—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
- C07D221/12—Phenanthridines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)

CH6848259A 1958-01-20 1959-01-19 Verfahren zur Herstellung eines parasiticiden Komplexsalzes CH364786A (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB187558A GB852650A (en)	1958-01-20	1958-01-20	Improvements in or relating to parasiticidal drugs

Publications (1)

Publication Number	Publication Date
CH364786A true CH364786A (de)	1962-10-15

Family

ID=9729565

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH6848259A CH364786A (de)	1958-01-20	1959-01-19	Verfahren zur Herstellung eines parasiticiden Komplexsalzes

Country Status (4)

Country	Link
CH (1)	CH364786A (fr)
DE (1)	DE1083826B (fr)
FR (2)	FR1283806A (fr)
GB (2)	GB809295A (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3305329A1 (de) *	1983-02-17	1984-08-23	Hoechst Ag, 6230 Frankfurt	Polyzyklische bisamidine, verfahren zu ihrer herstellung und ihre verwendung als chemotherapeutika

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1050956A (fr) *	1952-02-20	1954-01-12	Rhone Poulenc Sa	Nouveau sel de di (amidino-4' phénoxy) 1, 5 pentane et son procédé de préparation

1956
- 1956-03-27 GB GB960056A patent/GB809295A/en not_active Expired
1957
- 1957-03-22 DE DE1957N0013449 patent/DE1083826B/de active Pending
- 1957-03-26 FR FR734870A patent/FR1283806A/fr not_active Expired
1958
- 1958-01-20 GB GB187558A patent/GB852650A/en not_active Expired
1959
- 1959-01-19 CH CH6848259A patent/CH364786A/de unknown
- 1959-01-19 FR FR784341A patent/FR87952E/fr not_active Expired

Also Published As

Publication number	Publication date
GB852650A (en)	1960-10-26
FR87952E (fr)	1966-04-29
GB809295A (en)	1959-02-18
FR1283806A (fr)	1962-02-09
DE1083826B (de)	1960-06-23

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