CH373865A - Verfahren zur Erzeugung von Vitamin B12 durch Propionsäurebakterien - Google Patents

Verfahren zur Erzeugung von Vitamin B12 durch Propionsäurebakterien

Info

Publication number: CH373865A
Authority: CH; Switzerland
Prior art keywords: fermentation; vitamin; sep; sugar; fermentation medium
Prior art date: 1958-12-24

Application number

CH6772058A

Other languages

German (de)

English (en)

Inventor

Becher Elisabeth

Bernhauer Konrad Dr Prof

Wilharm Georg

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1958-12-24

Filing date

1958-12-24

Publication date

1963-12-15

1958-12-24 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1958-12-24 Priority to CH6772058A priority Critical patent/CH373865A/de

1959-12-09 Priority to BE585465A priority patent/BE585465A/fr

1959-12-23 Priority to ES0254882A priority patent/ES254882A1/es

1963-12-15 Publication of CH373865A publication Critical patent/CH373865A/de

Links

229930003779 Vitamin B12 Natural products 0.000 title claims description 12
235000019163 vitamin B12 Nutrition 0.000 title claims description 12
239000011715 vitamin B12 Substances 0.000 title claims description 12
238000000034 method Methods 0.000 title claims description 9
238000004519 manufacturing process Methods 0.000 title claims description 7
FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 title description 11
241000894006 Bacteria Species 0.000 title description 3
XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 title 2
235000019260 propionic acid Nutrition 0.000 title 1
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 title 1
239000002609 medium Substances 0.000 claims description 35
238000000855 fermentation Methods 0.000 claims description 34
230000004151 fermentation Effects 0.000 claims description 33
YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 12
GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims description 12
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 12
235000000346 sugar Nutrition 0.000 claims description 11
235000001014 amino acid Nutrition 0.000 claims description 9
150000001413 amino acids Chemical class 0.000 claims description 9
230000001580 bacterial effect Effects 0.000 claims description 9
239000000203 mixture Substances 0.000 claims description 9
241000186334 Propionibacterium freudenreichii subsp. shermanii Species 0.000 claims description 8
235000015097 nutrients Nutrition 0.000 claims description 8
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 7
239000005018 casein Substances 0.000 claims description 7
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 7
235000021240 caseins Nutrition 0.000 claims description 7
GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims description 6
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 6
229960002685 biotin Drugs 0.000 claims description 6
235000020958 biotin Nutrition 0.000 claims description 6
239000011616 biotin Substances 0.000 claims description 6
229910052757 nitrogen Inorganic materials 0.000 claims description 6
229940055726 pantothenic acid Drugs 0.000 claims description 6
235000019161 pantothenic acid Nutrition 0.000 claims description 6
239000011713 pantothenic acid Substances 0.000 claims description 6
LJUQGASMPRMWIW-UHFFFAOYSA-N 5,6-dimethylbenzimidazole Chemical compound C1=C(C)C(C)=CC2=C1NC=N2 LJUQGASMPRMWIW-UHFFFAOYSA-N 0.000 claims description 5
238000005119 centrifugation Methods 0.000 claims description 5
238000011534 incubation Methods 0.000 claims description 5
239000007788 liquid Substances 0.000 claims description 5
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 4
229940041514 candida albicans extract Drugs 0.000 claims description 4
150000003839 salts Chemical class 0.000 claims description 4
239000012138 yeast extract Substances 0.000 claims description 4
230000001476 alcoholic effect Effects 0.000 claims description 3
238000000605 extraction Methods 0.000 claims description 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 2
229910019142 PO4 Inorganic materials 0.000 claims description 2
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 2
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
150000001720 carbohydrates Chemical class 0.000 claims description 2
235000014633 carbohydrates Nutrition 0.000 claims description 2
230000015556 catabolic process Effects 0.000 claims description 2
239000000460 chlorine Substances 0.000 claims description 2
229910052801 chlorine Inorganic materials 0.000 claims description 2
-1 chlorine ions Chemical class 0.000 claims description 2
238000006731 degradation reaction Methods 0.000 claims description 2
239000000706 filtrate Substances 0.000 claims description 2
238000001914 filtration Methods 0.000 claims description 2
230000003301 hydrolyzing effect Effects 0.000 claims description 2
229910052742 iron Inorganic materials 0.000 claims description 2
230000007935 neutral effect Effects 0.000 claims description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 2
239000010452 phosphate Substances 0.000 claims description 2
239000011591 potassium Substances 0.000 claims description 2
229910052700 potassium Inorganic materials 0.000 claims description 2
235000018102 proteins Nutrition 0.000 claims description 2
108090000623 proteins and genes Proteins 0.000 claims description 2
102000004169 proteins and genes Human genes 0.000 claims description 2
230000002797 proteolythic effect Effects 0.000 claims description 2
239000011734 sodium Substances 0.000 claims description 2
229910052708 sodium Inorganic materials 0.000 claims description 2
229930003231 vitamin Natural products 0.000 claims description 2
235000013343 vitamin Nutrition 0.000 claims description 2
239000011782 vitamin Substances 0.000 claims description 2
229940088594 vitamin Drugs 0.000 claims description 2
AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 claims 2
230000001419 dependent effect Effects 0.000 claims 2
150000001868 cobalt Chemical class 0.000 claims 1
229910001429 cobalt ion Inorganic materials 0.000 claims 1
XLJKHNWPARRRJB-UHFFFAOYSA-N cobalt(2+) Chemical compound [Co+2] XLJKHNWPARRRJB-UHFFFAOYSA-N 0.000 claims 1
235000002639 sodium chloride Nutrition 0.000 claims 1
150000003722 vitamin derivatives Chemical class 0.000 claims 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 6
239000008103 glucose Substances 0.000 description 6
239000000243 solution Substances 0.000 description 6
TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 4
229920001817 Agar Polymers 0.000 description 3
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
239000008272 agar Substances 0.000 description 3
239000012141 concentrate Substances 0.000 description 3
OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 2
GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 2
238000005903 acid hydrolysis reaction Methods 0.000 description 2
BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 2
229910017052 cobalt Inorganic materials 0.000 description 2
239000010941 cobalt Substances 0.000 description 2
GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 2
230000000694 effects Effects 0.000 description 2
238000011081 inoculation Methods 0.000 description 2
229960004903 invert sugar Drugs 0.000 description 2
229910000359 iron(II) sulfate Inorganic materials 0.000 description 2
229910001629 magnesium chloride Inorganic materials 0.000 description 2
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 description 2
GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
102000009027 Albumins Human genes 0.000 description 1
108010088751 Albumins Proteins 0.000 description 1
229920000742 Cotton Polymers 0.000 description 1
241000588724 Escherichia coli Species 0.000 description 1
108010028690 Fish Proteins Proteins 0.000 description 1
108010068370 Glutens Proteins 0.000 description 1
241001134654 Lactobacillus leichmannii Species 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
241000199478 Ochromonas Species 0.000 description 1
239000005662 Paraffin oil Substances 0.000 description 1
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical class [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
244000061456 Solanum tuberosum Species 0.000 description 1
235000002595 Solanum tuberosum Nutrition 0.000 description 1
108010073771 Soybean Proteins Proteins 0.000 description 1
102000004142 Trypsin Human genes 0.000 description 1
108090000631 Trypsin Proteins 0.000 description 1
229930003451 Vitamin B1 Natural products 0.000 description 1
240000008042 Zea mays Species 0.000 description 1
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
235000002017 Zea mays subsp mays Nutrition 0.000 description 1
239000002253 acid Substances 0.000 description 1
239000002156 adsorbate Substances 0.000 description 1
235000021120 animal protein Nutrition 0.000 description 1
239000006286 aqueous extract Substances 0.000 description 1
244000052616 bacterial pathogen Species 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
239000008280 blood Substances 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
238000009835 boiling Methods 0.000 description 1
238000009395 breeding Methods 0.000 description 1
230000001488 breeding effect Effects 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
238000001816 cooling Methods 0.000 description 1
235000005822 corn Nutrition 0.000 description 1
238000012937 correction Methods 0.000 description 1
230000029087 digestion Effects 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
238000004821 distillation Methods 0.000 description 1
239000000284 extract Substances 0.000 description 1
239000006481 glucose medium Substances 0.000 description 1
235000021312 gluten Nutrition 0.000 description 1
238000002955 isolation Methods 0.000 description 1
239000008101 lactose Substances 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
238000012009 microbiological test Methods 0.000 description 1
238000002156 mixing Methods 0.000 description 1
229910052697 platinum Inorganic materials 0.000 description 1
238000012545 processing Methods 0.000 description 1
239000003531 protein hydrolysate Substances 0.000 description 1
230000017854 proteolysis Effects 0.000 description 1
229940079877 pyrogallol Drugs 0.000 description 1
238000005096 rolling process Methods 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
235000010265 sodium sulphite Nutrition 0.000 description 1
229940001941 soy protein Drugs 0.000 description 1
238000002798 spectrophotometry method Methods 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
229910021653 sulphate ion Inorganic materials 0.000 description 1
239000000725 suspension Substances 0.000 description 1
238000012360 testing method Methods 0.000 description 1
229960003495 thiamine Drugs 0.000 description 1
DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
239000012588 trypsin Substances 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
235000010374 vitamin B1 Nutrition 0.000 description 1
239000011691 vitamin B1 Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/42—Cobalamins, i.e. vitamin B12, LLD factor

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

CH6772058A 1958-12-24 1958-12-24 Verfahren zur Erzeugung von Vitamin B12 durch Propionsäurebakterien CH373865A (de)

Priority Applications (3)

Application Number	Priority Date	Filing Date	Title
CH6772058A CH373865A (de)	1958-12-24	1958-12-24	Verfahren zur Erzeugung von Vitamin B12 durch Propionsäurebakterien
BE585465A BE585465A (fr)	1958-12-24	1959-12-09	Procédé pour la production oe vitamines ou groupe B12 par l'action de bacteries propioniques.
ES0254882A ES254882A1 (es)	1958-12-24	1959-12-23	Un procedimiento para la producciën de cobalamina

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH6772058A CH373865A (de)	1958-12-24	1958-12-24	Verfahren zur Erzeugung von Vitamin B12 durch Propionsäurebakterien

Publications (1)

Publication Number	Publication Date
CH373865A true CH373865A (de)	1963-12-15

Family

ID=4528207

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH6772058A CH373865A (de)	1958-12-24	1958-12-24	Verfahren zur Erzeugung von Vitamin B12 durch Propionsäurebakterien

Country Status (3)

Country	Link
BE (1)	BE585465A (fr)
CH (1)	CH373865A (fr)
ES (1)	ES254882A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0087920A1 (fr) *	1982-02-26	1983-09-07	Nippon Oil Co. Ltd.	Procédé de préparation de la vitamine B12 par la technique de fermentation et le microorganisme produisant la vitamine B12

1958
- 1958-12-24 CH CH6772058A patent/CH373865A/de unknown
1959
- 1959-12-09 BE BE585465A patent/BE585465A/fr unknown
- 1959-12-23 ES ES0254882A patent/ES254882A1/es not_active Expired

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0087920A1 (fr) *	1982-02-26	1983-09-07	Nippon Oil Co. Ltd.	Procédé de préparation de la vitamine B12 par la technique de fermentation et le microorganisme produisant la vitamine B12

Also Published As

Publication number	Publication date
BE585465A (fr)	1960-06-09
ES254882A1 (es)	1960-07-16

Publication	Publication Date	Title
AT391323B (de)	1990-09-25	Mikroorganismus der species bacillus coagulans sowie ein verfahren zur herstellung von optisch reiner l(+)-milchsaeure
DE2161164B2 (de)	1980-11-27	Verfahren zur mikrobiologischen Erzeugung von Proteinmassen und Verwendung des proteinhaltigen Produkts
DE1807185C3 (de)	1979-10-04	Verfahren zur Herstellung von proteolytische Enzyme enthaltenden Aufbereitungen und deren Verwendung
DE2401519A1 (de)	1974-12-05	Mikrobiologisches verfahren zur herstellung fluessigen und trockenen futterkonzentrates von l-lysin und kristallinen l-lysins
CH373865A (de)	1963-12-15	Verfahren zur Erzeugung von Vitamin B12 durch Propionsäurebakterien
DE3123001C2 (fr)	1988-01-28
AT220292B (de)	1962-03-12	Verfahren zur Erzeugung von Vitaminen der B12-Gruppe durch Propionsäurebakterien
DE1091705B (de)	1960-10-27	Verfahren zur Erzeugung von Vitaminen der B-Gruppe durch Propionsaeurebakterien
AT215077B (de)	1961-05-10	Verfahren zur Herstellung 5, 6-Dimethylbenzimidazolcobalamin
DE1232914B (de)	1967-01-26	Verfahren zur biotechnischen Herstellung von 1-Threonin
AT208320B (de)	1960-03-25	Verfahren zur Herstellung von 1-Glutaminsäure
AT208319B (de)	1960-03-25	Verfahren zur Herstellung von 1-Glutaminsäure
DE1009583B (de)	1957-06-06	Verfahren zur biochemischen Herstellung von 2-Keto-1-gulonsaeure
DE1517837C (de)	1972-08-10	Verfahren zur biochemischen Herstellung von delta-(N-Acetyl)-L-Ornithin
DE3432570A1 (de)	1986-03-13	Verfahren zur mikrobiologischen herstellung von aldose-1-epimerase
DE2308059C3 (de)	1975-05-22	Verfahren zur biosynthetischen Herstellung von Griseofulvin
DE1517825C (de)	1971-01-07	Verfahren zur biotechnischen Her stellung von L Valin
CH380877A (de)	1964-08-15	Verfahren zur Herstellung von Vitamin B12
DE2253426A1 (de)	1974-05-30	Futtermittel fuer wiederkaeuer und verfahren zu seiner herstellung
DE1294310B (de)	1969-05-08	Verfahren zur Herstellung von 5'-Inosinsaeure durch Zuechten von Mikroorganismen
AT200544B (de)	1958-11-10	Verfahren zur Herstellung von 1-Glutaminsäure bzw. deren Salzen durch Fermentation
CH621148A5 (en)	1981-01-15	Process for obtaining bacterial strains and their use for the preparation of an optically active carboxylic acid
EP0003524A1 (fr)	1979-08-22	Procédé de production de D-arabite
DE1088447B (de)	1960-09-08	Verfahren zur biotechnischen Herstellung von 1-Glutaminsaeure
DE1195257B (de)	1965-06-24	Verfahren zur fermentativen Herstellung von 1-Glutaminsaeure

CH373865A - Verfahren zur Erzeugung von Vitamin B12 durch Propionsäurebakterien - Google Patents

Info

Links

Classifications

Landscapes

Priority Applications (3)

Applications Claiming Priority (1)

Publications (1)

Family

ID=4528207

Family Applications (1)

Country Status (3)

Cited By (1)

Cited By (1)

Also Published As

Similar Documents