CH412889A - Verfahren zur Herstellung von 2-Methyl-3-oxypyridinen - Google Patents

Verfahren zur Herstellung von 2-Methyl-3-oxypyridinen

Info

Publication number
CH412889A
CH412889A CH589562A CH589562A CH412889A CH 412889 A CH412889 A CH 412889A CH 589562 A CH589562 A CH 589562A CH 589562 A CH589562 A CH 589562A CH 412889 A CH412889 A CH 412889A
Authority
CH
Switzerland
Prior art keywords
methyl
compound
formula
oxazole
reacted
Prior art date
Application number
CH589562A
Other languages
German (de)
English (en)
Inventor
Pfister Karl
Everett Harris Elbert
Firestone Elizabeth
Armond Firestone Raymond
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of CH412889A publication Critical patent/CH412889A/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • C07D213/67—2-Methyl-3-hydroxy-4,5-bis(hydroxy-methyl)pyridine, i.e. pyridoxine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CH589562A 1961-05-15 1962-05-15 Verfahren zur Herstellung von 2-Methyl-3-oxypyridinen CH412889A (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10985361A 1961-05-15 1961-05-15
US16668862A 1962-01-16 1962-01-16

Publications (1)

Publication Number Publication Date
CH412889A true CH412889A (de) 1966-05-15

Family

ID=26807438

Family Applications (1)

Application Number Title Priority Date Filing Date
CH589562A CH412889A (de) 1961-05-15 1962-05-15 Verfahren zur Herstellung von 2-Methyl-3-oxypyridinen

Country Status (8)

Country Link
BE (1) BE617500A (da)
BR (1) BR6239058D0 (da)
CH (1) CH412889A (da)
DE (1) DE1470022C3 (da)
DK (1) DK104460C (da)
FR (1) FR1323941A (da)
GB (1) GB966805A (da)
SE (1) SE309236B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3620873A (en) * 1969-03-26 1971-11-16 Ercon Inc Making metal-plastic gasket materials
EP1640005A3 (en) * 1999-03-08 2006-06-07 Medicure International Inc. Pyridoxal analogues for the treatment of disorders caused by a deficiency in vitamin B6
CA2366602A1 (en) 1999-03-08 2000-09-14 Medicure Inc. Pyridoxal analogues for vitamin b-6 disorders
CA2376029A1 (en) 1999-07-13 2001-01-18 Medicure Inc. Use of pyridoxin derivatives for the treatment of diabetes and related complications
US6677356B1 (en) 1999-08-24 2004-01-13 Medicure International Inc. Treatment of cardiovascular and related pathologies
WO2001064692A1 (en) 2000-02-29 2001-09-07 Medicure International Inc. Cardioprotective phosphonates and malonates
US7442689B2 (en) 2000-02-29 2008-10-28 Medicure International Inc. Cardioprotective phosphonates and malonates
CA2404329A1 (en) 2000-03-28 2001-10-04 Medicure International Inc. Treatment of cerebrovascular disease
NZ523815A (en) 2000-07-07 2004-07-30 Medicure Int Inc Pyridoxine and pyridoxal analogues: cardiovascular therapeutics
US6548519B1 (en) 2001-07-06 2003-04-15 Medicure International Inc. Pyridoxine and pyridoxal analogues: novel uses
US6897228B2 (en) 2000-07-07 2005-05-24 Medicure International Inc. Pyridoxine and pyridoxal analogues: new uses

Also Published As

Publication number Publication date
SE309236B (da) 1969-03-17
GB966805A (en) 1964-08-19
FR1323941A (fr) 1963-04-12
DE1470022C3 (de) 1978-03-09
DE1470022B2 (de) 1977-07-21
DK104460C (da) 1966-05-23
BR6239058D0 (pt) 1973-05-24
BE617500A (fr) 1962-11-12
DE1470022A1 (de) 1969-01-16

Similar Documents

Publication Publication Date Title
DE2614406C2 (da)
CH412889A (de) Verfahren zur Herstellung von 2-Methyl-3-oxypyridinen
DE1795841B2 (de) l-a'-Chlort-benzyl^-di-sec-butylamino-acetyl-pyiTol, seine Salze und Verfahren zu deren Herstellung
EP0008645A1 (de) Alkoxyphenylpyrrolidone, Verfahren zu ihrer Herstellung und Arzneimittel auf Basis dieser Verbindungen
CH597199A5 (en) 3-Phenyl pyridaz-6-ones prodn.
EP0380712B1 (de) Verfahren zur Herstellung von 2,6-Dichlordiphenylaminessigsäurederivaten
DE2229223C3 (de) 2-Nitro-S-imidazol-Derivate und Verfahren zu deren Herstellung
DE2841644C2 (da)
DE69623117T2 (de) Verfahren zur herstellung von 4-hydroxy-2-pyrrolidon
CH619955A5 (da)
DE2635854A1 (de) Pyrrolin-2-on-derivate, verfahren zu ihrer herstellung und sie enthaltendes arzneimittel
DE2642608C2 (de) Verfahren zur Herstellung eines 4-Hydroxymethyl-2-pyrrolidinons
CH642370A5 (en) Process for the preparation of imidazo[2,1-a]isoindoles
EP0299277A2 (de) Verfahren zur Herstellung von substituierten Pyridylalkylketonen
AT250350B (de) Verfahren zur Herstellung von 4, 5-disubstituierten 2-Methyl-3-hydroxypyridine
EP0025501A1 (de) Neue N-Aminoalkylindol-Derivate und ihre Salze; Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2759297B1 (de) Verfahren zur Herstellung von 2-Oxo-1-pyrrolidin-acetamid
AT222103B (de) Verfahren zur Herstellung von 2-trans-β-Jonylidenessigsäure
AT283348B (de) Verfahren zur Herstellung von Indolderivaten und ihren neuen Salzen
DE2518516C3 (de) 2-(3,45-Trimethoxybenzyl)-3,4-dimethylpyridin
AT278787B (de) Verfahren zur herstellung von neuen carbonsaeuren und von deren salzen
AT208867B (de) Verfahren zur Herstellung von neuen substituierten heterocyclischen Säurehydraziden
DD203719A5 (de) Verfahren zur herstellung neuer, antibakteriell wirkender pyrido (1,2,3-de)(1,4)benzoxazin-5-carbonsaeure-derivate
DD150057A5 (de) Verfahren zur herstellung von 2-aminopyrazinen
AT356291B (de) Verfahren zur herstellung von in die dihydrolysergsaeure- und dihydroiso- lysergsaeure-reihe gehoerenden verbindungen