CH433595A - Verfahren zur Herstellung eines Trachom-Schutzimpfstoffes - Google Patents
Verfahren zur Herstellung eines Trachom-SchutzimpfstoffesInfo
- Publication number
- CH433595A CH433595A CH1097862A CH1097862A CH433595A CH 433595 A CH433595 A CH 433595A CH 1097862 A CH1097862 A CH 1097862A CH 1097862 A CH1097862 A CH 1097862A CH 433595 A CH433595 A CH 433595A
- Authority
- CH
- Switzerland
- Prior art keywords
- trachoma
- suspension
- vaccine
- yolk sac
- added
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title claims description 23
- 201000001371 inclusion conjunctivitis Diseases 0.000 title claims description 22
- 206010044325 trachoma Diseases 0.000 title claims description 22
- 238000000034 method Methods 0.000 title claims description 14
- 230000001681 protective effect Effects 0.000 title claims description 13
- 238000002360 preparation method Methods 0.000 title description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 16
- 241000700605 Viruses Species 0.000 claims description 14
- 239000000725 suspension Substances 0.000 claims description 14
- 210000001325 yolk sac Anatomy 0.000 claims description 13
- 102000004142 Trypsin Human genes 0.000 claims description 7
- 108090000631 Trypsin Proteins 0.000 claims description 7
- 239000012588 trypsin Substances 0.000 claims description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 6
- 238000005119 centrifugation Methods 0.000 claims description 6
- 239000008055 phosphate buffer solution Substances 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 241000287828 Gallus gallus Species 0.000 claims description 2
- 239000007853 buffer solution Substances 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 210000002257 embryonic structure Anatomy 0.000 claims description 2
- 235000013601 eggs Nutrition 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 4
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 210000003000 inclusion body Anatomy 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- 230000000890 antigenic effect Effects 0.000 description 2
- 239000007900 aqueous suspension Substances 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 239000003925 fat Substances 0.000 description 2
- 239000002480 mineral oil Substances 0.000 description 2
- 229910000160 potassium phosphate Inorganic materials 0.000 description 2
- 235000011009 potassium phosphates Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 238000002255 vaccination Methods 0.000 description 2
- 241000700198 Cavia Species 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- WDRWZVWLVBXVOI-QTNFYWBSSA-L dipotassium;(2s)-2-aminopentanedioate Chemical compound [K+].[K+].[O-]C(=O)[C@@H](N)CCC([O-])=O WDRWZVWLVBXVOI-QTNFYWBSSA-L 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- 230000012447 hatching Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 235000013919 monopotassium glutamate Nutrition 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/118—Chlamydiaceae, e.g. Chlamydia trachomatis or Chlamydia psittaci
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1697161 | 1961-09-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH433595A true CH433595A (de) | 1967-04-15 |
Family
ID=11149600
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1097862A CH433595A (de) | 1961-09-20 | 1962-09-17 | Verfahren zur Herstellung eines Trachom-Schutzimpfstoffes |
Country Status (4)
| Country | Link |
|---|---|
| BR (1) | BR6243116D0 (fr) |
| CH (1) | CH433595A (fr) |
| FR (1) | FR2021M (fr) |
| GB (1) | GB940260A (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4328208A (en) * | 1981-05-20 | 1982-05-04 | Kurbanov Ildus A | Vaccine against chlamydous infections of farm animals |
-
1962
- 1962-09-17 CH CH1097862A patent/CH433595A/de unknown
- 1962-09-17 BR BR143116/62A patent/BR6243116D0/pt unknown
- 1962-09-17 GB GB35355/62A patent/GB940260A/en not_active Expired
- 1962-09-18 FR FR909722A patent/FR2021M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2021M (fr) | 1963-09-16 |
| BR6243116D0 (pt) | 1973-05-24 |
| GB940260A (en) | 1963-10-30 |
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