|
GB1188529A
(en)
*
|
1966-06-09 |
1970-04-15 |
Wellcome Found |
Pyramidine Derivatives
|
|
US3763156A
(en)
*
|
1970-01-28 |
1973-10-02 |
Boehringer Sohn Ingelheim |
2-heterocyclic amino-4-morpholinothieno(3,2-d)pyrimidines
|
|
RO62428A
(fr)
*
|
1971-05-04 |
1978-01-15 |
Thomae Gmbh Dr K |
Procede pour la preparation des thyeno-(3,2-d)-pyrimidines
|
|
GB1570494A
(en)
|
1975-11-28 |
1980-07-02 |
Ici Ltd |
Thienopyrimidine derivatives and their use as pesticides
|
|
US4670560A
(en)
*
|
1986-04-28 |
1987-06-02 |
Ortho Pharmaceutical Corporation |
Thienopyrimidine-2,4-dione derivatives and intermediates thereof
|
|
US4703120A
(en)
*
|
1986-04-28 |
1987-10-27 |
Ortho Pharmaceutical Corporation |
Furo(3,4-d)pyrimidine-2,4-dione derivatives and intermediates thereof
|
|
EP0276057B1
(de)
*
|
1987-01-21 |
1994-03-09 |
Merck & Co. Inc. |
Piperazinylpyrimidine als beta-adrenergische Rezeptoren blockierende Mittel
|
|
US5098902A
(en)
*
|
1991-03-18 |
1992-03-24 |
Warner-Lambert Company |
Method of treating neurodegenerative diseases
|
|
US6339089B2
(en)
|
1997-08-13 |
2002-01-15 |
Fujirebio Inc. |
Pyrimidine nucleus-containing compound and a medicament containing the same for a blood oxygen partial pressure amelioration, and a method for preparing the same
|
|
DE19944604A1
(de)
*
|
1999-09-17 |
2001-03-22 |
Merck Patent Gmbh |
Aminderivate
|
|
US6503914B1
(en)
*
|
2000-10-23 |
2003-01-07 |
Board Of Regents, The University Of Texas System |
Thienopyrimidine-based inhibitors of the Src family
|
|
WO2003055890A1
(en)
*
|
2001-12-21 |
2003-07-10 |
Bayer Pharmaceuticals Corporation |
Thienopyrimidine derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents
|
|
TW200410975A
(en)
*
|
2002-09-26 |
2004-07-01 |
Nihon Nohyaku Co Ltd |
New pesticide and method for using it, new substituted thienopyrimidine derivative, its intermediate, and method for producing it
|
|
GB0423653D0
(en)
*
|
2004-10-25 |
2004-11-24 |
Piramed Ltd |
Pharmaceutical compounds
|
|
EP1847543A1
(de)
|
2006-04-19 |
2007-10-24 |
Boehringer Ingelheim Pharma GmbH & Co. KG |
Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen
|
|
HRP20090395T1
(hr)
*
|
2006-04-19 |
2009-08-31 |
Boehringer Ingelheim International Gmbh |
Dihidrotienpirimidini za liječenje upalnih bolesti
|
|
PL2041139T3
(pl)
|
2006-04-26 |
2012-05-31 |
Hoffmann La Roche |
Związki farmaceutyczne
|
|
AU2007243466B2
(en)
*
|
2006-04-26 |
2012-01-19 |
F. Hoffmann-La Roche Ag |
Phosphoinositide 3-kinase inhibitor compounds and pharmaceutical compositions containing them
|
|
KR101533461B1
(ko)
|
2006-04-26 |
2015-07-02 |
에프. 호프만-라 로슈 아게 |
Pi3k저해제로 유용한 티에노[3,2-d]피리미딘 유도체
|
|
CA2671845C
(en)
*
|
2006-12-07 |
2015-03-24 |
Genentech, Inc. |
Phosphoinositide 3-kinase inhibitor compounds and methods of use
|
|
PE20081679A1
(es)
*
|
2006-12-07 |
2008-12-18 |
Hoffmann La Roche |
Compuestos del inhibidor de fosfoinositida 3-cinasa y metodos de uso
|
|
TW200924781A
(en)
|
2007-09-14 |
2009-06-16 |
Janssen Pharmaceutica Nv |
Thieno- and furo-pyrimidine modulators of the histamine H4 receptor
|
|
CN101932587A
(zh)
|
2007-09-24 |
2010-12-29 |
吉宁特有限公司 |
噻唑并嘧啶pi3k抑制剂化合物及使用方法
|
|
SI2610258T1
(sl)
|
2007-10-19 |
2014-12-31 |
Boehringer Ingelheim International Gmbh |
Substituirani piperidino-dihidrotienopirimidini
|
|
EP2215093B1
(de)
|
2007-10-19 |
2011-12-14 |
Boehringer Ingelheim International GmbH |
Neue piperazino-dihydrothienopyrimidin-derivate
|
|
RU2500681C2
(ru)
|
2007-10-19 |
2013-12-10 |
Берингер Ингельхайм Интернациональ Гмбх |
Замещенные гетероциклом пиперазинодигидротиенопиримидины
|
|
WO2009055730A1
(en)
|
2007-10-25 |
2009-04-30 |
Genentech, Inc. |
Process for making thienopyrimidine compounds
|
|
GB0721095D0
(en)
*
|
2007-10-26 |
2007-12-05 |
Piramed Ltd |
Pharmaceutical compounds
|
|
SI2215094T1
(sl)
|
2007-11-15 |
2016-05-31 |
Ym Biosciences Australia Pty Ltd |
N vsebujoče heterociklične spojine
|
|
JP5709766B2
(ja)
|
2009-03-12 |
2015-04-30 |
ジェネンテック, インコーポレイテッド |
造血器腫瘍の治療のためのホスホイノシチド3キナーゼ阻害剤化合物と化学療法剤の併用
|
|
MX2011012520A
(es)
|
2009-05-27 |
2011-12-12 |
Hoffmann La Roche |
Compuestos inhibidores de pi3k de pirimidina biciclicos selectivos para p110 delta y metodos de uso de los mismos.
|
|
SG182247A1
(en)
*
|
2009-05-27 |
2012-08-30 |
Hoffmann La Roche |
Bicyclic indole-pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use
|
|
AU2010314287A1
(en)
*
|
2009-10-12 |
2012-05-03 |
F. Hoffmann-La Roche Ag |
Combinations of a PI3K inhibitor and a MEK inhibitor
|
|
KR20130058672A
(ko)
|
2010-04-16 |
2013-06-04 |
제넨테크, 인크. |
PI3K/AKT 키나제 경로 억제제 효능에 대한 예측 바이오마커로서의 FOXO3a
|
|
US20140004209A1
(en)
|
2010-12-22 |
2014-01-02 |
Genentech, Inc. |
Autophagy inducer and inhibitor combination therapy for the treatment of neoplasms
|
|
US9802954B2
(en)
|
2011-08-24 |
2017-10-31 |
Boehringer Ingelheim International Gmbh |
Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma
|
|
US20130059866A1
(en)
|
2011-08-24 |
2013-03-07 |
Boehringer Ingelheim International Gmbh |
Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
|
|
FR2988722B1
(fr)
*
|
2012-04-03 |
2014-05-09 |
Sanofi Sa |
Nouveaux derives de thienopyrimidines, leurs procedes de preparation et leurs utilisations therapeutiques
|
|
CN103467482B
(zh)
*
|
2012-04-10 |
2017-05-10 |
上海璎黎药业有限公司 |
稠合嘧啶类化合物,其制备方法,中间体,组合物和应用
|
|
RU2015140573A
(ru)
|
2013-02-25 |
2017-03-30 |
Дженентек, Инк. |
Способы и композиции для обнаружения и лечения устойчивого к лекарственным средствам мутанта акт
|
|
CN103242341B
(zh)
*
|
2013-04-19 |
2015-12-09 |
中国科学院广州生物医药与健康研究院 |
噻吩并2,4取代嘧啶类化合物及其药物组合物与应用
|
|
JP6441910B2
(ja)
*
|
2013-09-30 |
2018-12-19 |
シャンハイ インリ ファーマシューティカル カンパニー リミティド |
縮合ピリミジン化合物、中間体、その調製方法、組成物及び使用
|
|
RU2545758C1
(ru)
*
|
2014-03-20 |
2015-04-10 |
Общество с ограниченной ответственностью "Алион" |
Бициклические пиримидины или их фармацевтически приемлемые соли-активаторы антиоксидантной программы и их применение в качестве цитопротекторов
|
|
US10174032B2
(en)
*
|
2014-05-05 |
2019-01-08 |
Signalrx Pharmaceuticals, Inc. |
Heterocyclic compound classes for signaling modulation
|
|
GB201410816D0
(en)
*
|
2014-06-17 |
2014-07-30 |
Ucb Biopharma Sprl And Katholieke Universiteit Leuven |
Therapeutic agents
|
|
US10646490B2
(en)
|
2015-03-02 |
2020-05-12 |
University Of Maryland, Baltimore County |
Thieno- and pyrrolopyrimidine analogues and prodrugs thereof as anticancer agents and methods of use thereof
|
|
US9434742B1
(en)
*
|
2015-03-02 |
2016-09-06 |
University Of Maryland, Baltimore County |
Thieno- and pyrrolopyrimidine analogues as anticancer agents and methods of use thereof
|
|
CN108135906A
(zh)
*
|
2015-07-24 |
2018-06-08 |
路易斯维尔大学研究基金会有限公司 |
治病化合物、组合物、方法、及化合物制备方法
|
|
DE102015012049A1
(de)
*
|
2015-09-15 |
2017-03-16 |
Merck Patent Gmbh |
Verbindungen als ASIC-Inhibitoren und deren Verwendungen
|
|
CA3004534C
(en)
*
|
2015-11-23 |
2023-11-07 |
Council Of Scientific & Industrial Research |
Fused pyrimidines as isoform selective phosphoinositide-3-kinase-alpha inhibitors and process for preparation thereof
|
|
WO2017112777A1
(en)
|
2015-12-22 |
2017-06-29 |
SHY Therapeutics LLC |
Compounds for the treatment of cancer and inflammatory disease
|
|
CN105820175B
(zh)
*
|
2016-04-13 |
2019-09-20 |
四川大学 |
一种噻吩并嘧啶类化合物及其制备方法和应用
|
|
CN107698603B
(zh)
*
|
2016-08-09 |
2022-04-08 |
南京红云生物科技有限公司 |
噻吩并嘧啶类化合物、其制备方法、药用组合物及其应用
|
|
GB201700814D0
(en)
|
2017-01-17 |
2017-03-01 |
Liverpool School Tropical Medicine |
Compounds
|
|
KR102736865B1
(ko)
|
2017-06-21 |
2024-12-03 |
샤이 테라퓨틱스 엘엘씨 |
암, 염증성 질환, 신경발달질환 및 섬유증 질환의 치료를 위하여 Ras 수퍼패밀리와 상호작용하는 화합물
|
|
JP7407461B2
(ja)
|
2018-12-19 |
2024-01-04 |
シャイ・セラピューティクス・エルエルシー |
がん、炎症性疾患、ras病、及び線維性疾患の処置のためのrasスーパーファミリーと相互作用する化合物
|
|
JP7659269B2
(ja)
*
|
2018-12-21 |
2025-04-09 |
ユニバーシティ・オブ・ノートル・ダム・デュ・ラック |
抗酸菌症治療のためのbdオキシダーゼ阻害剤の発見
|
|
WO2020167624A1
(en)
|
2019-02-13 |
2020-08-20 |
Ptc Therapeutics, Inc. |
Pyrrolo[2,3-d]pyrimidine compounds for treating familial dysautonomia
|
|
AU2020222881C1
(en)
|
2019-02-13 |
2026-01-22 |
Ptc Therapeutics, Inc. |
Thioeno(3,2-b) pyridin-7-amine compounds for treating familial dysautonomia
|
|
JP2024533264A
(ja)
*
|
2021-09-07 |
2024-09-12 |
ピーティーシー セラピューティクス, インコーポレイテッド |
神経原性疾患を処置するための方法
|
|
CN115991716B
(zh)
*
|
2021-10-19 |
2025-10-17 |
中国药科大学 |
嘧啶并环类化合物及其衍生物、制备方法、药物组合物和应用
|