CH507993A - Verfahren zur Herstellung von Eisen(III)-komplexverbindungen mit hydriertem Dextran - Google Patents

Verfahren zur Herstellung von Eisen(III)-komplexverbindungen mit hydriertem Dextran

Info

Publication number: CH507993A
Authority: CH; Switzerland
Prior art keywords: iron; solution; hydroxide; iii; filtered
Prior art date: 1967-07-13

Application number

CH1028468A

Other languages

German (de)

English (en)

Inventor

Zbigniew Mioduszewski Jan

Helena Mioduszewsk Mieczyslawa

Januariusz Kornacki Andrzej

Original Assignee

Kutnowskie Zakl Farma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1967-07-13

Filing date

1968-07-10

Publication date

1971-05-31

1967-07-13 Priority claimed from PL121668A external-priority patent/PL58639B1/pl

1968-07-10 Application filed by Kutnowskie Zakl Farma filed Critical Kutnowskie Zakl Farma

1971-05-31 Publication of CH507993A publication Critical patent/CH507993A/de

Links

229920002307 Dextran Polymers 0.000 title abstract description 7
206010022971 Iron Deficiencies Diseases 0.000 title abstract description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 30
238000000034 method Methods 0.000 claims abstract description 26
239000007795 chemical reaction product Substances 0.000 claims abstract description 25
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 19
-1 alkali metal salts Chemical class 0.000 claims abstract description 8
229910052783 alkali metal Inorganic materials 0.000 claims abstract description 6
239000000243 solution Substances 0.000 claims description 58
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 23
150000001875 compounds Chemical class 0.000 claims description 22
239000000203 mixture Substances 0.000 claims description 17
MSNWSDPPULHLDL-UHFFFAOYSA-K ferric hydroxide Chemical compound [OH-].[OH-].[OH-].[Fe+3] MSNWSDPPULHLDL-UHFFFAOYSA-K 0.000 claims description 16
VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 claims description 9
150000002500 ions Chemical class 0.000 claims description 8
238000004519 manufacturing process Methods 0.000 claims description 7
238000003756 stirring Methods 0.000 claims description 7
150000008044 alkali metal hydroxides Chemical class 0.000 claims description 6
239000007864 aqueous solution Substances 0.000 claims description 3
238000010438 heat treatment Methods 0.000 abstract description 9
238000001914 filtration Methods 0.000 abstract description 8
238000000502 dialysis Methods 0.000 abstract description 5
239000003814 drug Substances 0.000 abstract description 3
238000000909 electrodialysis Methods 0.000 abstract description 3
229960004887 ferric hydroxide Drugs 0.000 abstract description 3
231100000053 low toxicity Toxicity 0.000 abstract description 3
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract description 2
239000008103 glucose Substances 0.000 abstract description 2
238000002156 mixing Methods 0.000 abstract description 2
239000000047 product Substances 0.000 abstract 2
238000001816 cooling Methods 0.000 abstract 1
239000000706 filtrate Substances 0.000 abstract 1
235000014413 iron hydroxide Nutrition 0.000 abstract 1
IEECXTSVVFWGSE-UHFFFAOYSA-M iron(3+);oxygen(2-);hydroxide Chemical compound [OH-].[O-2].[Fe+3] IEECXTSVVFWGSE-UHFFFAOYSA-M 0.000 abstract 1
NCNCGGDMXMBVIA-UHFFFAOYSA-L iron(ii) hydroxide Chemical compound [OH-].[OH-].[Fe+2] NCNCGGDMXMBVIA-UHFFFAOYSA-L 0.000 abstract 1
239000000463 material Substances 0.000 abstract 1
230000000704 physical effect Effects 0.000 abstract 1
239000012258 stirred mixture Substances 0.000 abstract 1
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 34
229910052742 iron Inorganic materials 0.000 description 17
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 12
238000006243 chemical reaction Methods 0.000 description 9
239000012153 distilled water Substances 0.000 description 8
RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 7
239000002244 precipitate Substances 0.000 description 7
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 6
238000002347 injection Methods 0.000 description 6
239000007924 injection Substances 0.000 description 6
239000011780 sodium chloride Substances 0.000 description 6
239000011521 glass Substances 0.000 description 5
239000001509 sodium citrate Substances 0.000 description 5
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 5
229910021578 Iron(III) chloride Inorganic materials 0.000 description 4
230000015572 biosynthetic process Effects 0.000 description 4
150000001768 cations Chemical class 0.000 description 4
238000002360 preparation method Methods 0.000 description 4
239000007787 solid Substances 0.000 description 4
239000000126 substance Substances 0.000 description 4
239000000725 suspension Substances 0.000 description 4
231100000419 toxicity Toxicity 0.000 description 4
230000001988 toxicity Effects 0.000 description 4
230000002378 acidificating effect Effects 0.000 description 3
230000009286 beneficial effect Effects 0.000 description 3
239000002738 chelating agent Substances 0.000 description 3
239000003153 chemical reaction reagent Substances 0.000 description 3
230000002349 favourable effect Effects 0.000 description 3
150000002505 iron Chemical class 0.000 description 3
239000007788 liquid Substances 0.000 description 3
239000011541 reaction mixture Substances 0.000 description 3
229910000029 sodium carbonate Inorganic materials 0.000 description 3
239000007921 spray Substances 0.000 description 3
238000004659 sterilization and disinfection Methods 0.000 description 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
150000001340 alkali metals Chemical class 0.000 description 2
239000001913 cellulose Substances 0.000 description 2
229920002678 cellulose Polymers 0.000 description 2
238000005119 centrifugation Methods 0.000 description 2
230000009918 complex formation Effects 0.000 description 2
238000002242 deionisation method Methods 0.000 description 2
238000005115 demineralization Methods 0.000 description 2
230000002328 demineralizing effect Effects 0.000 description 2
238000001035 drying Methods 0.000 description 2
238000001704 evaporation Methods 0.000 description 2
230000008020 evaporation Effects 0.000 description 2
238000010907 mechanical stirring Methods 0.000 description 2
239000003960 organic solvent Substances 0.000 description 2
239000000843 powder Substances 0.000 description 2
238000001556 precipitation Methods 0.000 description 2
230000035484 reaction time Effects 0.000 description 2
159000000000 sodium salts Chemical class 0.000 description 2
230000001954 sterilising effect Effects 0.000 description 2
230000001225 therapeutic effect Effects 0.000 description 2
238000002560 therapeutic procedure Methods 0.000 description 2
DPEYHNFHDIXMNV-UHFFFAOYSA-N (9-amino-3-bicyclo[3.3.1]nonanyl)-(4-benzyl-5-methyl-1,4-diazepan-1-yl)methanone dihydrochloride Chemical compound Cl.Cl.CC1CCN(CCN1Cc1ccccc1)C(=O)C1CC2CCCC(C1)C2N DPEYHNFHDIXMNV-UHFFFAOYSA-N 0.000 description 1
NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 1
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
235000011114 ammonium hydroxide Nutrition 0.000 description 1
150000001450 anions Chemical class 0.000 description 1
239000010425 asbestos Substances 0.000 description 1
238000005341 cation exchange Methods 0.000 description 1
239000013522 chelant Substances 0.000 description 1
229920001429 chelating resin Polymers 0.000 description 1
239000000460 chlorine Substances 0.000 description 1
229910052801 chlorine Inorganic materials 0.000 description 1
238000005352 clarification Methods 0.000 description 1
238000010668 complexation reaction Methods 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
238000010908 decantation Methods 0.000 description 1
230000007423 decrease Effects 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
239000003792 electrolyte Substances 0.000 description 1
230000008030 elimination Effects 0.000 description 1
238000003379 elimination reaction Methods 0.000 description 1
239000004744 fabric Substances 0.000 description 1
239000008240 homogeneous mixture Substances 0.000 description 1
238000000265 homogenisation Methods 0.000 description 1
GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical group [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
150000001261 hydroxy acids Chemical class 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
150000002506 iron compounds Chemical class 0.000 description 1
239000000644 isotonic solution Substances 0.000 description 1
230000003472 neutralizing effect Effects 0.000 description 1
239000011148 porous material Substances 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
229910052895 riebeckite Inorganic materials 0.000 description 1
239000012266 salt solution Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
239000007858 starting material Substances 0.000 description 1
238000003860 storage Methods 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
239000004552 water soluble powder Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Inorganic Chemistry (AREA)
Biochemistry (AREA)
Materials Engineering (AREA)
Chemical Kinetics & Catalysis (AREA)
Polymers & Plastics (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

CH1028468A 1967-07-13 1968-07-10 Verfahren zur Herstellung von Eisen(III)-komplexverbindungen mit hydriertem Dextran CH507993A (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
PL121668A PL58639B1 (pl)		1967-07-13
PL121667A PL58638B1 (pl)		1967-07-13

Publications (1)

Publication Number	Publication Date
CH507993A true CH507993A (de)	1971-05-31

Family

ID=26652814

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH1028468A CH507993A (de)	1967-07-13	1968-07-10	Verfahren zur Herstellung von Eisen(III)-komplexverbindungen mit hydriertem Dextran

Country Status (6)

Country	Link
CH (1)	CH507993A (pl)
DE (1)	DE1768912A1 (pl)
DK (1)	DK122398B (pl)
ES (1)	ES356078A1 (pl)
GB (1)	GB1196855A (pl)
SE (1)	SE344950B (pl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK172860B1 (da)	1998-03-25	1999-08-16	Pharmacosmos Holding As	Jerndextranforbindelse til anvendelse som komponent i et terapeutisk middel til forebyggelse af eller behandling af jernman

1968
- 1968-07-10 CH CH1028468A patent/CH507993A/de not_active IP Right Cessation
- 1968-07-12 GB GB3350368A patent/GB1196855A/en not_active Expired
- 1968-07-12 DE DE19681768912 patent/DE1768912A1/de active Granted
- 1968-07-12 ES ES356078A patent/ES356078A1/es not_active Expired
- 1968-07-12 DK DK341568A patent/DK122398B/da unknown
- 1968-07-12 SE SE963968A patent/SE344950B/xx unknown

Also Published As

Publication number	Publication date
SE344950B (pl)	1972-05-08
GB1196855A (en)	1970-07-01
DE1768912A1 (de)	1972-05-10
ES356078A1 (es)	1970-03-16
DK122398B (da)	1972-02-28

Legal Events

Date	Code	Title	Description
1977-02-15	PL	Patent ceased

Publication	Publication Date	Title
DE69902154T2 (de)	2003-03-06	Eisen-dextran verbindung zur verwendung als komponente in einer therapeutischen zusammensetzung zur behandlung oder prophylaxe von eisenmangel, sowie verfahren zur herstellung der eisen-dextran verbindung und ihre anwendung zur herstellung einer parenteral anwendbaren therapeutischen zubereitung.
DE69324591T3 (de)	2004-02-12	Verbundmaterial mit kleinem durchmesser, welches ein wasserlösliches carboxylpolysaccharid und magnetisches eisenoxid enthaltet
DE2240782A1 (de)	1973-03-01	Verfahren zur herstellung eines eisensaccharid-komplexes
DE1767921A1 (de)	1971-10-21	Verfahren zur Herstellung neuer organischer Eisen (III)-Komplexverbindungen
DE60307249T2 (de)	2007-03-15	Eisen-dextrin verbindung zur behandlung von anämien durch eisenmangel
EP0044050B1 (de)	1985-02-13	Verfahren zur Herstellung von Eisen (III)-Hydroxid-Dextran-Komplexen und diese enthaltende pharmazeutische sterile Lösung
DE1618454A1 (de)	1971-03-25	Neues Chondroitinsulfat und Verfahren zu seiner Herstellung
DE2659799C2 (de)	1987-03-12	Eisen(III)-hydroxid-Dextrin-Carbonsäure-Komplex und Verfahren zu seiner Herstellung sowie ein einen Eisen(III)-hydroxid-Dextrin-Citronensäure-Komplex enthaltendes therapeutisches Präparat
DE2834702C2 (pl)	1988-11-10
WO2005111052A1 (de)	2005-11-24	Verfahren zur herstellung von eisen (iii) gluconatkomlex
DE68911694T2 (de)	1994-05-05	Mittel für die thermotherapie.
DE3019895C2 (pl)	1987-10-29
CH507993A (de)	1971-05-31	Verfahren zur Herstellung von Eisen(III)-komplexverbindungen mit hydriertem Dextran
DE3337506C2 (pl)	1991-07-04
DE938502C (de)	1956-02-02	Verfahren zur Herstellung einer kolloidalen Eisenzubereitung
DE3101001A1 (de)	1981-12-03	Verfahren zur konzentration und reinigung des antihaemophilie-faktors oder faktor viii
DE854245C (de)	1952-11-04	Verfahren zur Herstellung von Mitteln zur Inaktivierung proteolytischer Enzyme im Verdauungstraktus
DE1293144B (de)	1969-04-24	Verfahren zur Herstellung von Komplexverbindungen des Eisens mit Sorbit, Gluconsaeure und einem Oligosaccharid
DE960579C (de)	1957-03-21	Verfahren zur Herstellung eines in der Hitze sterilisierbaren Adrenocorticotropin-Praeparates
AT253118B (de)	1967-03-28	Verfahren zur Herstellung eines Wirkstoffes von Polypeptidnatur mit unspezifischer Immunisierungswirkung
DE1768912B (de)		Verfahren zur Herstellung von thera= peutisch verwendbaren Eisen Komplex= verbindungen des hydrierten Dextrans
AT376883B (de)	1985-01-10	Verfahren zur inaktivierung von vermehrungsfaehigen krankheitserregern
DE957160C (de)	1957-01-31	Verfahren zur Herstellung von biologisch aktiven Zubereitungen
EP3240531B1 (de)	2020-02-12	Arzneimittel auf der basis von maghämit zur gleichzeitigen reduzierung der gastrointestinalen natriumresorption und phosphatresorption
DE2247021C3 (de)	1979-08-16	Eisenkomplexverbindung, Verfahren zu deren Herstellung und sie enthaltendes Arzneimittel