CH510669A - Verfahren zur Herstellung von Isochinuclidin-Derivaten - Google Patents
Verfahren zur Herstellung von Isochinuclidin-DerivatenInfo
- Publication number
- CH510669A CH510669A CH821368A CH821368A CH510669A CH 510669 A CH510669 A CH 510669A CH 821368 A CH821368 A CH 821368A CH 821368 A CH821368 A CH 821368A CH 510669 A CH510669 A CH 510669A
- Authority
- CH
- Switzerland
- Prior art keywords
- preparation
- isoquinuclidine
- derivatives
- isoquinuclidine derivatives
- Prior art date
Links
- KPUSZZFAYGWAHZ-UHFFFAOYSA-N 3-azabicyclo[2.2.2]octane Chemical class C1CC2CCC1NC2 KPUSZZFAYGWAHZ-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3564767 | 1967-06-03 | ||
| JP762068 | 1968-02-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH510669A true CH510669A (de) | 1971-07-31 |
Family
ID=26341953
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH633171A CH511233A (de) | 1967-06-03 | 1968-06-04 | Verfahren zur Herstellung von Isochinuklidin-Derivaten |
| CH821368A CH510669A (de) | 1967-06-03 | 1968-06-04 | Verfahren zur Herstellung von Isochinuclidin-Derivaten |
| CH633271A CH518940A (de) | 1967-06-03 | 1968-06-04 | Verfahren zur Herstellung von Isochinuclidin-Derivaten |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH633171A CH511233A (de) | 1967-06-03 | 1968-06-04 | Verfahren zur Herstellung von Isochinuklidin-Derivaten |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH633271A CH518940A (de) | 1967-06-03 | 1968-06-04 | Verfahren zur Herstellung von Isochinuclidin-Derivaten |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US3639408A (de) |
| CH (3) | CH511233A (de) |
| DE (1) | DE1770561A1 (de) |
| FR (1) | FR1572766A (de) |
| GB (1) | GB1236488A (de) |
| NL (1) | NL6807826A (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4003905A (en) * | 1974-12-11 | 1977-01-18 | E. R. Squibb & Sons, Inc. | Diels-alder adducts of benzdiazepines |
| US3984418A (en) * | 1975-04-15 | 1976-10-05 | E. R. Squibb & Sons, Inc. | Hydrogenated diels-alder adducts of benzdiazepines |
| US4022790A (en) * | 1975-04-15 | 1977-05-10 | E. R. Squibb & Sons, Inc. | Hydrogenated diels-alder adducts of benzdiazepines |
| HU188022B (en) * | 1983-06-29 | 1986-03-28 | Richter Gedeon Vegyeszeti Gyar Rt,Hu | Process for production of derivatives of indolo /2,3-g/cyylopent /a/ indolizin |
| ES2435722T3 (es) * | 1997-09-04 | 2013-12-23 | Demerx, Inc. | Noribogaína en el tratamiento del dolor y de la adicción a drogas |
| US7220737B1 (en) | 1997-09-04 | 2007-05-22 | Novoneuron, Inc | Noribogaine in the treatment of pain and drug addiction |
| US8362007B1 (en) | 2010-05-11 | 2013-01-29 | Demerx, Inc. | Substituted noribogaine |
| US9394294B2 (en) | 2010-05-11 | 2016-07-19 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
| US8765737B1 (en) | 2010-05-11 | 2014-07-01 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
| US8741891B1 (en) | 2010-06-22 | 2014-06-03 | Demerx, Inc. | N-substituted noribogaine prodrugs |
| US9586954B2 (en) | 2010-06-22 | 2017-03-07 | Demerx, Inc. | N-substituted noribogaine prodrugs |
| US8802832B2 (en) | 2010-06-22 | 2014-08-12 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
| US8637648B1 (en) | 2010-06-22 | 2014-01-28 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
| JP6049615B2 (ja) | 2010-07-23 | 2016-12-21 | デマークス・インコーポレイテッドＤｅｍｅｒｘ，Ｉｎｃ． | ノリボガイン組成物 |
| EP2481740B1 (de) | 2011-01-26 | 2015-11-04 | DemeRx, Inc. | Verfahren und Zusammensetzungen zur Herstellung von Noribogain aus Voacangin |
| WO2013028999A1 (en) * | 2011-08-24 | 2013-02-28 | The Trustees Of Columbia University In The City Of New York | Small molecule inducers of gdnf as potential new therapeutics for neuropsychiatric disorders |
| US9617274B1 (en) | 2011-08-26 | 2017-04-11 | Demerx, Inc. | Synthetic noribogaine |
| CA3122767C (en) | 2011-12-08 | 2023-03-28 | Demerx, Inc. | Stereoselective total synthesis of noribogaine |
| EP2788003A4 (de) | 2011-12-09 | 2015-05-27 | Demerx Inc | Phosphatester von noribogain |
| CA2858820C (en) | 2012-01-25 | 2021-08-17 | Demerx, Inc. | Synthetic voacangine |
| US9150584B2 (en) | 2012-01-25 | 2015-10-06 | Demerx, Inc. | Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them |
| US9045481B2 (en) | 2012-12-20 | 2015-06-02 | Demerx, Inc. | Substituted noribogaine |
| US8940728B2 (en) | 2012-12-20 | 2015-01-27 | Demerx, Inc. | Substituted noribogaine |
| CA2896133A1 (en) | 2012-12-20 | 2014-06-26 | Demerx, Inc. | Substituted noribogaine |
| WO2015195673A2 (en) | 2014-06-18 | 2015-12-23 | Demerx, Inc. | Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them |
| US11840541B2 (en) | 2014-11-26 | 2023-12-12 | The Trustees Of Columbia University In The City Of New York | Opioid receptor modulators |
| WO2021178691A1 (en) | 2020-03-05 | 2021-09-10 | The Trustees Of Columbia University In The City Of New York | Ibogaine analogs as therapeutics for neurological and psychiatric disorders |
| US20230348465A1 (en) * | 2020-07-20 | 2023-11-02 | The Trustees Of Columbia University In The City Of New York | Ibogaine analogs as therapeutics for neurological and psychiatric disorders |
-
1968
- 1968-05-28 US US732520A patent/US3639408A/en not_active Expired - Lifetime
- 1968-05-31 GB GB26161/68A patent/GB1236488A/en not_active Expired
- 1968-06-04 NL NL6807826A patent/NL6807826A/xx unknown
- 1968-06-04 CH CH633171A patent/CH511233A/de not_active IP Right Cessation
- 1968-06-04 CH CH821368A patent/CH510669A/de not_active IP Right Cessation
- 1968-06-04 CH CH633271A patent/CH518940A/de not_active IP Right Cessation
- 1968-06-04 DE DE19681770561 patent/DE1770561A1/de active Pending
- 1968-07-01 FR FR1572766D patent/FR1572766A/fr not_active Expired
-
1970
- 1970-10-14 US US00080806A patent/US3716528A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| GB1236488A (en) | 1971-06-23 |
| CH511233A (de) | 1971-08-15 |
| US3639408A (en) | 1972-02-01 |
| DE1770561A1 (de) | 1971-11-04 |
| CH518940A (de) | 1972-02-15 |
| US3716528A (en) | 1973-02-13 |
| NL6807826A (de) | 1968-12-04 |
| FR1572766A (de) | 1969-06-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased |