ES2224430T3 - Noribogaina en el tratamiento del dolor y de la toxicomania. - Google Patents

Noribogaina en el tratamiento del dolor y de la toxicomania.

Info

Publication number
ES2224430T3
ES2224430T3 ES98944698T ES98944698T ES2224430T3 ES 2224430 T3 ES2224430 T3 ES 2224430T3 ES 98944698 T ES98944698 T ES 98944698T ES 98944698 T ES98944698 T ES 98944698T ES 2224430 T3 ES2224430 T3 ES 2224430T3
Authority
ES
Spain
Prior art keywords
noribogaine
pain
treatment
toxicomania
naloxone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98944698T
Other languages
English (en)
Inventor
Deborah C Mash
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novoneuron Inc
Original Assignee
Novoneuron Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novoneuron Inc filed Critical Novoneuron Inc
Application granted granted Critical
Publication of ES2224430T3 publication Critical patent/ES2224430T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

Uso de noribogaína en la fabricación de un medicamento para tratar la dependencia o el abuso de drogas durante la terapia de retirada, en el que es para administración concomitante con dicha noribogaína un antagonista de opioide.
ES98944698T 1997-09-04 1998-09-03 Noribogaina en el tratamiento del dolor y de la toxicomania. Expired - Lifetime ES2224430T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5792197P 1997-09-04 1997-09-04

Publications (1)

Publication Number Publication Date
ES2224430T3 true ES2224430T3 (es) 2005-03-01

Family

ID=22013572

Family Applications (3)

Application Number Title Priority Date Filing Date
ES98944698T Expired - Lifetime ES2224430T3 (es) 1997-09-04 1998-09-03 Noribogaina en el tratamiento del dolor y de la toxicomania.
ES03075683T Expired - Lifetime ES2395268T3 (es) 1997-09-04 1998-09-03 Noribogaína para el tratamiento del dolor y la drogadicción
ES10180121T Expired - Lifetime ES2435722T3 (es) 1997-09-04 1998-09-03 Noribogaína en el tratamiento del dolor y de la adicción a drogas

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES03075683T Expired - Lifetime ES2395268T3 (es) 1997-09-04 1998-09-03 Noribogaína para el tratamiento del dolor y la drogadicción
ES10180121T Expired - Lifetime ES2435722T3 (es) 1997-09-04 1998-09-03 Noribogaína en el tratamiento del dolor y de la adicción a drogas

Country Status (9)

Country Link
US (6) US7754710B2 (es)
EP (4) EP1327447B1 (es)
AT (2) ATE265213T1 (es)
AU (1) AU754088B2 (es)
CA (1) CA2302754C (es)
DE (1) DE69823520T2 (es)
ES (3) ES2224430T3 (es)
IL (2) IL134796A0 (es)
WO (1) WO1999011250A2 (es)

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PL2405915T3 (pl) 2009-03-10 2019-05-31 Euro Celtique Sa Kompozycje farmaceutyczne o natychmiastowym uwalnianiu zawierające oksykodon i nalokson
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WO2013085922A1 (en) * 2011-12-09 2013-06-13 Demerx, Inc. Phosphate esters of noribogaine
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WO2013112673A1 (en) 2012-01-25 2013-08-01 Demerx, Inc. Synthetic voacangine
EP2934541A4 (en) * 2012-12-20 2016-08-03 Demerx Inc SUBSTITUTED NORIBOGAIN
US9045481B2 (en) 2012-12-20 2015-06-02 Demerx, Inc. Substituted noribogaine
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US9192570B2 (en) 2013-12-20 2015-11-24 AntiOP, Inc. Intranasal naloxone compositions and methods of making and using same
EA201691656A2 (ru) * 2014-02-18 2017-03-31 Демеркс, Инк. Терапевтические способы с применением норибогаина и родственных соединений
EA201691647A1 (ru) * 2014-02-18 2017-01-30 Демеркс, Инк. Способы кратковременного и долгосрочного лечения зависимости от лекарственных средств
US9561232B2 (en) 2014-02-18 2017-02-07 Demerx, Inc. Low dose noribogaine for treating nicotine addiction and preventing relapse of nicotine use
US20150246055A1 (en) * 2014-03-03 2015-09-03 Demerx, Inc. Methods for acute and long-term treatment of opioid and opioid-like drug addiction
US20150258111A1 (en) * 2014-03-13 2015-09-17 Demerx, Inc. Methods and compositions for reducing tolerance to opioid analgesics using ibogaine and derivatives thereof
US9591978B2 (en) 2014-03-13 2017-03-14 Demerx, Inc. Methods and compositions for pre-screening patients for treatment with noribogaine
WO2015142346A1 (en) * 2014-03-20 2015-09-24 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US9550789B2 (en) 2014-06-18 2017-01-24 Demerx, Inc. Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them
US9549935B2 (en) 2014-07-14 2017-01-24 Demerx, Inc. Methods and compositions for treating migraines using noribogaine
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Also Published As

Publication number Publication date
US20120083485A1 (en) 2012-04-05
US20100311724A1 (en) 2010-12-09
ES2395268T3 (es) 2013-02-11
ES2435722T3 (es) 2013-12-23
US20070185085A1 (en) 2007-08-09
IL134796A (en) 2008-11-26
EP1327447A1 (en) 2003-07-16
IL134796A0 (en) 2001-04-30
DE69823520D1 (de) 2004-06-03
EP2246058A1 (en) 2010-11-03
EP2338494A1 (en) 2011-06-29
US8178524B2 (en) 2012-05-15
DE69823520T2 (de) 2005-05-12
EP1327447B1 (en) 2011-05-25
CA2302754A1 (en) 1999-03-11
AU9217498A (en) 1999-03-22
WO1999011250A2 (en) 1999-03-11
WO1999011250A3 (en) 1999-08-05
ATE265213T1 (de) 2004-05-15
AU754088B2 (en) 2002-11-07
EP2338494B1 (en) 2013-07-10
US20100311723A1 (en) 2010-12-09
EP1009407B1 (en) 2004-04-28
US7754710B2 (en) 2010-07-13
US20100311725A1 (en) 2010-12-09
EP1009407A2 (en) 2000-06-21
ATE510542T1 (de) 2011-06-15
CA2302754C (en) 2011-11-08
US20100311722A1 (en) 2010-12-09

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