CH524994A - Mittel zur Bestimmung von Pankreas-Enzymen in Körperflüssigkeiten - Google Patents

Mittel zur Bestimmung von Pankreas-Enzymen in Körperflüssigkeiten

Info

Publication number: CH524994A
Authority: CH; Switzerland
Prior art keywords: fluorescein; agent according; diester; fatty acid; agent
Prior art date: 1967-04-14

Application number

CH552768A

Other languages

German (de)

English (en)

Inventor

Meyer-Bertenrath Juergen Dr Dr

Hans Dr Med Kaffarnik

Original Assignee

Meyer Bertenrath Juergen Dr Dr

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1967-04-14

Filing date

1968-04-08

Publication date

1972-07-15

1968-04-08 Application filed by Meyer Bertenrath Juergen Dr Dr filed Critical Meyer Bertenrath Juergen Dr Dr

1972-07-15 Publication of CH524994A publication Critical patent/CH524994A/de

Links

108090000790 Enzymes Proteins 0.000 title claims abstract description 25
102000004190 Enzymes Human genes 0.000 title claims abstract description 25
239000000194 fatty acid Substances 0.000 title claims abstract description 15
230000000694 effects Effects 0.000 title abstract description 3
239000003795 chemical substances by application Substances 0.000 claims abstract description 25
229940088598 enzyme Drugs 0.000 claims abstract description 24
235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 14
229930195729 fatty acid Natural products 0.000 claims abstract description 14
POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims abstract description 11
150000004665 fatty acids Chemical class 0.000 claims abstract description 9
150000005690 diesters Chemical class 0.000 claims abstract description 8
108090000317 Chymotrypsin Proteins 0.000 claims abstract description 4
108090001060 Lipase Proteins 0.000 claims abstract description 4
102000004882 Lipase Human genes 0.000 claims abstract description 4
239000004367 Lipase Substances 0.000 claims abstract description 4
229960002376 chymotrypsin Drugs 0.000 claims abstract description 4
235000019421 lipase Nutrition 0.000 claims abstract description 4
235000019799 monosodium phosphate Nutrition 0.000 claims abstract description 4
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims abstract description 4
239000002775 capsule Substances 0.000 claims abstract description 3
210000000813 small intestine Anatomy 0.000 claims abstract 2
210000002784 stomach Anatomy 0.000 claims abstract 2
210000001124 body fluid Anatomy 0.000 claims description 8
239000010839 body fluid Substances 0.000 claims description 8
LYWNSVUNJBBQBQ-UHFFFAOYSA-N 4-[[3',6'-bis[[4-(diaminomethylideneamino)benzoyl]oxy]-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-yl]carbamothioylamino]benzoic acid Chemical compound C1=CC(N=C(N)N)=CC=C1C(=O)OC1=CC=C2C3(C4=CC=C(NC(=S)NC=5C=CC(=CC=5)C(O)=O)C=C4C(=O)O3)C3=CC=C(OC(=O)C=4C=CC(=CC=4)N=C(N)N)C=C3OC2=C1 LYWNSVUNJBBQBQ-UHFFFAOYSA-N 0.000 claims description 6
239000012928 buffer substance Substances 0.000 claims description 5
125000004432 carbon atom Chemical group C* 0.000 claims description 5
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 3
239000000463 material Substances 0.000 claims description 2
229910000403 monosodium phosphate Inorganic materials 0.000 claims description 2
TWJNQYPJQDRXPH-UHFFFAOYSA-N 2-cyanobenzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1C#N TWJNQYPJQDRXPH-UHFFFAOYSA-N 0.000 claims 1
235000021360 Myristic acid Nutrition 0.000 claims 1
TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims 1
230000001419 dependent effect Effects 0.000 claims 1
239000008298 dragée Substances 0.000 claims 1
239000000126 substance Substances 0.000 claims 1
GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 abstract description 24
150000002148 esters Chemical class 0.000 abstract description 9
-1 lauric acid ester Chemical class 0.000 abstract description 8
239000005639 Lauric acid Substances 0.000 abstract description 4
210000002700 urine Anatomy 0.000 abstract description 4
229940039227 diagnostic agent Drugs 0.000 abstract description 3
239000000032 diagnostic agent Substances 0.000 abstract description 3
230000007062 hydrolysis Effects 0.000 abstract description 3
238000006460 hydrolysis reaction Methods 0.000 abstract description 3
229910000162 sodium phosphate Inorganic materials 0.000 abstract description 2
TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 abstract description 2
238000012360 testing method Methods 0.000 description 10
238000000034 method Methods 0.000 description 6
210000004369 blood Anatomy 0.000 description 5
239000008280 blood Substances 0.000 description 5
230000002183 duodenal effect Effects 0.000 description 5
235000011389 fruit/vegetable juice Nutrition 0.000 description 5
239000000203 mixture Substances 0.000 description 5
230000037396 body weight Effects 0.000 description 4
230000029142 excretion Effects 0.000 description 4
102000019280 Pancreatic lipases Human genes 0.000 description 3
108050006759 Pancreatic lipases Proteins 0.000 description 3
238000010521 absorption reaction Methods 0.000 description 3
239000002253 acid Substances 0.000 description 3
229940116369 pancreatic lipase Drugs 0.000 description 3
239000000523 sample Substances 0.000 description 3
230000035945 sensitivity Effects 0.000 description 3
FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
NQPDZGIKBAWPEJ-UHFFFAOYSA-N Valeric acid Natural products CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
230000029087 digestion Effects 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 2
229940040461 lipase Drugs 0.000 description 2
239000000758 substrate Substances 0.000 description 2
GAWAYYRQGQZKCR-REOHCLBHSA-N (S)-2-chloropropanoic acid Chemical compound C[C@H](Cl)C(O)=O GAWAYYRQGQZKCR-REOHCLBHSA-N 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 1
108700023418 Amidases Proteins 0.000 description 1
208000016222 Pancreatic disease Diseases 0.000 description 1
206010033645 Pancreatitis Diseases 0.000 description 1
BAECOWNUKCLBPZ-HIUWNOOHSA-N Triolein Natural products O([C@H](OCC(=O)CCCCCCC/C=C\CCCCCCCC)COC(=O)CCCCCCC/C=C\CCCCCCCC)C(=O)CCCCCCC/C=C\CCCCCCCC BAECOWNUKCLBPZ-HIUWNOOHSA-N 0.000 description 1
PHYFQTYBJUILEZ-UHFFFAOYSA-N Trioleoylglycerol Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCCCCCCCC)COC(=O)CCCCCCCC=CCCCCCCCC PHYFQTYBJUILEZ-UHFFFAOYSA-N 0.000 description 1
241000209140 Triticum Species 0.000 description 1
235000021307 Triticum Nutrition 0.000 description 1
230000001476 alcoholic effect Effects 0.000 description 1
230000008033 biological extinction Effects 0.000 description 1
239000007853 buffer solution Substances 0.000 description 1
210000004027 cell Anatomy 0.000 description 1
210000000170 cell membrane Anatomy 0.000 description 1
239000003086 colorant Substances 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
238000001514 detection method Methods 0.000 description 1
238000003745 diagnosis Methods 0.000 description 1
235000013367 dietary fats Nutrition 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
229910000397 disodium phosphate Inorganic materials 0.000 description 1
235000019800 disodium phosphate Nutrition 0.000 description 1
210000001198 duodenum Anatomy 0.000 description 1
230000008030 elimination Effects 0.000 description 1
238000003379 elimination reaction Methods 0.000 description 1
239000003925 fat Substances 0.000 description 1
239000000945 filler Substances 0.000 description 1
125000001153 fluoro group Chemical group F* 0.000 description 1
230000002496 gastric effect Effects 0.000 description 1
230000001771 impaired effect Effects 0.000 description 1
238000011534 incubation Methods 0.000 description 1
238000011835 investigation Methods 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
235000019626 lipase activity Nutrition 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
208000024691 pancreas disease Diseases 0.000 description 1
230000001575 pathological effect Effects 0.000 description 1
230000035699 permeability Effects 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
238000011160 research Methods 0.000 description 1
238000012216 screening Methods 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
239000000243 solution Substances 0.000 description 1
108091016642 steapsin Proteins 0.000 description 1
238000010998 test method Methods 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1
PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
229940117972 triolein Drugs 0.000 description 1
230000002485 urinary effect Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
- C12Q2334/40—Triphenylmethane dye chromogens, e.g. fluorescein derivatives
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
- G01N2333/918—Carboxylic ester hydrolases (3.1.1)

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Physics & Mathematics (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Analytical Chemistry (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medicinal Preparation (AREA)

CH552768A 1967-04-14 1968-04-08 Mittel zur Bestimmung von Pankreas-Enzymen in Körperflüssigkeiten CH524994A (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DEM0073599		1967-04-14

Publications (1)

Publication Number	Publication Date
CH524994A true CH524994A (de)	1972-07-15

Family

ID=7315133

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH552768A CH524994A (de)	1967-04-14	1968-04-08	Mittel zur Bestimmung von Pankreas-Enzymen in Körperflüssigkeiten

Country Status (3)

Country	Link
AT (1)	AT282834B (fr)
CH (1)	CH524994A (fr)
FR (1)	FR7600M (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI63064C (fi) *	1980-04-09	1983-04-11	Ksv Chemicals Oy	Foerfarande foer fluorometrisk bestaemning av aktiviteten av fettspjaelkande enzymer och medel foer att genomfoera foerfarandet

1968
- 1968-04-08 CH CH552768A patent/CH524994A/de not_active IP Right Cessation
- 1968-04-11 AT AT360968A patent/AT282834B/de not_active IP Right Cessation
- 1968-04-11 FR FR147725A patent/FR7600M/fr not_active Expired

Also Published As

Publication number	Publication date
DE1598833A1 (de)	1970-10-29
FR7600M (fr)	1970-01-19
AT282834B (de)	1970-07-10
DE1598833B2 (de)	1975-12-04

Legal Events

Date	Code	Title	Description
1988-06-30	PL	Patent ceased

Publication	Publication Date	Title
Lin et al.	1993	Unique lipids of primate spermatozoa: desmosterol and docosahexaenoic acid.
DE69608268T2 (de)	2000-11-09	Caroboxy- oder tetrazolengruppen enthaltende dialkylether
DE2904305C2 (de)	1981-07-02	Reagens zur Lipasebestimmung und Verfahren zu seiner Herstellung
DE1945663C3 (de)	1981-11-26	Diagnostikum zur Bestimmung von Pankreas-Enzymen in Körperflüssigkeiten
DE2847202A1 (de)	1979-06-13	Verfahren zur bestimmung von triglyceriden
Watson	1970	Genesis of fat emboli
DE2749492C2 (de)	1982-11-04	Antithrombosemittel
DE1767748A1 (de)	1971-09-02	Mittel zur Bestimmung der weiblichen Fruchtbarkeitsperiode
Bailey et al.	1968	Lipid metabolism in helminth parasites—V. Absorption of fatty acids and monoglycerides from micellar solution by Hymenolepis diminuta (Cestoda)
DE1273226B (de)	1968-07-18	Diagnostisches Mittel zum Nachweis von Keton-Koerpern in Koerperfluessigkeiten und Herstellungsverfahren des Mittels
DE60201525T2 (de)	2006-03-02	Verfahren zur herstellung eines an wirkstoffen hochangereicherten extraktes der blätter von ginkgo biloba
DE2101796A1 (de)	1971-08-05	Verfahren zur Bestimmung von Tnglycenden im Blutserum
Wiggins et al.	1984	Myelination of the rat optic nerve during postnatal undernourishment and recovery: a morphometric analysis
DE69221040T2 (de)	1997-11-13	Aktivätsmessungen des amylin
CH524994A (de)	1972-07-15	Mittel zur Bestimmung von Pankreas-Enzymen in Körperflüssigkeiten
EP0626070A1 (fr)	1994-11-30	Procede de determination de l'hirudine et des inhibiteurs synthetiques de la thrombine.
EP1242825B1 (fr)	2005-03-09	Extraction de lipoproteines contenues dans des liquides organiques
DE1598833C3 (de)	1976-09-30	Perorales Diagnostikum zur Bestimmung von Pankreasenzymen in Körperflüssigkeiten
WO2009149871A1 (fr)	2009-12-17	Procédé à haut rendement pour analyser la composition en acides gras de phosphoglycérides plasmatiques
DE1197250B (de)	1965-07-22	Diagnostische Tablette zur Bestimmung von Albumin
EP0020895A1 (fr)	1981-01-07	Thromboplastine partielle
Javaid et al.	1971	Timed-release tablets employing lipase-lipid-sulfamethizole systems prepared by spray congealing
DE1962589U (de)	1967-06-22	Testkapsel zur bestimmung von pankreas-enzymen in koerperfluessigkeiten.
DE4117619C2 (fr)	1993-04-08
Nath et al.	1959	Effects of essential fatty acids, inositol, vitamin B12 and hydrolyzed glucose-cyclo-acetoacetate on blood coagulation factors in rabbits exhibiting hyperlipemia induced by feeding saturated fat