CH612675A5 - Process for the preparation of new 1-(2'-aroyl-1'-ethyl)-2-(4''-acetamido-1''-piperazinylmethyl)benzimidazo les - Google Patents

Process for the preparation of new 1-(2'-aroyl-1'-ethyl)-2-(4''-acetamido-1''-piperazinylmethyl)benzimidazo les

Info

Publication number: CH612675A5
Authority: CH; Switzerland
Prior art keywords: aroyl; ethyl; piperazinylmethyl; acetamido; benzimidazo
Prior art date: 1975-01-10

Application number

CH12876A

Other languages

English (en)

Inventor

Claude Fauran

Michel Turin

Thierry Imbert

Guy Raynaud

Nicole Dorme

Original Assignee

Delalande Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-01-10

Filing date

1976-01-07

Publication date

1979-08-15

1975-01-10 Priority claimed from FR7500724A external-priority patent/FR2297045A1/fr

1975-12-05 Priority claimed from FR7537297A external-priority patent/FR2333510A2/fr

1976-01-07 Application filed by Delalande Sa filed Critical Delalande Sa

1979-08-15 Publication of CH612675A5 publication Critical patent/CH612675A5/xx

Links

150000001556 benzimidazoles Chemical class 0.000 title abstract 2
208000002193 Pain Diseases 0.000 abstract 2
FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
206010020601 Hyperchlorhydria Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
208000007101 Muscle Cramp Diseases 0.000 abstract 1
206010030113 Oedema Diseases 0.000 abstract 1
208000008469 Peptic Ulcer Diseases 0.000 abstract 1
229910006124 SOCl2 Inorganic materials 0.000 abstract 1
208000005392 Spasm Diseases 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
238000005660 chlorination reaction Methods 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000005494 condensation Effects 0.000 abstract 1
238000009833 condensation Methods 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
231100000029 gastro-duodenal ulcer Toxicity 0.000 abstract 1
230000002757 inflammatory effect Effects 0.000 abstract 1
CWZMDINGMFZXMY-UHFFFAOYSA-N n-piperazin-1-ylacetamide Chemical compound CC(=O)NN1CCNCC1 CWZMDINGMFZXMY-UHFFFAOYSA-N 0.000 abstract 1
230000009278 visceral effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/10—Radicals substituted by halogen atoms or nitro radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

CH12876A 1975-01-10 1976-01-07 Process for the preparation of new 1-(2'-aroyl-1'-ethyl)-2-(4''-acetamido-1''-piperazinylmethyl)benzimidazo les CH612675A5 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR7500724A FR2297045A1 (fr)	1975-01-10	1975-01-10	Nouveaux (aroyl-2' eth-1' yl)-1 (acetamido-4'' piperazin-1'' yl methyl)-2 benzimidazoles a proprietes antisecretoire gastrique et antiulcereuse
FR7537297A FR2333510A2 (fr)	1975-12-05	1975-12-05	Nouveaux (aroyl-2' eth-1 yl)-1 (acetamido-4'' piperazin-1'' yl methyl)-2 benzimidazoles, leur application en therapeutique et leur procede de preparation

Publications (1)

Publication Number	Publication Date
CH612675A5 true CH612675A5 (en)	1979-08-15

Family

ID=26218682

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH12876A CH612675A5 (en)	1975-01-10	1976-01-07	Process for the preparation of new 1-(2'-aroyl-1'-ethyl)-2-(4''-acetamido-1''-piperazinylmethyl)benzimidazo les

Country Status (13)

Country	Link
JP (1)	JPS6020386B2 (2)
AU (1)	AU509084B2 (2)
CA (1)	CA1073455A (2)
CH (1)	CH612675A5 (2)
DE (1)	DE2557446C2 (2)
ES (1)	ES444064A1 (2)
GB (1)	GB1487128A (2)
IT (1)	IT1062803B (2)
LU (1)	LU74043A1 (2)
MX (1)	MX3428E (2)
NL (1)	NL7600224A (2)
SE (1)	SE421527B (2)
SU (1)	SU651701A3 (2)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2190439B1 (2) *	1972-07-06	1975-06-20	Delalande Sa

1975
- 1975-12-16 GB GB51396/75A patent/GB1487128A/en not_active Expired
- 1975-12-18 LU LU74043A patent/LU74043A1/xx unknown
- 1975-12-19 DE DE2557446A patent/DE2557446C2/de not_active Expired
1976
- 1976-01-03 ES ES444064A patent/ES444064A1/es not_active Expired
- 1976-01-06 MX MX001645U patent/MX3428E/es unknown
- 1976-01-07 CH CH12876A patent/CH612675A5/xx not_active IP Right Cessation
- 1976-01-08 JP JP761833A patent/JPS6020386B2/ja not_active Expired
- 1976-01-08 CA CA243,226A patent/CA1073455A/fr not_active Expired
- 1976-01-08 SE SE7600116A patent/SE421527B/xx unknown
- 1976-01-08 SU SU762305959A patent/SU651701A3/ru active
- 1976-01-08 AU AU10117/76A patent/AU509084B2/en not_active Expired
- 1976-01-09 IT IT67044/76A patent/IT1062803B/it active
- 1976-01-09 NL NL7600224A patent/NL7600224A/xx not_active Application Discontinuation

Also Published As

Publication number	Publication date
IT1062803B (it)	1985-02-11
DE2557446C2 (de)	1984-11-29
NL7600224A (nl)	1976-07-13
LU74043A1 (2)	1976-11-11
JPS6020386B2 (ja)	1985-05-21
SE421527B (sv)	1982-01-04
DE2557446A1 (de)	1976-07-15
SU651701A3 (ru)	1979-03-05
JPS51131885A (en)	1976-11-16
MX3428E (es)	1980-11-21
AU509084B2 (en)	1980-04-17
ES444064A1 (es)	1977-08-16
CA1073455A (fr)	1980-03-11
SE7600116L (sv)	1976-07-12
AU1011776A (en)	1977-07-14
GB1487128A (en)	1977-09-28

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Legal Events

Date	Code	Title	Description
1985-09-30	PL	Patent ceased
2024-10-31	PL	Patent ceased