CH625799A5 - - Google Patents

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Info

Publication number: CH625799A5
Authority: CH; Switzerland
Prior art keywords: compound; formula; esters; pharmaceutically acceptable; acceptable salts
Prior art date: 1974-07-10

Application number

CH691680A

Other languages

English (en)

French (fr)

Inventor

Hugh Cairns

Richard Hazard

John King

Thomas Brian Lee

Original Assignee

Fisons Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-07-10

Filing date

1980-09-16

Publication date

1981-10-15

1980-09-16 Application filed by Fisons Ltd filed Critical Fisons Ltd

1981-10-15 Publication of CH625799A5 publication Critical patent/CH625799A5/fr

Links

150000001875 compounds Chemical class 0.000 claims description 23
150000002148 esters Chemical class 0.000 claims description 11
150000003839 salts Chemical class 0.000 claims description 9
238000000034 method Methods 0.000 claims description 5
238000005984 hydrogenation reaction Methods 0.000 claims description 2
238000004519 manufacturing process Methods 0.000 claims description 2
239000002904 solvent Substances 0.000 claims description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
239000000427 antigen Substances 0.000 description 5
102000036639 antigens Human genes 0.000 description 5
108091007433 antigens Proteins 0.000 description 5
KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 4
-1 alkali metal salts Chemical class 0.000 description 4
208000006673 asthma Diseases 0.000 description 3
QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 2
BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 2
YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 2
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 2
150000003973 alkyl amines Chemical class 0.000 description 2
125000004432 carbon atom Chemical group C* 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
210000003238 esophagus Anatomy 0.000 description 2
239000000203 mixture Substances 0.000 description 2
230000003287 optical effect Effects 0.000 description 2
230000000144 pharmacologic effect Effects 0.000 description 2
239000011541 reaction mixture Substances 0.000 description 2
239000007787 solid Substances 0.000 description 2
239000000725 suspension Substances 0.000 description 2
208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
206010012438 Dermatitis atopic Diseases 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
208000009793 Milk Hypersensitivity Diseases 0.000 description 1
201000010859 Milk allergy Diseases 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
125000002252 acyl group Chemical group 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
229910052783 alkali metal Inorganic materials 0.000 description 1
229910052784 alkaline earth metal Inorganic materials 0.000 description 1
201000009961 allergic asthma Diseases 0.000 description 1
150000003863 ammonium salts Chemical class 0.000 description 1
230000037396 body weight Effects 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
239000003054 catalyst Substances 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
JJCFRYNCJDLXIK-UHFFFAOYSA-N cyproheptadine Chemical compound C1CN(C)CCC1=C1C2=CC=CC=C2C=CC2=CC=CC=C21 JJCFRYNCJDLXIK-UHFFFAOYSA-N 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
230000000694 effects Effects 0.000 description 1
230000032050 esterification Effects 0.000 description 1
238000005886 esterification reaction Methods 0.000 description 1
RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
LOAKCJHVAZDMKD-UHFFFAOYSA-N ethyl 5-(2-hydroxypropoxy)-4-oxo-8-propylchromene-2-carboxylate Chemical compound O1C(C(=O)OCC)=CC(=O)C2=C1C(CCC)=CC=C2OCC(C)O LOAKCJHVAZDMKD-UHFFFAOYSA-N 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
201000005298 gastrointestinal allergy Diseases 0.000 description 1
210000005095 gastrointestinal system Anatomy 0.000 description 1
150000003840 hydrochlorides Chemical class 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
201000001371 inclusion conjunctivitis Diseases 0.000 description 1
201000010659 intrinsic asthma Diseases 0.000 description 1
239000007788 liquid Substances 0.000 description 1
229910052744 lithium Inorganic materials 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
150000007530 organic bases Chemical class 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
230000000750 progressive effect Effects 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
206010044325 trachoma Diseases 0.000 description 1
238000005809 transesterification reaction Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyrane Compounds (AREA)

CH691680A 1974-07-10 1980-09-16 CH625799A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB30647/74A GB1488707A (en)	1974-07-10	1974-07-10	5-(2-hydroxy-propoxy)-4-oxo-8-propyl-4h-1-benzopyran-2-carboxylic acid and derivatives thereof

Publications (1)

Publication Number	Publication Date
CH625799A5 true CH625799A5 (de)	1981-10-15

Family

ID=10310913

Family Applications (6)

Application Number	Title	Priority Date	Filing Date
CH897275A CH613201A5 (de)	1974-07-10	1975-07-09
CH117082A CH637650A5 (fr)	1974-07-10	1975-07-09	Procede de preparation d'un acide chromone carboxylique.
CH362279A CH615673A5 (de)	1974-07-10	1979-04-17
CH691680A CH625799A5 (de)	1974-07-10	1980-09-16
CH442682A CH639083A5 (fr)	1974-07-10	1982-07-20	Procede de preparation d'un acide chromone carboxylique.
CH53983A CH640529A5 (fr)	1974-07-10	1983-01-31	Procede de preparation d'un acide chromone carboxylique.

Family Applications Before (3)

Application Number	Title	Priority Date	Filing Date
CH897275A CH613201A5 (de)	1974-07-10	1975-07-09
CH117082A CH637650A5 (fr)	1974-07-10	1975-07-09	Procede de preparation d'un acide chromone carboxylique.
CH362279A CH615673A5 (de)	1974-07-10	1979-04-17

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
CH442682A CH639083A5 (fr)	1974-07-10	1982-07-20	Procede de preparation d'un acide chromone carboxylique.
CH53983A CH640529A5 (fr)	1974-07-10	1983-01-31	Procede de preparation d'un acide chromone carboxylique.

Country Status (22)

Country	Link
US (1)	US4335048A (de)
JP (1)	JPS5134164A (de)
AR (1)	AR207470A1 (de)
BE (1)	BE831178A (de)
BR (1)	BR7504313A (de)
CA (1)	CA1065330A (de)
CH (6)	CH613201A5 (de)
DD (1)	DD118627A5 (de)
DE (1)	DE2530289A1 (de)
DK (1)	DK146127C (de)
ES (1)	ES439261A1 (de)
FI (1)	FI751997A7 (de)
FR (1)	FR2277578A1 (de)
GB (1)	GB1488707A (de)
IE (1)	IE41577B1 (de)
IL (1)	IL47606A (de)
LU (1)	LU72945A1 (de)
NL (1)	NL7508162A (de)
NO (1)	NO143501C (de)
SE (1)	SE419337B (de)
YU (2)	YU174175A (de)
ZA (1)	ZA754128B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ187192A (en) *	1977-05-06	1982-02-23	Fisons Ltd	Prophylactic or curative treatment of allergic conditions in domestic animals using compounds with sodium cromoglycate-like activity
US4317833A (en) *	1978-12-27	1982-03-02	Fisons Limited	Method for the reduction of excess gastric acid secretion
JPS597933Y2 (ja) *	1979-06-14	1984-03-12	積水ハウス株式会社	壁体の隙間閉塞構造
EP0040489A1 (de) *	1980-05-17	1981-11-25	FISONS plc	Mischungen, Salze, Packungen und pharmazeutische Zusammensetzungen mit Gehalt an 5-(2-Hydroxypropoxy)-4-oxo-8-propyl-4H-1-benzopyran-2-carbonsäure oder einem Derivat derselben und einem H2-Rezeptoren antagonisierenden Antihistamin
EP0104018A3 (de) *	1982-09-21	1985-06-26	FISONS plc	Benzopyran, Thiabenzopyran und Quinolinverbindungen und diese enthaltende pharmazeutische Zusammensetzungen
US5659051A (en) *	1993-07-13	1997-08-19	Sumitomo Chemical Company, Limited	Process of producing 2-cyano-4-oxo-4H-benzopyran compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1049289A (en) *	1962-08-18	1966-11-23	Benger Lab Ltd	Chromone derivatives and pharmaceutical compositions containing them
NL140730B (nl) *	1963-09-27	1974-01-15	Fisons Pharmaceuticals Ltd	Werkwijze voor de bereiding van gesubstitueerde chromoncabonzuur-2-derivaten met remmende werking op anafylactische reacties.
US3686320A (en) *	1965-03-25	1972-08-22	Fisons Pharmaceuticals Ltd	Bis-phenoxy compounds
GB1147976A (en) *	1965-12-21	1969-04-10	Fisons Pharmaceuticals Ltd	Chromone derivatives
GB1190194A (en) *	1966-07-05	1970-04-29	Fisons Pharmaceuticals Ltd	Bis-Phenoxy Compounds and Chromanone and Chromone Derivatives
US3629920A (en) *	1967-06-12	1971-12-28	Hurth Masch Zahnrad Carl	Gear cutter
YU35250B (en) *	1970-08-25	1980-10-31	Fisons Ltd	Process for obtaining 4-oxo-4h-1-benzopyran derivatives
GB1389227A (en) *	1971-09-16	1975-04-03	Fisons Ltd	Chromone-2-carboxylic acid derivatives methods for their preparation and compositions containing them

1974
- 1974-07-10 GB GB30647/74A patent/GB1488707A/en not_active Expired
1975
- 1975-01-01 AR AR259483A patent/AR207470A1/es active
- 1975-06-27 ZA ZA00754128A patent/ZA754128B/xx unknown
- 1975-06-30 IL IL47606A patent/IL47606A/xx unknown
- 1975-07-07 DE DE19752530289 patent/DE2530289A1/de not_active Withdrawn
- 1975-07-07 IE IE1505/75A patent/IE41577B1/en unknown
- 1975-07-08 YU YU01741/75A patent/YU174175A/xx unknown
- 1975-07-08 BR BR5527/75D patent/BR7504313A/pt unknown
- 1975-07-08 DK DK309075A patent/DK146127C/da not_active IP Right Cessation
- 1975-07-09 NL NL7508162A patent/NL7508162A/xx not_active Application Discontinuation
- 1975-07-09 FR FR7521558A patent/FR2277578A1/fr active Granted
- 1975-07-09 CH CH897275A patent/CH613201A5/xx not_active IP Right Cessation
- 1975-07-09 FI FI751997A patent/FI751997A7/fi not_active Application Discontinuation
- 1975-07-09 NO NO752461A patent/NO143501C/no unknown
- 1975-07-09 BE BE158136A patent/BE831178A/xx not_active IP Right Cessation
- 1975-07-09 ES ES74439261A patent/ES439261A1/es not_active Expired
- 1975-07-09 SE SE7507887A patent/SE419337B/xx unknown
- 1975-07-09 CH CH117082A patent/CH637650A5/fr not_active IP Right Cessation
- 1975-07-10 DD DD187239A patent/DD118627A5/xx unknown
- 1975-07-10 CA CA231,228A patent/CA1065330A/en not_active Expired
- 1975-07-10 JP JP50084036A patent/JPS5134164A/ja active Pending
- 1975-07-10 LU LU72945A patent/LU72945A1/xx unknown
1979
- 1979-04-17 CH CH362279A patent/CH615673A5/fr not_active IP Right Cessation
1980
- 1980-02-19 US US06/122,284 patent/US4335048A/en not_active Expired - Lifetime
- 1980-09-16 CH CH691680A patent/CH625799A5/fr not_active IP Right Cessation
1981
- 1981-07-03 YU YU01657/81A patent/YU165781A/xx unknown
1982
- 1982-07-20 CH CH442682A patent/CH639083A5/fr not_active IP Right Cessation
1983
- 1983-01-31 CH CH53983A patent/CH640529A5/fr not_active IP Right Cessation

Also Published As

Publication number	Publication date
NL7508162A (nl)	1976-01-13
BR7504313A (pt)	1976-07-06
LU72945A1 (de)	1976-05-31
YU165781A (en)	1982-02-28
DD118627A5 (de)	1976-03-12
DK309075A (da)	1976-01-11
NO143501C (no)	1981-02-25
US4335048A (en)	1982-06-15
FR2277578B1 (de)	1979-02-23
IE41577B1 (en)	1980-01-30
BE831178A (fr)	1976-01-09
NO143501B (no)	1980-11-17
YU174175A (en)	1982-02-28
CH637650A5 (fr)	1983-08-15
DE2530289A1 (de)	1976-01-29
IL47606A (en)	1979-09-30
IL47606A0 (en)	1975-08-31
CH640529A5 (fr)	1984-01-13
NO752461L (de)	1976-01-13
FI751997A7 (de)	1976-01-11
CA1065330A (en)	1979-10-30
SE419337B (sv)	1981-07-27
CH613201A5 (de)	1979-09-14
ZA754128B (en)	1976-06-30
DK146127B (da)	1983-07-04
ES439261A1 (es)	1977-06-01
CH639083A5 (fr)	1983-10-31
GB1488707A (en)	1977-10-12
AR207470A1 (es)	1976-10-08
CH615673A5 (de)	1980-02-15
IE41577L (en)	1976-01-10
DK146127C (da)	1983-11-28
SE7507887L (sv)	1976-01-12
AU8289275A (en)	1977-01-13
JPS5134164A (en)	1976-03-23
FR2277578A1 (fr)	1976-02-06

Legal Events

Date	Code	Title	Description
1982-11-15	PFA	Name/firm changed	Owner name: FISONS PLC
1985-03-29	PL	Patent ceased
2024-10-31	PL	Patent ceased

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