CH634348A5 - Process for the activation of immobilised microorganisms - Google Patents

Process for the activation of immobilised microorganisms Download PDF

Info

Publication number: CH634348A5
Authority: CH; Switzerland
Prior art keywords: peptone; cortisol; conversion; glucose; fluoro
Prior art date: 1976-07-06

Application number

CH835577A

Other languages

German (de)

English (en)

Inventor

Per-Olof Larsson

Klaus Hermann Mosbach

Sten Albert Ohlson

Original Assignee

Fermenta Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-07-06

Filing date

1977-07-06

Publication date

1983-01-31

1977-07-06 Application filed by Fermenta Ab filed Critical Fermenta Ab

1983-01-31 Publication of CH634348A5 publication Critical patent/CH634348A5/de

Links

238000000034 method Methods 0.000 title claims description 19
244000005700 microbiome Species 0.000 title claims description 14
230000004913 activation Effects 0.000 title description 6
230000008569 process Effects 0.000 title description 4
JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims description 38
238000006243 chemical reaction Methods 0.000 claims description 27
229960000890 hydrocortisone Drugs 0.000 claims description 20
239000001888 Peptone Substances 0.000 claims description 18
108010080698 Peptones Proteins 0.000 claims description 18
235000019319 peptone Nutrition 0.000 claims description 18
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 14
239000008103 glucose Substances 0.000 claims description 14
150000003431 steroids Chemical class 0.000 claims description 11
241000203720 Pimelobacter simplex Species 0.000 claims description 8
229960005205 prednisolone Drugs 0.000 claims description 8
OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 claims description 7
230000003213 activating effect Effects 0.000 claims description 5
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239000003242 anti bacterial agent Substances 0.000 claims description 4
229940088710 antibiotic agent Drugs 0.000 claims description 4
150000001875 compounds Chemical class 0.000 claims description 4
239000000203 mixture Substances 0.000 claims description 4
239000011541 reaction mixture Substances 0.000 claims 2
230000000694 effects Effects 0.000 description 17
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JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 10
238000005805 hydroxylation reaction Methods 0.000 description 8
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
WHBHBVVOGNECLV-OBQKJFGGSA-N 11-deoxycortisol Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 WHBHBVVOGNECLV-OBQKJFGGSA-N 0.000 description 5
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UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
239000004380 Cholic acid Substances 0.000 description 1
LPZCCMIISIBREI-MTFRKTCUSA-N Citrostadienol Natural products CC=C(CC[C@@H](C)[C@H]1CC[C@H]2C3=CC[C@H]4[C@H](C)[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)C(C)C LPZCCMIISIBREI-MTFRKTCUSA-N 0.000 description 1
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ARVGMISWLZPBCH-UHFFFAOYSA-N Dehydro-beta-sitosterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)CCC(CC)C(C)C)CCC33)C)C3=CC=C21 ARVGMISWLZPBCH-UHFFFAOYSA-N 0.000 description 1
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229910021577 Iron(II) chloride Inorganic materials 0.000 description 1
LKDRXBCSQODPBY-AMVSKUEXSA-N L-(-)-Sorbose Chemical compound OCC1(O)OC[C@H](O)[C@@H](O)[C@@H]1O LKDRXBCSQODPBY-AMVSKUEXSA-N 0.000 description 1
KWYHDKDOAIKMQN-UHFFFAOYSA-N N,N,N',N'-tetramethylethylenediamine Chemical compound CN(C)CCN(C)C KWYHDKDOAIKMQN-UHFFFAOYSA-N 0.000 description 1
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XYNPYHXGMWJBLV-VXPJTDKGSA-N Tomatidine Chemical compound O([C@@H]1[C@@H]([C@]2(CC[C@@H]3[C@@]4(C)CC[C@H](O)C[C@@H]4CC[C@H]3[C@@H]2C1)C)[C@@H]1C)[C@@]11CC[C@H](C)CN1 XYNPYHXGMWJBLV-VXPJTDKGSA-N 0.000 description 1
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WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
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229960002537 betamethasone Drugs 0.000 description 1
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OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 description 1
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RUDATBOHQWOJDD-BSWAIDMHSA-N chenodeoxycholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-BSWAIDMHSA-N 0.000 description 1
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BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 description 1
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OSVMTWJCGUFAOD-KZQROQTASA-N formestane Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1O OSVMTWJCGUFAOD-KZQROQTASA-N 0.000 description 1
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NMCUIPGRVMDVDB-UHFFFAOYSA-L iron dichloride Chemical compound Cl[Fe]Cl NMCUIPGRVMDVDB-UHFFFAOYSA-L 0.000 description 1
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USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes

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Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Wood Science & Technology (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Dispersion Chemistry (AREA)
Mycology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

CH835577A 1976-07-06 1977-07-06 Process for the activation of immobilised microorganisms CH634348A5 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE7607698A SE427116B (sv)	1976-07-06	1976-07-06	Transformation av steroider och antibiotika med immobiliserade levande mikroorganismer som aktiveras

Publications (1)

Publication Number	Publication Date
CH634348A5 true CH634348A5 (en)	1983-01-31

Family

ID=20328400

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH835577A CH634348A5 (en)	1976-07-06	1977-07-06	Process for the activation of immobilised microorganisms

Country Status (15)

Country	Link
JP (1)	JPS5326383A (da)
AT (1)	AT372403B (da)
BE (1)	BE856358A (da)
CA (1)	CA1101348A (da)
CH (1)	CH634348A5 (da)
DE (1)	DE2729490A1 (da)
DK (1)	DK292677A (da)
ES (1)	ES460368A1 (da)
FI (1)	FI58941C (da)
FR (1)	FR2357507A1 (da)
GB (1)	GB1560850A (da)
IE (1)	IE45676B1 (da)
IT (1)	IT1079745B (da)
NL (1)	NL7707449A (da)
SE (1)	SE427116B (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE441009B (sv) *	1982-03-08	1985-09-02	Kjell Nilsson	Sett att immobilisera levande biomaterial i perlformiga polymerer
DE3241829A1 (de) *	1982-11-09	1984-05-10	Schering AG, 1000 Berlin und 4709 Bergkamen	Biokatalysator
GB2162198B (en) *	1984-07-27	1987-12-02	Ki Med I	Process for producing dense nutrient medium for culturing microorganisms and macroorganism cell cultures
GB9622884D0 (en) *	1996-11-02	1997-01-08	Duramed Europ Ltd	A method for th e preparation of steroids in the pregene class

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3767790A (en) *	1972-02-11	1973-10-23	Nat Patent Dev Corp	Microorganisms
FR2320349A1 (fr) *	1975-08-06	1977-03-04	Agronomique Inst Nat Rech	Procede enzymatique utilisant des microorganismes inclus

1976
- 1976-07-06 SE SE7607698A patent/SE427116B/xx unknown
1977
- 1977-06-28 FI FI772012A patent/FI58941C/fi not_active IP Right Cessation
- 1977-06-30 AT AT0465577A patent/AT372403B/de not_active IP Right Cessation
- 1977-06-30 DE DE19772729490 patent/DE2729490A1/de not_active Ceased
- 1977-06-30 DK DK292677A patent/DK292677A/da not_active Application Discontinuation
- 1977-07-01 BE BE178985A patent/BE856358A/xx not_active IP Right Cessation
- 1977-07-04 ES ES460368A patent/ES460368A1/es not_active Expired
- 1977-07-05 IT IT50134/77A patent/IT1079745B/it active
- 1977-07-05 NL NL7707449A patent/NL7707449A/xx not_active Application Discontinuation
- 1977-07-05 CA CA282,058A patent/CA1101348A/en not_active Expired
- 1977-07-05 IE IE1392/77A patent/IE45676B1/en unknown
- 1977-07-05 GB GB28177/77A patent/GB1560850A/en not_active Expired
- 1977-07-05 FR FR7720678A patent/FR2357507A1/fr active Granted
- 1977-07-06 CH CH835577A patent/CH634348A5/de not_active IP Right Cessation
- 1977-07-06 JP JP8086277A patent/JPS5326383A/ja active Pending

Also Published As

Publication number	Publication date
IE45676L (en)	1978-01-06
CA1101348A (en)	1981-05-19
DK292677A (da)	1978-01-07
SE7607698L (sv)	1978-01-07
ATA465577A (de)	1983-02-15
JPS5326383A (en)	1978-03-11
FI58941B (fi)	1981-01-30
FR2357507A1 (fr)	1978-02-03
IT1079745B (it)	1985-05-13
NL7707449A (nl)	1978-01-10
DE2729490A1 (de)	1978-01-12
SE427116B (sv)	1983-03-07
BE856358A (fr)	1978-01-02
FI772012A7 (da)	1978-01-07
FI58941C (fi)	1981-05-11
FR2357507B1 (da)	1981-10-16
ES460368A1 (es)	1978-10-01
GB1560850A (en)	1980-02-13
IE45676B1 (en)	1982-10-20
AT372403B (de)	1983-10-10

Legal Events

Date	Code	Title	Description
1987-03-31	PL	Patent ceased
2024-10-31	PL	Patent ceased

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DE3787194T2 (de)	1994-03-31	Verfahren zur Erhaltung der Nitrilhydrierungsaktivität.
DE2513929C2 (de)	1985-07-18	Verfahren zur Immobilisierung intakter mikrobiologischer Zellen
DE2232645C3 (de)	1979-03-29	Verfahren zur Durchführung einer enzymkatalysierten Umwandlung eines Substrats
DE1939341C2 (de)	1982-12-16	Cephalosporinderivate und Verfahren zur ihrer Herstellung
DE2219454A1 (de)	1972-11-02	Cephalosporinderivate
DE2729490A1 (de)	1978-01-12	Verfahren zur aktivierung immobilisierter lebender mikroorganismen
DE2413694C3 (da)	1979-11-22
CH656642A5 (de)	1986-07-15	Verfahren zur intensivierung der mikrobiologischen umsetzung von steroidverbindungen.
EP0210493B1 (de)	1992-01-02	Wässrige Suspensionen von Agglomeraten, ihre Herstellung und Verwendung
DE3739017A1 (de)	1988-06-01	Mycobacterium-mikroorganismenstamm und verfahren zur mikrobiologischen herstellung von 9(alpha)-(hydroxy)-4-androsten-3,17-di-(on)
US4246346A (en)	1981-01-20	Antibiotic and steroid transformation process
EP0492495A2 (de)	1992-07-01	Immobilisierte D-Aminosäureoxidase und dessen Verwendung zur Herstellung von Arzneimitteln
DE2349816A1 (de)	1974-04-11	Verfahren zur mikrobiologischen reduktion von 10(11)-ungesaettigten prostaglandinen
DE2439923A1 (de)	1975-03-20	Verfahren zum fixieren von enzymen auf traegermaterialien
DE3315722A1 (de)	1984-10-31	Verfahren zur herstellung von 3-oxo-(delta)(pfeil hoch)1(pfeil hoch)(pfeil hoch),(pfeil hoch)(pfeil hoch)4(pfeil hoch)-steroiden
EP0120213B1 (de)	1987-01-28	Verfahren zur biotechnologischen Herstellung von L-Äpfelsäure
WO1982000833A1 (en)	1982-03-18	Method for the determination of total cholesterol
WO1995009244A1 (de)	1995-04-06	Verfahren zur herstellung von arabinonukleotiden
DE3510963C2 (de)	1986-10-30	Verfahren zur Herstellung eines Coenzyms in reduzierter Form
DE1543462B2 (de)	1974-03-28	Verfahren zur mikrobiologischen 11-Hydroxylierung von Steroiden der Pregnanreihe in Gegenwart von Dimethylsutfoxyd
DE1593327C (de)	1971-12-30	Verfahren zur Herstellung von Delta hoch 1,4 -Androstadien-3,17-dion, Delta hoch 1,4 -Androstadien-3,11,17-trion bzw. Delta hoch 1,4 -Androstadien-1 lalpha-ol-3,17-dion
EP0126876B1 (de)	1989-10-04	Verfahren zur Herstellung von 3-Oxo-delta-1,4-steroiden
DE2050983C3 (de)	1977-06-02	Verfahren zur Herstellung von alpha-Amino benzylpenicillin
DE1793750C3 (de)	1976-08-05	Verfahren zur Herstellung von Fluorverbindungen der Pregnanreihe
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