CH638052A5 - Verfahren und automatisierte analysenvorrichtung zur bestimmung einer immunochemisch reaktionsfaehigen substanz in einer koerperfluessigkeit. - Google Patents
Verfahren und automatisierte analysenvorrichtung zur bestimmung einer immunochemisch reaktionsfaehigen substanz in einer koerperfluessigkeit. Download PDFInfo
- Publication number
- CH638052A5 CH638052A5 CH1125478A CH1125478A CH638052A5 CH 638052 A5 CH638052 A5 CH 638052A5 CH 1125478 A CH1125478 A CH 1125478A CH 1125478 A CH1125478 A CH 1125478A CH 638052 A5 CH638052 A5 CH 638052A5
- Authority
- CH
- Switzerland
- Prior art keywords
- particles
- test
- reactance
- reagent
- receptor
- Prior art date
Links
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- 238000004458 analytical method Methods 0.000 title description 2
- 238000012360 testing method Methods 0.000 claims description 64
- 239000003153 chemical reaction reagent Substances 0.000 claims description 44
- 239000002245 particle Substances 0.000 claims description 33
- 230000005291 magnetic effect Effects 0.000 claims description 22
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- 102000004169 proteins and genes Human genes 0.000 claims description 14
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- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims description 12
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 9
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- 239000000427 antigen Substances 0.000 claims description 6
- 102000036639 antigens Human genes 0.000 claims description 6
- 108091007433 antigens Proteins 0.000 claims description 6
- 229910052759 nickel Inorganic materials 0.000 claims description 6
- 239000002184 metal Substances 0.000 claims description 5
- 229910044991 metal oxide Inorganic materials 0.000 claims description 5
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- 230000002285 radioactive effect Effects 0.000 claims description 3
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims description 2
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 claims description 2
- 229910052804 chromium Inorganic materials 0.000 claims description 2
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- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 5
- 102000009027 Albumins Human genes 0.000 description 4
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- 241000283707 Capra Species 0.000 description 4
- 229920002292 Nylon 6 Polymers 0.000 description 4
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 4
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 3
- 108091006905 Human Serum Albumin Proteins 0.000 description 3
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- 229940098773 bovine serum albumin Drugs 0.000 description 3
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- 239000010941 cobalt Substances 0.000 description 3
- 229910017052 cobalt Inorganic materials 0.000 description 3
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- 238000005259 measurement Methods 0.000 description 3
- 150000002739 metals Chemical class 0.000 description 3
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- 239000012071 phase Substances 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 229910000077 silane Inorganic materials 0.000 description 3
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000004952 Polyamide Substances 0.000 description 2
- 108010071390 Serum Albumin Proteins 0.000 description 2
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- 239000000956 alloy Substances 0.000 description 2
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- 239000003085 diluting agent Substances 0.000 description 2
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- 239000011554 ferrofluid Substances 0.000 description 2
- 239000011888 foil Substances 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 230000005415 magnetization Effects 0.000 description 2
- 230000000737 periodic effect Effects 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 229920002647 polyamide Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- SZUVGFMDDVSKSI-WIFOCOSTSA-N (1s,2s,3s,5r)-1-(carboxymethyl)-3,5-bis[(4-phenoxyphenyl)methyl-propylcarbamoyl]cyclopentane-1,2-dicarboxylic acid Chemical compound O=C([C@@H]1[C@@H]([C@](CC(O)=O)([C@H](C(=O)N(CCC)CC=2C=CC(OC=3C=CC=CC=3)=CC=2)C1)C(O)=O)C(O)=O)N(CCC)CC(C=C1)=CC=C1OC1=CC=CC=C1 SZUVGFMDDVSKSI-WIFOCOSTSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 229920002799 BoPET Polymers 0.000 description 1
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 108010078791 Carrier Proteins Proteins 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 229910052693 Europium Inorganic materials 0.000 description 1
- 230000005355 Hall effect Effects 0.000 description 1
- 241000709721 Hepatovirus A Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241000701076 Macacine alphaherpesvirus 1 Species 0.000 description 1
- 239000005041 Mylar™ Substances 0.000 description 1
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- 229910019142 PO4 Inorganic materials 0.000 description 1
- 229920002845 Poly(methacrylic acid) Polymers 0.000 description 1
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229920003182 Surlyn® Polymers 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 229910000828 alnico Inorganic materials 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000003139 biocide Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000005387 chalcogenide glass Substances 0.000 description 1
- 150000004770 chalcogenides Chemical class 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- AYTAKQFHWFYBMA-UHFFFAOYSA-N chromium(IV) oxide Inorganic materials O=[Cr]=O AYTAKQFHWFYBMA-UHFFFAOYSA-N 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 229940126543 compound 14 Drugs 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000011162 core material Substances 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- YYXLGGIKSIZHSF-UHFFFAOYSA-N ethene;furan-2,5-dione Chemical compound C=C.O=C1OC(=O)C=C1 YYXLGGIKSIZHSF-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000005294 ferromagnetic effect Effects 0.000 description 1
- 230000005307 ferromagnetism Effects 0.000 description 1
- 208000005252 hepatitis A Diseases 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 229920000554 ionomer Polymers 0.000 description 1
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 1
- 235000013980 iron oxide Nutrition 0.000 description 1
- VBMVTYDPPZVILR-UHFFFAOYSA-N iron(2+);oxygen(2-) Chemical class [O-2].[Fe+2] VBMVTYDPPZVILR-UHFFFAOYSA-N 0.000 description 1
- 239000006194 liquid suspension Substances 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 229920000620 organic polymer Polymers 0.000 description 1
- 239000013610 patient sample Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
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- 229920000728 polyester Polymers 0.000 description 1
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- 239000011541 reaction mixture Substances 0.000 description 1
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- 239000011780 sodium chloride Substances 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84821777A | 1977-11-03 | 1977-11-03 | |
| US05/942,261 US4219335A (en) | 1978-09-18 | 1978-09-18 | Immunochemical testing using tagged reagents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH638052A5 true CH638052A5 (de) | 1983-08-31 |
Family
ID=27126757
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1125478A CH638052A5 (de) | 1977-11-03 | 1978-11-01 | Verfahren und automatisierte analysenvorrichtung zur bestimmung einer immunochemisch reaktionsfaehigen substanz in einer koerperfluessigkeit. |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS5912139B2 (fr) |
| AU (1) | AU522995B2 (fr) |
| CA (1) | CA1122503A (fr) |
| CH (1) | CH638052A5 (fr) |
| DE (1) | DE2847282A1 (fr) |
| DK (1) | DK489678A (fr) |
| FI (1) | FI783346A7 (fr) |
| FR (1) | FR2408142A1 (fr) |
| GB (1) | GB2008767B (fr) |
| IE (1) | IE47482B1 (fr) |
| IL (1) | IL55856A (fr) |
| IT (1) | IT1101280B (fr) |
| LU (1) | LU80471A1 (fr) |
| NL (1) | NL7810910A (fr) |
| NO (1) | NO151099C (fr) |
| SE (1) | SE431257B (fr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2136130B (en) * | 1983-02-28 | 1987-02-11 | Theodore Henry Krueger | Chemical assay systems and methods |
| CA1220818A (fr) * | 1983-05-05 | 1987-04-21 | Hugh A.O. Hill | Methodes d'essais biologiques utilisant des agents de liaison specifiques |
| GB8314523D0 (en) * | 1983-05-25 | 1983-06-29 | Lowe C R | Diagnostic device |
| EP0139373A1 (fr) * | 1983-08-26 | 1985-05-02 | The Regents Of The University Of California | Système pour immunoessais multiples |
| JPS6055265A (ja) * | 1983-09-06 | 1985-03-30 | Fujirebio Inc | 磁性粒子を用いた抗原、抗体の測定方法 |
| GB8331514D0 (en) * | 1983-11-25 | 1984-01-04 | Janssen Pharmaceutica Nv | Visualization method |
| AU596946B2 (en) * | 1984-07-10 | 1990-05-24 | F. Hoffmann-La Roche Ltd | Methods of assay |
| FI844027A7 (fi) * | 1984-10-12 | 1986-04-13 | Labsystems Oy | Immunologiskt bestaemningsfoerfarande. |
| JPH0823558B2 (ja) * | 1984-11-27 | 1996-03-06 | オ−ジエニクス リミテツド | 検定装置 |
| LU86239A1 (fr) * | 1986-01-02 | 1987-09-03 | Sanders Probel Lab | Methode de detection d'agents reactifs et moyens de mise en oeuvre de cette methode |
| US4794089A (en) * | 1986-03-25 | 1988-12-27 | Midwest Research Microscopy, Inc. | Method for electronic detection of a binding reaction |
| US5374524A (en) * | 1988-05-10 | 1994-12-20 | E. I. Du Pont De Nemours And Company | Solution sandwich hybridization, capture and detection of amplified nucleic acids |
| US5137804A (en) * | 1988-05-10 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Assay device and immunoassay |
| GB2270976A (en) * | 1992-09-18 | 1994-03-30 | Marconi Gec Ltd | Immunoassay/separation process using an auxiliary species on a support |
| RU2225985C2 (ru) * | 1998-09-08 | 2004-03-20 | Тиботек Н.В. | Способ быстрого скрининга анализируемых проб |
| US6544480B1 (en) | 1999-10-26 | 2003-04-08 | Tibotec Bvba | Device and related method for dispensing small volumes of liquid |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1479661A (en) * | 1972-06-26 | 1977-07-13 | Gen Electric | Method and apparatus for detection and purification of proteins and antibodies |
| GB1500127A (en) * | 1973-10-10 | 1978-02-08 | Abbott Lab | Reactive matrices |
| US4020151A (en) * | 1976-02-17 | 1977-04-26 | International Diagnostic Technology, Inc. | Method for quantitation of antigens or antibodies on a solid surface |
| IL49685A (en) * | 1976-05-31 | 1978-10-31 | Technion Res & Dev Foundation | Specific binding assay method for determining the concentration of materials and reagent means therefor |
| US4087248A (en) * | 1976-07-26 | 1978-05-02 | Miles Laughton E | Multiple assay machine and method |
-
1978
- 1978-10-03 SE SE7810351A patent/SE431257B/sv not_active IP Right Cessation
- 1978-10-31 DE DE19782847282 patent/DE2847282A1/de not_active Withdrawn
- 1978-10-31 CA CA315,018A patent/CA1122503A/fr not_active Expired
- 1978-11-01 GB GB7842707A patent/GB2008767B/en not_active Expired
- 1978-11-01 CH CH1125478A patent/CH638052A5/de not_active IP Right Cessation
- 1978-11-02 IL IL55856A patent/IL55856A/xx unknown
- 1978-11-02 FR FR7831041A patent/FR2408142A1/fr active Granted
- 1978-11-02 AU AU41283/78A patent/AU522995B2/en not_active Expired
- 1978-11-02 IE IE2168/78A patent/IE47482B1/en unknown
- 1978-11-02 IT IT7829378A patent/IT1101280B/it active
- 1978-11-02 FI FI783346A patent/FI783346A7/fi unknown
- 1978-11-02 JP JP53134678A patent/JPS5912139B2/ja not_active Expired
- 1978-11-02 DK DK489678A patent/DK489678A/da not_active Application Discontinuation
- 1978-11-02 NL NL7810910A patent/NL7810910A/xx not_active Application Discontinuation
- 1978-11-02 NO NO783691A patent/NO151099C/no unknown
- 1978-11-03 LU LU80471A patent/LU80471A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5491296A (en) | 1979-07-19 |
| NL7810910A (nl) | 1979-05-07 |
| JPS5912139B2 (ja) | 1984-03-21 |
| FR2408142A1 (fr) | 1979-06-01 |
| IE47482B1 (en) | 1984-04-04 |
| FR2408142B1 (fr) | 1984-02-17 |
| CA1122503A (fr) | 1982-04-27 |
| NO151099B (no) | 1984-10-29 |
| GB2008767B (en) | 1982-06-30 |
| NO783691L (no) | 1979-05-04 |
| SE7810351L (sv) | 1979-05-04 |
| DE2847282A1 (de) | 1979-05-10 |
| SE431257B (sv) | 1984-01-23 |
| IL55856A0 (en) | 1979-01-31 |
| IT1101280B (it) | 1985-09-28 |
| DK489678A (da) | 1979-05-04 |
| LU80471A1 (fr) | 1979-06-15 |
| AU522995B2 (en) | 1982-07-08 |
| IT7829378A0 (it) | 1978-11-02 |
| IE782168L (en) | 1980-03-18 |
| FI783346A7 (fi) | 1979-05-04 |
| NO151099C (no) | 1985-02-06 |
| GB2008767A (en) | 1979-06-06 |
| AU4128378A (en) | 1979-05-17 |
| IL55856A (en) | 1981-11-30 |
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