CH639843A5 - Procede pour la fabrication en serie de comprimes a usage medical et appareil pour sa mise en oeuvre. - Google Patents

Procede pour la fabrication en serie de comprimes a usage medical et appareil pour sa mise en oeuvre. Download PDF

Info

Publication number: CH639843A5
Authority: CH; Switzerland
Prior art keywords: lubricant; punches; tablets; point; cavity
Prior art date: 1979-07-13

Application number

CH518080A

Other languages

English (en)

French (fr)

Inventor

Masaki Yamamoto

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-07-13

Filing date

1980-07-07

Publication date

1983-12-15

1980-07-07 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

1983-12-15 Publication of CH639843A5 publication Critical patent/CH639843A5/fr

Links

238000000034 method Methods 0.000 title claims description 15
238000004519 manufacturing process Methods 0.000 title claims description 9
239000000314 lubricant Substances 0.000 claims description 60
239000003826 tablet Substances 0.000 claims description 49
238000002347 injection Methods 0.000 claims description 16
239000007924 injection Substances 0.000 claims description 16
230000006835 compression Effects 0.000 claims description 9
238000007906 compression Methods 0.000 claims description 9
239000011159 matrix material Substances 0.000 claims description 8
239000007932 molded tablet Substances 0.000 claims description 5
239000000428 dust Substances 0.000 claims description 4
239000000463 material Substances 0.000 claims description 3
230000000630 rising effect Effects 0.000 claims 1
239000000843 powder Substances 0.000 description 13
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 10
239000000203 mixture Substances 0.000 description 10
238000000465 moulding Methods 0.000 description 7
CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 5
239000008116 calcium stearate Substances 0.000 description 5
235000013539 calcium stearate Nutrition 0.000 description 5
235000019359 magnesium stearate Nutrition 0.000 description 5
239000002245 particle Substances 0.000 description 5
230000008021 deposition Effects 0.000 description 3
239000008187 granular material Substances 0.000 description 3
238000005507 spraying Methods 0.000 description 3
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
229920000168 Microcrystalline cellulose Polymers 0.000 description 2
239000003814 drug Substances 0.000 description 2
239000008101 lactose Substances 0.000 description 2
235000019813 microcrystalline cellulose Nutrition 0.000 description 2
239000008108 microcrystalline cellulose Substances 0.000 description 2
229940016286 microcrystalline cellulose Drugs 0.000 description 2
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
239000002211 L-ascorbic acid Substances 0.000 description 1
235000000069 L-ascorbic acid Nutrition 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
238000009825 accumulation Methods 0.000 description 1
229960001138 acetylsalicylic acid Drugs 0.000 description 1
MANKSFVECICGLK-UHFFFAOYSA-K aloxiprin Chemical compound [OH-].[Al+3].CC(=O)OC1=CC=CC=C1C([O-])=O.CC(=O)OC1=CC=CC=C1C([O-])=O MANKSFVECICGLK-UHFFFAOYSA-K 0.000 description 1
229940024544 aluminum aspirin Drugs 0.000 description 1
229960005070 ascorbic acid Drugs 0.000 description 1
238000007664 blowing Methods 0.000 description 1
239000007891 compressed tablet Substances 0.000 description 1
238000010276 construction Methods 0.000 description 1
238000010586 diagram Methods 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
239000012530 fluid Substances 0.000 description 1
210000004051 gastric juice Anatomy 0.000 description 1
238000010030 laminating Methods 0.000 description 1
238000003475 lamination Methods 0.000 description 1
239000007788 liquid Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
238000005192 partition Methods 0.000 description 1
238000003825 pressing Methods 0.000 description 1
239000000243 solution Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
- B30B15/0005—Details of, or accessories for, presses; Auxiliary measures in connection with pressing for briquetting presses
- B30B15/0011—Details of, or accessories for, presses; Auxiliary measures in connection with pressing for briquetting presses lubricating means
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
- B30B11/005—Control arrangements

Landscapes

Engineering & Computer Science (AREA)
Mechanical Engineering (AREA)
Medicinal Preparation (AREA)
Medical Preparation Storing Or Oral Administration Devices (AREA)

CH518080A 1979-07-13 1980-07-07 Procede pour la fabrication en serie de comprimes a usage medical et appareil pour sa mise en oeuvre. CH639843A5 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP8940779A JPS5614098A (en)	1979-07-13	1979-07-13	Externally lubricating tablet making machine

Publications (1)

Publication Number	Publication Date
CH639843A5 true CH639843A5 (fr)	1983-12-15

Family

ID=13969782

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH518080A CH639843A5 (fr)	1979-07-13	1980-07-07	Procede pour la fabrication en serie de comprimes a usage medical et appareil pour sa mise en oeuvre.

Country Status (7)

Country	Link
US (1)	US4373888A (2)
JP (1)	JPS5614098A (2)
CH (1)	CH639843A5 (2)
DE (1)	DE3026058A1 (2)
FR (1)	FR2460662B1 (2)
GB (1)	GB2053787B (2)
IT (1)	IT1141602B (2)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3131402A1 (de) *	1981-08-07	1983-02-24	Kilian & Co GmbH, 5000 Köln	Verfahren und tablettenpresse zum aufeinanderfolgenden herstellen einer vielzahl von tabletten mit gleichem gewicht
FR2575406B1 (fr) *	1984-12-28	1987-04-10	Pont A Mousson	Machine pour la fabrication de bouteilles en matiere plastique avec mise en place de coupelles stabilisatrices et pressurisation interne au moyen d'un gaz
DE3520203A1 (de) *	1985-06-05	1986-12-11	Wilhelm Fette Gmbh, 2053 Schwarzenbek	Rundlaeufer-tablettiermaschine und verfahren zur steuerung ihrer druckrollen
GB8530365D0 (en) *	1985-12-10	1986-01-22	Univ Bath	Manufacture of moulded products
JPS6410857U (2) *	1987-07-07	1989-01-20
DE3930127A1 (de) *	1989-09-09	1991-03-21	Fette Wilhelm Gmbh	Rundlauf-tablettiermaschine
US5158728A (en) *	1991-04-12	1992-10-27	Elizabeth-Hata International, Inc.	Multi-layer medicinal tablet forming machine and method for using the same
JP2681601B2 (ja) *	1993-11-01	1997-11-26	協和醗酵工業株式会社	外部滑沢式打錠機
DE4412117A1 (de) *	1994-04-08	1995-10-12	Fette Wilhelm Gmbh	Verfahren und Vorrichtung zum Aufbringen von pulverförmigem Schmier- oder Trennmittel auf die Preßwerkzeuge in Tablettiermaschinen
US5838571A (en) *	1996-01-29	1998-11-17	Alza Corporation	Tablet press monitoring and controlling method and apparatus
DK0914818T3 (da) *	1996-06-14	2005-07-04	Kyowa Hakko Kogyo Kk	Intraoralt hurtigt desintegrerbar tablet
US8071128B2 (en)	1996-06-14	2011-12-06	Kyowa Hakko Kirin Co., Ltd.	Intrabuccally rapidly disintegrating tablet and a production method of the tablets
DE19647089A1 (de) *	1996-11-14	1998-05-28	Bayer Ag	Vorrichtung zum kontrollierten Aufsprühen von pulverförmigen Schmiermitteln auf Stempel und Matrizen von Tablettenpressen
JPH11169437A (ja)	1997-12-03	1999-06-29	Kyowa Hakko Kogyo Co Ltd	錠剤の製造方法
JP4568426B2 (ja) *	1998-04-08	2010-10-27	協和発酵キリン株式会社	錠剤の製造方法及び錠剤
KR20010042593A (ko)	1998-04-10	2001-05-25	히라타 다다시	정제의 제조방법 및 정제
DK2263660T3 (en)	1998-05-18	2018-01-02	Takeda Pharmaceuticals Co	Orally disintegrating tablets.
JP3983476B2 (ja) *	1998-10-13	2007-09-26	協和醗酵工業株式会社	粉体材料の塗布方法、錠剤の製造方法、上杵用の粉体材料の塗布装置、下杵用の粉体材料の塗布装置、粉体材料の塗布装置、及び外部滑沢式打錠機
US6482349B1 (en)	1998-11-02	2002-11-19	Sumitomo Special Metals Co., Ltd.	Powder pressing apparatus and powder pressing method
JP3737331B2 (ja) *	1999-03-31	2006-01-18	Ｓｐｓシンテックス株式会社	粉体の自動充填方法及び装置
EP1179414A4 (en) *	1999-04-19	2005-07-13	Kikusui Seisakusyo Ltd	POWDER COMPRESSION MOLDING MACHINE OF THE ROTARY TYPE
GB2361453B (en) *	2000-01-27	2003-10-15	Victor Ken Seng Wu	Lubrication device adapted to be used in a punching machine
JP3983669B2 (ja)	2000-12-08	2007-09-26	協和醗酵工業株式会社	錠剤の製造装置
US9358214B2 (en)	2001-10-04	2016-06-07	Adare Pharmaceuticals, Inc.	Timed, sustained release systems for propranolol
WO2003041698A1 (fr) *	2001-11-13	2003-05-22	Kyowa Hakko Kogyo Co., Ltd.	Comprimes contenant des acides amines se desintegrant rapidement dans la cavite buccale et procede de fabrication de ces comprimes
IL166360A0 (en) *	2002-07-19	2006-01-16	Smi Inc	Method and apparatus for making miniature tablets
US8367111B2 (en)	2002-12-31	2013-02-05	Aptalis Pharmatech, Inc.	Extended release dosage forms of propranolol hydrochloride
US8747895B2 (en)	2004-09-13	2014-06-10	Aptalis Pharmatech, Inc.	Orally disintegrating tablets of atomoxetine
JP2008514253A (ja) *	2004-09-24	2008-05-08	バイオプログレス・テクノロジー・リミテッド	粉体圧密化およびエンローブにおける付加的改良
EP1944006A3 (en) *	2004-09-24	2008-07-23	BioProgress Technology Limited	Additional improvements in powder compaction and enrobing
US9884014B2 (en)	2004-10-12	2018-02-06	Adare Pharmaceuticals, Inc.	Taste-masked pharmaceutical compositions
NZ728442A (en)	2004-10-21	2018-05-25	Adare Pharmaceuticals Inc	Taste-masked pharmaceutical compositions with gastrosoluble pore-formers
US9161918B2 (en)	2005-05-02	2015-10-20	Adare Pharmaceuticals, Inc.	Timed, pulsatile release systems
EP2257279B1 (en) *	2008-02-28	2016-08-17	AbbVie Inc.	Preparation of tablets
AU2010325746B2 (en)	2009-12-02	2016-02-25	Adare Pharmaceuticals S.R.L.	Fexofenadine microcapsules and compositions containing them
CN102582111A (zh) *	2012-01-18	2012-07-18	金坛市威克压片机械制造有限公司	一种压片机装料深度微调装置
DE102016123279B4 (de) *	2016-12-01	2019-02-21	Fette Compacting Gmbh	Verfahren und System zum Zuführen eines Schmier- oder Trennmittels zu Presswerkzeugen einer Tablettenpresse
JP2019111565A (ja) *	2017-12-25	2019-07-11	株式会社菊水製作所	制御装置、制御方法
EP3662898A1 (en) *	2018-12-07	2020-06-10	Tillotts Pharma AG	Solid composition comprising mesalazine
USD959696S1 (en)	2020-03-18	2022-08-02	Laura Patricia Matamoros Vargas	Mold for vaginal ovules
USD947406S1 (en)	2020-03-18	2022-03-29	Laura Patricia Matamoros Vargas	Mold for vaginal ovules

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE265970C (2) *
US3158111A (en) *	1962-06-06	1964-11-24	Smith Kline French Lab	Method and apparatus for forming tablets
US3255716A (en) *	1962-12-10	1966-06-14	Upjohn Co	Measurement of forces within a tableting machine
US3332367A (en) *	1965-07-15	1967-07-25	Upjohn Co	Apparatus for making tablets
GB1335153A (en) *	1971-09-02	1973-10-24	Purex Corp	Method of tabletting halocyanuric acid
DE2520662C3 (de) *	1975-05-09	1983-11-03	Wilhelm Fette Gmbh, 2053 Schwarzenbek	Einrichtung zum Überwachen der Preßkräfte der Stempel einer Tablettenpresse
US4047866A (en) *	1976-11-22	1977-09-13	The Dow Chemical Company	Automatic self-lubricating rotary tablet press
CH628572A5 (de) *	1977-04-20	1982-03-15	Thomae Gmbh Dr K	Verfahren zum bespruehen der verdichtungswerkzeuge von maschinen zur herstellung von formlingen.
DE2742572B1 (de) *	1977-09-22	1979-03-29	Fette Wilhelm Gmbh	Verfahren zum Herstellen von Tabletten und Tablettenpresse

1979
- 1979-07-13 JP JP8940779A patent/JPS5614098A/ja active Granted
1980
- 1980-07-02 US US06/165,399 patent/US4373888A/en not_active Expired - Lifetime
- 1980-07-07 CH CH518080A patent/CH639843A5/fr not_active IP Right Cessation
- 1980-07-09 DE DE19803026058 patent/DE3026058A1/de active Granted
- 1980-07-11 IT IT68105/80A patent/IT1141602B/it active
- 1980-07-11 FR FR8015459A patent/FR2460662B1/fr not_active Expired
- 1980-07-11 GB GB8022804A patent/GB2053787B/en not_active Expired

Also Published As

Publication number	Publication date
GB2053787B (en)	1983-10-19
FR2460662A1 (fr)	1981-01-30
US4373888A (en)	1983-02-15
IT1141602B (it)	1986-10-01
FR2460662B1 (fr)	1985-10-04
GB2053787A (en)	1981-02-11
IT8068105A0 (it)	1980-07-11
JPS6219278B2 (2)	1987-04-27
DE3026058A1 (de)	1981-06-04
JPS5614098A (en)	1981-02-10

Legal Events

Date	Code	Title	Description
1993-03-31	PL	Patent ceased
2024-10-31	PL	Patent ceased

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