CH640415A5 - Therapeutic preparations for the treatment of pain - Google Patents

Therapeutic preparations for the treatment of pain Download PDF

Info

Publication number: CH640415A5
Authority: CH; Switzerland
Prior art keywords: alkyl; trifluoromethyl; carbon atoms; formula; alkoxy
Prior art date: 1979-04-10

Application number

CH341179A

Other languages

German (de)

English (en)

Inventor

Dietmar Dr Roemer

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-04-10

Filing date

1979-04-10

Publication date

1984-01-13

1979-04-10 Application filed by Sandoz Ag filed Critical Sandoz Ag

1979-04-10 Priority to CH341179A priority Critical patent/CH640415A5/de

1980-04-02 Priority to DE19803012837 priority patent/DE3012837A1/de

1980-04-03 Priority to GB8011256A priority patent/GB2047534B/en

1980-04-08 Priority to IT48364/80A priority patent/IT1143133B/it

1980-04-08 Priority to PT71066A priority patent/PT71066A/pt

1980-04-08 Priority to NL8002041A priority patent/NL8002041A/nl

1980-04-08 Priority to SE8002642A priority patent/SE445708B/sv

1980-04-08 Priority to AU57223/80A priority patent/AU538643B2/en

1980-04-08 Priority to HU80834A priority patent/HU183119B/hu

1980-04-09 Priority to AT0191680A priority patent/AT378916B/de

1980-04-09 Priority to IE724/80A priority patent/IE49676B1/en

1980-04-09 Priority to NZ193379A priority patent/NZ193379A/en

1980-04-09 Priority to CA000349456A priority patent/CA1147261A/en

1980-04-09 Priority to FR8007936A priority patent/FR2453648A1/fr

1980-04-09 Priority to JP4578480A priority patent/JPS55141413A/ja

1980-04-09 Priority to IL59786A priority patent/IL59786A/xx

1980-04-10 Priority to ES490453A priority patent/ES8105148A1/es

1980-04-10 Priority to AR280632A priority patent/AR228255A1/es

1980-04-10 Priority to PH23883A priority patent/PH17681A/en

1982-08-11 Priority to US06/407,153 priority patent/US4442084A/en

1984-01-13 Publication of CH640415A5 publication Critical patent/CH640415A5/de

1985-12-30 Priority to MY127/85A priority patent/MY8500127A/xx

Links

238000002360 preparation method Methods 0.000 title claims abstract description 6
230000001225 therapeutic effect Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 claims abstract description 27
125000004432 carbon atom Chemical group C* 0.000 claims abstract description 25
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract description 24
125000000217 alkyl group Chemical group 0.000 claims abstract description 21
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 20
239000001257 hydrogen Substances 0.000 claims abstract description 20
239000000460 chlorine Substances 0.000 claims abstract description 14
229910052801 chlorine Inorganic materials 0.000 claims abstract description 12
-1 6,7-methylenedioxy Chemical group 0.000 claims abstract description 11
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims abstract description 10
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims abstract description 10
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims abstract description 10
125000003545 alkoxy group Chemical group 0.000 claims abstract description 10
125000004414 alkyl thio group Chemical group 0.000 claims abstract description 10
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims abstract description 10
229910052794 bromium Inorganic materials 0.000 claims abstract description 10
229910052731 fluorine Inorganic materials 0.000 claims abstract description 10
239000011737 fluorine Substances 0.000 claims abstract description 10
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract description 10
125000001424 substituent group Chemical group 0.000 claims abstract description 10
229910052757 nitrogen Inorganic materials 0.000 claims abstract description 9
125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 9
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims abstract description 5
125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 claims abstract description 5
125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 5
125000004435 hydrogen atom Chemical class [H]* 0.000 claims abstract description 4
229910052799 carbon Inorganic materials 0.000 claims abstract description 3
150000002431 hydrogen Chemical class 0.000 claims description 14
239000003158 myorelaxant agent Substances 0.000 claims description 6
239000000825 pharmaceutical preparation Substances 0.000 claims description 6
KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims description 4
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 4
239000004480 active ingredient Substances 0.000 claims description 4
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 4
125000001207 fluorophenyl group Chemical group 0.000 claims description 4
229910052736 halogen Inorganic materials 0.000 claims description 4
150000002367 halogens Chemical group 0.000 claims description 4
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 4
229910052760 oxygen Inorganic materials 0.000 claims description 4
239000001301 oxygen Substances 0.000 claims description 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
150000003839 salts Chemical class 0.000 claims description 4
229910052717 sulfur Inorganic materials 0.000 claims description 4
239000011593 sulfur Chemical group 0.000 claims description 4
125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims description 3
NTURVSFTOYPGON-UHFFFAOYSA-N Dihydroquinazoline Chemical compound C1=CC=C2C=NCNC2=C1 NTURVSFTOYPGON-UHFFFAOYSA-N 0.000 claims description 3
239000002253 acid Substances 0.000 claims description 3
125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 2
125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims description 2
OZOMQRBLCMDCEG-VIZOYTHASA-N 1-[(e)-[5-(4-nitrophenyl)furan-2-yl]methylideneamino]imidazolidine-2,4-dione Chemical compound C1=CC([N+](=O)[O-])=CC=C1C(O1)=CC=C1\C=N\N1C(=O)NC(=O)C1 OZOMQRBLCMDCEG-VIZOYTHASA-N 0.000 claims description 2
HJICZLOIHNWNNY-UHFFFAOYSA-N 8-(4-fluorophenyl)-5-propan-2-yl-[1,3]dioxolo[4,5-g]quinazolin-6-one Chemical compound N=1C(=O)N(C(C)C)C2=CC=3OCOC=3C=C2C=1C1=CC=C(F)C=C1 HJICZLOIHNWNNY-UHFFFAOYSA-N 0.000 claims description 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
230000001760 anti-analgesic effect Effects 0.000 claims description 2
230000003110 anti-inflammatory effect Effects 0.000 claims description 2
125000004799 bromophenyl group Chemical group 0.000 claims description 2
150000001721 carbon Chemical group 0.000 claims description 2
125000000068 chlorophenyl group Chemical group 0.000 claims description 2
125000000623 heterocyclic group Chemical group 0.000 claims description 2
125000001841 imino group Chemical group [H]N=* 0.000 claims description 2
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
230000000694 effects Effects 0.000 description 4
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
238000004519 manufacturing process Methods 0.000 description 4
239000003826 tablet Substances 0.000 description 4
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
229920000168 Microcrystalline cellulose Polymers 0.000 description 3
229920002472 Starch Polymers 0.000 description 3
239000008101 lactose Substances 0.000 description 3
235000019813 microcrystalline cellulose Nutrition 0.000 description 3
239000008108 microcrystalline cellulose Substances 0.000 description 3
229940016286 microcrystalline cellulose Drugs 0.000 description 3
239000008107 starch Substances 0.000 description 3
235000019698 starch Nutrition 0.000 description 3
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
108010010803 Gelatin Proteins 0.000 description 2
229930195725 Mannitol Natural products 0.000 description 2
239000011230 binding agent Substances 0.000 description 2
239000002775 capsule Substances 0.000 description 2
229920000159 gelatin Polymers 0.000 description 2
239000008273 gelatin Substances 0.000 description 2
235000019322 gelatine Nutrition 0.000 description 2
235000011852 gelatine desserts Nutrition 0.000 description 2
239000003979 granulating agent Substances 0.000 description 2
239000000314 lubricant Substances 0.000 description 2
235000019359 magnesium stearate Nutrition 0.000 description 2
239000000594 mannitol Substances 0.000 description 2
235000010355 mannitol Nutrition 0.000 description 2
239000001267 polyvinylpyrrolidone Substances 0.000 description 2
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
239000003755 preservative agent Substances 0.000 description 2
239000000375 suspending agent Substances 0.000 description 2
239000000725 suspension Substances 0.000 description 2
239000012730 sustained-release form Substances 0.000 description 2
239000000454 talc Substances 0.000 description 2
235000012222 talc Nutrition 0.000 description 2
229910052623 talc Inorganic materials 0.000 description 2
239000000080 wetting agent Substances 0.000 description 2
FNQJDLTXOVEEFB-UHFFFAOYSA-N 1,2,3-benzothiadiazole Chemical compound C1=CC=C2SN=NC2=C1 FNQJDLTXOVEEFB-UHFFFAOYSA-N 0.000 description 1
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
239000005964 Acibenzolar-S-methyl Substances 0.000 description 1
241000416162 Astragalus gummifer Species 0.000 description 1
229920002261 Corn starch Polymers 0.000 description 1
RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
235000021355 Stearic acid Nutrition 0.000 description 1
ZWUKMNZJRDGCTQ-UHFFFAOYSA-N Tizanidine hydrochloride Chemical compound Cl.ClC=1C=CC2=NSN=C2C=1NC1=NCCN1 ZWUKMNZJRDGCTQ-UHFFFAOYSA-N 0.000 description 1
229920001615 Tragacanth Polymers 0.000 description 1
235000010443 alginic acid Nutrition 0.000 description 1
239000000783 alginic acid Substances 0.000 description 1
229920000615 alginic acid Polymers 0.000 description 1
229960001126 alginic acid Drugs 0.000 description 1
150000004781 alginic acids Chemical class 0.000 description 1
230000000202 analgesic effect Effects 0.000 description 1
206010003246 arthritis Diseases 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
239000001506 calcium phosphate Substances 0.000 description 1
229910000389 calcium phosphate Inorganic materials 0.000 description 1
235000011010 calcium phosphates Nutrition 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
239000003086 colorant Substances 0.000 description 1
239000008120 corn starch Substances 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
239000007884 disintegrant Substances 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000019634 flavors Nutrition 0.000 description 1
235000003599 food sweetener Nutrition 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
239000008187 granular material Substances 0.000 description 1
150000003840 hydrochlorides Chemical class 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
239000007788 liquid Substances 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
235000010981 methylcellulose Nutrition 0.000 description 1
229960002900 methylcellulose Drugs 0.000 description 1
ODJOWHUVBHWDDK-UHFFFAOYSA-N n-(1-methylindazol-4-yl)-4,5-dihydro-1,3-oxazol-2-amine Chemical compound C1=CC=C2N(C)N=CC2=C1NC1=NCCO1 ODJOWHUVBHWDDK-UHFFFAOYSA-N 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
229920001993 poloxamer 188 Polymers 0.000 description 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
239000000843 powder Substances 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000000243 solution Substances 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
229940032147 starch Drugs 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000007916 tablet composition Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

CH341179A 1979-04-10 1979-04-10 Therapeutic preparations for the treatment of pain CH640415A5 (en)

Priority Applications (21)

Application Number	Priority Date	Filing Date	Title
CH341179A CH640415A5 (en)	1979-04-10	1979-04-10	Therapeutic preparations for the treatment of pain
DE19803012837 DE3012837A1 (de)	1979-04-10	1980-04-02	Analgetische und myotonolytische praeparate
GB8011256A GB2047534B (en)	1979-04-10	1980-04-03	Analgesic and myotonolytic compositions
IT48364/80A IT1143133B (it)	1979-04-10	1980-04-08	Composizioni analgesiche e miotonolitiche
PT71066A PT71066A (en)	1979-04-10	1980-04-08	Process for the preparation of a pharmaceutical composition having analgesic and myotonolytical activity
NL8002041A NL8002041A (nl)	1979-04-10	1980-04-08	Werkwijze voor het bereiden van een analgetisch en myotonolytisch geneesmiddel.
SE8002642A SE445708B (sv)	1979-04-10	1980-04-08	Farmaceutiskt preparat innehallande ett kinazolinon och 5-klor-4-(2-imidazolin-2-yl-amino)-2,1,3-bensotiadiazol
AU57223/80A AU538643B2 (en)	1979-04-10	1980-04-08	Quinazolinone/myotonolytic synergystic combination
HU80834A HU183119B (en)	1979-04-10	1980-04-08	Process for producing analgesic and tone-delivering compositions containing quinazoline derivatives and benzothiadiazol derivatives
AT0191680A AT378916B (de)	1979-04-10	1980-04-09	Verfahren zur herstellung eines pharmazeutischen kombinationspraeparates
IE724/80A IE49676B1 (en)	1979-04-10	1980-04-09	Analgesic and myotonolytic preparations
NZ193379A NZ193379A (en)	1979-04-10	1980-04-09	Analgesic and/or myotonolytic compositions based on an analgesically active quinazolinone and a centrally active myotonolytic
CA000349456A CA1147261A (en)	1979-04-10	1980-04-09	Analgesic and myotonolytic preparations
FR8007936A FR2453648A1 (fr)	1979-04-10	1980-04-09	Nouvelles compositions pharmaceutiques a base d'une quinazolinone exercant une action analgesique et d'un agent myotonolytique
JP4578480A JPS55141413A (en)	1979-04-10	1980-04-09	Analgesic and muscle stiffness relaxing medicine
IL59786A IL59786A (en)	1979-04-10	1980-04-09	Pharmaceutical compositions comprising a quinazolinone derivative and a myotonolytic agent
ES490453A ES8105148A1 (es)	1979-04-10	1980-04-10	Un procedimiento para la preparacion de una composicion far-maceutica de quinazolinonas analgesicas
AR280632A AR228255A1 (es)	1979-04-10	1980-04-10	Procedimiento para la produccion de una preparacion sinergistica que tiene una actividad analgesica y miotonolitica mejorada
PH23883A PH17681A (en)	1979-04-10	1980-04-10	Analgesic and myotonolytic preparations
US06/407,153 US4442084A (en)	1979-04-10	1982-08-11	Analgesic and myotonolytic preparations
MY127/85A MY8500127A (en)	1979-04-10	1985-12-30	Analgesic and myotonolytic preparations

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH341179A CH640415A5 (en)	1979-04-10	1979-04-10	Therapeutic preparations for the treatment of pain

Publications (1)

Publication Number	Publication Date
CH640415A5 true CH640415A5 (en)	1984-01-13

Family

ID=4255400

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH341179A CH640415A5 (en)	1979-04-10	1979-04-10	Therapeutic preparations for the treatment of pain

Country Status (3)

Country	Link
JP (1)	JPS55141413A (it)
AT (1)	AT378916B (it)
CH (1)	CH640415A5 (it)

1979
- 1979-04-10 CH CH341179A patent/CH640415A5/de not_active IP Right Cessation
1980
- 1980-04-09 JP JP4578480A patent/JPS55141413A/ja active Granted
- 1980-04-09 AT AT0191680A patent/AT378916B/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
ATA191680A (de)	1985-03-15
JPS55141413A (en)	1980-11-05
JPH0132806B2 (it)	1989-07-10
AT378916B (de)	1985-10-25

Legal Events

Date	Code	Title	Description
1991-12-31	PL	Patent ceased
2024-10-31	PL	Patent ceased

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DE2708236A1 (de)	1977-09-08	3-aryl-2-oxazolidinone, verfahren zu ihrer herstellung und arzneimittel
DE68925004T2 (de)	1996-05-15	Verwendung von 2,3,4,5-Tetrahydro-1H-3-Benzazepinen bei der Behandlung von neurologischen Störungen.
DE3420193A1 (de)	1985-12-05	Neue substituierte pyrrolidinone, verfahren zu ihrer herstellung und arzneimittel
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DE3517820C2 (it)	1992-07-30
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DE69802921T2 (de)	2002-08-29	Arzneizubereitungen in trockner form zur oralen verabreichung einer cyclischen quaternären ammoniumverbindung
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DE3739779A1 (de)	1989-06-08	Pharmazeutische praeparate
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DE2817924A1 (de)	1978-11-02	3-(1-piperazinyl)-1,2,4-benzotriazine und ihre n-oxide
AT393625B (de)	1991-11-25	Verfahren zur herstellung eines neuen therapeutischen praeparates enthaltend co-dergocrine und einen calciumantagonisten
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