CH642544A5 - Composition pharmaceutique d'erythromycine. - Google Patents

Composition pharmaceutique d'erythromycine. Download PDF

Info

Publication number: CH642544A5
Authority: CH; Switzerland
Prior art keywords: erythromycin; solution; propylene glycol; ethanol; acid
Prior art date: 1978-10-20

Application number

CH938879A

Other languages

English (en)

French (fr)

Inventor

Harun Takruri

Jane Ellen Chavers

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-10-20

Filing date

1979-10-18

Publication date

1984-04-30

1979-10-18 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1984-04-30 Publication of CH642544A5 publication Critical patent/CH642544A5/fr

Links

ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title claims 39
229960003276 erythromycin Drugs 0.000 title claims 19
239000008194 pharmaceutical composition Substances 0.000 title claims 9
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 33
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 32
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 24
239000000243 solution Substances 0.000 claims 15
235000019441 ethanol Nutrition 0.000 claims 11
239000002253 acid Substances 0.000 claims 10
231100000252 nontoxic Toxicity 0.000 claims 8
230000003000 nontoxic effect Effects 0.000 claims 8
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 7
208000002874 Acne Vulgaris Diseases 0.000 claims 5
206010000496 acne Diseases 0.000 claims 5
238000010790 dilution Methods 0.000 claims 5
239000012895 dilution Substances 0.000 claims 5
239000004480 active ingredient Substances 0.000 claims 4
238000000034 method Methods 0.000 claims 4
239000000203 mixture Substances 0.000 claims 4
206010033733 Papule Diseases 0.000 claims 3
230000003115 biocidal effect Effects 0.000 claims 3
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
239000011521 glass Substances 0.000 claims 2
239000000546 pharmaceutical excipient Substances 0.000 claims 2
238000002360 preparation method Methods 0.000 claims 2
NWXMGUDVXFXRIG-PMXORCKASA-N (4r,4as,5as,6s,12ar)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide Chemical compound C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]4(O)C(=O)C3=C(O)C2=C1O NWXMGUDVXFXRIG-PMXORCKASA-N 0.000 claims 1
LQZZUXJYWNFBMV-UHFFFAOYSA-N 1-dodecanol group Chemical class C(CCCCCCCCCCC)O LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims 1
NZJXADCEESMBPW-UHFFFAOYSA-N 1-methylsulfinyldecane Chemical compound CCCCCCCCCCS(C)=O NZJXADCEESMBPW-UHFFFAOYSA-N 0.000 claims 1
XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 claims 1
XEUCQOBUZPQUMQ-UHFFFAOYSA-N Glycolone Chemical group COC1=C(CC=C(C)C)C(=O)NC2=C1C=CC=C2OC XEUCQOBUZPQUMQ-UHFFFAOYSA-N 0.000 claims 1
OJMMVQQUTAEWLP-UHFFFAOYSA-N Lincomycin Natural products CN1CC(CCC)CC1C(=O)NC(C(C)O)C1C(O)C(O)C(O)C(SC)O1 OJMMVQQUTAEWLP-UHFFFAOYSA-N 0.000 claims 1
239000004098 Tetracycline Substances 0.000 claims 1
WPMWEFXCIYCJSA-UHFFFAOYSA-N Tetraethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCO WPMWEFXCIYCJSA-UHFFFAOYSA-N 0.000 claims 1
238000010521 absorption reaction Methods 0.000 claims 1
230000001476 alcoholic effect Effects 0.000 claims 1
239000003242 anti bacterial agent Substances 0.000 claims 1
229940088710 antibiotic agent Drugs 0.000 claims 1
239000007864 aqueous solution Substances 0.000 claims 1
238000001704 evaporation Methods 0.000 claims 1
230000008020 evaporation Effects 0.000 claims 1
239000004615 ingredient Substances 0.000 claims 1
230000007794 irritation Effects 0.000 claims 1
OJMMVQQUTAEWLP-KIDUDLJLSA-N lincomycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@@H](C)O)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 OJMMVQQUTAEWLP-KIDUDLJLSA-N 0.000 claims 1
229960005287 lincomycin Drugs 0.000 claims 1
238000004519 manufacturing process Methods 0.000 claims 1
150000007524 organic acids Chemical class 0.000 claims 1
230000035515 penetration Effects 0.000 claims 1
239000000843 powder Substances 0.000 claims 1
239000002904 solvent Substances 0.000 claims 1
239000011877 solvent mixture Substances 0.000 claims 1
238000003860 storage Methods 0.000 claims 1
239000000126 substance Substances 0.000 claims 1
229960002180 tetracycline Drugs 0.000 claims 1
229930101283 tetracycline Natural products 0.000 claims 1
235000019364 tetracycline Nutrition 0.000 claims 1
150000003522 tetracyclines Chemical class 0.000 claims 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Dermatology (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Birds (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

CH938879A 1978-10-20 1979-10-18 Composition pharmaceutique d'erythromycine. CH642544A5 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US95315978A	1978-10-20	1978-10-20

Publications (1)

Publication Number	Publication Date
CH642544A5 true CH642544A5 (fr)	1984-04-30

Family

ID=25493654

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH938879A CH642544A5 (fr)	1978-10-20	1979-10-18	Composition pharmaceutique d'erythromycine.

Country Status (13)

Country	Link
EP (1)	EP0010437B1 (2)
JP (1)	JPS5557519A (2)
AU (1)	AU529422B2 (2)
BE (1)	BE879471A (2)
CA (1)	CA1129772A (2)
CH (1)	CH642544A5 (2)
DE (1)	DE2967163D1 (2)
FR (1)	FR2439016A1 (2)
GB (1)	GB2031728B (2)
IE (1)	IE49086B1 (2)
LU (1)	LU81799A1 (2)
NZ (1)	NZ191847A (2)
ZA (1)	ZA795492B (2)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS59104326A (ja) *	1982-12-04	1984-06-16	Toyo Jozo Co Ltd	マクロライド抗生物質の安定な経口用製剤および安定化法
US4886545A (en) *	1986-01-31	1989-12-12	Nelson Research & Development Company	Compositions comprising 1-substituted azacycloalkanes and their uses
US4808411A (en) *	1987-06-05	1989-02-28	Abbott Laboratories	Antibiotic-polymer compositions
FI883338A7 (fi) *	1987-07-16	1989-01-17	Bristol Myers Squibb Co	Doksorubisiinihydrokloridin vesiliuoksia
FI883337L (fi) *	1987-07-16	1989-01-17	Bristol Myers Co	Icke-vattenloesningar av doxorubicinhydroklorin.
JPH0737389B2 (ja) *	1989-08-29	1995-04-26	久光製薬株式会社	プロスタグランジンｅ１含有の軟膏剤
DE19549794B4 (de) *	1994-10-26	2009-07-30	Novartis Ag	Pharmazeutische Zusammensetzungen
GB2327611B (en) *	1994-10-26	1999-06-02	Novartis Ag	Macrolide compositions
US5723447A (en) *	1996-07-02	1998-03-03	Rhone Merieux, Inc.	Water miscible erythromycin solutions
US6239112B1 (en) *	1998-07-09	2001-05-29	Merial, Inc.	Water miscible macrolide solutions
RU2161955C1 (ru) *	1999-07-16	2001-01-20	Эпштейн Олег Ильич	Способ изменения физико-химических или физико-химических и биологических свойств вещества
US20040116522A1 (en) *	2001-03-30	2004-06-17	Yutaka Yamagata	Medicinal solutions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4000263A (en) *	1975-05-02	1976-12-28	Westwood Pharmaceuticals, Inc.	Erythromycin solution
FR2378523A1 (fr) *	1977-01-26	1978-08-25	Grupper Charles	Medicament pour le traitement de l'acne

1979
- 1979-10-15 ZA ZA00795492A patent/ZA795492B/xx unknown
- 1979-10-15 AU AU51790/79A patent/AU529422B2/en not_active Expired
- 1979-10-15 NZ NZ191847A patent/NZ191847A/xx unknown
- 1979-10-17 CA CA337,789A patent/CA1129772A/en not_active Expired
- 1979-10-18 LU LU81799A patent/LU81799A1/fr unknown
- 1979-10-18 FR FR7925929A patent/FR2439016A1/fr active Granted
- 1979-10-18 BE BE1/9572A patent/BE879471A/fr not_active IP Right Cessation
- 1979-10-18 CH CH938879A patent/CH642544A5/fr not_active IP Right Cessation
- 1979-10-19 DE DE7979302271T patent/DE2967163D1/de not_active Expired
- 1979-10-19 JP JP13583179A patent/JPS5557519A/ja active Granted
- 1979-10-19 EP EP79302271A patent/EP0010437B1/en not_active Expired
- 1979-10-19 GB GB7936426A patent/GB2031728B/en not_active Expired
- 1979-10-19 IE IE1995/79A patent/IE49086B1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU5179079A (en)	1980-04-24
IE791995L (en)	1980-04-20
FR2439016A1 (fr)	1980-05-16
DE2967163D1 (en)	1984-09-13
EP0010437B1 (en)	1984-08-08
NZ191847A (en)	1982-05-31
LU81799A1 (fr)	1980-01-25
CA1129772A (en)	1982-08-17
JPS5557519A (en)	1980-04-28
AU529422B2 (en)	1983-06-09
GB2031728A (en)	1980-04-30
BE879471A (fr)	1980-04-18
ZA795492B (en)	1981-05-27
EP0010437A2 (en)	1980-04-30
IE49086B1 (en)	1985-07-24
JPH0157097B2 (2)	1989-12-04
EP0010437A3 (en)	1981-05-13
FR2439016B1 (2)	1983-05-27
GB2031728B (en)	1983-02-16

Legal Events

Date	Code	Title	Description
1999-11-15	PL	Patent ceased

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US8900634B2 (en)	2014-12-02	Diethylstilbestrol dosage form and methods of treatment using thereof
OA10678A (fr)	2002-11-20	Nouvelles formulations liquides stables à base de paracétamol et leur mode de préparation
AU758989B2 (en)	2003-04-03	Cosolvent formulations
LU81799A1 (fr)	1980-01-25	Solution stable d'erythromycine
EP0221176A1 (en)	1987-05-13	PHARMACEUTICAL CARRIERS FOR REDUCING THE TRANSDERMAL FLOW.
US3070499A (en)	1962-12-25	Parenteral aqueous solutions of fat soluble vitamins
JPS6321648B2 (2)	1988-05-09
DE2218147C2 (de)	1983-08-18	Pharmazeutische Zubereitung
EP2116241B1 (en)	2016-04-27	Pharmaceutical composition
AU766031B2 (en)	2003-10-09	Iodine preparation compositon
Dayton et al.	1961	Metabolism of sulfinpyrazone (Anturane) and other thio analogues of phenylbutazone in man
Fang et al.	1968	Hypoglycemic activity and chemical structure of the salicylates
RS50685B (sr)	2010-06-30	Koncentrovani vodeni rastvor ambroksola
EP0896819A1 (en)	1999-02-17	Antiglucocorticoid drug
US4132777A (en)	1979-01-02	Antifungal compositions and method
FR2614203A1 (fr)	1988-10-28	Composition pharmaceutique pour le traitement des maladies de la peau et son procede de preparation.
US4894237A (en)	1990-01-16	Antiinflammatory pharmaceutical composition endowed with sustained effect for topical use
JPS609486B2 (ja)	1985-03-11	ステロイド組成物
JPS59219218A (ja)	1984-12-10	局所用作用持続組成物
WO1996033743A1 (fr)	1996-10-31	Compositions pulverulentes et solubles dans l'eau et leurs applications
RU2823711C2 (ru)	2024-07-29	Фармацевтические композиции луликоназола для местного применения
Herbai	1971	Effect of Adrenalectomy, Corticosteroids and some other Anti‐Inflammatory Agents, Salazopyrin®, Thyroxine and Vitamin A on the Exchangeable Sulphate Pool and on Sulphate Incorporation in Vivo into Costal Cartilage of the Mouse
US5543432A (en)	1996-08-06	Application of trace elements to animals