CH644017A5 - Pharmazeutisches praeparat fuer die humanmedizin. - Google Patents

Pharmazeutisches praeparat fuer die humanmedizin. Download PDF

Info

Publication number: CH644017A5
Authority: CH; Switzerland
Prior art keywords: weight; percent; preparation; preparation according; monosaccharide
Prior art date: 1977-12-23

Application number

CH1304478A

Other languages

German (de)

English (en)

Inventor

Robert James Bywater

Peter Martin Newsome

John Reginald Ryder

James Ingram Wells

Original Assignee

Beecham Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-12-23

Filing date

1978-12-21

Publication date

1984-07-13

1978-12-21 Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd

1984-07-13 Publication of CH644017A5 publication Critical patent/CH644017A5/de

Links

239000000825 pharmaceutical preparation Substances 0.000 title claims description 23
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 67
238000002360 preparation method Methods 0.000 claims description 55
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 21
239000008121 dextrose Substances 0.000 claims description 21
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 20
150000002772 monosaccharides Chemical class 0.000 claims description 20
150000003839 salts Chemical class 0.000 claims description 18
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 17
150000001413 amino acids Chemical class 0.000 claims description 15
239000004471 Glycine Substances 0.000 claims description 10
239000011780 sodium chloride Substances 0.000 claims description 9
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
239000003792 electrolyte Substances 0.000 claims description 6
239000002245 particle Substances 0.000 claims description 6
239000001508 potassium citrate Substances 0.000 claims description 5
QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims description 5
239000000314 lubricant Substances 0.000 claims description 4
235000015870 tripotassium citrate Nutrition 0.000 claims description 4
239000004480 active ingredient Substances 0.000 claims description 3
239000003814 drug Substances 0.000 claims description 2
229960001031 glucose Drugs 0.000 description 19
206010012735 Diarrhoea Diseases 0.000 description 11
235000001014 amino acid Nutrition 0.000 description 11
239000000796 flavoring agent Substances 0.000 description 7
235000019634 flavors Nutrition 0.000 description 7
229910000402 monopotassium phosphate Inorganic materials 0.000 description 5
235000019796 monopotassium phosphate Nutrition 0.000 description 5
PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 5
239000000843 powder Substances 0.000 description 5
239000004615 ingredient Substances 0.000 description 4
BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 4
235000008733 Citrus aurantifolia Nutrition 0.000 description 3
235000011941 Tilia x europaea Nutrition 0.000 description 3
239000002253 acid Substances 0.000 description 3
230000037396 body weight Effects 0.000 description 3
125000004432 carbon atom Chemical group C* 0.000 description 3
239000000470 constituent Substances 0.000 description 3
229930182830 galactose Natural products 0.000 description 3
239000004571 lime Substances 0.000 description 3
239000000463 material Substances 0.000 description 3
238000000034 method Methods 0.000 description 3
150000004682 monohydrates Chemical group 0.000 description 3
WCUXLLCKKVVCTQ-UHFFFAOYSA-M potassium chloride Inorganic materials [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 3
239000000243 solution Substances 0.000 description 3
239000000126 substance Substances 0.000 description 3
238000002560 therapeutic procedure Methods 0.000 description 3
SPFMQWBKVUQXJV-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;hydrate Chemical compound O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O SPFMQWBKVUQXJV-BTVCFUMJSA-N 0.000 description 2
239000005995 Aluminium silicate Substances 0.000 description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 2
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
229920002472 Starch Polymers 0.000 description 2
235000004279 alanine Nutrition 0.000 description 2
WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 2
235000012211 aluminium silicate Nutrition 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
239000008119 colloidal silica Substances 0.000 description 2
229960000673 dextrose monohydrate Drugs 0.000 description 2
NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 2
XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
239000000203 mixture Substances 0.000 description 2
229960005181 morphine Drugs 0.000 description 2
239000007968 orange flavor Substances 0.000 description 2
229960003975 potassium Drugs 0.000 description 2
239000001103 potassium chloride Substances 0.000 description 2
235000011164 potassium chloride Nutrition 0.000 description 2
208000026775 severe diarrhea Diseases 0.000 description 2
239000007787 solid Substances 0.000 description 2
239000008107 starch Substances 0.000 description 2
235000019698 starch Nutrition 0.000 description 2
LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
RMTFNDVZYPHUEF-XZBKPIIZSA-N 3-O-methyl-D-glucose Chemical compound O=C[C@H](O)[C@@H](OC)[C@H](O)[C@H](O)CO RMTFNDVZYPHUEF-XZBKPIIZSA-N 0.000 description 1
244000003034 Arancio amaro Species 0.000 description 1
239000004475 Arginine Substances 0.000 description 1
229930003347 Atropine Natural products 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
206010008631 Cholera Diseases 0.000 description 1
241000207199 Citrus Species 0.000 description 1
101000737830 Conus generalis Alpha-conotoxin GeXXA Proteins 0.000 description 1
RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 description 1
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
229930193140 Neomycin Natural products 0.000 description 1
239000008896 Opium Substances 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
VVWYOYDLCMFIEM-UHFFFAOYSA-N Propantheline Chemical compound C1=CC=C2C(C(=O)OCC[N+](C)(C(C)C)C(C)C)C3=CC=CC=C3OC2=C1 VVWYOYDLCMFIEM-UHFFFAOYSA-N 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 1
230000009056 active transport Effects 0.000 description 1
239000003463 adsorbent Substances 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
239000003793 antidiarrheal agent Substances 0.000 description 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
239000008122 artificial sweetener Substances 0.000 description 1
235000021311 artificial sweeteners Nutrition 0.000 description 1
125000004429 atom Chemical group 0.000 description 1
RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 description 1
229960000396 atropine Drugs 0.000 description 1
238000009835 boiling Methods 0.000 description 1
239000001110 calcium chloride Substances 0.000 description 1
229910001628 calcium chloride Inorganic materials 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
235000020971 citrus fruits Nutrition 0.000 description 1
238000012937 correction Methods 0.000 description 1
230000018044 dehydration Effects 0.000 description 1
238000006297 dehydration reaction Methods 0.000 description 1
230000000741 diarrhetic effect Effects 0.000 description 1
235000005911 diet Nutrition 0.000 description 1
230000037213 diet Effects 0.000 description 1
ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
230000000694 effects Effects 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
230000002496 gastric effect Effects 0.000 description 1
229940050410 gluconate Drugs 0.000 description 1
-1 glycine and alanine Chemical class 0.000 description 1
239000008187 granular material Substances 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
208000037951 infantile gastroenteritis Diseases 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
230000000968 intestinal effect Effects 0.000 description 1
210000000936 intestine Anatomy 0.000 description 1
230000001678 irradiating effect Effects 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
239000007788 liquid Substances 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
235000013336 milk Nutrition 0.000 description 1
239000008267 milk Substances 0.000 description 1
210000004080 milk Anatomy 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
239000011707 mineral Substances 0.000 description 1
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
229960004927 neomycin Drugs 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
229960001027 opium Drugs 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
230000001575 pathological effect Effects 0.000 description 1
239000001814 pectin Substances 0.000 description 1
229920001277 pectin Polymers 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
230000008855 peristalsis Effects 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
230000035479 physiological effects, processes and functions Effects 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
229960002635 potassium citrate Drugs 0.000 description 1
235000011082 potassium citrates Nutrition 0.000 description 1
159000000001 potassium salts Chemical class 0.000 description 1
229960000697 propantheline Drugs 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
229940124530 sulfonamide Drugs 0.000 description 1
150000003456 sulfonamides Chemical class 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
229910000404 tripotassium phosphate Inorganic materials 0.000 description 1
235000019798 tripotassium phosphate Nutrition 0.000 description 1
SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Inorganic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

CH1304478A 1977-12-23 1978-12-21 Pharmazeutisches praeparat fuer die humanmedizin. CH644017A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB5387577		1977-12-23

Publications (1)

Publication Number	Publication Date
CH644017A5 true CH644017A5 (de)	1984-07-13

Family

ID=10469271

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH1304478A CH644017A5 (de)	1977-12-23	1978-12-21	Pharmazeutisches praeparat fuer die humanmedizin.

Country Status (15)

Country	Link
JP (1)	JPS54101437A (fr)
AU (1)	AU4282278A (fr)
BE (1)	BE872647A (fr)
CA (1)	CA1119517A (fr)
CH (1)	CH644017A5 (fr)
DE (1)	DE2854281A1 (fr)
FR (1)	FR2412313A1 (fr)
GB (1)	GB2012163B (fr)
IE (1)	IE47698B1 (fr)
IT (1)	IT1111383B (fr)
NL (1)	NL7812403A (fr)
NZ (1)	NZ189122A (fr)
OA (1)	OA06135A (fr)
PH (1)	PH14262A (fr)
ZA (1)	ZA786856B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0059057A1 (fr) *	1981-02-20	1982-09-01	Beecham Group Plc	Traitement de la diarrhée
US4542123A (en) *	1982-01-11	1985-09-17	Massachusetts Institute Of Technology	Composition and method for increasing brain tyrosine levels
EP0112061A3 (fr) *	1982-11-20	1985-08-14	Beecham Group Plc	Composition pharmaceutique et vétérinaire contenant du guanoxabenz
CA1217723A (fr) *	1983-01-13	1987-02-10	Robert W. Phillips	Traitement contre la diarrhee chez les mammiferes
GB8528307D0 (en) *	1985-11-18	1985-12-24	Beecham Group Plc	Veterinary compositions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ183492A (en) *	1976-03-27	1980-04-28	Beecham Group Ltd	Veterinary rehydration compositions containing monosaccharide amino acid and citric acid or citrate

1978
- 1978-12-06 ZA ZA00786856A patent/ZA786856B/xx unknown
- 1978-12-07 NZ NZ189122A patent/NZ189122A/xx unknown
- 1978-12-08 BE BE192233A patent/BE872647A/fr unknown
- 1978-12-13 PH PH21944A patent/PH14262A/en unknown
- 1978-12-15 DE DE19782854281 patent/DE2854281A1/de not_active Withdrawn
- 1978-12-15 FR FR7835352A patent/FR2412313A1/fr active Granted
- 1978-12-20 JP JP15908578A patent/JPS54101437A/ja active Pending
- 1978-12-20 IE IE2515/78A patent/IE47698B1/en unknown
- 1978-12-21 AU AU42822/78A patent/AU4282278A/en active Pending
- 1978-12-21 NL NL7812403A patent/NL7812403A/xx not_active Application Discontinuation
- 1978-12-21 IT IT52414/78A patent/IT1111383B/it active
- 1978-12-21 GB GB7849575A patent/GB2012163B/en not_active Expired
- 1978-12-21 CH CH1304478A patent/CH644017A5/de not_active IP Right Cessation
- 1978-12-22 CA CA000318507A patent/CA1119517A/fr not_active Expired
- 1978-12-22 OA OA56691A patent/OA06135A/fr unknown

Also Published As

Publication number	Publication date
IT1111383B (it)	1986-01-13
ZA786856B (en)	1979-11-28
IE782515L (en)	1979-06-23
DE2854281A1 (de)	1979-07-05
CA1119517A (fr)	1982-03-09
AU4282278A (en)	1979-06-28
OA06135A (fr)	1981-06-30
NL7812403A (nl)	1979-06-26
NZ189122A (en)	1980-12-19
IE47698B1 (en)	1984-05-30
IT7852414A0 (it)	1978-12-21
PH14262A (en)	1981-04-23
BE872647A (fr)	1979-06-08
JPS54101437A (en)	1979-08-10
FR2412313B1 (fr)	1982-06-25
GB2012163A (en)	1979-07-25
GB2012163B (en)	1982-09-22
FR2412313A1 (fr)	1979-07-20

Legal Events

Date	Code	Title	Description
1986-08-29	PL	Patent ceased
2024-10-31	PL	Patent ceased

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JPS61260021A (ja)	1986-11-18	制瀉剤組成物
DK166430B1 (da)	1993-05-24	Fremgangsmaade til fremstilling af et monosaccharidholdigt praeparat
DE69128760T2 (de)	1998-04-30	Antidiarrhoeika
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DE69201077T2 (de)	1995-05-11	Alginsäure enthaltende Arzneisuspension.
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DE60112584T2 (de)	2006-06-01	Verfahren zur Herstellung einer flüssigen Dosierungseinheit und Kit