CH659391A5 - Koffein enthaltende, analgetische und antiinflammatorische pharmazeutische zubereitung. - Google Patents

Koffein enthaltende, analgetische und antiinflammatorische pharmazeutische zubereitung. Download PDF

Info

Publication number: CH659391A5
Authority: CH; Switzerland
Prior art keywords: analgesic; pharmaceutical preparation; caffeine; preparation according; narcotic
Prior art date: 1982-07-22

Application number

CH1546/84A

Other languages

German (de)

English (en)

Inventor

Abraham Sunshine

Eugene M Laska

Carole E Siegel

Original Assignee

Richardson Vicks Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-07-22

Filing date

1983-07-21

Publication date

1987-01-30

1983-07-21 Application filed by Richardson Vicks Inc filed Critical Richardson Vicks Inc

1987-01-30 Publication of CH659391A5 publication Critical patent/CH659391A5/de

Links

230000000202 analgesic effect Effects 0.000 title claims description 128
239000000825 pharmaceutical preparation Substances 0.000 title claims description 32
230000003110 anti-inflammatory effect Effects 0.000 title claims description 31
RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims description 262
LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims description 130
229960001948 caffeine Drugs 0.000 claims description 130
VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims description 130
239000004084 narcotic analgesic agent Substances 0.000 claims description 58
239000003814 drug Substances 0.000 claims description 56
229940079593 drug Drugs 0.000 claims description 49
238000002360 preparation method Methods 0.000 claims description 41
HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims description 22
229960001680 ibuprofen Drugs 0.000 claims description 21
230000031990 negative regulation of inflammatory response Effects 0.000 claims description 21
HUPFGZXOMWLGNK-UHFFFAOYSA-N diflunisal Chemical compound C1=C(O)C(C(=O)O)=CC(C=2C(=CC(F)=CC=2)F)=C1 HUPFGZXOMWLGNK-UHFFFAOYSA-N 0.000 claims description 19
RDJGLLICXDHJDY-NSHDSACASA-N (2s)-2-(3-phenoxyphenyl)propanoic acid Chemical compound OC(=O)[C@@H](C)C1=CC=CC(OC=2C=CC=CC=2)=C1 RDJGLLICXDHJDY-NSHDSACASA-N 0.000 claims description 18
229960000616 diflunisal Drugs 0.000 claims description 18
229960001419 fenoprofen Drugs 0.000 claims description 18
CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 claims description 18
CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 claims description 17
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238000011282 treatment Methods 0.000 claims description 16
150000003839 salts Chemical class 0.000 claims description 15
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239000002671 adjuvant Substances 0.000 claims description 10
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XLMALTXPSGQGBX-GCJKJVERSA-N dextropropoxyphene Chemical compound C([C@](OC(=O)CC)([C@H](C)CN(C)C)C=1C=CC=CC=1)C1=CC=CC=C1 XLMALTXPSGQGBX-GCJKJVERSA-N 0.000 claims description 9
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BCXHDORHMMZBBZ-DORFAMGDSA-N (4r,4ar,7s,7ar,12bs)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;sulfuric acid Chemical compound OS(O)(=O)=O.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC BCXHDORHMMZBBZ-DORFAMGDSA-N 0.000 claims description 6
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RJMIEHBSYVWVIN-LLVKDONJSA-N (2r)-2-[4-(3-oxo-1h-isoindol-2-yl)phenyl]propanoic acid Chemical compound C1=CC([C@H](C(O)=O)C)=CC=C1N1C(=O)C2=CC=CC=C2C1 RJMIEHBSYVWVIN-LLVKDONJSA-N 0.000 claims description 5
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YZLZPSJXMWGIFH-BCXQGASESA-N nalbuphine hydrochloride Chemical compound [H+].[Cl-].C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]1(O)CC[C@@H]3O)CN2CC1CCC1 YZLZPSJXMWGIFH-BCXQGASESA-N 0.000 claims description 5
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230000003000 nontoxic effect Effects 0.000 claims description 4
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230000000977 initiatory effect Effects 0.000 claims description 2
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OQGYMIIFOSJQSF-UHFFFAOYSA-N 22205-05-6 Chemical compound Cl.C1C2=CC=C(O)C=C2C2(C)C(C)C1N(CC=C(C)C)CC2 OQGYMIIFOSJQSF-UHFFFAOYSA-N 0.000 claims 1
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VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 18
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150000001875 compounds Chemical class 0.000 description 14
CPJSUEIXXCENMM-UHFFFAOYSA-N phenacetin Chemical compound CCOC1=CC=C(NC(C)=O)C=C1 CPJSUEIXXCENMM-UHFFFAOYSA-N 0.000 description 14
QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 description 14
238000012360 testing method Methods 0.000 description 14
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CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 12
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DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 description 11
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HYYBABOKPJLUIN-UHFFFAOYSA-N mefenamic acid Chemical compound CC1=CC=CC(NC=2C(=CC=CC=2)C(O)=O)=C1C HYYBABOKPJLUIN-UHFFFAOYSA-N 0.000 description 10
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XADCESSVHJOZHK-UHFFFAOYSA-N Meperidine Chemical group C=1C=CC=CC=1C1(C(=O)OCC)CCN(C)CC1 XADCESSVHJOZHK-UHFFFAOYSA-N 0.000 description 8
229960001395 fenbufen Drugs 0.000 description 8
ZPAKPRAICRBAOD-UHFFFAOYSA-N fenbufen Chemical compound C1=CC(C(=O)CCC(=O)O)=CC=C1C1=CC=CC=C1 ZPAKPRAICRBAOD-UHFFFAOYSA-N 0.000 description 8
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MLKXDPUZXIRXEP-MFOYZWKCSA-N sulindac Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)=O)C=C1 MLKXDPUZXIRXEP-MFOYZWKCSA-N 0.000 description 8
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238000009472 formulation Methods 0.000 description 7
OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 description 7
238000000034 method Methods 0.000 description 7
201000008482 osteoarthritis Diseases 0.000 description 7
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BQNSLJQRJAJITR-UHFFFAOYSA-N 1,1,2-trichloro-1,2-difluoroethane Chemical compound FC(Cl)C(F)(Cl)Cl BQNSLJQRJAJITR-UHFFFAOYSA-N 0.000 description 6
USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical group C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 description 6
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ZWJINEZUASEZBH-UHFFFAOYSA-N fenamic acid Chemical class OC(=O)C1=CC=CC=C1NC1=CC=CC=C1 ZWJINEZUASEZBH-UHFFFAOYSA-N 0.000 description 6
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IDKAXRLETRCXKS-UHFFFAOYSA-N fenclofenac Chemical compound OC(=O)CC1=CC=CC=C1OC1=CC=C(Cl)C=C1Cl IDKAXRLETRCXKS-UHFFFAOYSA-N 0.000 description 1
229950011481 fenclozic acid Drugs 0.000 description 1
RDJGLLICXDHJDY-UHFFFAOYSA-N fenoprofen Chemical compound OC(=O)C(C)C1=CC=CC(OC=2C=CC=CC=2)=C1 RDJGLLICXDHJDY-UHFFFAOYSA-N 0.000 description 1
229960002679 fentiazac Drugs 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000019634 flavors Nutrition 0.000 description 1
235000003599 food sweetener Nutrition 0.000 description 1
229950010931 furofenac Drugs 0.000 description 1
ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
230000002496 gastric effect Effects 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
235000010417 guar gum Nutrition 0.000 description 1
239000000665 guar gum Substances 0.000 description 1
229960002154 guar gum Drugs 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
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230000028993 immune response Effects 0.000 description 1
230000006872 improvement Effects 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
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238000007917 intracranial administration Methods 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
238000011835 investigation Methods 0.000 description 1
229950011455 isoxepac Drugs 0.000 description 1
QFGMXJOBTNZHEL-UHFFFAOYSA-N isoxepac Chemical compound O1CC2=CC=CC=C2C(=O)C2=CC(CC(=O)O)=CC=C21 QFGMXJOBTNZHEL-UHFFFAOYSA-N 0.000 description 1
NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
235000005772 leucine Nutrition 0.000 description 1
RWTWIZDKEIWLKQ-DYWKTHLTSA-N levorphanol tartrate Chemical compound OC(=O)C(O)C(O)C(O)=O.C1C2=CC=C(O)C=C2[C@]23CCN(C)[C@H]1[C@@H]2CCCC3 RWTWIZDKEIWLKQ-DYWKTHLTSA-N 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000008297 liquid dosage form Substances 0.000 description 1
239000003509 long acting drug Substances 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
238000005259 measurement Methods 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
229940013798 meclofenamate Drugs 0.000 description 1
230000003340 mental effect Effects 0.000 description 1
239000002480 mineral oil Substances 0.000 description 1
235000010446 mineral oil Nutrition 0.000 description 1
235000013379 molasses Nutrition 0.000 description 1
230000036651 mood Effects 0.000 description 1
229960004715 morphine sulfate Drugs 0.000 description 1
GRVOTVYEFDAHCL-RTSZDRIGSA-N morphine sulfate pentahydrate Chemical compound O.O.O.O.O.OS(O)(=O)=O.O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O.O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O GRVOTVYEFDAHCL-RTSZDRIGSA-N 0.000 description 1
229940072709 motrin Drugs 0.000 description 1
210000003205 muscle Anatomy 0.000 description 1
229940089466 nalfon Drugs 0.000 description 1
229960000938 nalorphine Drugs 0.000 description 1
229940090008 naprosyn Drugs 0.000 description 1
229960000916 niflumic acid Drugs 0.000 description 1
239000000820 nonprescription drug Substances 0.000 description 1
239000006186 oral dosage form Substances 0.000 description 1
230000000399 orthopedic effect Effects 0.000 description 1
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OFPXSFXSNFPTHF-UHFFFAOYSA-N oxaprozin Chemical compound O1C(CCC(=O)O)=NC(C=2C=CC=CC=2)=C1C1=CC=CC=C1 OFPXSFXSNFPTHF-UHFFFAOYSA-N 0.000 description 1
239000008177 pharmaceutical agent Substances 0.000 description 1
239000005426 pharmaceutical component Substances 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
230000035479 physiological effects, processes and functions Effects 0.000 description 1
239000006187 pill Substances 0.000 description 1
229960000851 pirprofen Drugs 0.000 description 1
PIDSZXPFGCURGN-UHFFFAOYSA-N pirprofen Chemical compound ClC1=CC(C(C(O)=O)C)=CC=C1N1CC=CC1 PIDSZXPFGCURGN-UHFFFAOYSA-N 0.000 description 1
208000030428 polyarticular arthritis Diseases 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
229940072710 ponstel Drugs 0.000 description 1
230000002980 postoperative effect Effects 0.000 description 1
229960003101 pranoprofen Drugs 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
239000000047 product Substances 0.000 description 1
230000000506 psychotropic effect Effects 0.000 description 1
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical group O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
230000002040 relaxant effect Effects 0.000 description 1
238000012552 review Methods 0.000 description 1
238000010079 rubber tapping Methods 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
239000004208 shellac Substances 0.000 description 1
ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
229940113147 shellac Drugs 0.000 description 1
235000013874 shellac Nutrition 0.000 description 1
239000001632 sodium acetate Substances 0.000 description 1
235000017281 sodium acetate Nutrition 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
OGPIIGMUPMPMNT-UHFFFAOYSA-M sodium meclofenamate (anhydrous) Chemical compound [Na+].CC1=CC=C(Cl)C(NC=2C(=CC=CC=2)C([O-])=O)=C1Cl OGPIIGMUPMPMNT-UHFFFAOYSA-M 0.000 description 1
ZJXLSCXDGPDZOL-UHFFFAOYSA-M sodium;2-[5-(4-chlorobenzoyl)-1,4-dimethylpyrrol-2-yl]acetate;dihydrate Chemical compound O.O.[Na+].C1=C(CC([O-])=O)N(C)C(C(=O)C=2C=CC(Cl)=CC=2)=C1C ZJXLSCXDGPDZOL-UHFFFAOYSA-M 0.000 description 1
238000002693 spinal anesthesia Methods 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
238000007619 statistical method Methods 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
229940065721 systemic for obstructive airway disease xanthines Drugs 0.000 description 1
239000003826 tablet Substances 0.000 description 1
229940095374 tabloid Drugs 0.000 description 1
229940066690 talwin Drugs 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
229960001312 tiaprofenic acid Drugs 0.000 description 1
229950002345 tiopinac Drugs 0.000 description 1
229950006150 tioxaprofen Drugs 0.000 description 1
229960002905 tolfenamic acid Drugs 0.000 description 1
YEZNLOUZAIOMLT-UHFFFAOYSA-N tolfenamic acid Chemical compound CC1=C(Cl)C=CC=C1NC1=CC=CC=C1C(O)=O YEZNLOUZAIOMLT-UHFFFAOYSA-N 0.000 description 1
QGUALMNFRILWRA-UHFFFAOYSA-M tolmetin sodium Chemical compound [Na+].C1=CC(C)=CC=C1C(=O)C1=CC=C(CC([O-])=O)N1C QGUALMNFRILWRA-UHFFFAOYSA-M 0.000 description 1
231100000027 toxicology Toxicity 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
230000002792 vascular Effects 0.000 description 1
230000006442 vascular tone Effects 0.000 description 1
239000000052 vinegar Substances 0.000 description 1
235000021419 vinegar Nutrition 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
239000001993 wax Substances 0.000 description 1
239000002023 wood Substances 0.000 description 1
229940075420 xanthine Drugs 0.000 description 1
229950007802 zidometacin Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pain & Pain Management (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

CH1546/84A 1982-07-22 1983-07-21 Koffein enthaltende, analgetische und antiinflammatorische pharmazeutische zubereitung. CH659391A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US40059782A	1982-07-22	1982-07-22

Publications (1)

Publication Number	Publication Date
CH659391A5 true CH659391A5 (de)	1987-01-30

Family

ID=23584242

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH1546/84A CH659391A5 (de)	1982-07-22	1983-07-21	Koffein enthaltende, analgetische und antiinflammatorische pharmazeutische zubereitung.

Country Status (15)

Country	Link
JP (3)	JPS59501459A (fr)
AT (2)	AT389226B (fr)
AU (1)	AU558485B2 (fr)
BE (1)	BE897356A (fr)
CA (1)	CA1217429A (fr)
CH (1)	CH659391A5 (fr)
DE (1)	DE3390116C2 (fr)
FR (1)	FR2530469A1 (fr)
GB (1)	GB2134786B (fr)
IE (1)	IE55367B1 (fr)
IT (1)	IT1206502B (fr)
NL (1)	NL191432C (fr)
SE (1)	SE466481B (fr)
WO (1)	WO1984000488A1 (fr)
ZA (2)	ZA835326B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4559343A (en) *	1982-09-07	1985-12-17	Alcon Laboratories, Inc.	Nonirritating aqueous ophthalmic compositions comfort formulation for ocular therapeutic agents
US4567183A (en) *	1983-03-11	1986-01-28	Analgesic Associates	Analgesic and anti-inflammatory compositions comprising xanthines and methods of using same
US4558051A (en) *	1983-10-11	1985-12-10	Richardson-Vicks, Inc.	Analgesic and anti-inflammatory compositions comprising xanthines and methods of using same
CH664085A5 (de) *	1985-02-08	1988-02-15	Ciba Geigy Ag	Pharmazeutische praeparate mit analgetischer wirksamkeit, sowie deren herstellung.
CH669523A5 (fr) *	1986-06-25	1989-03-31	Mepha Ag
GB8626098D0 (en) *	1986-10-31	1986-12-03	Euro Celtique Sa	Controlled release hydromorphone composition
US20040115290A1 (en)	2001-06-20	2004-06-17	Tripp Matthew L.	Modulation of inflammation by hops fractions and derivatives
JP2005515966A (ja)	2001-07-06	2005-06-02	エンドーファーマシューティカルズ，インコーポレイティド	鎮痛薬としての使用のための６−ヒドロキシ−オキシモルホンの経口投与
DE60223254T2 (de)	2001-07-06	2008-08-14	Penwest Pharmaceuticals Co.	Verzögert freisetzende formulierungen von oxymorphon
US8329216B2 (en)	2001-07-06	2012-12-11	Endo Pharmaceuticals Inc.	Oxymorphone controlled release formulations
US8158160B2 (en)	2001-11-13	2012-04-17	Eric Hauser Kuhrts	Anti-inflammatory cyclooxygenase inhibitors
US7914831B2 (en) *	2004-02-27	2011-03-29	Metaproteomics, Llc	Synergistic anti-inflammatory pharmaceutical compositions and related methods using curcuminoids or methylxanthines
JP2006282644A (ja) *	2005-04-05	2006-10-19	Idemitsu Kosan Co Ltd	疲労回復剤
TW201247195A (en) *	2011-04-28	2012-12-01	Kowa Co	Stable pharmaceutical composition
JP7523879B2 (ja) *	2016-10-31	2024-07-29	エスエス製薬株式会社	医薬組成物
JP2021054728A (ja) *	2019-09-27	2021-04-08	興和株式会社	医薬品
JP6811453B1 (ja) *	2020-06-24	2021-01-13	医療法人すぎやま内科	経皮吸収用組成物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3439094A (en) *	1967-07-20	1969-04-15	Warner Lambert Pharmaceutical	Analgesic compositions containing namol xenyrate,caffeine and acetyl-rho-aminophenol
JPS5423132A (en) *	1977-07-19	1979-02-21	Dai Ichi Seiyaku Co Ltd	Analgesic composition
JPS54154416A (en) *	1978-05-26	1979-12-05	Tdk Electronics Co Ltd	High dielectric constant porcelain composition
US4234601A (en) *	1978-12-18	1980-11-18	Mcneilab, Inc.	Analgesic potentiation
US4237140A (en) *	1979-05-18	1980-12-02	E. I. Du Pont De Nemours And Company	Analgesic mixture of nalbuphine and acetaminophen
US4315936A (en) *	1979-12-17	1982-02-16	Ortho Pharmaceutical Corporation	Analgesic composition
JPS56154416A (en) *	1980-04-30	1981-11-30	Kaken Pharmaceut Co Ltd	Antipyretic analgesic composition
US4322427A (en) *	1981-04-16	1982-03-30	Bristol-Myers Company	Analgetic compositions and methods of use

1983
- 1983-07-21 CA CA000432886A patent/CA1217429A/fr not_active Expired
- 1983-07-21 ZA ZA835326A patent/ZA835326B/xx unknown
- 1983-07-21 FR FR8312109A patent/FR2530469A1/fr active Pending
- 1983-07-21 GB GB08406704A patent/GB2134786B/en not_active Expired
- 1983-07-21 IE IE1715/83A patent/IE55367B1/en not_active IP Right Cessation
- 1983-07-21 DE DE3390116T patent/DE3390116C2/de not_active Expired - Lifetime
- 1983-07-21 NL NL8320240A patent/NL191432C/xx not_active IP Right Cessation
- 1983-07-21 CH CH1546/84A patent/CH659391A5/de not_active IP Right Cessation
- 1983-07-21 JP JP58502643A patent/JPS59501459A/ja active Pending
- 1983-07-21 IT IT8322173A patent/IT1206502B/it active
- 1983-07-21 ZA ZA835324A patent/ZA835324B/xx unknown
- 1983-07-21 WO PCT/US1983/001121 patent/WO1984000488A1/fr not_active Ceased
- 1983-07-21 AU AU18816/83A patent/AU558485B2/en not_active Expired
- 1983-07-21 AT AT0903983A patent/AT389226B/de not_active IP Right Cessation
- 1983-07-21 JP JP58502781A patent/JPS59501460A/ja active Pending
- 1983-07-22 BE BE0/211220A patent/BE897356A/fr unknown
1984
- 1984-03-20 SE SE8401538A patent/SE466481B/sv not_active IP Right Cessation
1988
- 1988-10-05 AT AT0245988A patent/AT389998B/de not_active IP Right Cessation
1994
- 1994-07-18 JP JP6165470A patent/JPH07165583A/ja active Pending

Also Published As

Publication number	Publication date
JPS59501460A (ja)	1984-08-16
FR2530469A1 (fr)	1984-01-27
NL191432C (nl)	1995-07-04
SE8401538D0 (sv)	1984-03-20
AU558485B2 (en)	1987-01-29
ZA835324B (en)	1984-09-26
GB2134786A (en)	1984-08-22
ZA835326B (en)	1984-09-26
IT8322173A0 (it)	1983-07-21
WO1984000488A1 (fr)	1984-02-16
SE466481B (sv)	1992-02-24
NL191432B (nl)	1995-03-01
CA1217429A (fr)	1987-02-03
IT1206502B (it)	1989-04-27
JPH07165583A (ja)	1995-06-27
IE831715L (en)	1984-01-22
NL8320240A (nl)	1984-06-01
GB8406704D0 (en)	1984-04-18
IE55367B1 (en)	1990-08-29
DE3390116C2 (de)	1994-06-16
JPS59501459A (ja)	1984-08-16
BE897356A (fr)	1983-11-14
GB2134786B (en)	1986-05-08
AU1881683A (en)	1984-02-23
AT389226B (de)	1989-11-10
ATA245988A (de)	1989-08-15
AT389998B (de)	1990-02-26
SE8401538L (sv)	1984-03-20
ATA903983A (de)	1989-04-15
DE3390116T1 (de)	1985-01-10

Legal Events

Date	Code	Title	Description
2003-08-15	PL	Patent ceased

Publication	Publication Date	Title
AT389997B (de)	1990-02-26	Verfahren zur herstellung analgetischer und anti-inflammatorischer mittel
AT390878B (de)	1990-07-10	Verfahren zur herstellung einer pharmazeutischen zubereitung unter einsatz eines analgetischen und antiinflammatorischen nichtsteroiden wirkstoffes
DE69006684T2 (de)	1994-06-09	Verwendung einer Zusammensetzung zur Herstellung eines Arzneimittels zur Behandlung der Symptome der Unenthaltsamkeit.
US4486436A (en)	1984-12-04	Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same
DE69434891T2 (de)	2007-07-05	Verwendung von NMDA-Antagonisten zur Behandlung von Schmerzen
DE3854518T2 (de)	1996-02-22	Mischungen gegen husten/erkältungen mit gehalt an nichtsedierenden antihistaminika.
DE69930243T2 (de)	2006-12-07	Behandlung iatrogenen und altersbedingten bluthochdruck mit vitamin b6-derivative, und pharmazeutische zusammensetzungen verwendbar dazu
DE60016602T2 (de)	2005-11-03	Zusammensetzung enthaltend ein tramadol und ein antikonvulsives arzneimittel
DE69805202T2 (de)	2002-12-05	Verwendung von benzhydrylsulfinylderivaten zur behandlung der schläfigkeit medikamentösen ursprungs
DE60132723T2 (de)	2009-01-29	Zusammensetzungen bestehend aus Dipeptidylpeptidase-IV Inhibitoren und Antidiabetica
DE69636413T2 (de)	2007-03-29	Verabreichungsmedium für analgetische, entzündungshemmende und antipyretische wirkstoffe und pharmazeutische zusammensetzungen enthaltend solches medium und wirkstoffe
AT389998B (de)	1990-02-26	Verfahren zur herstellung einer analgetischen und antiinflammatorischen pharmazeutischen zubereitung
DE3390114C2 (fr)	1990-07-05
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