CH678272A5 - - Google Patents

Download PDF

Info

Publication number: CH678272A5
Authority: CH; Switzerland
Prior art keywords: carrier according; medicament; medicament carrier; drug; adr
Prior art date: 1988-10-13

Application number

CH385288A

Other languages

German (de)

English (en)

Inventor

Sumiaki Tsuru

Ichiro Masuno

Original Assignee

Ars Japan Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-13

Filing date

1988-10-14

Publication date

1991-08-30

1988-10-14 Application filed by Ars Japan Kk filed Critical Ars Japan Kk

1991-08-30 Publication of CH678272A5 publication Critical patent/CH678272A5/de

Links

239000003814 drug Substances 0.000 claims description 57
239000002245 particle Substances 0.000 claims description 19
239000000463 material Substances 0.000 claims description 12
239000011148 porous material Substances 0.000 claims description 11
239000001506 calcium phosphate Substances 0.000 claims description 8
235000011010 calcium phosphates Nutrition 0.000 claims description 8
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 8
229910000389 calcium phosphate Inorganic materials 0.000 claims description 6
239000004372 Polyvinyl alcohol Substances 0.000 claims description 4
229920002451 polyvinyl alcohol Polymers 0.000 claims description 4
229920002101 Chitin Polymers 0.000 claims description 3
229920001661 Chitosan Polymers 0.000 claims description 3
WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims description 3
239000011147 inorganic material Substances 0.000 claims description 3
229910010272 inorganic material Inorganic materials 0.000 claims description 2
239000011368 organic material Substances 0.000 claims 2
239000000969 carrier Substances 0.000 claims 1
230000003111 delayed effect Effects 0.000 claims 1
AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 54
229940079593 drug Drugs 0.000 description 38
206010028980 Neoplasm Diseases 0.000 description 26
229940009456 adriamycin Drugs 0.000 description 25
210000001367 artery Anatomy 0.000 description 13
239000000126 substance Substances 0.000 description 12
238000002347 injection Methods 0.000 description 10
239000007924 injection Substances 0.000 description 10
230000000694 effects Effects 0.000 description 8
230000035876 healing Effects 0.000 description 7
229910052586 apatite Inorganic materials 0.000 description 6
VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 6
241000699670 Mus sp. Species 0.000 description 5
239000011575 calcium Substances 0.000 description 4
210000004027 cell Anatomy 0.000 description 4
239000003937 drug carrier Substances 0.000 description 4
230000002401 inhibitory effect Effects 0.000 description 4
238000000034 method Methods 0.000 description 4
102000008186 Collagen Human genes 0.000 description 3
108010035532 Collagen Proteins 0.000 description 3
238000010521 absorption reaction Methods 0.000 description 3
210000004369 blood Anatomy 0.000 description 3
239000008280 blood Substances 0.000 description 3
238000001354 calcination Methods 0.000 description 3
229920001436 collagen Polymers 0.000 description 3
239000000203 mixture Substances 0.000 description 3
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
241000699666 Mus <mouse, genus> Species 0.000 description 2
238000002583 angiography Methods 0.000 description 2
230000000903 blocking effect Effects 0.000 description 2
210000004204 blood vessel Anatomy 0.000 description 2
KIZFHUJKFSNWKO-UHFFFAOYSA-M calcium monohydroxide Chemical compound [Ca]O KIZFHUJKFSNWKO-UHFFFAOYSA-M 0.000 description 2
229910000394 calcium triphosphate Inorganic materials 0.000 description 2
229960004679 doxorubicin Drugs 0.000 description 2
230000008030 elimination Effects 0.000 description 2
238000003379 elimination reaction Methods 0.000 description 2
210000003734 kidney Anatomy 0.000 description 2
210000004185 liver Anatomy 0.000 description 2
208000014018 liver neoplasm Diseases 0.000 description 2
239000011159 matrix material Substances 0.000 description 2
RFWLACFDYFIVMC-UHFFFAOYSA-D pentacalcium;[oxido(phosphonatooxy)phosphoryl] phosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O RFWLACFDYFIVMC-UHFFFAOYSA-D 0.000 description 2
102000004169 proteins and genes Human genes 0.000 description 2
108090000623 proteins and genes Proteins 0.000 description 2
210000001519 tissue Anatomy 0.000 description 2
239000004604 Blowing Agent Substances 0.000 description 1
206010019695 Hepatic neoplasm Diseases 0.000 description 1
206010061218 Inflammation Diseases 0.000 description 1
239000002246 antineoplastic agent Substances 0.000 description 1
239000002981 blocking agent Substances 0.000 description 1
239000002775 capsule Substances 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
210000000170 cell membrane Anatomy 0.000 description 1
229910010293 ceramic material Inorganic materials 0.000 description 1
238000003745 diagnosis Methods 0.000 description 1
238000001035 drying Methods 0.000 description 1
239000000975 dye Substances 0.000 description 1
238000010304 firing Methods 0.000 description 1
238000004108 freeze drying Methods 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
150000004676 glycans Chemical class 0.000 description 1
210000002767 hepatic artery Anatomy 0.000 description 1
206010073071 hepatocellular carcinoma Diseases 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
230000002163 immunogen Effects 0.000 description 1
239000007943 implant Substances 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
230000003993 interaction Effects 0.000 description 1
230000000968 intestinal effect Effects 0.000 description 1
230000000622 irritating effect Effects 0.000 description 1
230000007794 irritation Effects 0.000 description 1
239000003446 ligand Substances 0.000 description 1
201000007270 liver cancer Diseases 0.000 description 1
230000005923 long-lasting effect Effects 0.000 description 1
229920002521 macromolecule Polymers 0.000 description 1
230000003211 malignant effect Effects 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
229940126601 medicinal product Drugs 0.000 description 1
210000001616 monocyte Anatomy 0.000 description 1
210000003205 muscle Anatomy 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
239000000243 solution Substances 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
230000017105 transposition Effects 0.000 description 1
230000001875 tumorinhibitory effect Effects 0.000 description 1
238000002604 ultrasonography Methods 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Engineering & Computer Science (AREA)
Dermatology (AREA)
Inorganic Chemistry (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CH385288A 1988-10-13 1988-10-14 CH678272A5 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19883834944 DE3834944A1 (de)	1988-10-13	1988-10-13	Arzneimittelfreigabevorrichtung

Publications (1)

Publication Number	Publication Date
CH678272A5 true CH678272A5 (da)	1991-08-30

Family

ID=6365078

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH385288A CH678272A5 (da)	1988-10-13	1988-10-14

Country Status (2)

Country	Link
CH (1)	CH678272A5 (da)
DE (1)	DE3834944A1 (da)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1994022423A1 (en) *	1993-04-07	1994-10-13	Bukh Meditec A/S	Drug administration system

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19527306C1 (de) *	1995-07-26	1997-02-27	Haerle Anton	Pharmakafreisetzende Körperchen
AU4011497A (en) *	1996-07-23	1998-02-10	Anton Harle	Pharmaceutical releasing corpuscle
MY133943A (en)	2000-08-22	2007-11-30	Synthes Gmbh	Bone replacement material
AU2003249828B2 (en)	2003-08-08	2007-06-14	Synthes Gmbh	Method for impregnating a porous bone substitute material
AU2004320279A1 (en)	2004-06-03	2005-12-15	Synthes Gmbh	Device for impregnating a porous bone replacement material
US8641667B2 (en)	2005-10-20	2014-02-04	DePuy Synthes Products, LLC	Perfusion device and method

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2807132C2 (de) *	1978-02-20	1983-11-03	Battelle-Institut E.V., 6000 Frankfurt	Implantierbares Pharmaka-Depot
JPS55122710A (en) *	1979-02-13	1980-09-20	Kyocera Corp	Ceramic small granule for drug administration
IE58110B1 (en) *	1984-10-30	1993-07-14	Elan Corp Plc	Controlled release powder and process for its preparation

1988
- 1988-10-13 DE DE19883834944 patent/DE3834944A1/de not_active Ceased
- 1988-10-14 CH CH385288A patent/CH678272A5/de not_active IP Right Cessation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1994022423A1 (en) *	1993-04-07	1994-10-13	Bukh Meditec A/S	Drug administration system

Also Published As

Publication number	Publication date
DE3834944A1 (de)	1990-04-26

Legal Events

Date	Code	Title	Description
1996-06-14	PL	Patent ceased

Publication	Publication Date	Title
DE69531254T2 (de)	2004-07-01	Arzneistofffreisetzendes chirurgisches implantat bzw. pflastermaterial
DE69429507T2 (de)	2002-05-16	Magnetisch reagierende zusammensetzung als träger für biologisch aktive substanzen und verfahren für ihre herstellung und verwendung
DE69423582T2 (de)	2000-09-07	Arzneimittelzusammensetzung mit kontrollierter Wirkstoffabgabe
DE3854656T2 (de)	1996-06-20	Depotimplantat mit gesteuerter Wirkstoffabgabe zur Behandlung von Krankheiten des Nervensystems.
DE69032125T2 (de)	1998-07-02	Gelwundverbandszusammensetzungen und verfahren zu deren gebrauch
DE1642155C3 (de)	1974-05-16	Wundverschlußmittel
DE2645553C2 (de)	1986-11-06	Medikamente enthaltendes Granulat von Serumalbumin
DE3927113C2 (de)	1993-11-25	Mittel zur Behandlung von schweren Schmerzzuständen und Verfahren zu ihrer Herstellung
EP2222327B1 (de)	2017-02-15	Topische anwendung und formulierung von erythropoietin für die wundheilung der haut
DE69829662T2 (de)	2006-02-02	Vorrichtung und verfahren zur wundbehandlung
DE3486448T2 (de)	1997-10-09	Bioadhäsive Mittel
EP1140235B1 (de)	2002-08-28	Fibrinklebergranulat und verfahren zu dessen herstellung
DE69912998T2 (de)	2004-09-02	Herzklappe und verfahren zu herstellung eines biologischen gewebes
DE3415246A1 (de)	1985-01-10	Mittel zum embolisieren von blutgefaessen
EP1124589B1 (de)	2003-01-08	Fibrin-gewebekleber-formulierung und verfahren zu dessen herstellung
DE4200080A1 (de)	1993-09-30	Pharmazeutische Zusammensetzung zur Wund-, Narben- und Keloidbehandlung
CH673774A5 (da)	1990-04-12
AT411326B (de)	2003-12-29	Hämostatische collagen-pellets
US5164186A (en)	1992-11-17	Drug-releaser
DE3586569T2 (de)	1993-02-04	Verband und verfahren zu seiner herstellung.
CH678272A5 (da)	1991-08-30
EP1485120A1 (de)	2004-12-15	Verwendung eines oder mehrerer von plasma und zellwandbestandteilen befreiten natürlichen oder modifizierten sauerstoffbinder zur externen behandlung offener, insbesondere chronischer wunden
DE3240909A1 (de)	1983-05-11	Zubereitung zur wundheilung und verfahren zu ihrer herstellung
DE3826419A1 (de)	1989-02-16	Die wundheilung foerderndes arzneimittelpraeparat und verfahren zu seiner herstellung
DE2412128A1 (de)	1974-10-10	Chirurgischer verband und verfahren zur bildung desselben in situ

CH678272A5 - - Google Patents

Info

Links

Classifications

Landscapes

Applications Claiming Priority (1)

Publications (1)

Family

ID=6365078

Family Applications (1)

Country Status (2)

Cited By (1)

Families Citing this family (6)

Family Cites Families (3)

Cited By (1)

Also Published As

Similar Documents

Legal Events