CH692199A8 - Composes pyridiques et compositions pharmaceutique - Google Patents

Composes pyridiques et compositions pharmaceutique Download PDF

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Publication number
CH692199A8
CH692199A8 CH02364/97A CH236497A CH692199A8 CH 692199 A8 CH692199 A8 CH 692199A8 CH 02364/97 A CH02364/97 A CH 02364/97A CH 236497 A CH236497 A CH 236497A CH 692199 A8 CH692199 A8 CH 692199A8
Authority
CH
Switzerland
Prior art keywords
compounds
pharmaceutical compositions
pyridic
oxydation
dihydropyridines
Prior art date
Application number
CH02364/97A
Other languages
English (en)
Other versions
CH692199A5 (fr
Inventor
Danielle Straumann
Shyam Sunder Dr. Chatterjee
Julio Gomez Alvarez-Builla
Jose Minguez M Ortega
De Casa-Juana Munoz Fau
Original Assignee
Cermol S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cermol S.A. filed Critical Cermol S.A.
Priority to CH02364/97A priority Critical patent/CH692199A8/fr
Priority to ES98945453T priority patent/ES2206989T3/es
Priority to AU92771/98A priority patent/AU747150B2/en
Priority to PCT/IB1998/001555 priority patent/WO1999019302A1/fr
Priority to US09/529,112 priority patent/US6482841B1/en
Priority to CA002306789A priority patent/CA2306789A1/fr
Priority to PT98945453T priority patent/PT1023267E/pt
Priority to DE69818286T priority patent/DE69818286T2/de
Priority to EP98945453A priority patent/EP1023267B1/fr
Priority to AT98945453T priority patent/ATE250034T1/de
Priority to JP2000515875A priority patent/JP2001519415A/ja
Publication of CH692199A5 publication Critical patent/CH692199A5/fr
Publication of CH692199A8 publication Critical patent/CH692199A8/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
CH02364/97A 1997-10-09 1997-10-09 Composes pyridiques et compositions pharmaceutique CH692199A8 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
CH02364/97A CH692199A8 (fr) 1997-10-09 1997-10-09 Composes pyridiques et compositions pharmaceutique
ES98945453T ES2206989T3 (es) 1997-10-09 1998-10-07 Compuestos de piridilo y composiciones farmaceuticas que los contienen.
AU92771/98A AU747150B2 (en) 1997-10-09 1998-10-07 Pyridyl compounds and pharmaceutical compositions containing them
PCT/IB1998/001555 WO1999019302A1 (fr) 1997-10-09 1998-10-07 Composes de pyridyle et compositions pharmaceutiques contenant ces composes
US09/529,112 US6482841B1 (en) 1997-10-09 1998-10-07 Pyridyl compounds and pharmaceutical compositions containing them
CA002306789A CA2306789A1 (fr) 1997-10-09 1998-10-07 Composes de pyridyle et compositions pharmaceutiques contenant ces composes
PT98945453T PT1023267E (pt) 1997-10-09 1998-10-07 Compostos de piridilo e composicoes farmaceuticas que os contem
DE69818286T DE69818286T2 (de) 1997-10-09 1998-10-07 Pyridylverbindungen und diese enthaltende pharmazeutische zubereitungen
EP98945453A EP1023267B1 (fr) 1997-10-09 1998-10-07 Composes de pyridyle et compositions pharmaceutiques contenant ces composes
AT98945453T ATE250034T1 (de) 1997-10-09 1998-10-07 Pyridylverbindungen und diese enthaltende pharmazeutische zubereitungen
JP2000515875A JP2001519415A (ja) 1997-10-09 1998-10-07 ピリジル化合物およびこれを含有した薬剤組成物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH02364/97A CH692199A8 (fr) 1997-10-09 1997-10-09 Composes pyridiques et compositions pharmaceutique

Publications (2)

Publication Number Publication Date
CH692199A5 CH692199A5 (fr) 2002-03-15
CH692199A8 true CH692199A8 (fr) 2002-06-14

Family

ID=4232069

Family Applications (1)

Application Number Title Priority Date Filing Date
CH02364/97A CH692199A8 (fr) 1997-10-09 1997-10-09 Composes pyridiques et compositions pharmaceutique

Country Status (11)

Country Link
US (1) US6482841B1 (fr)
EP (1) EP1023267B1 (fr)
JP (1) JP2001519415A (fr)
AT (1) ATE250034T1 (fr)
AU (1) AU747150B2 (fr)
CA (1) CA2306789A1 (fr)
CH (1) CH692199A8 (fr)
DE (1) DE69818286T2 (fr)
ES (1) ES2206989T3 (fr)
PT (1) PT1023267E (fr)
WO (1) WO1999019302A1 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE267810T1 (de) * 2000-06-08 2004-06-15 Bayer Chemicals Ag Verfahren zur herstellung von pyridinen durch oxidation von dihydropyridinen mittels methylnitrit
DE10115945A1 (de) * 2001-03-30 2002-10-02 Bayer Ag Substituierte 2-Carba-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
US7183410B2 (en) * 2001-08-02 2007-02-27 Bidachem S.P.A. Stable polymorph of flibanserin
US20030060475A1 (en) * 2001-08-10 2003-03-27 Boehringer Ingelheim Pharma Kg Method of using flibanserin for neuroprotection
US10675280B2 (en) 2001-10-20 2020-06-09 Sprout Pharmaceuticals, Inc. Treating sexual desire disorders with flibanserin
UA78974C2 (en) * 2001-10-20 2007-05-10 Boehringer Ingelheim Pharma Use of flibanserin for treating disorders of sexual desire
US20040048877A1 (en) * 2002-05-22 2004-03-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions containing flibanserin
WO2004058711A1 (fr) * 2002-12-30 2004-07-15 Eos Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ticaret A.S. Isolation de derive de dihydropyridine et sels de preparation de celui-ci
MX2007011119A (es) * 2005-03-15 2007-11-14 Lupin Ltd Composiciones farmaceuticas de amlodipino y benazepril.
CA2617546C (fr) 2005-08-03 2014-07-15 Boehringer Ingelheim International Gmbh Utilisation de la flibanserine dans le traitement de l'obesite
WO2007048803A1 (fr) 2005-10-29 2007-05-03 Boehringer Ingelheim International Gmbh Derives de benzimidazolone utiles pour le traitement des troubles premenstruels et d'autres troubles sexuels chez la femme
WO2007099070A1 (fr) * 2006-02-28 2007-09-07 Boehringer Ingelheim International Gmbh Traitement ou prevention de la cardiopathie valvulaire par la flibanserine
BRPI0712039A2 (pt) * 2006-05-09 2011-12-20 Boehringer Ingelheim Int uso de flibanserina para o tratamento de distúrbios de desejo sexual pós-menopausa
WO2008000760A1 (fr) 2006-06-30 2008-01-03 Boehringer Ingelheim International Gmbh Flibansérine dans le traitement de l'incontinence urinaire et des maladies associées
CA2657043A1 (fr) * 2006-07-14 2008-01-17 Boehringer Ingelheim International Gmbh Utilisation de flibanserine pour le traitement de troubles sexuels chez les femmes
CA2660476C (fr) 2006-08-14 2015-11-17 Boehringer Ingelheim International Gmbh Formulations de flibanserine et leur procede de fabrication
CL2007002214A1 (es) 2006-08-14 2008-03-07 Boehringer Ingelheim Int Composicion farmaceutica en la forma de comprimido, donde al menos la longitud del comprimido en el estado anterior de la aplicacion es al menos 7/12 del diametro pilorico del paciente y despues de ingerirlo en estado alimentado, la longitud del comp
WO2008022932A2 (fr) 2006-08-25 2008-02-28 Boehringer Ingelheim International Gmbh Système de libération contrôlée et procédé de préparation correspondant
US8304601B2 (en) * 2007-01-23 2012-11-06 Keiko Fujikawa Mouse model for eye disease
PE20091188A1 (es) * 2007-09-12 2009-08-31 Boehringer Ingelheim Int Compuesto 1-[2-(4-(3-trifluorometil-fenil)piperazin-1-il)etil]-2,3-dihidro-1h-benzimidazol-2-ona (flibanserina), sus sales de adicion y composiciones farmaceuticas que los contienen
EP3408266B1 (fr) * 2016-01-26 2020-11-18 Atatürk Üniversitesi Bilimsel Arastirma Projeleri Birimi N3,n6-bis (2- (5-méthoxy-1h-indol-3-yl)éthyl) -2,6-diméthyl-4-(2-nitrophényle)pyridine -3,5-dicarboxamide et son utilisation dans le domaine de la neurotoxicité
CN109020875B (zh) * 2018-08-27 2020-05-22 北京市药品检验所 二氢吡啶类化合物脱氢芳构化方法及在药品检测中的用途
US12441687B2 (en) * 2019-05-31 2025-10-14 Rdiscovery, LLC Drp1-filamin complex formation inhibitors
CN112457242B (zh) * 2020-12-03 2021-11-23 广州隽沐生物科技股份有限公司 一种拉西地平杂质b的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3209276A1 (de) * 1982-03-13 1983-09-15 Bayer Ag, 5090 Leverkusen Arzneimittel mit antihypoxischer und ischaemie-protektiver wirkung
EP0179239A3 (fr) * 1984-09-17 1986-08-13 Sterling Drug Inc. Acide 7-(pyridinyl)-/-alkyl-1,4-dihydro-4-oxo-3-quinoléine carboxylique ayant une activité antibactérienne et sa préparation
US4698350A (en) * 1984-09-17 1987-10-06 Sterling Drug Inc. 1-ethyl-6-fluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic acid and antibacterial use thereof
CA1312611C (fr) 1987-07-01 1993-01-12 Yamanouchi Pharmaceutical Co., Ltd. Derives pyridine, procede pour leur production et composition pharmaceutique en contenant
GB8905526D0 (en) 1989-03-10 1989-04-19 Fujisawa Pharmaceutical Co N-containing heterocyclic compounds,processes for the preparation thereof and composition comprising the same
DE4200714A1 (de) 1992-01-14 1993-07-15 Bayer Ag Spezieller 1,4-dihydropyridin-3,5-dicarbonsaeureester, verfahren zu seiner herstellung und seine pharmazeutische verwendung
JP3286645B2 (ja) 1993-03-26 2002-05-27 メルシャン株式会社 光学活性１，４−ジヒドロピリジン誘導体およびその製造方法
DE4430639A1 (de) 1994-08-29 1996-03-07 Bayer Ag Verwendung von 5-substituierten Pyridin- und Hexahydrochinolin-3-carbonsäurederivaten
JP4431638B2 (ja) * 1996-01-29 2010-03-17 アメリカ合衆国 ジヒドロピリジン―、ピリジン―、ベンゾピラン―オン―およびトリアゾロキナゾリン誘導体、それらの製造およびそれらのアデノシン受容体アンタゴニストとしての用途

Also Published As

Publication number Publication date
ES2206989T3 (es) 2004-05-16
CA2306789A1 (fr) 1999-04-22
DE69818286T2 (de) 2004-07-01
AU747150B2 (en) 2002-05-09
ATE250034T1 (de) 2003-10-15
DE69818286D1 (de) 2003-10-23
PT1023267E (pt) 2004-01-30
AU9277198A (en) 1999-05-03
US6482841B1 (en) 2002-11-19
JP2001519415A (ja) 2001-10-23
CH692199A5 (fr) 2002-03-15
WO1999019302A1 (fr) 1999-04-22
EP1023267A1 (fr) 2000-08-02
EP1023267B1 (fr) 2003-09-17

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