CL2004000366A1 - USE OF A COMBINATION OF A QUINASA P38 INHIBITING DERIVED COMPOUND OF PIRAZOL, AND AN ACE INHIBITOR TO TREAT RENAL DYSFUNCTION, CARDIOVASCULAR AND VASCULAR DISEASE, RETINOPATHY, NEUROPATIA, EDOTEL, INSOTUNATIO OPINION. - Google Patents

USE OF A COMBINATION OF A QUINASA P38 INHIBITING DERIVED COMPOUND OF PIRAZOL, AND AN ACE INHIBITOR TO TREAT RENAL DYSFUNCTION, CARDIOVASCULAR AND VASCULAR DISEASE, RETINOPATHY, NEUROPATIA, EDOTEL, INSOTUNATIO OPINION.

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Publication number
CL2004000366A1
CL2004000366A1 CL200400366A CL2004000366A CL2004000366A1 CL 2004000366 A1 CL2004000366 A1 CL 2004000366A1 CL 200400366 A CL200400366 A CL 200400366A CL 2004000366 A CL2004000366 A CL 2004000366A CL 2004000366 A1 CL2004000366 A1 CL 2004000366A1
Authority
CL
Chile
Prior art keywords
quinasa
combination
cardiovascular
neuropatia
insotunatio
Prior art date
Application number
CL200400366A
Other languages
Spanish (es)
Inventor
E Rudolph Ricardo Rocha Os Amy
Original Assignee
Pharmacia Corp Sa Organizada B
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp Sa Organizada B filed Critical Pharmacia Corp Sa Organizada B
Publication of CL2004000366A1 publication Critical patent/CL2004000366A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

USO DE UN INHIBIDOR QUINASA p38 (POR EJEMPLO, UN INHIBIDOR DE QUINASA p38 D EPIRAZOL SUSTITUIDO) Y UNA COMBINACION DE UN INHIBIDOR DE QUINASA p38 CON UN INHIBIDOR DE ENZIMA CONVERTIDORA DE ANGIOTENSINA (ACE) UTILES PARA PREPARAR UN MEDICAMENTO PARA TRATAR UNA CONDICION CARDIOVASCULAR, ES DECIR, HIPERTENSION O FALLA CARDIACA O UNA CONDICION ASOCIADA CON UNA CONDICION CARDIOVASCULAR. COMPRENDE TAMBIEN COMPOSICIONES FARMACEUTICAS QUE CONTIENEN LAS ANTEDICHAS COMBINACIONES.USE OF A QUINASA P38 INHIBITOR (FOR EXAMPLE, A QUINASA P38 D EPIRAZOL INHIBITOR REPLACED) AND A COMBINATION OF A QUINASA P38 INHIBITOR WITH AN ANGIOTENSIN CONVERTER ENZYMA INHIBITOR (ACE) TO PREPARATE A MEDICATION THAT IS TO SAY, HYPERTENSION OR HEART FAILURE OR A CONDITION ASSOCIATED WITH A CARDIOVASCULAR CONDITION. UNDERSTAND ALSO PHARMACEUTICAL COMPOSITIONS CONTAINING THE ABOVE COMBINATIONS.

CL200400366A 2003-02-26 2004-02-25 USE OF A COMBINATION OF A QUINASA P38 INHIBITING DERIVED COMPOUND OF PIRAZOL, AND AN ACE INHIBITOR TO TREAT RENAL DYSFUNCTION, CARDIOVASCULAR AND VASCULAR DISEASE, RETINOPATHY, NEUROPATIA, EDOTEL, INSOTUNATIO OPINION. CL2004000366A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45052903P 2003-02-26 2003-02-26

Publications (1)

Publication Number Publication Date
CL2004000366A1 true CL2004000366A1 (en) 2005-01-07

Family

ID=32927663

Family Applications (1)

Application Number Title Priority Date Filing Date
CL200400366A CL2004000366A1 (en) 2003-02-26 2004-02-25 USE OF A COMBINATION OF A QUINASA P38 INHIBITING DERIVED COMPOUND OF PIRAZOL, AND AN ACE INHIBITOR TO TREAT RENAL DYSFUNCTION, CARDIOVASCULAR AND VASCULAR DISEASE, RETINOPATHY, NEUROPATIA, EDOTEL, INSOTUNATIO OPINION.

Country Status (4)

Country Link
US (2) US20040167197A1 (en)
CL (1) CL2004000366A1 (en)
TW (2) TW200508226A (en)
WO (2) WO2004075852A2 (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6979686B1 (en) * 2001-12-07 2005-12-27 Pharmacia Corporation Substituted pyrazoles as p38 kinase inhibitors
WO2005061486A1 (en) * 2003-12-19 2005-07-07 Pharmacia Corporation Crystalline form of 2-{4-‘3-(4-chloro-2-fluorophenyl)-4-pyrimidin-4-yl-1h-pyrazol-5-yl!piperidin-1-yl}-2-oxoethanol
GB0405381D0 (en) * 2004-03-10 2004-04-21 Univ Wales Medicine A method and means for treating heart failure
EP1778686B9 (en) * 2004-08-12 2009-07-08 Pfizer Limited Triazolopyridinylsulfanyl derivatives as p38 map kinase inhibitors
DE602005020462D1 (en) * 2004-08-25 2010-05-20 Essentialis Inc PHARMACEUTICAL FORMULATIONS OF CALIUM ATP CHANNEL OPENERS AND THEIR USES
US20060281791A1 (en) * 2005-04-29 2006-12-14 Children's Medical Center Corporation Methods of increasing proliferation of adult mammalian cardiomyocytes through p38 map kinase inhibition
US7799777B2 (en) 2006-01-05 2010-09-21 Essentialis, Inc. Salts of potassium ATP channel openers and uses thereof
AU2012203517B2 (en) * 2006-01-05 2014-04-24 Soleno Therapeutics, Inc. Salts of potassium ATP channel openers and uses thereof
ES2329419T3 (en) 2006-01-31 2009-11-25 F. Hoffmann-La Roche Ag 7H-PIRIDO (3,4-D) PIRIMIDIN-8-ONAS, ITS PREPARATION AND USE AS INHIBITORS OF KINASE PROTEINS.
US9090604B2 (en) 2006-07-27 2015-07-28 E I Du Pont De Nemours And Company Fungicidal azocyclic amides
WO2008013622A2 (en) * 2006-07-27 2008-01-31 E. I. Du Pont De Nemours And Company Fungicidal azocyclic amides
US8293481B2 (en) * 2006-11-10 2012-10-23 Mayo Foundation For Medical Education And Research Biomarkers for chronic vascular dysfunction
MX2009013176A (en) * 2007-06-05 2011-03-02 Western States Biopharmaceuticals Inc SURFACE MOLECULES INDUCTING T-CELL CITOSINES AND METHODS OF USE.
US20080318909A1 (en) * 2007-06-14 2008-12-25 Sparagna Genevieve C Use Of Linoleic Compounds Against Heart Failure
FR2917975B1 (en) * 2007-06-26 2009-10-16 Ceva Sante Animale Sa COMPOSITIONS AND TREATMENT OF CARDIAC INSUFFICIENCY IN NON-HUMAN MAMMAL ANIMALS
CN101795691A (en) * 2007-07-02 2010-08-04 伊森舍丽斯有限公司 Salts of potassium atp channel openers and uses thereof
JP2010533147A (en) * 2007-07-13 2010-10-21 アデックス ファルマ エス．エイ． Pyrazole derivatives as modulators of metabotropic glutamate receptors
FR2921063B1 (en) * 2007-09-13 2009-12-11 Sod Conseils Rech Applic LIGANDS OF CANNABINOID RECEPTORS
US20090270356A1 (en) * 2008-04-28 2009-10-29 Ceva Sante Animale Sa Compositions and treatments of heart failure in non-human mammal animals
GB0908193D0 (en) 2009-05-13 2009-06-24 Albright Patents Treatment of disease state
AU2009346606B2 (en) 2009-05-20 2016-06-02 Heart Metabolics Limited Treatment of heart failure with normal ejection fraction
TWI730959B (en) 2015-05-19 2021-06-21 英商葛蘭素史克智慧財產發展有限公司 Heterocyclic amides as kinase inhibitors
US10286036B2 (en) 2017-05-12 2019-05-14 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis
US20190224275A1 (en) 2017-05-12 2019-07-25 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis
WO2018224037A1 (en) * 2017-06-09 2018-12-13 南京明德新药研发股份有限公司 Carboxylic acid derivative as at2r receptor antagonist
WO2025254418A1 (en) * 2024-06-03 2025-12-11 동아에스티 주식회사 Crystalline polymorph of aminopyrimidine derivative and preparation method therefor

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1054655B (en) * 1975-08-27 1981-11-30 Lepetit Spa CONDENSED DERIVATIVES OF L ISOKINOLINE
US4105776A (en) * 1976-06-21 1978-08-08 E. R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4046889A (en) * 1976-02-13 1977-09-06 E. R. Squibb & Sons, Inc. Azetidine-2-carboxylic acid derivatives
JPS559058A (en) * 1978-07-06 1980-01-22 Dainippon Pharmaceut Co Ltd 1-(3-mercapto-2-methylpropanoyl)prolyl amino acid derivative
US4175127A (en) * 1978-09-27 1979-11-20 Smithkline Corporation Pyridyl substituted 2,3-dihydroimidazo[2,1-b]thiazoles
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4508729A (en) * 1979-12-07 1985-04-02 Adir Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
ZA817261B (en) * 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
US4470972A (en) * 1981-04-28 1984-09-11 Schering Corporation 7-Carboxyalkylaminoacyl-1,4-dithia-7-azaspiro[4.4]-nonane-8-carboxylic acids
US4337201A (en) * 1980-12-04 1982-06-29 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted prolines
US4410520A (en) * 1981-11-09 1983-10-18 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4623304A (en) * 1981-12-08 1986-11-18 Sanyo Electric Co., Ltd. Hermetically sealed rotary compressor
IE55867B1 (en) * 1981-12-29 1991-02-14 Hoechst Ag New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation
US4555502A (en) * 1982-09-30 1985-11-26 Merck & Co., Inc. Aminoacyl-containing dipeptide derivatives useful as antihypertensives
JPS6058233B2 (en) * 1982-05-24 1985-12-19 田辺製薬株式会社 2-oxoimidazolidine derivative and its production method
US4452790A (en) * 1982-06-23 1984-06-05 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
SU1435151A3 (en) * 1984-04-10 1988-10-30 Санкио Компани Лимитед (Фирма) Method of producing derivatives of perhydrothiazepin or acid-additive pharmaceutically acceptable salts thereof
SE8801423D0 (en) * 1988-04-18 1988-04-18 Dominator Ab PNEUMATIC VALVE FOR CONTROL OF COMPRESSIVE AIR MEMBRANE PUMPS
US5656644A (en) * 1994-07-20 1997-08-12 Smithkline Beecham Corporation Pyridyl imidazoles
IL104369A0 (en) * 1992-01-13 1993-05-13 Smithkline Beecham Corp Novel compounds and compositions
US5593992A (en) * 1993-07-16 1997-01-14 Smithkline Beecham Corporation Compounds
US5670527A (en) * 1993-07-16 1997-09-23 Smithkline Beecham Corporation Pyridyl imidazole compounds and compositions
US5593991A (en) * 1993-07-16 1997-01-14 Adams; Jerry L. Imidazole compounds, use and process of making
US5599984A (en) * 1994-01-21 1997-02-04 The Picower Institute For Medical Research Guanylhydrazones and their use to treat inflammatory conditions
TW440562B (en) * 1994-05-20 2001-06-16 Taiho Pharmaceutical Co Ltd Condensed-indan derivative and pharmaceutically acceptable salts thereof
US6268392B1 (en) * 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US5717100A (en) * 1995-10-06 1998-02-10 Merck & Co., Inc. Substituted imidazoles having anti-cancer and cytokine inhibitory activity
US6083949A (en) * 1995-10-06 2000-07-04 Merck & Co., Inc. Substituted imidazoles having anti-cancer and cytokine inhibitory activity
ZA97175B (en) * 1996-01-11 1997-11-04 Smithkline Beecham Corp Novel substituted imidazole compounds.
US6087496A (en) * 1998-05-22 2000-07-11 G. D. Searle & Co. Substituted pyrazoles suitable as p38 kinase inhibitors
US6514977B1 (en) * 1997-05-22 2003-02-04 G.D. Searle & Company Substituted pyrazoles as p38 kinase inhibitors
PL336990A1 (en) * 1997-05-22 2000-07-31 Searle & Co 3(5)-heteroaryl group substituted pyrazoles as inhibitors of kinase p 38
AU7726898A (en) * 1997-05-22 1998-12-11 G.D. Searle & Co. Pyrazole derivatives as p38 kinase inhibitors
US6093742A (en) * 1997-06-27 2000-07-25 Vertex Pharmaceuticals, Inc. Inhibitors of p38
US6130235A (en) * 1998-05-22 2000-10-10 Scios Inc. Compounds and methods to treat cardiac failure and other disorders
KR20010100986A (en) * 1998-11-06 2001-11-14 로저 에이. 윌리암스 Combination therapy of angiotensin converting enzyme inhibitor and aldosterone antagonist for reducing morbidity and mortality from cardiovascular disease
US6509361B1 (en) * 1999-05-12 2003-01-21 Pharmacia Corporation 1,5-Diaryl substituted pyrazoles as p38 kinase inhibitors
IL161009A0 (en) * 2001-09-25 2004-08-31 Pharmacia Corp Process for making substituted pyrazoles
US6872725B2 (en) * 2001-09-25 2005-03-29 Pharmacia Corporation Solid-state forms of N-(2-hydroxyacetyl)-5-(4-piperidyl)-4-(4-pyrimidinyl)-3-(4-chlorophenyl) pyrazole
US20040082551A1 (en) * 2002-06-05 2004-04-29 Benson Alan G. Novel pyrazoles and their use as p38 kinase inhibitors

Also Published As

Publication number Publication date
TW200500361A (en) 2005-01-01
WO2004075857A2 (en) 2004-09-10
US20040167197A1 (en) 2004-08-26
WO2004075857A3 (en) 2005-08-18
US20050203072A1 (en) 2005-09-15
WO2004075852A2 (en) 2004-09-10
TW200508226A (en) 2005-03-01
WO2004075852A3 (en) 2005-07-28

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