CL2004000574A1 - Proceso para preparar un compuesto 17-espirolactona o la sal de lactona abierta por carbonilacion del correspondiente 17-alquenil o alquinil derivado, los intermediarios que se usan y su proceso de obtencion. - Google Patents

Proceso para preparar un compuesto 17-espirolactona o la sal de lactona abierta por carbonilacion del correspondiente 17-alquenil o alquinil derivado, los intermediarios que se usan y su proceso de obtencion.

Info

Publication number
CL2004000574A1
CL2004000574A1 CL200400574A CL2004000574A CL2004000574A1 CL 2004000574 A1 CL2004000574 A1 CL 2004000574A1 CL 200400574 A CL200400574 A CL 200400574A CL 2004000574 A CL2004000574 A CL 2004000574A CL 2004000574 A1 CL2004000574 A1 CL 2004000574A1
Authority
CL
Chile
Prior art keywords
carbonilation
espirolactone
compound
intermediaries
alquinil
Prior art date
Application number
CL200400574A
Other languages
English (en)
Inventor
S Franczyk Ii Grace M Thaddeus
Original Assignee
Pharmacia Corp Sa Organizada B
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp Sa Organizada B filed Critical Pharmacia Corp Sa Organizada B
Publication of CL2004000574A1 publication Critical patent/CL2004000574A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA LA PREARACION DE UN COMPUESTO ESTEROIDE QUE COMPRENDE UNA 17-ESPIROLACTONA O UNA ESTRUCTURA DE LACTONA ABIERTA CORRESPNDIENTE DE FORMULA 1503 MEDIANTE CARBONILACION DE UN SUSTRATO 17-ALQUENILO O 17-ALQUINILO. SE PUEDE PREPARAR UN INTERMEDIARIO 17-ALQUENILO MEDIANTE SEMI-HIDROGENACION DE UN GRUPO D17-ALQUINILO. COMPRENDE ADEMAS ESQUEMAS ADICIONALES DE REACCION PARA LA PREPARACION DE UN ESTEROIDE 3-CETO-9,11-EPOXI-17-ESPIROLACTONA TAL COMO EPLERENONA. INCLUYE NUEVOS INTERMEDIARIOS Y METODOS PARA FORMAR DICHOS NUEVOS INTERMEDIARIOS, O CONVERTIRLOS EN OTROS INTERMEDIARIOS O PRODUCTOS MEDIANTE SEMI-HIDROGENACION, CARBONILACION 6,7-DESHIDROGENACION, FURILACION U OTRAS TRANSFORMACIONES O COMBINACIONES DE LOS MISMOS.
CL200400574A 2003-03-21 2004-03-19 Proceso para preparar un compuesto 17-espirolactona o la sal de lactona abierta por carbonilacion del correspondiente 17-alquenil o alquinil derivado, los intermediarios que se usan y su proceso de obtencion. CL2004000574A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45671603P 2003-03-21 2003-03-21

Publications (1)

Publication Number Publication Date
CL2004000574A1 true CL2004000574A1 (es) 2005-02-11

Family

ID=33098145

Family Applications (1)

Application Number Title Priority Date Filing Date
CL200400574A CL2004000574A1 (es) 2003-03-21 2004-03-19 Proceso para preparar un compuesto 17-espirolactona o la sal de lactona abierta por carbonilacion del correspondiente 17-alquenil o alquinil derivado, los intermediarios que se usan y su proceso de obtencion.

Country Status (15)

Country Link
US (2) US20060264412A1 (es)
EP (1) EP1606306A2 (es)
JP (1) JP2006520802A (es)
KR (1) KR20050114254A (es)
CN (1) CN1839145A (es)
AR (1) AR043744A1 (es)
AU (1) AU2004223881A1 (es)
BR (1) BRPI0408618A (es)
CA (1) CA2519770A1 (es)
CL (1) CL2004000574A1 (es)
MX (1) MXPA05010011A (es)
RU (1) RU2005132467A (es)
TW (1) TW200505459A (es)
WO (1) WO2004085458A2 (es)
ZA (1) ZA200507351B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1321128C (zh) * 2005-07-15 2007-06-13 浙江医药股份有限公司新昌制药厂 孕甾－4－烯－7，21－二甲酸，9，11－环氧－17－羟基－3－氧代，γ－内酯，甲酯，(7α,11α,17α)－的制备方法
WO2008137050A2 (en) * 2007-05-01 2008-11-13 Sicor Inc. A process for preparing drospirenone and intermediate thereof
WO2009111574A2 (en) * 2008-03-05 2009-09-11 Evestra, Inc. BISMETHYLENE-17α CARBOLACTONES AND RELATED USES
EP2367808A4 (en) * 2008-11-25 2012-05-09 Evestra Inc PROGESTATIVE 3- (6,6-ETHYLENE-17b-HYDROXY-3-OXO-17a-PREGNA-4-EN-17a-YL) PROPIONIC ACID g-LACTONE
US8334375B2 (en) * 2009-04-10 2012-12-18 Evestra, Inc. Methods for the preparation of drospirenone
EP2415778B1 (en) * 2010-08-03 2013-05-15 Newchem S.p.A. Methods for the preparation of Drospirenone and intermediates thereof
AU2012331089A1 (en) * 2011-11-04 2014-05-22 Bayer Intellectual Property Gmbh 18-methyl-6,7-methylene-3-oxo-17-pregn-4-ene-21,17beta-carbolactones, pharmaceutical preparations comprising said compounds and use thereof in the treatment of endometriosis
CN104262450A (zh) * 2014-09-19 2015-01-07 江苏嘉逸医药有限公司 依普利酮的制备及精制方法
US10350223B2 (en) 2015-03-03 2019-07-16 Richard W. Yee Compositions and methods for treating ocular diseases
CN105753930A (zh) * 2016-03-30 2016-07-13 北京万全德众医药生物技术有限公司 依普利酮的一种合成方法
CN107312060B (zh) * 2017-06-26 2019-04-23 淮海工学院 一种制备螺内酯的方法
CN114409726B (zh) * 2022-01-24 2023-07-04 东华大学 桦木醇环烯烃衍生物及其用途和制备方法
CN117624274B (zh) * 2023-10-19 2024-08-27 浙江晟创制药有限公司 一种依普利酮中间体δ9,11-坎利酮的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2888471A (en) * 1955-03-25 1959-05-26 Syntex Sa Process for preparing 17alpha-ethinyl-delta1, 4-androstadiene-17 beta-ol-3-one
SE7801152L (sv) * 1977-02-22 1978-08-23 Roussel Uclaf Sett att framstella 17alfa-acetylen-derivat av androst-4-en
US4270994A (en) * 1980-02-20 1981-06-02 G. D. Searle & Co. Electrochemical dehydrogenation of steroidal Δ3,5 enol ethers under basic conditions to provide steroidal Δ4,6 dienones
US4559332A (en) * 1983-04-13 1985-12-17 Ciba Geigy Corporation 20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof
US5236913A (en) * 1985-07-24 1993-08-17 Akzo N.V. 11-methylene-oestr-15-enes, processes for their preparation, and pharmaceutical compositions
US5276023A (en) * 1989-08-08 1994-01-04 Roussel Uclaf 19-nor-steroid esters
PT973791E (pt) * 1995-12-11 2007-09-26 Searle Llc Processo para a preparação de um composto epoxi
DE19633685C1 (de) * 1996-08-12 1997-10-09 Schering Ag Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens
DK0944644T3 (da) * 1996-12-11 2003-02-03 Searle & Co Fremgangsmåde til fremstilling af 3-keto-7-alfa-alkoxycarbonyl-delta-4,5-steroider og mellemprodukter, som er nyttite derfor
CN1653081A (zh) * 2002-03-22 2005-08-10 法玛西雅公司 甾族化合物的c－17螺甾内酯化和6,7氧化
US7235655B2 (en) * 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone

Also Published As

Publication number Publication date
JP2006520802A (ja) 2006-09-14
BRPI0408618A (pt) 2006-03-07
CN1839145A (zh) 2006-09-27
US20050090663A1 (en) 2005-04-28
WO2004085458A3 (en) 2006-03-16
TW200505459A (en) 2005-02-16
WO2004085458A9 (en) 2006-06-08
RU2005132467A (ru) 2007-04-27
ZA200507351B (en) 2008-04-30
KR20050114254A (ko) 2005-12-05
US20060264412A1 (en) 2006-11-23
AR043744A1 (es) 2005-08-10
EP1606306A2 (en) 2005-12-21
WO2004085458A2 (en) 2004-10-07
MXPA05010011A (es) 2006-05-25
CA2519770A1 (en) 2004-10-07
AU2004223881A1 (en) 2004-10-07

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